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A Positioning System based on Communication Satellites and the Chinese Area Positioning System(CAPS)

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Chinese Journal of Astronomy and Astrophysics 2008年第6期8卷 611-630页

作者： guo-Xiang Ai hu-li Shi Hai-tao Wu Yi-hua yan Yu-Jing Bian Yong-hui hu Zhi-gang li Ji guo Xian-De Cai National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China National Time Service Center Chinese Academy of Sciences Lintong 710600 China

The Chinese Area Positioning System （CAPS） is a positioning system based on satellite communication that is fundamentally different from the 3＂G＂（GPS, GLONASS and GAliLEO） systems. The latter use special-purpose navigation satellites to broadcast navigation information generated on-board to users, while the CAPS transfers ground-generated navigation information to users via the communication satellite. In order to achieve accurate Positioning, Velocity and Time （PVT）, the CAPS employs the following strategies to over- come the three main obstacles caused by using the communication satellite：（a） by real-time following-up frequency stabilization to achieve stable frequency; （b） by using a single carrier in the transponder with 36 MHz band-width to gain sufficient power; （c） by incorporating Decommissioned Geostationary Orbit communication satellite （DGEO）, barometric pressure and Inclined Geostationary Orbit communication satellite （IGSO） to achieve the 3-D posi- tioning. Furthermore, the abundant transponders available on DGEO can be used to realize the large capacity of communication as well as the integrated navigation and communication. With the communication functions incorporated, five new functions appear in the CAPS：（1） combination of navigation and communication; （2） combination of navigation and high accu- racy orbit measurement; （3） combination of navigation message and wide/local area differen- tial processing; （4） combination of the switching of satellites, frequencies and codes; and （5） combination of the navigation message and the barometric altimetry. The CAPS is thereby labelled a PVT5C system of high accuracy. In order to validate the working principle and the performance of the CAPS, a trial system was established in the course of two years at a cost of about 20 million dollars. The trial constellation consists of two GEO satellites located at E87.5° and E110.5°, two DGEOs located at E130° and E142°, as well as barometric altimetry as a virtual s

关键词： astronomy application satellite navigation satellite communication astrometry astronomic technique

A proposed direct measurement of cross section at Gamow window for key reaction 19F(p,α) 16O in Asymptotic Giant Branch stars with a planned accelerator in CJPL

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Science China(Physics,Mechanics & Astronomy) 2016年第5期59卷 76-82页

作者： JianJun He ShiWei Xu ShaoBo Ma Jun hu liYong Zhang ChangBo Fu Ningtao Zhang gang lian Jun Su YunJu li ShengQuan yan yangPing Shen SuQing Hou BaoLu Jia tao Zhang XiaoPeng Zhang Bing guo Shigeru Kubono WeiPing liu Institute of Modern Physics Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy of Sciences Beijing 100049 China Department of Physics Shanghai Jiao Tong University Shanghai 200240 China China Institute of Atomic Energy P. O. Box 275(10) Beijing 102413 China RIKEN Nishina Center 2-1 Hirosawa Wako Saitama 351-0198 Japan

In 2014, the National Natural Science Foundation of China （NSFC） approved the Jinping Underground Nuclear Astrophysics laboratory （JUNA） project, which aims at direct cross-section measurements of four key stellar nuclear reactions right down to the Gamow windows. In order to solve the observed fluorine overabundances in Asymptotic Giant Branch （AGB） stars, measuring the key 19F（p,a）16O reaction at effective burning energies （i.e., at Gamow window） is established as one of the scientific research sub-projects. The present paper describes this sub-project in details, including motivation, status, experimental setup, yield and background estimation, aboveground test, as well as other relevant reactions.

