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PCDH17 restricts dendritic spine morphogenesis by regulating ROCK2-dependent control of the actin cytoskeleton,modulating emotional behavior

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Zoological Research 2024年第3期45卷 535-550页

作者： Laidong Yu fangfang Zeng Mengshu fan Kexuan Zhang Jingjing Duan Yalu Tan Panlin Liao Jin Wen Chenyu Wang Meilin Wang Jialong Yuan Xinxin Pang yan Huang yangzhou Zhang Jia-Da Li Zhuohua Zhang Zhonghua Hu Hunan Key Laboratory of Molecular Precision Medicine Department of Critical Care MedicineXiangya HospitalCentral South UniversityChangshaHunan 410008China Center for Medical Genetics and Hunan Key Laboratory of Medical Genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Provincial Clinical Research Center for Critical Care Medicine Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Animal Models for Human diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China MOE Key Lab of Rare Pediatric diseases School of Life SciencesCentral South UniversityChangshaHunan 410008China Department of Neurosciences University of South China Medical SchoolHengyangHunan 421001China

Proper regulation of synapse formation and elimination is critical for establishing mature neuronal circuits and maintaining brain *** abnormalities,such as defects in the density and morphology of postsynaptic dendritic spines,underlie the pathology of various neuropsychiatric *** 17(PCDH17)is associated with major mood disorders,including bipolar disorder and ***,the molecular mechanisms by which PCDH17 regulates spine number,morphology,and behavior remain *** this study,we found that PCDH17 functions at postsynaptic sites,restricting the number and size of dendritic spines in excitatory *** overexpression of PCDH17 in the ventral hippocampal CA1 results in spine loss and anxiety-and depression-like behaviors in ***,PCDH17 interacts with actin-relevant proteins and regulates actin filament(F-actin)***,PCDH17 binds to ROCK2,increasing its expression and subsequently enhancing the activity of downstream targets such as LIMK1 and the phosphorylation of cofilin serine-3(Ser3).Inhibition of ROCK2 activity with belumosudil(KD025)ameliorates the defective F-actin organization and spine structure induced by PCDH17 overexpression,suggesting that ROCK2 mediates the effects of PCDH17 on F-actin content and spine ***,these findings reveal a novel mechanism by which PCDH17 regulates synapse development and behavior,providing pathological insights into the neurobiological basis of mood disorders.

关键词： Synapse development Dendritic spine Mood disorder Actin cytoskeleton Animal behavior

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Thirty Years of Experience of Acute Flaccid Paralysis Surveillance for Polio — China, 1993–2022

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China CDC weekly 2024年第16期6卷 344-349页

作者： Hong yang Ning Wen Chunxiang fan Fuzhen Wang Yong Zhang Lei Cao Shuangli Zhu Lixin Hao Dongmei yan Lei Wang Quanwei Song Miao Wang Yifan Song Chao Ma Zhijie An Lance ERodewald Huaqing Wang Zundong Yin National Key Laboratory of Intelligent Tracking and Forecasting for Infectious diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina Institute for Viral disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Detecting poliovirus infections proves to be highly challenging due to their asymptomatic nature and infectious potential,highlighting the crucial importance of effective detection methods in the context of polio eradication *** many countries,including China,the primary approach for identifying polio outbreaks has been through acute flaccid paralysis(AFP)*** this study,we conducted an evaluation spanning three decades(1993–2022)to assess the effectiveness of AFP surveillance in ***:Data on all AFP cases identified since 1993 and national-level AFP surveillance system quality indicators aligned with the World Health Organization(WHO)standards were collected for *** quality indicators assess surveillance sensitivity,completeness,timeliness of detection notification,case investigation,and laboratory *** sensitivity is determined by the non-polio AFP(NPAFP)detection rate among children under 15 years of ***:Between 1993 and 2022,a total of 150,779 AFP cases were identified and *** this pool,surveillance identified 95 cases of wild poliovirus(WPV)and 24 cases due to vaccinederived *** 1995 onwards,the detection rate of NPAFP cases consistently adhered to the WHO and national standards of≥1 case per 100,000,falling between 1.38 and *** in 1997,all timeliness indicators consistently achieved the criteria of 80%,apart from the consistency in meeting standards set for the rate of positive specimens sent to the national ***:AFP surveillance has been instrumental in China’s accomplishment of maintaining a polio-free *** ongoing adherence to key performance indicators,ensuring sensitivity and prompt specimen collection,demonstrates that AFP surveillance is proficient in detecting poliovirus in *** we move into the post-eradication phase,AFP surveillance remains crucial for the sustained absence of polioviruses in the long term.

