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Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1908-1924页

作者： Hui-yan Wang yan Diao Pei-zhu Tan Huan Liang Department of Clinical Laboratory Harbin Medical University Cancer HospitalHarbin 150086Heilongjiang ProvinceChina Department of Clinical Laboratory Heilongjiang Province HospitalHarbin 150000Heilongjiang ProvinceChina Translational Medicine Center of Northern China Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

BACKGROUND As the primary microtubule organizing center in animal cells,centrosome abnormalities are involved in human colon *** To explore the role of centrosome-related genes(CRGs)in colon *** CRGs were collected from public *** clustering analysis was performed to separate the Cancer Genome Atlas *** Cox and least absolute shrinkage selection operator regression analyses were performed to identify candidate prognostic CRGs and construct a centrosome-related signature(CRS)to score colon cancer patients.A nomogram was developed to evaluate the CRS risk in colon cancer *** integrated bioinformatics analysis was conducted to explore the correlation between the CRS and tumor immune microenvironment and response to immunotherapy,chemotherapy,and targeted ***-cell transcriptome analysis was conducted to examine the immune cell landscape of core prognostic *** A total of 726 CRGs were collected from public databases.A CRS was constructed,which consisted of the following four genes:TSC1,AXIN2,COPS7A,and *** cancer patients with a high-risk signature had poor *** with a high-risk signature exhibited decreased levels of plasma cells and activated memory CD4+T *** treatment response,patients with a high-risk signature were resistant to immunotherapy,chemotherapy,and targeted ***7A expression was relatively high in endothelial cells and ***1 expression was high in endothelial cells,fibroblasts,and malignant *** We constructed a centrosome-related prognostic signature that can accurately predict the prognosis of colon cancer patients,contributing to the development of individualized treatment for colon cancer.

关键词： Colon cancer Centrosome Signature Prognostic Immune microenvironment Therapy

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Footprints of axion-like particle in pulsar timing array data and James Webb Space Telescope observations

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 55-62页

作者： Shu-Yuan Guo Maxim Khlopov Xuewen Liu Lei Wu Yongcheng Wu bin zhu Department of Physics Yantai UniversityYantai 264005 China Institute of Physics Southern Federal UniversityRostov on Don 344090 Russia National Research Nuclear University MEPhI(Moscow Engineering Physics Institute) Moscow 115409 Russia Virtual Institute of Astroparticle Physics Paris 75018 France Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023 China

Several pulsar timing array(PTA) collaborations have recently reported the evidence for a stochastic gravitational-wave background(SGWB), which can unveil the formation of primordial seeds of inhomogeneities in the early universe. With the SGWB parameters inferred from PTAs data, we can make a prediction of the seeds for early galaxy formation from the domain walls in the axion-like particles(ALPs) field distribution. This also naturally provides a solution to the observation of high redshifts by the James Webb Space Telescope. The predicted photon coupling of the ALP is within the reach of future experimental searches.

关键词： stochastic gravitational-wave background pulsar timing array axion-like particle JWST

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The Distribution of Surnames in Xiantao City through Isonymy

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Journal of Geodesy and Geoinformation Science 2024年第2期7卷 52-65页

作者： ZHANG Jingjing zhu yan XIAO Hong College of Chinese Language and Literature Wuhan UniversityWuhan 430072China College of Literature and Communication China Three Gorges UniversityYichang 443002China School of Foreign Languages China University of GeosciencesWuhan 430072China

The population migration in Hubei Province was frequent in history,accompanied by the migration of surnames,so it is important to study their population *** take Xiantao City as an example to explore the isonymic structure of small and medium-sized cities in *** surname distributions of 223327 residents registered in 2013 were analyzed in 5 towns and 105 villages of *** number of different surnames found was *** for surnames,theα-value reflects the influence of ethnic composition on the abundance of *** correlation between the isonymic distance and the geographic distance between villages was calculated and indicated that Euclidean distance was weakly correlated with the geographic distance(r=0.177±0.012),and the isonymic distance increased with the geographical ***,the dendrogram and PCA built from the matrix of Euclidean distances between villages identified a main surname differentiation between the urban and rural areas.