关键词： Jinping Underground Nuclear Astrophysics laboratory (JUNA) direct measurement Gamow window cross section AGBstar nucleosynthesis

A Strigolactone Biosynthesis Gene Contributed to the Green Revolution in Rice

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Molecular Plant 2020年第6期13卷 923-932页

作者： Yuexing Wang lianguang Shang Hong Yu Longjun Zeng Jiang hu Shen Ni Yuchun rao Sanfeng li Jinfang Chu Xiangbing Meng Lei Wang Ping hu Jijun yan Shujing Kang Minghao Qu Hai lin tao Wang Quan Wang Xingming hu Hongqi Chen Bing Wang Zhenyu Gao Longbiao guo Dali Zeng Xudong Zhu guosheng Xiong Jiayang li Qian Qian State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research(Beijing)Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Plant Phenomics Research Center Nanjing Agricultural UniversityNanjing 210095China College of Chemistry and life Sciences Zhejiang Normal UniversityJinhua 321004China

Plant architecture is a complex agronomic trait and a major factor of crop yield,which is affected by several important ***(SLs)are identified as a new class hormoneinhibiting branching in many plant species and have been shown to be involved in various developmental *** and chemical modulation of the SL pathway is recognized as a promising approach to modify plant ***,whether and how the genes involved in the SL pathway could be utilized in breeding still remain ***,we demonstrate that a partial loss-of-function allele of the SL biosynthesis gene,HIGH TILLERING AND DWARF 1/DWARF17(HTD1/D17),which encodes CAROTENOID CLEAVAGE DIOXYGENASE 7(CCD7),increases tiller number and improves grain yield in *** found that the HTD1 gene had been widely utilized and co-selected with Semidwarf 1(SD1),both contributing to the improvement of plant architecture in modern rice varieties since the Green Revolution in the *** how phytohormone pathway genes regulate plant architecture and how they have been utilized and selected in breeding will lay the foundation for developing the rational approaches toward improving crop yield.

关键词： rice strigolactones tiller number Green Revolution

Development of a MWDC prototype of the CSR external-target experiment

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Nuclear Science and Techniques 2024年第10期35卷 121-134页

作者： Zhou-Bo He Zhi Qin Peng Ma He-Run yang Xiang-Lun Wei Chen-Gui Lu Xiang-Jie Wen Xiu-ling Zhang tao Chen Zhi-Jie li Yuan-Sheng yang Mei-Qiang Zhan Can-Wen liu Meng li Tian-li Qiu Yi-Wei Gong Xin-Jie huang Xiao-Hao Yin Zhi-Xuan He Jun-Wei Zhang Hai-Chuan Zou Sheng-Wei Fu Dong guo Jun-Wei yan Zhe Cao Zhi Deng Jie Kong Zhi-gang Xiao Rong-Jiang hu li-Min Duan Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Physics Tsinghua UniversityBeijing 100084China University of Science and Technology of China Hefei 230026China Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China North China University of Water Resources and Electric Power Zhengzhou 450000China

The cooling storage ring(CSR)external-target experiment(CEE)is a spectrometer used in construction to study the properties of nuclear matter in high-baryon density regions at the Heavy-Ion Research Facility in Lanzhou(HIRFL).This study presents the design,simulation,manufacturing,and testing of a half-size prototype of a multi-wire drift chamber(MWDC)for the ***,the performance of the MWDC connected to homemade electronics was *** results demonstrated that an energy resolution of 18.5% for 5.9-keV X-rays and a position resolution of 194μm for protons can be achieved by the current *** the size of the largest MWDC reached 176 cm×314 cm,a set of 98 cm×98 cm prototypes was built using the new *** positioning accuracy of the anode wires in this prototype is better than 20μ*** optimization,using commercially available electronics,the prototype can achieved an energy resolution of 19.7%for a^(55)Fe X-ray *** CEE-MWDC detector and electronics were simultaneously *** energy resolution of 22%was achieved for the^(55)Fe source;the track residuals were approximately 330μm for the cosmic *** results demonstrate that the current design and techniques meet the requirements of the CEE-MWDC array.

