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Significance of serum glucagon-like peptide-1 and matrix Gla protein levels in patients with diabetes and osteoporosis

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World Journal of Clinical Cases 2022年第5期10卷 1527-1535页

作者： Fei-Fei Xie Yu-fang Zhang yan-fang hu Yun-Yun Xie Xiao-Ying Wang Shu-Zhen Wang Bao-Qiang Xie Department of Endocrinology Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Osteoporosis is a systemic bone disease characterized by decreased bone mass,impaired bone mass,and reduced bone strength that leads to increased bone fragility and *** 2 diabetes mellitus(T2DM)complicated with osteoporosis is a common systemic metabolic bone disease,and reduced bone mass and bone strength are considered the main clinical features;however,the pathogenesis of this disease has not been fully *** occurrence is considered related to sex,age,and genetic *** are many risk factors for diabetes complicated with ***,exploring these risk factors will help prevent *** To investigate the relationships among serum glucagon-like peptide-1(GLP-1)levels,matrix Gla protein(MGP)levels,and diabetes with *** Sixty patients with T2DM complicated with osteoporosis confirmed by the endocrinology department of our hospital were selected as the case *** T2DM patients with bone loss were selected as the control *** healthy participants were selected as the healthy *** general data,bone mineral density index,and bone metabolic markers of the three groups were *** relationships among GLP-1 levels,MGP levels,and the bone mineral density index of the case group were analyzed using linear correlation analysis and a logistic regression *** Differences in sex,smoking,and drinking among the case group,control group,and healthy group were not statistically significant(P>0.05).The mean age of the case group was older than those of the control and healthy groups(P<0.05).The body mass index,fasting plasma glucose level,HbA1c level,hypertension rate,and coronary heart disease rate of the case and control groups were higher than those of the healthy group(P<0.05).The serum GLP-1 and MGP levels of the case group were lower than those of the control and healthy groups;these differences were statistically significant(P<0.05).The serum GLP-1 and MGP levels of the control gr

关键词： Glucagon-like peptide-1 Matrix Gla protein Diabetes mellitus Osteoporosis Bone mineral density Systemic bone disease

New correction method for controlled-source electromagnetics source effects

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Transactions of Nonferrous Metals Society of China 2020年第12期30卷 3356-3366页

作者： Bo YUAN Di-quan LI yan-fang hu Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring of Ministry of Education(Central South University) Changsha 410083China hunan Key Laboratory of Non-ferrous and Geological Hazard Detection Changsha 410083China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China

A novel method for source effect correction based on integral equation method is *** taking the electrical horizontal field Ex of current source as an example,the correction method is validated using both simulated data and field *** results show that the correction method is feasible and effective for isotropic *** the field data are processed,the correction method normalizes the sources with different geological structures,which eliminates the geological difference among sources,and retains the geological difference among *** correction results are in line with the expectation in whole.

关键词： source effect controlled-source electromagnetics source overprint effect shadow effect

Application of pseudo-random frequency domain electromagnetic method in mining areas with strong interferences

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Transactions of Nonferrous Metals Society of China 2020年第3期30卷 774-788页

作者： yan-fang hu Di-quan LI Bo YUAN Guang-yun SUO Zi-jie LIU Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationCentral South UniversityChangsha 410083China hunan Key Laboratory of Nonferrous and Geological Hazard Detection Control South UniversityChangsha 410083China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China Research Institute No.230 CNNCChangsha 410011China

Due to the strong electromagnetic interferences and human interference,traditional electromagnetic methods cannot obtain high quality resistivity data of mineral deposits in Chinese *** wide field electromagnetic method(WFEM),in which the pseudo-random signal is taken as the transmitter source,can extract high quality resistivity data in areas with sever interference by only measuring the electric field *** use the WFEM to extract the resistivity information of the Dongguashan mine in southeast *** with the audio magnetotelluric(AMT)method,and the controlled source audio-frequency magnetotelluric(CSAMT) method,the WFEM can obtain data with higher quality and simpler *** inversion results indicate that the WFEM can accurately identify the location of the main ore-body,which can be used for deep mine exploration in areas with strong interference.

