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Xylyl derived oxacalixcrowns:Synthesis and crystal structure

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Chinese Chemical Letters 2013年第4期24卷 279-282页

作者： Xiao-yan Li chun Hu Ming-Liang Ma Yahu A.Liu Xian-Qiang Mi Biao Jiang Ke Wen Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development East China Normal University Medicinal Chemistry ChemBridge Research Laboratories Inc. Sustainable Technology Research Center Shanghai Advanced Research InstituteChinese Academy of Science

Oxacalixcrowns 1, 2 and 3 were synthesized via reactions of dihydroxyoxacalix[2]arene[2]pyrazine S with ortho-, meta- and para-bis（bromomethyl）benzenes in a 1：1 fashion. The structures and conformations of 1, 2 and... 详细信息

关键词： OxacalixareneOxacalixcrownCrown etherMacrocycle

Skull optical clearing window for in vivo imaging of the mouse cortex at synaptic resolution

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Light(Science & Applications) 2017年第1期6卷 150-158页

作者： yan-Jie Zhao Ting-Ting Yu Chao Zhang Zhao Li Qing-Ming Luo Tong-Hui xu Dan Zhu Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and TechnologyWuhan 430074China MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical EngineeringSchool of Engineering SciencesHuazhong University of Science and TechnologyWuhan 430074China

Imaging cells and microvasculature in the living brain is crucial to understanding an array of neurobiological ***,we introduce a skull optical clearing window for imaging cortical structures at synaptic *** with two-photon microscopy,this technique allowed us to repeatedly image neurons,microglia and microvasculature of *** applied it to study the plasticity of dendritic spines in critical periods and to visualize dendrites and microglia after laser *** its easy handling and safety,this method holds great promise for application in neuroscience research.

关键词： cranial window dendritic spines optical clearing synaptic resolution two-photon imaging

Expression Patterns of ABA and GA Metabolism Genes and Hormone Levels during Rice Seed Development and Imbibition: A Comparison of Dormant and Non-Dormant Rice Cultivars

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Journal of Genetics and Genomics 2014年第6期41卷 327-338页

作者： yang Liu Jun Fang Fan xu Jinfang Chu Cunyu yan Michael R.Schlappi Youping Wang Chengcai Chu State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental BiologyChinese Academy of Sciences National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental Biology Chinese Academy of Sciences Department of Biological Sciences Marquette University College of Life Sciences Yangzhou University

Seed dormancy is an important agronomic trait in cereals. Using deep dormant （N22）, medium dormant （ZH11）, and non-dormant （G46B） rice cultivars, we correlated seed dormancy phenotypes with abscisic acid （ABA） and gibberellin （GA） metabolism gene expression profiles and phytohormone levels during seed development and imbibition. A time course analysis of ABA and GA content during seed development showed that N22 had a high ABA level at early and middle seed developmental stages, while at late developmental stage it declined to the level of ZHll; however, its ABA/GA ratio maintained at a high level throughout seed development. By contrast, G46B had the lowest ABA content during seed development though at early developmental stage its ABA level was close to that of ZH11, and its ABA/GA ratio peaked at late developmental stage that was at the same level of ZHll. Compared with N22 and G46B, ZH11 had an even and medium ABA level during seed development and its ABA/GA ratio peaked at the middle developmental stage. Moreover, the seed development time-point having high ABA/GA ratio also had relatively high transcript levels for key genes in ABA and GA metabolism pathways across three cultivars. These indicated that the embryo-imposed dormancy has been induced before the late developmental stage and is determined by ABA/GA ratio. A similar analysis during seed imbibition showed that ABA was synthesized in different degrees for the three cultivars. In addition, water uptake assay for intact mature seeds suggested that water could permeate through husk barrier into seed embryo for all three cultivars; however, all three cultivars showed distinct colors by vanillin-staining indicative of the existence of flavans in their husks, which are dormancy inhibition compounds responsible for the husk-imposed dormancy.

关键词： Seed development Seed imbibition Gene expression Abscisic acid (ABA) Gibberellin (GA) ABA/GA ratio Rice

Facile immobilization of heparin on bioabsorbable iron via mussel adhesive protein(MAPs)

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Progress in Natural Science:Materials International 2014年第5期24卷 458-465页

作者： xuchen xu Ming Li Qian Liu Zhaojun Jia Yuying Shi yan Cheng Yufeng Zheng L.Q. Ruan Center for Biomedical Materials and Tissue Engineering Academy for Advanced Interdisciplinary StudiesPeking University Department of Materials Science and Engineering College of Engineering Peking University Department of Mechanical Systems Engineering Graduate School of Science and TechnologyKumamoto University

Motivated by adhesive proteins in mussels, strategies using dopamine to modified surface have become particularly attractive. In the present work, we developed a novel and convenient method to modify the biodegradable Fe plates with heparin. Iron was first treated by a facile one-step p H-induced polymerization of dopamine, and then a high density heparin was successfully grafted onto the surface via coupling with polydopamine(PDA) active layer. Heparin immobilization contributed much longer blood clotting coagulation time than the pure Fe sample, and hence reduced the risk of thrombosis. Cell viability tests suggested that the heparin modified Fe plates were more favorable to the proliferation of ECV304 cells. In summary, the heparin modified Fe plates with good anti-thrombus properties and inhibiting the proliferation of VSMC cells provide great prospects for biodegradable iron.