关键词： CEE MWDC Garfield++ ^(55)Fe source Position resolution

Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia

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Neuroscience Bulletin 2019年第6期35卷 1102-1105页

作者： liansheng Zhao huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren gang li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao yan liwen Tan Qi Chen Guigang yang Tianlan Lu lifang Wang Fuquan Zhang Jianli yang Keqing li Luxian Lv Qingrong Tan Yinfei li hua Yu Hongyan Zhang Xin Ma Fude yang lingjiang li Chuanyue Wang huiyao Wang Xiaojing li Wanjun guo Xun hu yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen tao li Chinese Antipsychotics Pharmacogenomics Consortium Psychiatric Laboratory and Mental Health Center the State Key Laboratory of BiotherapyWest China Hospital of Sichuan UniversityChengdu 610041China West China Brain Research Center West China Hospital of Sichuan UniversityChengdu 610041China The National Engineering Research Center for Miniaturized Detection Systems College of Life ScienceNorthwest UniversityXi'an 710069China Shaanxi lifegen Co. LtdXi'an 712000China Biomolecular Science Research Centre Sheffield Hallam UniversitySheffield S11WBUK Peking University Sixth Hospital(Institute of Mental Health) Beijing 100083China National Clinical Research Center for Mental Disorders and Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100871China Second Xiangya Hospital Central South UniversityChangsha 410011China Beijing Anding Hospital Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100088China Beijing huiLongGuan Hospital Beijing 102200China Wuxi Mental Health Center Nanjing Medical UniversityWuxi 214121China Institute of Mental Health Tianjin Anding HospitalTianjin 300222China Tianjin Medical University General Hospital Tianjin Medical UniversityTianjin 300052China Hebei Mental Health Center Baoding 071000China Second Affiliated Hospital of Xinxiang Medical University Xinxiang 453003China Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi'an 710032China huaxi Biobank West China Hospital of Sichuan UniversityChengdu 610041China 不详

Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia.

关键词： drugs Dopamine Schizophrenia

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST)

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Research in Astronomy and Astrophysics 2012年第9期12卷 1197-1242页

作者： Xiang-Qun Cui Yong-Heng Zhao Yao-Quan Chu guo-Ping li Qi li li-Ping Zhang Hong-Jun Su Zheng-Qiu Yao Ya-Nan Wang Xiao-Zheng Xing Xin-Nan li Yong-Tian Zhu gang Wang Bo-Zhong Gu A-li Luo Xin-Qi Xu Zhen-Chao Zhang Gen-Rong liu Hao-Tong Zhang De-hua yang Shu-Yun Cao Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Ying Chen Jia-Ru Chu Lei Feng Xue-Fei Gong Yong-hui Hou Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu Lei Jia Fang-hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-hua li yan li Ye-Ping li Guan-Qunliu Zhi-gang liu huo-Ming Shi Zheng-Hong Tang Qing-Sheng tao Xiang-yan Yuan Chao Zhai Jing Zhang yan-Xia Zhang Yong Zhang Ming Zhao Fang Zhou guo-hua Zhou Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China yzhao @ *** Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Tecfinologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

The Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST, also called the guo Shou Jing Telescope) is a special reflecting Schmidt telescope. LAMOST’s special design allows both a large aperture (effective aperture of 3.6 m–4.9 m) and a wide field of view (FOV) (5°). It has an innovative active reflecting Schmidt configuration which continuously changes the mirror’s surface that adjusts during the observation process and combines thin deformable mirror active optics with segmented active optics. Its primary mirror (6.67m×6.05 m) and active Schmidt mirror (5.74m×4.40 m) are both segmented, and composed of 37 and 24 hexagonal sub-mirrors respectively. By using a parallel controllable fiber positioning technique, the focal surface of 1.75 m in diameter can accommodate 4000 optical fibers. Also, LAMOST has 16 spectrographs with 32 CCD cameras. LAMOST will be the telescope with the highest rate of spectral acquisition. As a national large scientific project, the LAMOST project was formally proposed in 1996, and approved by the Chinese government in 1997. The construction started in 2001, was completed in 2008 and passed the official acceptance in June 2009. The LAMOST pilot survey was started in October 2011 and the spectroscopic survey will launch in September 2012. Up to now, LAMOST has released more than 480 000 spectra of objects. LAMOST will make an important contribution to the study of the large-scale structure of the Universe, structure and evolution of the Galaxy, and cross-identification of multiwaveband properties in celestial objects.

