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Improvement in corrosion resistance of Mg_(97)Zn_(1)Y_(2)alloy by Zr addition

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China Foundry 2024年第6期21卷 634-640页

作者： Di-qing Wan Yu-meng Sun yan-dan xue Shao-yun Dong Guo-liang Han Yu Wang Fan yang Hao Tang Yong-yong Wang School of Materials Science and Engineering East China Jiaotong UniversityNanchang 330013China

Magnesium alloys,known for their exceptional lightweight properties,have presented challenges in various applications due to their limited corrosion *** this study,the corrosion resistance of Mg_(97)Zn_(1)Y_(2)magnesium alloys was enhanced by incorporating Zr elements into the Mg_(97)Zn_(1)Y_(2)matrix,which is distinguished by long periodic stacking ordered(LPSO)*** show that Mg_(97)Zn_(1)Y_(2)-xwt.%Zr(x=0,0.1,0.3,0.6)alloys containing Zr exhibit reduced hydrogen evolution rates and decreased corrosion levels compared with that without Zr,when immersed in a 3.5wt.%NaCl *** of 0.3wt.%Zr results in the most significant improvement,with a corrosion rate as low as 2.261 mL·cm^(-2),representing an 86%reduction from 16.438 mL·cm^(-2)of the base ***,alloys with Zr additions demonstrate a more positive corrosion potential and lower corrosion current density than does the matrix alloy(64.92μA·cm^(-2)).The lowest corrosion current density,21.61μA·cm^(-2),occurs with the addition of 0.3wt.%*** introduction of Zr induces a change in the microstructure of the LPSO phases,increasing the charge transfer resistance within the alloy and thus effectively improving its corrosion resistance.

关键词： magnesium alloys alloying corrosion resistance zirconium

Aging kinetics of 14H-LPSO precipitates in Mg-Zn-Y alloy

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China Foundry 2020年第1期17卷 42-47页

作者： Di-qing Wan Hou-bin Wang Zhu-min Li Ying-lin Hu Jia-jun Hu yan-dan xue Lin-sen Wang Kang-jin Fang School of Materials Science and Engineering East China Jiaotong University

Alloys with long-period stacking ordered structures(LPSO)have good properties and are highly ***-Zn-Y alloy containing LPSO phase was prepared by the traditional casting method,and the aging heat treatment was performed at different temperatures and *** microstructure and phase constitutions of the alloy were observed by means of optical microscopy and scanning electron microscopy *** show the microstructure of as-cast Mg95.5Zn1.5Y3 mainly consists ofα-Mg,W phases and LPSO *** the aging treatment,fine lamellar-shaped 14H-LPSO phase is formed at the grain boundaries and precipitates from the supersaturated magnesium matrix,and the volume fraction increases as the aging time *** controlling the aging time,Mg-Zn-Y alloys with different volume fractions of 14H-LPSO phase were *** aging kinetics equation of the 14H-LPSO phase is summarized,that is f=1-exp(-0.2705 t 0.6368).The phase transformation mechanism of 14H-LPSO in Mg95.5Zn1.5Y3 alloy can be described as the change of dislocation energy.

关键词： magnesium alloy LPSO phase aging kinetics equation

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前牙区牙龈生物型研究进展

口腔医学研究 2019年第2期35卷 116-118页

作者：闫雪丹张丽娜任秀云山西医科大学口腔医学院.口腔医院牙周科山西太原030001

牙龈生物型是反映患者牙周组织个体化差异的指标之一,前牙区的牙龈生物型常常涉及微笑美学区治疗的预后。近年来临床口腔医师对于前牙区牙龈生物型的研究逐渐增多,不同牙龈生物型患者对于牙周、正畸、修复、种植等多学科治疗过程的效果... 详细信息

牙龈生物型是反映患者牙周组织个体化差异的指标之一,前牙区的牙龈生物型常常涉及微笑美学区治疗的预后。近年来临床口腔医师对于前牙区牙龈生物型的研究逐渐增多,不同牙龈生物型患者对于牙周、正畸、修复、种植等多学科治疗过程的效果反馈也不同。本文就其分类、常见临床判定方法以及前牙区生物型的临床意义做一综述。

关键词：前牙牙龈生物型牙龈厚度

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乡村振兴视角下水产养殖证管理制度再探究

中国渔业经济 2021年第4期39卷 11-22页

作者：吴娟张燕雪丹杨杨上海海洋大学海洋文化与法律学院上海201306

"十四五"是继续深化农业农村改革、全面推进乡村振兴的关键阶段。作为水产养殖管理的基础性制度,养殖证管理制度的重新定位与改革是稳定农村水产养殖生产关系、规范养殖管理、实现绿色养殖的关键。本文在回顾养殖证制度发展历史的基础上... 详细信息