关键词： pseudo-random signal frequency domain electromagnetic method wide field electromagnetic method(WFEM) strong interference anti-interference capability Dongguashan copper deposit

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2015年版《中国药典》澄清度检查法研究

中国药学杂志 2017年第9期52卷 802-808页

作者：常艳余方键胡昌勤中国食品药品检定研究院北京100050

目的探讨2015年版《中国药典》通则0902澄清度第二法(浊度仪法)测定中出现问题的成因并提出解决方案。方法 2015年版《中国药典》和现行版《欧洲药典》澄清度检查第二法。结果由于浊度仪法的分辨力远高于目测法,当浊度标准原液吸光度符... 详细信息

目的探讨2015年版《中国药典》通则0902澄清度第二法(浊度仪法)测定中出现问题的成因并提出解决方案。方法 2015年版《中国药典》和现行版《欧洲药典》澄清度检查第二法。结果由于浊度仪法的分辨力远高于目测法,当浊度标准原液吸光度符合要求时(A=0.12~0.15),由其稀释配制的各级号标准液的浊度示值均成区间分布。因此,在实际工作中可出现采用第二法测定难以判断供试品是否符合规定的情况。结论本实验对上述两国药典澄清度检查法中的诸操作环结进行了系统比较,发现浊度标准液配制方法的差异,导致《中国药典》各浊度标准液的浊度值约为欧洲药典对应浊度值的75%。

关键词：澄清度仪器分析法限度合格判断 2015年版《中国药典》

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao fang Qiuxia Peng Wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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关于黑曲霉生产纤维二糖酶发酵条件的研究

四川大学学报（自然科学版） 2002年第5期39卷 938-942页

作者：孟勇王忠彦苗艳芳胡承四川大学生命科学院成都610064

作者通过单因子及正交试验 ,研究了C源、N源、磷酸盐及吐温 80对纤维二糖酶产量的影响 ,并对温度、时间、pH值和培养基含水量等培养条件进行优化 ,使黑曲霉生产纤维二糖酶的酶活量由 *** / g增至 90 8.2U/ g ,提高了 16 5 % .

关键词：黑曲霉纤维二糖酶发酵条件单因子试验正交试验发酵生产碳源氮源

High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen fang huang Lijie Mao Zhimin Zhang Han Lin Qixin yan Xiangyu Lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

Computed tomography enterography-based radiomics for assessing mucosal healing in patients with small bowel Crohn's disease

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World Journal of Gastroenterology 2025年第3期31卷 62-72页

作者： Hao Ding Yuan-Yuan fang Wen-Jie Fan Chen-Yu Zhang Shao-Fei Wang Jing hu Wei Han Qiao Mei Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Radiation Oncology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Gastroenterology Suzhou First People's HospitalSuzhou 234099Anhui ProvinceChina

BACKGROUND Mucosal healing(MH)is the major therapeutic target for Crohn's disease(CD).As the most commonly involved intestinal segment,small bowel(SB)assessment is crucial for CD ***,it poses a significant challenge due to its limited accessibility through conventional endoscopic *** To establish a noninvasive radiomic model based on computed tomography enterography(CTE)for MH assessment in SBCD *** Seventy-three patients diagnosed with SBCD were included and divided into a training cohort(n=55)and a test cohort(n=18).Radiomic features were obtained from CTE images to establish a radiomic *** demographics were analysed to establish a clinical model.A radiomic-clinical nomogram was constructed by combining significant clinical and radiomic *** diagnostic efficacy and clinical benefit were evaluated via receiver operating characteristic(ROC)curve analysis and decision curve analysis(DCA),*** Of the 73 patients enrolled,25 patients achieved *** radiomic-clinical nomogram had an area under the ROC curve of 0.961(95%confidence interval:0.886-1.000)in the training cohort and 0.958(0.877-1.000)in the test cohort and provided superior clinical benefit to either the clinical or radiomic models alone,as demonstrated by *** These results indicate that the CTE-based radiomic-clinical nomogram is a promising imaging biomarker for MH and serves as a potential noninvasive alternative to enteroscopy for MH assessment in SBCD patients.

关键词： Crohn’s disease Computed tomography enterography Mucosal healing Nomogram Radiomics