关键词： techniques: wide field telescope - active optics - multi fiber - spectroscopy survey - data reduction

Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)

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Cancer Communications 2022年第12期42卷 1314-1330页

作者： Yuankai Shi lin Wu Xinmin Yu Puyuan Xing yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya li Junye Wang Mengzhao Wang Yunpeng liu yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi tao Sun gang Wu Yongqian Shu Qisen guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei li Hongrui Niu Wenwei hu lijun Wang Jianan huang yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao yanqi Wang Luyao Sun Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijingP.R.China Department II of Thoracic Medicine Hunan Cancer HospitalChangshaHunanP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Respiratory Diseases The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China The Third Department of Chemotherapy Weihai Municipal HospitalWeihaiShandongP.R.China Department of Medical Oncology Linyi Cancer HospitalLinyiShandongP.R.China Oncology Department General Hospital of Chinese People’s Liberation ArmyBeijingP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Oncology Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiangP.R.China Department of Medical Oncology Xuzhou Central HospitalXuzhou Medical UniversityXuzhouJiangsuP.R.China Department of Medical Oncology Shanghai Pulmonary HospitalTongji UniversityShanghaiP.R.China Department of Lung Cancer Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityThe Third Clinical Medical CollegeFujian Medical UniversityXiamenFujianP.R.China Department of Medical Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Oncology Affiliated Hospital of Jining Medical UniversityJiningShandongP.R.China Department of Respiratory and Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingP.R.China Department of Medical Oncology Key L

Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are *** study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic ***:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based *** were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance *** primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and ***:Between August 25,2017,and November 7,2018,290 patients were *** FAS,10 patients fromthe docetaxel armwere *** OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;Plimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel *** biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;Plimab treatme

关键词： Non-small cell lung cancer Carcinoma squamous cell Sintilimab Immunotherapy Survival Randomized controlled trial

Data release of the LAMOST pilot survey

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Research in Astronomy and Astrophysics 2012年第9期12卷 1243-1246页

作者： A-li Luo Hao-Tong Zhang Yong-Heng Zhao gang Zhao Xiang-Qun Cui guo-Ping li Yao-Quan Chu Jian-Rong Shi gang Wang Jian-Nan Zhang Zhong-Rui Bai Xiao-yan Chen Feng-Fei Wang yan-Xin guo Jian-Jun Chen Bing Du Xiao Kong Ya-Juan Lei Yin-Bi li Yi-Han Song Yue Wu yan-Xia Zhang Xin-lin Zhou Fang Zuo Peng Du lin He Wen Hou Yi-Qiao Dong Jian li Guang-Wei li Shuang li Jing Song Yuan Tian Meng-Xin Wang Yong-hui Hou Zhi-Ying huo Hong-Zhuan hu Ning-Sheng hu Zhong-Wen hu Lei Jia Fang-hua Jiang Xiang Jiang Zi-Bo Jiang Ge Jin Ai-hua li Qi li Yin-Dun Mao Zheng-Hong Tang Qing-Sheng tao liang-Ping Tu Da-Qing Wang Dan Wang Jian-Ping Wang Lei Wang Shou-Guan Wang Shu-Qing Wang Ya-Nan Wang You Wang Yue-Fei Wang Ming-Zhi Wei Xiang-Xiang Xue Xiao-Zheng Xing ling-Zhe Xu Xin-Qi Xu yan Xu De-hua yang Shi-Hai yang Zheng-Qiu Yao Yong Yu hui Yuan Chao Zhai En-Peng Zhang Jing Zhang li-Ping Zhang WeiZhang Yong Zhang Zhen-Chao Zhang Ming Zhao Fang Zhou Yong-Tian Zhu Jie Zhu Si-Cheng Zou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China lal @ lamost o rg Nanjing Institute of Astronomical Optics and Technology National Astronomical ObservatoriesChinese Academy of Sciences Nanjing 210042 China University of Science and Technologyof China Hefei 230026 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Architecture Design and Research Chinese Academy of Sciences Beijing 100190China

This paper describes the data release of the LAMOST pilot survey, which includes data reduction, calibration, spectral analysis, data products and data access. The accuracy of the released data and the information about the FITS headers of spectra are also introduced. The released data set includes 319 000 spectra and a catalog of these objects.