关键词： Xiantao City surname distribution isonymy isolation by distance urban and rural areas

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Toughening ultrastrong low-density steel by textured δ-ferrite lamellas

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Defence Technology（防务技术） 2024年第2期32卷 405-411页

作者： bin Hu Guosen zhu Guohui Shen Zheng Wang Qinghua Wen Xiao Shen Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingXue Yuan Rd.30Beijing 100083China Shougang Research Institute of Technology Yangzhuang Street 69Beijing 100043China Steel Institute RWTH Aachen UniversityIntzestraße 152072AachenGermany

By both the Charpy V-notched impact and the projectile tests, we here investigated the dynamic fracture behavior of a recently developed ultrastrong lightweight steel comprising a hierarchical martensitic matrix, dispersed ultra-fine-retained austenite grains and oriented δ-ferrite lamellas, the latter being due to high Al and Si contents employed for low-density design. This steel shows a superior combination of specific ultimate tensile strength and impact toughness to other ultrastrong steels and has successfully arrested a real steel-cored bullet shot. These are attributed to the densely textured δ-ferrite lamellas that can deflect the propagating cracks until they are trapped and enclosed besides austenite-to-martensite transformation crack closure, leading to more energy consumed before failure. These results suggest a new pathway for toughening ultrastrong lightweight steels.

关键词： Ultrastrong and light steel d-Ferrite lamellas Crack propagation Toughness

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Multiple conductive network for KTi_(2)(PO_(4))_(3)anode based on MXene as a binder for high-performance potassium storage

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Chinese Chemical Letters 2024年第8期35卷 539-544页

作者： Tong Su Yue Wang Qizhen zhu Mengyao Xu Ning Qiao bin Xu State Key Laboratory of Organic-Inorganic Composites Beijing Key Laboratory of Electrochemical Process and Technology for MaterialsBeijing University of Chemical TechnologyBeijing 100029China

KTi_(2)(PO_(4))_(3)is a promising anode material for potassium storage,but suffers from low conductivity and difficult balance between high capacity and good structural ***,the Ti_(3)C_(2)T_(x)MXene is used as a multifunctional binder to fabricate the KTi_(2)(PO_(4))_(3)electrode by the traditional homogenizing-coating *** MXene nanosheets,together with the conductive agent super P nanoparticles,construct a multiple conductive network for fast electron/ion transfer and high electrochemical ***,the network ensures the structural stability of the KTi_(2)(PO_(4))_(3)electrode during the de-intercalation/intercalation of 4 K^(+)ions,which is beneficial for simultaneously achieving high capacity and good cycle ***,the MXene-bonded KTi_(2)(PO_(4))_(3)electrode delivers a reversible capacity of 255.2 mAh/g at 50 mA/g,outstanding rate capability with 132.3 mAh/g at 2 A/g,and ex-cellent cycle performance with 151.6 mAh/g at 1 A/g after 2000 *** work not only suggests a high-performance anode material for potassium-ion batteries,but also demonstrates that the MXene is a promising binder material for constructing conductive electrodes in rechargeable batteries.

关键词： MXene Ti_(3)C_(2)T_(x) KTi_(2)(PO_(4))_(3) Anode Conductive network Potassium storage

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Data Quality Control Method of a New Drifting Observation Technology Named Drifting Air-Sea Interface Buoy

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Journal of Ocean University of China 2024年第1期23卷 11-22页

作者： LI Shuo WANG bin DENG Zeng’an WU Baoqin zhu Xiande CHEN Zhaohui National Ocean Technology Center Tianjin 300112China School of Marine Science and Technology Tianjin UniversityTianjin 300072China Key Laboratory of Ocean Observation Technology Ministry of Natural ResourcesTianjin 300112China People’s Liberation Army 92859 Tianjin 300061China Physical Oceanography Laboratory Ocean University of ChinaQingdao 266100China

