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Baseline predictors of virological response for chronic hepatitis B patients

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World Journal of Gastroenterology 2009年第34期15卷 4311-4315页

作者： Xue-jie Wu yan Wang ji chen Gui-Qiang Wang Department of Infectious Diseases Peking University First Hospital Beijing 100034 China

AIM： To determine which baseline factors of chronic hepatitis B patients are predictive of virological response to Peginterferon α-2b therapy. METHODS： A total of 21 HBeAg-positive chronic hepatitis B （CriB） patients treated with Peginterferon α-2b were recruited. They were treated with Peginterferon α-2b （0.5-1.0 μg/kg per week） for 24 wk and followed up for 24 wk. Clinical and laboratory data of the patients were determined at pretreatment and at week 12, at 24 during treatment, and at week 48 during follow up. RESULTS： Ten patients achieved a virological response at the end of treatment. Their baseline serum alanine aminotransferase （ALT）, thyroid-stimulating hormone （TSH）, and total thyroxin （TT4） levels were significantly different from those who failed treatment. The positive predictive values （PPV） and negative predictive values （NPV） of ALT, TSH, and TT4 were 75% and 89 %, 75% and 89 %, and 75% and 75%, respectively. Moreover, combinations of the baseline ALT and TT4, ALT and TSH, TT4 and TSH levels had much higher PPV and NPV （86% and 88%, 89% and 100%, 83% and 100%, respectively）.CONCLUSION： Baseline serum ALT, TSH, and TT4 levels, especially in combination, have high predictive values of virological response to Peginterferon α-2b in HBeAg-positive CriB patients.

关键词： Chronic hepatitis B Hepatitis B virus Predictors Virological response Peginterferon

Sn/n3O4-x heterostructure rich in oxygen vacancies with enhanced visible light photocatalytic oxidation performance

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维普期刊数据库

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International Journal of Minerals,Metallurgy and Materials 2021年第1期28卷 150-159页

作者： Rui-qi yang Na Liang Xuan-yu chen Long-wei Wang Guo-xin Song yan-chen ji Na Ren Ya-wei Lü jian Zhang Xin Yu Institute for Advanced Interdisciplinary Research(IAIR) University of JinanJinan 250022China School of physics and electronics Hunan UniversityChangsha 410082China Institute Charles Gerhardt UMR 5253CNRS-UM-ENSCMUniversitéde MontpellierPlace Eugène BataillonF-34095 Montpellier cedex 5France

Sn3O4, a common two-dimensional semiconductor photocatalyst, can absorb visible ***, owing to its rapid recombination of photogenerated electron-hole pairs, its absorption is not sufficient for practical *** this work, a Sn nanoparticle/Sn3O4-x nanosheet heterostructure was prepared by in situ reduction of Sn3O4 under a H2 *** Schottky junctions formed between Sn and Sn3O4-x can enhance the photogenerated carrier separation *** the hydrogenation process, a portion of the oxygen in the semiconductor can be extracted by hydrogen to form water, resulting in an increase in oxygen vacancies in the *** heterostructure showed the ability to remove Rhodamine *** cytocompatibility experiments proved that Sn/Sn3O4-x can significantly enhance cell compatibility and reduce harm to *** work provides a new method for the fabrication of a Schottky junction composite photocatalyst rich in oxygen vacancies with enhanced photocatalytic performance.

关键词： photocatalysis tin oxide oxygen vacancy Schottky junction photodegradation

Molecular Characteristics of S1 Gene of Infectious Bronchitis Virus Isolated from Chicken Proventriculus

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Agricultural Sciences in China 2003年第1期2卷 107-112页

作者： chenG Li-qin, ZHOU ji-yong, John Dikki, SHEN Xing-yan, chen ji-gang and ZHANG De-yongInstitute of Preventive Veterinary Medicine , College of Animal Sciences , Zhejiang University , Hangzhou 310029 , P.R.China Institute of Preventive Veterinary Medicine College of Animal SciencesZhejiang University Hangzhou 310029 P. R. China

Infectious bronchitis virus was isolated from swollen proventriculi of clinically ill chicken. The suspected virus samples (2/97, 3/97, 1/98) were adapted in SPF chicken embryos for virus isolation and identification. All the virus isolates were able to agglutinate chicken erythrocytes after treatment with trypsin, and interfer with the reproduction of Newcastle disease virus in chicken embryos, and have low antigenic relat-edness values with reference positive IBV. The isolates 2/97, 3/97, 1/98 RNAs extracted from the allantoic fluid of inoculated embryonated eggs were converted to cDNA by reverse transcription with 3'-primer of S1 gene of (IBV). Polymerase chain reaction (PCR) was performed with two primers which span the S1 gene. Amplified product of 1. 93 kb was subjected to EcoR I and BamH I digestion and the fragments obtained were the same as expected size. The PCR product was ligated to pBlueScript-SK ( + ) vector, and its nucleotide sequence was determined by the dideoxy-mediated chain termination method. Nucleotide sequence analysis showed 73. 6 - 99. 7% homology between the isolated IBV and the IBV strains in GenBank. The homology of amino acid was 71. 4 - 99.4%.