关键词： techniques: spectroscopic survey — data reduction — data release

Efficacy and safety of sirolimus early conversion protocol in liver transplant patients with hepatocellular carcinoma:A single-arm, multicenter, prospective study

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 106-112页

作者： Ren-Yi Su Sun-Bin ling Qiao-Nan Shan Xu-Yong Wei Rui Wang Chang-Ku Jia li Zhuang Tian Shen li-Min Ding Zhi-Dan Xu Lai-Bang Luo li-Bo Sun Guang-Ming li Tai-Shi Fang Nan Jiang Kun Zhang Zhao-Jie Su Zhi-Hai Peng Ren Lang tao Jiang Qiang He lin-Sen Ye yang yang Yu-Ting He Wen-Zhi guo liu-Gen Lan Xu-Yong Sun Dong Chen Zhi-Shui Chen Da-Wei Zhou Shao-Jun Ye Qi-Fa Ye Min Tian Jian-hua Shi Bo Wang Jiang liu Qian Lu Wei rao Jin-Zhen Cai tao Lv Jia-Yin yang Pu-Sen Wang lin Zhong Jing-Sheng Ma Qi-Gen li Sheng-Dong Wu Chang-Jiang Lu Cai-De Lu Dong-hua Zhang Xuan Wang Zi-Qiang li Mu-Jian Teng Jun-Jie li Wen-tao Jiang Jian-hua li Quan-Bao Zhang Ning-Qi Zhu Zheng-Xin Wang Kang He Qiang Xia Shao-hua Song Zhi-Ren Fu Wei Qiu guo-Yue Lv Rui-Peng Song Ji-Zhou Wang Zheng Wang Jian Zhou gang Chen Ying-Peng Zhao li li Ze-Min hu Qi-Jie Luo Zhong-Zhou Si Bin Xie Xiao-Shun He Zhi-Yong guo Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery The Center for Integrated Oncology and Precision MedicineAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310006China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Transplantation Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang 330006China liver Transplantation Center Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Department of Hepatic Surgery National Clinical Research Center for Infectious DiseaseShenzhen Third People’s HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen 518112China Department of General Surgery Xiang’an Hospital of Xiamen UniversityXiamen 361000China Deartment of Hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Hepatic Surgery and liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of liver Transplantation The Second Affiliated Hospital of Guangxi Medical UniversityNanning 530000China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Hepatobiliary Diseases of Wuhan University Transplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationZhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Hepatobiliary Surgery The First Affiliated Hos

Mammalian target of rapamycin(m TOR) inhibitor as an attractive drug target with promising antitumor effects has been widely investigated. High quality clinical trial has been conducted in liver transplant(LT) recipients in Western countries. However, the pertinent studies in Eastern world are paucity. Therefore, we designed a clinical trial to test whether sirolimus can improve recurrence-free survival(RFS) in hepatocellular carcinoma(HCC) patients beyond the Milan criteria after LT. This is an open-labeled, single-arm, prospective, multicenter, and real-world study aiming to evaluate the clinical outcomes of early switch to sirolimus-based regimens in HCC patients after LT. Patients with a histologically proven HCC and beyond the Milan criteria will be enrolled. The initial immunosuppressant regimens are center-specifc for the frst 4-6 weeks. The following regimens integrated sirolimus into the regimens as a combination therapy with reduced calcineurin inhibitors based on the condition of patients and centers. The study is planned for 4 years in total with a 2-year enrollment period and a 2-year follow-up. We predict that sirolimus conversion regimen will provide survival benefts for patients particular in the key indicator RFS as well as better quality of life. If the trial is conducted successfully, we will have a continued monitoring over a longer follow-up time to estimate indicator of overall survival. We hope that the outcome will provide better evidence for clinical decision-making and revising treatment guidelines based on Chinese population data.

关键词： Sirolimus Immunosuppressive agents Hepatocellular carcinoma liver transplantation Conversion