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A Service Relevance Based Matching Algorithm on Grid Environment

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 269-272页

作者： QIN Wen-yan XU li-zhen HE Jie-yue Department of Computer Science and Engineering Southeast University Nanjing 210096 Jiangsu China

This paper presents a semantic metadata description model for grid services, and furthermore, a service relevance based matching algorithm is proposed. Some rea sonable parameters interpreting services characterizations are considered to advise matching process, whose weightiness and service relevance dramatically contribute to the decision making of service matching degree, And what＇s more, matching is secondly executed on the bases of experience adaptation of matching factors, which improves matching degree in gird service retrieve greatly.

关键词： grid ontology semantic metadata service relevance match

Zn Accumulation and Subcellular Distribution in the Zn Hyperaccumulator Sedurn alfredii Hance

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Pedosphere 2006年第5期16卷 616-623页

作者： li Ting-Qiang yanG Xiao-E yanG Jin-yan HE zhen-li MOE Key Laboratory of Environment Remediation and Ecosystem Health Zhejiang University Huajianchi Campus Hangzhou 310029 （China）

Zn accumulation and subcellular distribution in leaves of the hyperaccumulating ecotype （HE） and non-hyperaccumulating ecotype （NHE） of Sedum alfredii Hance were studied using radiotracer and gradient centrifugation techniques. Leaf Zn accumulation in the HE of S. alfredii was 18.5-26.7 times greater than that in the NHE when the plants were grown at 1-500μmol Zn L-1. Leaf section uptake of 65Zn was highly dependent on external Zn levels. Greater 65Zn uptake in HE was noted only at external Zn levels 〉 100μmol L-1. Zinc subcellular distribution in the leaves of the two ecotypes of S. alfredii was： cell wall 〉 soluble fraction 〉 cell organelle. However, more Zn was distributed to the leaf cell wall and soluble fractions for HE than for NHE. In the leaf of HE, 91%-94% of the Zn was found in the cell walls and the soluble fraction and only 6%-9% Zn was distributed in the cell organelle fraction. For NHE, about 20%-26% Zn was recovered in the cell organelle fraction. In stems, Zn distribution to the ceil wail fraction was approximately two fold greater in the HE than that in the NHE. For the hyperaccumulating ecotype of S. alfredii, the cell wall and the vacuole played a very important role in Zn tolerance and hyperaccumulation.

关键词： compartmentation Sedum alfredii Hance subcellular distribution Zn hyperaccumulator

Monocular posterior scleritis presenting as acute conjunctivitis:A case report

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World Journal of Clinical Cases 2020年第20期8卷 5030-5035页

作者： yan-zhen li Xiu-Hong Qin Jian-Min Lu Yong-Ping Wang Department of Ophthalmology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Posterior scleritis is a rare inflammatory ocular disease,characterized by severe and painful inflammation of the *** is often misdiagnosed or underdiagnosed,due to its general and varying clinical presentation profile,which primarily involves pain and visual impairment but which can include eyelid edema,choroidal folds,serous retinal detachment,disc edema,hard exudates in fovea and subretinal *** report here a case of posterior scleritis,with symptoms of eye pain and red eye,initially misdiagnosed as acute *** SUMMARY A 56-year-old man presented to a local hospital with complaint of pain and redness in the right *** initial diagnosis was acute conjunctivitis and he was given antibiotic *** week-long continuance of the symptoms despite treatment,he presented to our *** examination revealed a shallow anterior chamber in the right eye and vision reduction to *** testing by optical coherence tomography,ultrasound biomicroscopy,and fundus photography indicated diagnosis of posterior *** patient was given methylprednisolone(oral)on a tapered reduction schedule(starting with 70 mg/d).According to the peaks and troughs of symptoms,compound betamethasone injection was administered into the bulb,culminating in discontinuation of the oral *** optical coherence tomography showed the subretinal fluid near the optic disc to be completely absorbed after *** Posterior scleritis should be among the differential diagnosis of eye pain and redness,and diagnosis requires further ophthalmic accessory examination,such as by optical coherence tomography.