"十四五"是继续深化农业农村改革、全面推进乡村振兴的关键阶段。作为水产养殖管理的基础性制度,养殖证管理制度的重新定位与改革是稳定农村水产养殖生产关系、规范养殖管理、实现绿色养殖的关键。本文在回顾养殖证制度发展历史的基础上,结合2019年新一轮水产养殖证发放要求,从渔民权益、政府管理、社会功效和国家海洋战略四个角度对新时期养殖证的功能进行了定位。同时,根据这一新定位分析了当前养殖证制度运行中存在的主要问题,并进一步提出改革渔业行政管理体制和部门职权关系、完善法律法规、提高规划编制水平、规范养殖证申请、发放和事中事后监管等建议。

关键词：养殖证管理制度功能定位渔业行政管理乡村振兴

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun Nie Jing Zhang xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue Han yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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艾司西酞普兰致低钠血症的文献分析

临床药物治疗杂志 2016年第5期14卷 28-31页

作者：赵敏梅丹闫雪莲民航总医院药剂科北京100123 中国医学科学院北京协和医院药剂科北京100730

目的:探讨艾司西酞普兰致低钠血症的发生规律和特点,为临床预防低钠血症提供理论依据。方法:检索2002年至2016年3月国内外学术期刊报道的艾司西酞普兰致低钠血症文献进行统计分析。结果:共有14例报道,其中男性6例,女性8例,年龄≥65岁的... 详细信息

目的:探讨艾司西酞普兰致低钠血症的发生规律和特点,为临床预防低钠血症提供理论依据。方法:检索2002年至2016年3月国内外学术期刊报道的艾司西酞普兰致低钠血症文献进行统计分析。结果:共有14例报道,其中男性6例,女性8例,年龄≥65岁的老年患者10例(71.4%)。低钠血症发生时间最短为用药后2 d,最长为用药后120 d,10例(71.4%)发生在用药3周内。临床主要表现为头痛、昏迷、意识不清、嗜睡、幻觉、谵妄。所有患者经过停药、限水、补钠治疗后,血钠水平恢复。结论:临床处方时要关注患者的年龄及合并用药,特别是高龄、女性、联合使用利尿剂的患者,应定期监测血钠水平,尤其在用药3周内,以便早期识别低钠血症的发生。

关键词：艾司西酞普兰低钠血症抗利尿激素分泌异常综合征

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第一鳃弓外胚间充质细胞体外培养模型的构建

中国组织工程研究与临床康复 2010年第32期14卷 5983-5987页

作者：闫征斌侯景秋闫雪丹王天祥刘屹松大庆油田总医院口腔科黑龙江省大庆市163001 佳木斯大学口腔医学院黑龙江省佳木斯市154004 大庆油田总医院康复科黑龙江省大庆市163001

背景:在牙颌面的发育形成过程中,第一鳃弓作为过渡结构,发挥着不可替代的重要作用。目前,国内外对于第一鳃弓外胚间充质细胞的研究资料相对较少。目的:分离培养小鼠第一鳃弓外胚间充质细胞。方法:显微解剖E9.5胎鼠第一鳃弓,采用组织块... 详细信息

背景:在牙颌面的发育形成过程中,第一鳃弓作为过渡结构,发挥着不可替代的重要作用。目前,国内外对于第一鳃弓外胚间充质细胞的研究资料相对较少。目的:分离培养小鼠第一鳃弓外胚间充质细胞。方法:显微解剖E9.5胎鼠第一鳃弓,采用组织块法和酶消化法对其进行原代培养,通过细胞形态观察、细胞生长曲线描记、计算细胞倍增时间和特异性标记物检测对其细胞生物学特性进行研究。结果与结论:组织块法原代培养细胞的时间7～10d,上皮细胞成分较多,酶消化法原代培养细胞时间两三天,上皮细胞成分较少,两组细胞传代后细胞形态、细胞生长曲线、群体倍增时间无明显差异。特异性标记物CD57/HNK1、波形丝蛋白免疫细胞化学染色呈均一表达。提示采用酶消化法可以在短时间内获得数量充足、纯度较高、满足实验要求的细胞。

关键词：第一鳃弓分化发育外胚间充质细胞牙再生

Scapular metastasis from acinic cell carcinoma of parotid gland:A case report

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World Journal of Clinical Cases 2025年第9期13卷 41-46页

作者： Deng-Qun Sun Chang-Chun Chen Duo-An Zheng Hai-yan Xing xue Peng Department of General Surgery The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Radiology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina Department of Pathology The Chinese People’s Armed Police Forces Anhui Provincial Corps HospitalHefei 230001Anhui ProvinceChina

BACKGROUND Acinic cell carcinoma(ACC)is a malignant epithelial neoplasm that commonly occurs in the parotid *** is known to have a high recurrence rate and the potential to metastasize to the lung or cervical lymph ***,few cases of ACC with bone metastasis have been reported in the medical *** SUMMARY The clinical significance of this case report lies in the unique site of occurrence of the metastasis:To the best of our knowledge,this report is the only literature documenting ACC arising in a shoulder *** Unusual presentations of uncommon malignancies can present diagnostic challenges for both surgeons and *** is important to be aware of these rare occurrences in order to provide the best possible treatment for patients.

关键词： Acinic cell carcinoma Shoulder mass Scapular Metastasis Case report