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Outcome of conservative treatment and subsequent assisted reproductive technology for patients with early-stage endometrial adenocarcinoma and poor fertility potential

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Chinese Medical Journal 2012年第19期125卷 3578-3580页

作者： TONG Xiao-mei ZHU Hai-yan LIN Xiao-na JIANG Ling-ying XU Wei-hai LIU Liu ZHANG Song-ying Assisted Reproduction Unit Department of Obstetrics and GynecologySir Run Run Shaw HospitalZhejiang UniversityZhejiangHangzhouZhejiang 310016China

Conservative treatment with high doses of progestin is an alternative to standard hysterectomy for young patients with early-stage endometrial adenocarcinoma who desire to preserve their fertility. Here we report a patient with well-differentiated early-stage endometrial adenocarcinoma and poor fertility potential who failed to become pregnant in two in vitro fertilization-embryo transfer cycles and suffered a relapse after conservative treatment. This case illustrates that assessment of fertility potential is critical at the time of initial evaluation and conservative treatment planning for patients with endometrial adenocarcinoma.

关键词： endometrial carcinoma progestin assisted reproductive technology

Detection of ALK translocation in non-small cell lung carcinoma(NSCLC) and its clinicopathological significance using the Ventana immunohistochemical staining method: a single-center large-scale investigation of 1,504 Chinese Han patients

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Chinese Journal of Cancer Research 2016年第5期28卷 495-502页

作者： Lin yang yun Ling Lei Guo Di Ma Xuemin Xue Bingning Wang Junling Li Jianming ying Department of Pathology Cancer HospitalChinese Academy of Medical Sciences Internal Department Cancer HospitalChinese Academy of Medical Sciences

Objective： The novel fully automated immunohistochemistry （IHC） assay-Ventana anaplastic lymphoma kinase （ALK）-DSF3 for screening ALK rearrangements has been approved by China＇s Food and Drug Administration in 2013, our previous study disclosed a highly specificity and sensitivity nearly 100%, and its efficacy needs to be evaluated in a large cohort of primary lung adenocarcinoma patients, and to compare clinicopathological features with ALK （＋） and ALK （-） lung ***： A total of 1,504 consecutive surgical lung adenocareinoma eases of Chinese Han population were collected and re-diagnosed according to the 2011 multidisciplinary classification of lung adenocarcinoma. Fully automated Ventana ALK-D5F3 IHC staining with a binary scoring was adopted to evaluate staining and correlated with dinieopathologieal characters, including age, sex, differentiation degree, histological subtype, lymph node metastasis, and clinical staging. ALK （＋） patients were followed-up, and targeted therapy of ALKinhibitors was adopted and observed in patients with stage IV according to the NCCN ***： ALK positive adenocarcinomas were identified in 6.6% of the surgically resected 1,504 NSCLCs, and significantly younger than the negative group （P〈0.05）.Mucinous adenocarcinoma （28.2%） was determined to be predominant in ALK （＋） cases, followed by the solid type （11.7%）, specific type （6.8%）, papillary type （5.6%）, acinar type （5.5%）, and lepidic type （3.1%）, and the differences were statistically significant （χ2=42.01 1, P〈0.05）. ALK （＋） adenocarcinoma with lymph node metastasis （10.8%） were significantly higher than that without lymph node metastasis （4.5%）（g2=19.809, P〈0.05）; and ALK （＋） in phase Ⅳ （20%） was significantly higher than phaseⅢ （12.9%）, phase Ⅱ （4.2%）, phase Ⅰ （4.5%）, and phase 0 （0）（g2=36.068, P〈0.05）. Multivariate logistic regression disclosed that patient age, AJCC staging, and histological mucinous subtype were correlated with ALK positive staini

关键词： Anaplastic lymphoma kinase (ALK) rearrangements fully automated immunohistochemistry (IHC) clinicopathological analysis targeted therapy

Lymphocyte Subsets and Sister-chromatid Exchanges in the Students Exposed to Formaldehyde Vapor

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Biomedical and Environmental Sciences 1999年第2期12卷 88-94页

作者： ying CHEN-JIANG YE XIAO-LEI XIE HONG yan WEN-SHENG ZHAO MEI-ying XIA TONG AND YIN SHU-YI.(Department of Environmental Health, Tongji Medical University, Wuhan 430030, China Department of Public Health, Wenzhou Medical College, Wenzhou 317400, China Department of Anatomy,Tongji Medical University, Wuhan 430030, China) Department of Environmental Health Tongji Medical University Wuhan 430030 China Department of Public Health Wenzhou Medical College Wenzhou 317400 China Department of Anatomy Tongji Medical University Wuhan 430030 China

The present report evaluates the effects of formaldehyde (FA) exposure on peripheral lymphocytes by using heth genetic and immunological parameters. Twenty-three non-smoking students in the study had inhalation exposure to 0.508 ±0. 299 mg/m3 of FA for a Period of 8 weeks (3h × 3 times each week) during anatomy classes. As for composition of lymphocyte subsets after FA exposare,significant increase was found in the percentage of CD19(B cells), while sighficant decrease was observed in CD3(total T cells), CD4(T helper-inducer cells), and CD8(T cytotoxic-suppressior cells) with a P 0 .05) was reported between lymphocyte prolifendion rate and sisterchromatid exchange (SCE) at the exposure level and duration. It is suggested that the lymphocyte subsets may be most susceptible to the effects of FA, though a single immunological endpoint is rarely related with pathophysiological interpretation.