关键词： sustained prompt surveillance

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Application of Structured Health Education and Combined 5A Nursing Model in Self-control of Vulnerable Chronic diseases: Take Coronary Heart disease as an Example

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Journal of Clinical and Nursing Research 2024年第6期8卷 206-213页

作者： fan Li Shun Yuan Chen Zhang yan Li Qun Kong Qingjun ding Qilu Institute of Technology Jinan 250200China

Objective:To explore the intervention effect of the Structured Health Education course and 5A nursing model for self-control of elderly patients with coronary heart ***:Using the random sampling method,124 elderly CAD patients admitted to the First Affiliated Hospital of Bengbu Medical University were randomly divided into an experimental group and a control *** control group line routine health education,experimental group take structured health education combined with 5A nursing before and after the intervention using a coronary heart disease assessment questionnaire,coronary heart disease self-control scale evaluation of two groups of intervention,compare two groups before and after intervention blood pressure,blood sugar,body mass index,lipid index level and complications within 8 months after ***:After the course intervention,the disease cognition and self-behavior of the experimental group were higher than that of the control group,and the differences were statistically significant(all P<0.1).Conclusion:This course is suitable for elderly patients with coronary heart *** 5A model improves the cognitive and management ability of elderly patients to a certain extent,which is worthy of clinical application.

关键词： Old age Coronary heart disease Self-control Structured health education 5A nursing

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机械设计与低温锂电池全流程数字化智能制造的联系及应用

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储能科学与技术 2024年第7期13卷 2486-2488页

作者：范龙张研黄河水利职业技术学院机械工程学院河南开封475004

随着现代制造技术、信息技术和数字化技术的飞速发展,低温锂电池生产迎来了技术升级。对此本文综述了机械设计与低温锂电池数字化智能制造的联系以及技术优化进展。首先分析了低温锂电池产业数字化、智能化的发展流程,包括低温锂电池数... 详细信息

随着现代制造技术、信息技术和数字化技术的飞速发展,低温锂电池生产迎来了技术升级。对此本文综述了机械设计与低温锂电池数字化智能制造的联系以及技术优化进展。首先分析了低温锂电池产业数字化、智能化的发展流程,包括低温锂电池数字化制造和二阶段的智能化制造;然后重点探讨了机械设计为低温锂电池数字化智能制造产业带来的优化变革。从产业发展角度来看,与机械设计技术深度融合,可以从多个方面优化现有的低温锂电池数字化智能制造技术,对后者的产业结构调整和技术升级具有重要的指导作用。

关键词：机械设计数字化制造智能制造技术融合

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Unveiling of Terahertz Emission from Ultrafast Demagnetization and the Anomalous Hall Effect in a Single Ferromagnetic Film

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Chinese Physics Letters 2024年第4期41卷 45-50页

作者：蓝志强李章顺徐浩然刘凡金钻明彭滟朱亦鸣 Terahertz Technology Innovation Research Institute Terahertz Spectrum and Imaging Technology Cooperative Innovation CenterShanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China

Using THz emission spectroscopy,we investigate the elementary spin dynamics in ferromagnetic single-layer Fe on a sub-picosecond *** demonstrate that THz radiation changes its polarity with reversal of the magnetization applied by the external magnetic *** addition,it is found that the sign of THz polarity excited from different sides is defined by the thickness of the Fe layer and Fe/dielectric *** on the thickness and symmetry dependences of THz emission,we experimentally distinguish between the two major contributions:ultrafast demagnetization and the anomalous Hall *** experimental results not only enrich understanding of THz electromagnetic generation induced by femtosecond laser pulses but also provide a practical way to access laser-induced ultrafast spin dynamics in magnetic structures.

关键词： magnetic magnetization polarity

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Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of yangqing Chenfei formula(养清尘肺方) for the treatment of silicosis

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Journal of Traditional Chinese Medicine 2024年第4期44卷 784-793页

作者： HU Yuanyuan LIU Xinguang ZHAO Peng WU Jinyan yan Xinhua HOU Runsu WANG Xiangcheng yanG fan TIAN Xinrong LI Jiansheng Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200032China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory diseases by Henan and Education Ministry of P.R.China.Zhengzhou 450046China Henan Key Laboratory of Chinese Medicine for Respiratory disease Henan University of Chinese MedicineZhengzhou 450046China