An integral quality control(QC)procedure that integrates various QC methods and considers the design indexes and operational status of the instruments for the observations of drifting air-sea interface buoy was developed in the order of basic in-spection followed by targeted *** innovative method of combining a moving Hampel filter and local anomaly detection com-plies with statistical laws and physical processes,which guarantees the QC performance of meteorological *** sets of observation data were used to verify the applicability and effectiveness of the QC procedure,and the effect was evaluated using the observations of the Kuroshio Extension Observatory buoy as the *** results showed that the outliers in the time series can be correctly identified and processed,and the quality of data improved *** linear correlation between the quality-controlled observations and the reference increased,and the difference *** correlation coefficient of wind speed before and after QC increased from 0.77 to 0.82,and the maximum absolute error decreased by approximately 2.8ms^(-1).In addition,air pressure and relative humidity were optimized by 10^(-3)–10^(-2) orders of *** the sea surface temperature,the weight of coefficients of the continuity test algorithm was optimized based on the sea area of data acquisition,which effectively expanded the applicability of the algorithm.

关键词： drifting air-sea interface buoy quality control oceanic variables meteorological variables continuity test

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Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis

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Chinese Journal of Integrative Medicine 2024年第10期30卷 917-926页

作者： OU Jin-ying LIU Shan-hong TANG Dong-kai SHI Ling-zhu yan Li-jun HUANG Jing-yan ZOU Li-fang QUAN Jing-yu YOU yan-ting CHEN Yu-yao YU Lin-zhong LU Zi-bin Third Level Research Laboratory of State Administration of Traditional Chinese Medicine School of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou510515China Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics Guangzhou510515China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou510515China

Objective:To explore the protective effect and the underlying mechanism of silibinin(SIB),one of the active compounds from Silybum marianum(L.)Gaertn in ***:Mouse peritoneal macrophage were isolated via intraperitoneally injection of BALB/c mice with thioglycolate *** viability was assessed using the cell counting kit-8,while cytotoxicity was determined through lactate dehydrogenase cytotoxicity *** protein expressions of interleukin(IL)-1α,IL-1β,and IL-18 were determined by enzyme-linked immunosorbent *** lipopolysaccharide(LPS)levels were measured by employing both the limulus amoebocyte lysate assay and flow ***,proximity ligation assay was employed for the LPS and caspase-11 *** were divided into 4 groups:the control,LPS,high-dose-SIB(100 mg/kg),and low-dose-SIB(100 mg/kg)groups(n=8).Zebrafish were divided into 4 groups:the control,LPS,high-dose-SIB(200μmol/L),and low-dose-SIB(100μmol/L)groups(n=30 for survival experiment and n=10 for gene expression analysis).The expression of caspase-11,gasdermin D(GSDMD),and N-GSDMD was determined by Western blot and the expressions of caspy2,gsdmeb,and IL-1βwere detected using quantitative real-time *** observation was performed through hematoxylineosin staining,and protein levels in bronchoalveolar lavage fluid were quantified using the bicinchoninicacid protein ***:SIB noticeably decreased caspase-11 and GSDMD-mediated pyroptosis and suppressed the secretion of IL-1α,IL-1β,and IL-18 induced by LPS(Pbinding of caspase-11 and intracellular LPS(P<0.05).SIB also attenuated the expression of caspase-11 and N-terminal fragments of GSDMD,inhibited the relative cytokines,prolonged the survival time,and up-regulated the survival rate in the endotoxemia models(P<0.05).Conclusions:SIB can inhibit pyroptosis in the LPS-mediated endotoxemia model,at l

关键词： silibinin caspase-11 endotoxemia pyroptosis inflammation

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Interaction between systemic iron parameters and left ventricular structure and function in the preserved ejection fraction population:a two-sample bidirectional Mendelian randomization study

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Journal of Geriatric Cardiology 2024年第1期21卷 64-80页