关键词： Posterior scleritis Eye pain Sclera Differential diagnosis Optical coherence tomography Case report

Synthesis of novel chiral N,P-containing multidentate ligands and their applications in asymmetric transfer hydrogenation

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Chinese Chemical Letters 2011年第11期22卷 1269-1272页

作者： Shen Luan Yu yan Yun li zhen Rong Dong Juan Ni Zhang Qi li Jing Xing Gao State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green ChemicalProductions of Alcohols-Ethers-Esters and Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis（o-formylphenyl）phenylphosphane and various chiral *** structures were fully characterized by IR,EI-MS and *** catalytic systems,prepared in situ from the multidentate ligands and iridium（I） complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee.

关键词： Chiral multidentate aminophosphine ligand Iridium complex Propiophenone Asymmetric transfer hydrogenation

Combined treatment with valproic acid and estrogen has neuroprotective effects in ovariectomized mice with Alzheimer’s disease

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Neural Regeneration Research 2021年第10期16卷 2078-2085页

作者： yan-zhen li Yuan-Jie liu Wei Zhang Shi-Fang Luo Xin Zhou Gui-Qiong He Chongqing Key Laboratory of Neurobiology Chongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Galactophore Chongqing University Cancer HospitalChongqingChina

Postmenopausal women with Alzheimer’s disease exhibit dramatically reduced sensitivity to estrogen replacement therapy,which is though to be related to an estrogen receptor(ER)α/ERβratio imbalance arising from a significantly decreased level of ERs of the *** aim of our study was to investigate whether valproic acid(VPA)can enhance the beneficial effects of estrogen on cognitive function through restoration of ERαand ERβexpression in the *** removed the ovaries of female APP/PS1 mice to simulate the low estrogen levels present in postmenopausal women and then administered VPA(30 mg/kg,intraperitoneal injection,once daily),17β-estradiol(E2)(2.4μg,intraperitoneal injection,once daily),liquiritigenin(LG)(50μg/kg,intragastric infusion,once daily),VPA+E2,or VPA+LG for 4 successive *** with treatment with a single drug,treatment with VPA+E2 or VPA+LG significantly increased the level of glycogen synthase kinase 3β,increased the expression of estrogen receptorα,reduced the expression of small ubiquitin-like modifiers,and increased the level of estrogen receptorβ.This resulted in enhanced sensitivity to estrogen therapy,reduced amyloidβaggregation,reduced abnormal phosphorylation of the tau protein,reduced neuronal loss,increased dendritic spine and postsynaptic density,and significantly alleviated memory loss and learning impairment in Alzheimer’s *** study was approved by the Chongqing Medical University Animal Protection and Ethics Committee,China on March 6,2013.

关键词： 17β-estradiol amyloidβ dementia estrogen receptorα estrogen receptorβ glycogen synthase kinase-3β liquiritigenin menopause neuron loss tau

Trehalose and trehalose-hydrolyzing enzyme in the haemolymph of Locusta rnigratoria infected with Metarhizium anisopliae strain CQMa102

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Insect Science 2007年第4期14卷 277-282页

作者： HUA ZHAO ZHONG-KANG WANG YOU-PING YIN yan-liNG li zhen-LUN li GUO-XIONG PENG YU-XIAN XIA GeneticEngineeringResearchCenter CollegeofBioengineeringChongqingUniversityChongqingChina

Topical application of the Metarhizium anisopliae var. acridum specialist strain CQMa 102 to the locust Locusta migratoria manilensis results in changes of the concentrations of trehalose and glucose in the haemolymph. Micrographs of the locust haemolymph shows Metarhizium anisopliae can effectivly penetrate the external skeleton of locust and after 2 days infection, the hyphae body will appear in the haemolymph of infected insects. The time in decrease of trehalose concentration coincided with that in increase of trehalose-hydrolysing enzyme activity in the haemolymph of the fungus-infected insects. Overlay gel analysis indicated there was considerably more trehalose-hydrolysing activity in the haemolymph of locusts infected by fungus than in controls. A comparable isoform was identified in in vitro culture of the fungus, suggesting a fungal origin for the in vivo enzyme. Haemolymph trehalose decreased significantly during mycosis of locusts by M. anisopliae. All these results suggested that this fungus may take advantage of competing nutrient utilization against the insect by its trehalose-hydrolyzing enzyme secretion. It may provide fundamental knowledge for fungal pathogenesis.