OBJECTIVE:To explore the mechanisms of yangqing Chenfei formula(养清尘肺方,YCF)in the treatment of silicosis through a comprehensive strategy consisting of serum pharmacochemistry,network pharmacology analysis,and in vitro ***:An ultrahigh-performance liquid chromatography-tandem mass spectrometry method was used to confirm the active components in YCF-medicated ***,we obtained targets for active components and genes for silicosis from multiple ***,a protein-protein interaction network was constructed,and Kyoto Encyclopedia of Genes and Genomes pathway and biological process analyses were conducted to elucidate the mechanisms of YCF for the treatment of ***,we validated the important components and mechanisms in ***:Altogether,19 active components were identified from rat serum after YCF *** identified 724 targets for 19 components,which were mainly related to inflammation[phosphatidy linositol 3 kinase/protein kinase B,forkhead box O,hypoxia inducible factor,and T-cell receptor signaling pathway,nitric oxide biosynthetic process],fibrotic processes[vascular endothelial growth factor signaling pathway,extracellular signal regulated kinase(ERK)1 and ERK2 cascade,smooth muscle cell proliferation],and apoptosis(negative regulation of apoptotic process).In addition,218 genes for silicosis were identified and were mainly associated with the inflammatory response and immune process[cytokine-cytokine receptor interaction,tumor necrosis factor alpha(TNF-α),toll-like receptor,and nucleotide binding oligomerization domain-like receptor signaling pathway].Taking an intersection of active component targets and silicosis genes,we obtained 61 common genes that were mainly related to the inflammatory response and apoptosis,such as the phosphatidylinositol-3-kinase/protein kinase B signaling pathway,mitogen activated protein kinases signaling pathway,TNF signaling pathway,toll-like receptor signaling pathway,b

关键词： silicosis network treatment

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1990年以来柴达木盆地小柴旦湖扩张及影响分析

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湖泊科学 2024年第3期36卷 927-938页

作者：祝存兄樊启顺严应存校瑞香青海省防灾减灾重点实验室西宁810001 青海省气象科学研究所西宁810001 中国科学院青海盐湖研究所盐湖资源绿色高值利用重点实验室西宁810008 青海省盐湖地质与环境重点实验室西宁810008

柴达木盆地盐湖对维系区域生态平衡、保障农业安全和国民经济发展具有重要的作用。受青藏高原气候暖湿化影响,盆地湖泊格局发生了一系列变化。为分析盆地盐湖变化特征,本文以小柴旦湖为例,基于长时间序列卫星数据,利用随机森林法提取盐... 详细信息

柴达木盆地盐湖对维系区域生态平衡、保障农业安全和国民经济发展具有重要的作用。受青藏高原气候暖湿化影响,盆地湖泊格局发生了一系列变化。为分析盆地盐湖变化特征,本文以小柴旦湖为例,基于长时间序列卫星数据,利用随机森林法提取盐湖水域范围并解构、评估“点—线—面”形态变化,同时构建矿化度指数表征盐湖资源禀赋。结果表明:(1)1990—2022年小柴旦湖面积呈“缓减—缓增—快增”的阶段性变化特征,岸线长度呈阶段性变化(2016年后增长明显),湖泊质心总体向西北方向迁移,截止2022年湖泊质心累计迁移距离为2363.49 m。(2)1990—2022年矿化度指数波动下降,呈“淡化”态势。(3)气象数据显示研究区年平均气温升高、年降水量增多、年潜在蒸散量下降,处于暖湿化轻度转型期,降水增多、蒸发下降、增温引起的冰雪融水增加综合叠加效应引起区域水资源增加,进而导致湖泊扩张和“淡化”。(4)小柴旦湖扩张和“淡化”对社会经济和生态平衡影响明显,一方面,影响湖区周边基础设施,近70 km^(2)区域受淹没直接影响,包括德小高速公路、柳格高速公路部分路段;另一方面,作为资源型湖泊,小柴旦湖盐湖矿产资源开发利用潜力下降,“淡化”或将引起湖泊生态系统失衡。(5)未来应适当调整小柴旦湖开发利用方向,挖掘“雪山—荒漠—盐湖—湿地—公路”视觉多元化立体景观资源,平衡盐湖“资源”与“生态”属性。本研究从湖泊动态变化研究的视角,结合多种方法开展了有益的尝试,分析结果可为柴达木盆地盐湖资源和生态环境保护及基础设施建设提供决策支撑。

关键词：盐湖卫星遥感随机森林质心矿化度小柴旦湖

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制冷机房顶部楼板与管道振动分析及控制设计

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噪声与振动控制 2024年第4期44卷 258-265页

作者：陈頔韩梦涛王凡嵇严胡小明中信建筑设计研究总院有限公司武汉430014 华中科技大学建筑与城市规划学院武汉430074

制冷机房内通常设置有多台制冷主机和循环水泵,当机房位于噪声敏感房间正下方时,对上方区域产生的噪声和振动影响不容忽视。针对某办公建筑内制冷机房上方楼板产生的振动与噪声问题开展分析研究,首先对振源进行诊断,然后进行改造,设计... 详细信息