关键词： Iron Heparin Dopamine Surface modification Biodegradable stent Hemocompatibility

Inhibitory effect of compound NS5806 on cardiac transient outward potassium channel dependents on interaction between auxiliary subunits

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中国药理学与毒理学杂志 2017年第10期31卷 1027-1028页

作者： Hong-xue ZHANG Hua ZHANG Yu-hong WANG yan-fang xu Department of Pharmacology Hebei Medical University the Key Laboratory of New Drug Pharmacology and Toxicolog Hebei Province the Key Laboratory of Neural and Vascular Biology Ministry of Education Institute of Masteria Medica Chinese Academy of Medical Sciences & Peking Union Medical College

OBJECTIVE Transient outward potassium current(I_(to)) plays a crucial role in cardiac phase 1 repolarization and the channels are assembled by pore-forming α-subunits(K_v4.2 or K_v4.3) and auxiliary subunits(KCh IP2 and DPP6).Previous studies have found that the compound NS5806 increases I_(to) in canine ventricular cardiomyocytes through slowing current ***,we reported that NS5806 produced an acute inhibitory action on I_(to) in mouse ventricular cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes(hi PS-CM).METHODS Whole-cell patch-clamp was used to record I_(to) in native myocytes and in HEK cells expressing cloned K_v4.x/KCh IP2/DPP6 channels;Western-blot detected the channel protein *** In isolated mouse ventricular cardiomyocytes,NS5806(0.1-30 μmol·L^(-1)) inhibited I_(to) in a concentration-dependent manner with IC50 of 6.6±1.9 μmol·L^(-1).The current decay was significantly accelerated with a time constant from 53.8±5.5 to 41.8±3.0 ms at +60 m V(P<0.01).Similarly,NS5806 concentration-dependently reduced the I_(to) peak current amplitude with an acceleration of current *** addition,NS5806 increased I Kv4.2/KCh IP2 and delayed current decay,but decreased I Kv4.2/KCh IP2/DPP6 with the acceleration of current *** inhibitory action on the current was more potent if DPP6 expression level was increased from K_v4.2/KCh IP2/DPP6 1∶1∶1 to 1∶1∶***-blot showed a higher expression of DPP6 protein in mouse heart and in hi PS-CM compared to canine ***,specific knock-down DPP6 expression by si RNA antagonized the inhibitory action of NS5806 in hi *** results pointed to an important role of DPP6 subunit in the regulation of NS5806 on the *** using molecular docking simulation,five interaction sites with high possibility between KCh IP2 and DPP6 were *** of those sites changed the inhibitory action of NS58056 into excitatory effect on the current with the delay of current

关键词： NS5806 Ito hiPS-CM molecular docking

A robust interphase via in-situ pre-reconfiguring lithium anode surface for long-term lithium-oxygen batteries

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Journal of Energy Chemistry 2022年第9期31卷 186-194,I0006页

作者： Pan xu Xiaodong Lin Zongqiang Sun Kaixuan Li Wenjie Dou Qing Hou Zhiyou Zhou Jiawei yan Mingsen Zheng Ruming Yuan Quanfeng Dong Collaborative Innovation Centre of Chemistry for Energy Materials(iChEM) State Key Laboratory of Physical Chemistry of Solid SurfacesDepartment of ChemistryCollege of Chemistry and Chemical EngineeringEngineering Research Centre of Electrochemical Technologies of Ministry of EducationXiamen UniversityXiamen 361005FujianChina

Lithium-oxygen(Li-O) battery is considered as one of the most promising alternatives because of its ultrahigh theoretical energy density. However, their cycling stability is severely restricted by the uncontrollable dendrite growth and serious oxygen corrosion issue on Li surface. Herein, a sulfur-modified Li surface can be successfully constructed via chemical reaction of guanylthiourea(GTU) molecule on Li,which can induce the selectively fast decomposition of lithium bis(trifluoromethanesulfonyl)imide(LiTFSI) to form a smooth and stable inorganics-rich solid-electrolyte interphase(IR-SEI) during the subsequent electrochemical process. Such an IR-SEI cannot only offer a highly reversible and stable Li plating/stripping chemistry with dendrite-free property(10 mA cm^(-2)-10 mAh cm^(-2), > 0.5 years;3 mA cm^(-2)-3 m Ah cm^(-2), > 1 year) but also endows the Li metal an anti-oxygen corrosion function, thereby significantly improving the cycling stability of Li-Obatteries. This work provides a new idea for constructing functional solid-electrolyte interphase(SEI) to achieve highly stable Li metal anode.