关键词： Metarhizium anisopliae Locusta migratoria manilensis trehalose-hydrolysingenzymes trehalose glucose mycosis

A lindqvist-type [W_(6)O_(19)]^(2-) organic–inorganic compound: synthesis, characterization, antibacterial activity and preliminary studies on the mechanism of action

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Tungsten 2022年第2期4卷 121-129页

作者： Meng Zhao Xi-Yu Zhu yan-zhen li Jiang-Nan Chang Ming-Xue li li-Hua Ma Xiao-Yuan Guo Henan Key Laboratory of Polyoxometalate Chemistry Institute of Molecular and Crystal EngineeringSchool of Chemistry and Chemical EngineeringHenan UniversityKaifeng475004China Agricultural Products’Quality and Safety Testing Center of Kaifeng Kaifeng Agriculture and Rural BureauHenan475004China

In this paper,a new organic–inorganic hybrid compound[Co(L)_(2)]2[W_(6)O_(19)](1)(HL=2-acetylpyridine thiosemicarbazone)was prepared and *** compound 1 exhibits remarkable antibacterial activity by determination of minimum inhibitory concentration(MIC)against Staphylococcus aureus(***,0.06μg·mL^(−1))and Escherichia coli(***,0.24μg·mL^(−1)),***,the potential mechanism of compound 1 was studied in *** potential causes of bacteria death were cell wall/membrane disruption,inhibition of intracellular respiratory chain dehydrogenases(RCD)activity,destruction of reactive oxygen species(ROS)and depletion of glutathione(GSH).

关键词： Isopolytungstate Thiosemicarbazone Bioactivity Mechanism of action

Multicomponent Reaction in Ionic liquid: A Novel and Green Synthesis of 1, 4-Dihydropyridine Derivatives

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Chinese Chemical Letters 2006年第2期17卷 150-152页

作者： Xin Ying ZHANG yan zhen li Xue Sen FAN Gui Rong QU Xue Yuan HU Jian Ji WANG College of Chemistry and Environmental Science Henan Key Laboratory for Environmental Pollution Control Henan Normal University Xinxiang 453007

An efficient and green method for the synthesis of 1, 4-dihydropyridine derivatives mediated in an ionic liquid, [bmim][BF4], through a four-component condensation process of aldehydes, 1, 3-dione, Meldrum＇s acid and... 详细信息

关键词： 1,4-Dihydropyridines ionic liquids multicomponent reaction green chemistry.

New therapy for oral ulcer:Evodia rutaecarpa patch combined with acupoint application

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Traditional Medicine Research 2023年第9期8卷 23-33页

作者： yan-li zhen Jian-Peng Qin Yu-Fen li Jian Zhang Xiao-Hui Yu Ji li Dong-Kai Wang Department of Pharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

Background:Oral ulcer is the most common and easily recurrent disease in stomatology,which influence the patients’communication,normal dietary,and *** rutaecarpa(ER)is a traditional Chinese herbal medicine recorded in ancient Chinese medical books,which has a medicinal history of more than 2,000 ***,the application of ER at plantar Yongquan point(KI1)is effective in the treatment of oral *** purpose of this study was to combine the modern transdermal drug delivery system with traditional Chinese medicine to develop the transdermal absorption patch of ER and apply it to the treatment of oral ulcer at Yongquan point of ***:Firstly,the medicinal materials of ER were extracted and the extracted materials were prepared into dispersed ER *** formulation and preparation process were screened by orthogonal design method and single factor investigation *** adhesive and transdermal properties of the patch were used as the evaluation index of the ***,Wistar rats were used as experimental animals to establish a rat model of mouth *** rats were randomly divided into normal group,model group(A),model group(B),low dose group,medium dose group and high dose *** efficacy of ER on rat’s oral ulcer model was evaluated through three aspect such as apparent index,pathological index and biochemical ***:The patch had suitable adhesion and good skin penetration,which was an effective treatment for oral *** vivo pharmacodynamic studies,compared with the normal group,the body mass and food intake of rats in each group after modeling decreased,the amount of drinking water increased,the tissue structure of oral mucosa was damaged,and the levels of inflammatory factors(TNF-α,IL-6)and malondialdehyde increased,the levels of anti-inflammatory factors(IL-10),cell growth factor(epidermal growth factor,TGF-β_(1))and superoxide dismutase *** with the model group,the body weight and food

关键词： oral ulcer Evodia rutaecarpa patch traditional Chinese medicine acupoint application pharmacodynamic