关键词： Chicken Infectious bronchitis virus S1 gene Molecular characteristics

Clinical Study on Anti-activated Platelets of the Xiefuzhuyu Concentrated Pill in patients with unstable angina

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Clinical Study on Anti-activated Platelets of the Xiefuzhuyu...

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

全国中青年中西医结合学术（英语）交流会议

作者： Lei yan, chen Ke-ji, Wang Jun-hui, et al

Objective: To assess the platelet activation in patients with unstable angina (UA) and to seek the clinical efficacy of Xiefuzhuyu concentrated pill (XCP) on anti-platelets activation in UA patients. Methods: 45 UA patients (aged 66.4±5.6 years) were observed and treated with XCP in the UA patients, whole blood of CD62p and CD41/45 expression on Platelet surface in UA patients were measured by flow cytometry as well as specific monoclonal antibodys. Results: The expressions of CD62p and CD41/45 increased significantly in the UA patients, at the same time, there being increasing rates of platelets aggregation and adhesiveness in the same UA subjects . After effectively treated with XCP, the CD62p expression decreased evidently from 24.22±7.92 to 21.42 ±8.01 (P0.05) . Conclusions: There is elevated platelet activation in UA Patients. The effects of Xieguantong Pill on restraining activated platelets shows a good clinical efficacy. It was guessed that the XCP to inhibit the expression of CD62P and CD41/45 may be it is one of the mechanisms in promoting blood circulation and removing blood stasis.

关键词： Xiefuzhuyu Concentrated Pill platelet activation clinical study

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cnki会议

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie Wei Hongyu chen Guoqiang Ma Wensheng yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

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种公禽繁殖系统对光要素的应答机制研究进展

中国畜牧兽医 2017年第9期44卷 2692-2698页

作者：孙研研陈继兰中国农业科学院北京畜牧兽医研究所农业部动物遗传育种与繁殖(家禽)重点实验室北京100193

光照是生物体重要的生活环境因素之一。禽类具有优越的感光机能,光线通过其光感受器被感知,并转变为生物学信号,从而对生长发育、繁殖和行为等方面产生影响。在现代养禽业中,人工优化光照环境已成为提高动物生产性能的一项重要手段。近... 详细信息

光照是生物体重要的生活环境因素之一。禽类具有优越的感光机能,光线通过其光感受器被感知,并转变为生物学信号,从而对生长发育、繁殖和行为等方面产生影响。在现代养禽业中,人工优化光照环境已成为提高动物生产性能的一项重要手段。近年来,随着种用母鸡笼养、人工授精技术的广泛应用及精液处理、包装和存储技术的发展,在家禽养殖中,也逐步将种公禽单独饲养。研究光照对种公禽繁殖性能的影响,一方面可以进一步解析种公禽繁殖系统对光要素的生物应答机制,另一方面可为生产中采用精细化的光照条件提高种公禽繁殖效率提供科学依据。笔者就禽类的光感受器,参与光—性信号传导的激素,以及光照节律、光照强度和光波长对种公禽性成熟和繁殖性能的影响等方面的研究进展进行综述,以期为其在生产中的应用奠定基础。

关键词：种公禽光照繁殖激素

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu Zhang yanyu Zhang yan Zeng Xingxing chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

ESTABLISHMENT OF SOMACLONES FROMNULLI SOMICWHEAT（TRITICUMAESTIVUML．）THROUGH YOUNG INFLO RE SCENC EC

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西北农业学报 1996年第2期 28-31页

作者： Xue Xiuzhuang, yan Bo, chen jianli, ji Wanquan and Wang Qiuying (Wheat Research Centre of Shaanxi Province, yangling Shaanxi\ 712100) \ \

以阿勃小麦缺体植株未抽出的幼穗为外植体，通过离体培养获得了幼穗愈伤组织和再生植株，从而建立了这些缺体的体细胞无性系。不同缺体间在幼穗愈伤组织诱导率及分化率上表现明显差异，阿勃２Ｄ缺体的幼穗愈伤组织诱导率和分化率最高。... 详细信息

以阿勃小麦缺体植株未抽出的幼穗为外植体，通过离体培养获得了幼穗愈伤组织和再生植株，从而建立了这些缺体的体细胞无性系。不同缺体间在幼穗愈伤组织诱导率及分化率上表现明显差异，阿勃２Ｄ缺体的幼穗愈伤组织诱导率和分化率最高。缺体小麦幼穗愈伤组织诱导率和分化率与缺失的染色体有关

关键词：缺体小麦幼穗培养体细胞无性系建立