作者： Xiong-bin MA Yong-Ming LIU yan-Lin LV Lin QIAN The First Clinical Medical College of Lanzhou University LanzhouGansuChina Geriatric Cardiovascular Department and Gansu Clinical Research Center for Geriatric Diseases First Hospital of Lanzhou UniversityGansuChina

BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is *** Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction *** Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association *** without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50%(n=16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome *** dataset included LV end-diastolic volume,LV endsystolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the *** In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β=-0.1365;95%confidence interval[CI]:-0.2092 to-0.0638;P=0.0002)after Bonferroni ***,no significant relationships were observed between other iron and LV *** Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β=-0.0699;95%CI:-0.1087 to-0.0311;P=0.0004).No heterogeneity or pleiotropic effects evidence was observed in the *** We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.

关键词： fraction function parameters

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Law of dynamic deformation of bone

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Chinese Medical Journal 2019年第21期132卷 2636-2637页

作者： Juan Wang Wei Chen Zhi-Yong Hou Hong-Zhi Lyu yan-bin zhu Ying-Ze Zhang Department of Orthopedic Surgery the Third Hospital of Hebei Medical UniversityShijiazhuangHebei 050051China Hebei Institute of Orthopedic Research ShijiazhuangHebei 050051China Key Laboratory of Biomechanics of Hebei Province ShijiazhuangHebei 050051China

Human bones change *** a human,bones usually start to form at the 7thweek of the embryonic period and continue to develop until the human has reached skeletal *** this stage of development,themass,density,morphology,hardness and strength of human bones are constantly *** are studies that describe the dynamic changes in bone morphology in each part of the human body from the embryonic period to *** example,the femoral neck torsion angle(FNTA)is approximately 30 to 40 degrees at birth,and the angle gradually recedes to 10 to 15 degrees by early *** have a large femoral neck-shaft angle(NSA),and this angle decreases gradually to an angle common in *** studies have focused on the physiological and molecular mechanisms by which bones sense,transduce,and respond to mechanical loads and have investigated the effects of aging processes on the relationship between cortical bone properties(such as cross-sectional geometry and bone mineral density)and mechanical function.[1,2]

关键词： deformation dynamic angle

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Application of Bionic Technology in Marine Cruise Equipment:Research Progress and Development Trends

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Journal of Bionic Engineering 2024年第3期21卷 1117-1155页

作者： Kunhui Luo Lan yan Zhiyi zhu Zhongqiu Wang Hongru Wang Feng Jiang School of Electromechanical and Automation Huaqiao UniversityXiamen36102China National Local Joint Engineering Research Center for Intelligent Manufacturing Technology of Brittle Material Products Xiamen361021China Institute of Oceanographic Instrumentation Shandong Academy of SciencesQilu University of Technology(Shandong Academy of Sciences)Qingdao266100China Shandong Provincial Key Laboratory of Marine Monitoring Instrument Equipment Technology Qingdao266100China National Engineering and Technological Research Center of Marine Monitoring Equipment Qingdao266100China Institute of Manufacturing Engineering Huaqiao UniversityXiamen361021China

This article provides an overview of the application of bionic technology in marine cruising equipment,discussing its research progress and future development *** cruising is a crucial means of gaining insights into the marine environment and conducting scientific ***,conventional marine cruising equipment faces numerous challenges when dealing with complex and ever-changing marine *** technology,as a means of drawing inspiration from the structure and functions of living organisms,offers new approaches and methods to address the challenges faced by marine cruising equipment and has found widespread *** article primarily focuses on the applications and historical developments of bionic technology in propulsion methods,drag reduction,and surface *** summarizes the design principles,manufacturing techniques,and optimization methods for marine biomimetic cruising ***,this paper analyzes the achievements,challenges,and future directions of bionic technology in marine cruising *** application of bionic technology in marine cruising equipment holds vast potential for development,enabling us to better confront the challenges of marine exploration and research by drawing wisdom from nature and driving advancements in marine science.

关键词： Marine cruising equipment Bionic technology Propulsion methods Drag reduction Surface antifouling

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