制冷机房内通常设置有多台制冷主机和循环水泵,当机房位于噪声敏感房间正下方时,对上方区域产生的噪声和振动影响不容忽视。针对某办公建筑内制冷机房上方楼板产生的振动与噪声问题开展分析研究,首先对振源进行诊断,然后进行改造,设计管道隔振支座,最后对比改造前、后的测试数据。改造后办公室内背景噪声和振动加速度均方根值达到国家规范标准,隔振支座隔振效率良好,使原有的振动与噪声问题得到解决。该项目结果表明:当制冷机房上方为噪声敏感房间时,管道吊架不宜与楼板直接连接,应该将吊架通过隔振系统连接在梁、柱上或设置管道落地隔振支座;为保证立柱的稳定性,应将所有立柱连接起来形成系统。研究成果可为制冷机房内管道的隔振降噪提供一种效果良好的方式。

关键词：振动与波制冷机房楼板管道隔振支座降噪

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纤维素在亚/超临界甲醇中液化条件对主要化合物产物的影响

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燃料化学学报 2017年第6期45卷 660-668页

作者：孙娇王娅莉解新安黎巍李璐李雁樊荻魏星华南农业大学食品学院广东广州510642

在反应温度240-320℃、甲醇用量0-200 mL、反应时间0-200 min的条件下,采用间歇式高温高压反应釜对玉米秸秆纤维素在亚/超临界甲醇中进行液化实验,结合GC-MS分析,研究不同液化反应条件下,生物油中轻油、重油产率及液化产物中烃类、醇类... 详细信息

在反应温度240-320℃、甲醇用量0-200 mL、反应时间0-200 min的条件下,采用间歇式高温高压反应釜对玉米秸秆纤维素在亚/超临界甲醇中进行液化实验,结合GC-MS分析,研究不同液化反应条件下,生物油中轻油、重油产率及液化产物中烃类、醇类、酯类、酸类等主要化合物的组分分布及其变化规律。结果表明,反应温度和甲醇用量对化合物的分布与含量影响较大,反应温度和甲醇用量增加,促进纤维素向烃类、醇类、酯类转化,各化合物含量随之增加,并使轻油、重油产率升高,当反应条件为:甲醇用量160 mL,温度320℃,反应时间30 min时,生物油产率达到最高25.1%。生物油中组分含量顺序为:烃类>醇类>酯类>酸类,各化合物最高相对含量分别为77.2%、19.0%、30.9%、20.8%。初步分析发现,随着温度的升高和甲醇量的增加,自由基活性逐渐增强,当甲醇用量超过160 mL、温度超过300℃时,醇类以及酯类等化合物进一步发生氧化、缩合等反应形成酸类等化合物,造成化合物产率减小,进而使生物油产率降低。

关键词：秸秆纤维素甲醇反应温度反应时间

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Unraveling the trans-epithelial absorption of novel dark blue pigment from Vaccinium bracteatum Thunb. leaves on the Caco-2 intestinal cell

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Food Science and Human Wellness 2024年

作者： Mingcong fan Weijia Lian Wenjun Yao Tingting Li Jiajia Zhao Qiang Li yanming Guan yan Li Haifeng Qian Zhiming Rao Li Wang School of Food Science and Technology， State Key Laboratory of Food Science and Technology， National Engineering Research Center for Functional Food， Jiangnan University College of Cooking Science and Technology， Jiangsu College of Tourism School of Biotechnology， Jiangnan University Department of Food Science and Engineering， College of Light Industry and Food Engineering， Nanjing Forestry University China National Research Institute of Food and Fermentation Industries Co.Ltd China National Institute of Standardization

The dark blue pigment (DBP) is a health ingredient from Vaccinium bracteatum Thunb. leaves used as a functional food supplement. However， the details of transepithelial absorption on the intestinal epithelial cells are barely understood. This study aimed to clarify the absorption properties of DBP in the Caco-2 cell monolayer model and evaluate the effect on the endo-metabolism and barrier function of Caco-2 cells. The results showed that the DBP did not show the dose-dependent toxic effect to Caco-2 cells between 0.25 and 1.5 mg/mL， which did not cause disorder in the normal cell metabolism and absorption activity. The Caco-2 cells monolayer model could absorb DBP by passive and active transport， and the absorptive pattern was dose-dependent when the concentration was more than 0.25 mg/mL. During DBP absorption， an increase in mRNA and protein expressions of glucose transporters demonstrated that the glucose transporters were the potential transporter of DBP. But the glucose transport amounts were significantly lowered after 30 min of DBP treatment， indicating that DBP owned the inhibitory effect on glucose transportation. Furthermore， DBP also owned protective effects on the barrier function of intestinal epithelial cells.

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