关键词： Solid-electrolyte interphase Guanylthiourea Sulfur-modified Li surface Li metal Li-O_(2)batteries

ZmcrtRB3 Encodes a Carotenoid Hydroxylase that Affects the Accumulation of α-carotene in Maize Kernel

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Journal of Integrative Plant Biology 2012年第4期54卷 260-269页

作者： Yi Zhou Yingjia Han Zhigang Li yang Fu Zhiyuan Fu Shutu xu Jiansheng Li Jianbing yan Xiaohong yang National Maize Improvement Center Key Laboratory of Crop Genomics and Genetic ImprovementChina Agricultural University100193 BeijingChina Zhengzhou Sub-center of Chinese National Maize Improvement Center Henan Agricultural UniversityZhengzhou 450002China National Key Laboratory of Crop Improvement Huazhong Agricultural UniversityWuhan 430070China

α-carotene is one of the important components of pro-vitamin A, which is able to be converted into vitamin A in the human body. One maize （Zea mays L.） ortholog of carotenoid hydroxylases in Arabidopsis thaliana, ZmcrtRB3, was cloned and its role in carotenoid hydrolyzations was addressed. ZmcrtRB3 was mapped in a quantitative trait locus （QTL） cluster for carotenoid-related traits on chromosome 2 （bin 2.03） in a recombinant inbred line （RIL） population derived from By804 and B73. Candidate-gene association analysis identified 18 polymorphic sites in ZmcrtRB3 significantly associated with one or more carotenoid-related traits in 126 diverse yellow maize inbred lines. These results indicate that the enzyme ZmcrtRB3 plays a role in hydrolyzing both α- andβ-carotenes, while polymorphisms in ZmcrtRB3 contributed more variation in α-carotene than that inβ-carotene. Two single nucleotide polymorphisms （SNPs）, SNP1343 in 5＇untranslated region and SNP2172 in the second intron, consistently had effects on or-carotene content and composition with explained phenotypic variations ranging from 8.7% to 34.8%. There was 1.7- to 3.7-fold change between the inferior and superior hapiotype for α-carotene content and composition. Thus, SNP1343 and SNP2172 are potential polymorphic sites to develop functional markers for applying marker-assisted selection in the improvement of pro-vitamin A carotenoids in maize kernels.

关键词： α-carotene association analysis maize pro-vitamin A ZmcrtRB3.

The Research of Thangka Buddha Gesture Segmentation Algorithm

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计算机科学与技术汇刊（中英文版） 2015年第4期4卷 72-75页

作者： yan xu Mathematics and Computer Science College Northwest University for Nationalities Lanzhou 730030 China

Cycling hydrogen desorption properties and microstructures of MgH_(2)-AlH_(3)-NbF_(5) hydrogen storage materials

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Rare Metals 2021年第4期40卷 1003-1007页

作者： Xiao-Sheng Liu Hai-Zhen Liu Ning Qiu yan-Bing Zhang Guang-Yao Zhao Li xu Zhi-Qiang Lan Jin Guo Guangxi Novel Battery Materials Research Center of Engineering Technology School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Guangxi Key Laboratory of Processing for Non-ferrous Metallic and Featured Materials School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Guangxi Colleges and Universities Key Laboratory of Novel Energy Materials and Related Technology School of Physical Science and TechnologyGuangxi UniversityNanning 530004China State Key Laboratory of Advanced Power Transmission Technology Global Energy Interconnection Research Institute Co.LtdBeijing 102209China Department of AC Construction State Grid Co.LtdBeijing 100031China State Grid DC Project Construction Branch Company Beijing 100052China

Magnesium hydride(MgH_(2)) is a candidate material for hydrogen ***_(2)-AlH_(3) composite shows superior hydrogen desorption properties than pure MgH_(2).However,this composite still suffers from poor cycling *** this work,NbF_(5) was utilized to improve the cycling properties of the MgH_(2)-AlH_(3) *** hydrogen desorption studies show that NbF_(5) significantly improves the cycling stability of MgH_(2)-AlH_(3).The MgH_(2)-AlH_(3)-NbF_(5) composite can release about 2.7 wt% of hydrogen at 300℃ for 1 h and the hydrogen desorption capacity can maintain at 2.7 wt% for more than100 *** comparison,the hydrogen desorption capacity of the MgH_(2)-AlH_(3) composite is decreasing with the cycle number *** capacity is reduced from a maximum value of 3.3 wt% to about 1.0 wt% after 40 ***-Emmett-Teller(BET) surface area measurements show that the particle size of MgH_(2)-AlH_(3) composite decreases after cycling,which means pulverization of the ***_(5) can to some extent suppress the pulverization of the composite during cycling,which partially contributes to the improvement of the cycling hydrogen desorption properties of the material.

关键词： Hydrogen storage materials Magnesium hydride Aluminum hydride Niobium fluoride Cycling properties