关键词： Res FA DNA Lymphocyte Subsets and Sister-chromatid Exchanges in the Students Exposed to Formaldehyde Vapor Heck

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三层机织大提花披巾的开发及CAD技术应用

毛纺科技 2014年第2期42卷 25-27页

作者：徐蕴燕南通纺织职业技术学院江苏南通226007

介绍了三层机织大提花披巾开发及CAD技术在产品设计中的应用,研究原料、纱线、经纬密度、后整理工艺对织物性能的影响,分析织物组织、花型、染色方式的选择对于提高生产管理、减少成本、提高效益的作用。特别对CAD技术意匠设计中彩稿输... 详细信息

介绍了三层机织大提花披巾开发及CAD技术在产品设计中的应用,研究原料、纱线、经纬密度、后整理工艺对织物性能的影响,分析织物组织、花型、染色方式的选择对于提高生产管理、减少成本、提高效益的作用。特别对CAD技术意匠设计中彩稿输入、勾边、纬纱排列、建立意匠色与轧孔规律对应关系、梭箱升降设计、纹板文件设计作了详细描述。CAD技术作为现代化高科技设计工具在开发中的应用是增强产品市场竞争力的有效手段。

关键词：毛织物披巾三层大提花 CAD意匠

Evaluation preparation technology of Xiaochaihu granules using fingerprint-peak pattern matching

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Journal of Pharmaceutical Analysis 2011年第2期1卷 119-124页

作者： Yu-Qiong Wu Yu- Qiang Gou Jing Han ying-yan Bi Shi-Lan Feng Fang-Di Hu Chun- Ming Wang School of Pharmacy Lanzhou University Lanzhou 730000 China the Second People's Hospital of Gansu Province Lanzhou 730000 China Center for Disease Control and Prevention Lanzhou Military Area Command of Chinese People's Liberation Army Lanzhou 730000 China College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

An approach was proposed to evaluate preparation technology by means of fingerprint-peak matching technology of high performance liquid chromatography with diode array detector （HPLC-DAD）. Similarity and hierarchical clustering analysis （HCA） were applied to identify the 15 batches of Xiaochaihu granules from different manufacturers and our laboratory, and peak pattern matching between the composite formulae and Radix Bupleuri Chinensis, which was one of the main ingredients of Xiaochaihu granules, was utilized to evaluate the preparation technology of Xiaochaihu granules via the indexes of the relative deviation of retention time （RT） and UV spectrum feature similarity of their corresponding peaks. Eleven matching peaks were found between Xiaochaihu granules and Radix Bupleuri Chinensis. However, the saikosaponin A and saikosaponin D, which are the important active components in Radix Bupleuri Chinensis, were not found in Xiaochaihu granules from any manufacturers. The peak areas of 11 characteristic peaks of Xiaochaihu granules samples formed a matrix of 11 × 15. The result of HCA showed that Xiaochaihu granules samples were divided into four kinds of category. Xiaochaihu granules samples from the same manufacturer were basically clustered of the same category. The results suggested that the saikosaponin A and saikosaponin D are prone to structural transformation under the condition of decoction and in the presence of the organic acidic components. These active components, existing in raw herb, might transform to a series of non-active secondary saikosaponin due to unfavourable preparation technology. So the conventional decoction-based preparation technology of Xiaochaihu granules might greatly affect its quality and therapeutic effectiveness. This study demonstrates that fingerprint-peak matching technology can not only be used for quality control of this composite formulae, but also provide some guidance for preparation technology of Xiaochaihu granules.

关键词： Xiaochaihu granules Radix Bupleuri Chinensis fingerprint-peak matching hierarchical clustering analysis

Laparoscopic vs open D2 gastrectomy for locally advanced gastric cancer: A meta-analysis

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World Journal of Gastroenterology 2014年第44期20卷 16750-16764页

作者： Zhen-Hong Zou Li-ying Zhao Ting-Yu Mou yan-Feng Hu Jiang Yu Hao Liu Hao Chen Jia-Ming Wu Sheng-Li An Guo-Xin Li Department of General Surgery The Second Affiliated Hospital of Nanchang University Department of General Surgery Nanfang Hospital Southern Medical University Department of Biostatistics Southern Medical University

AIM: To conduct a meta-analysis comparing laparoscopic (LGD2) and open D2 gastrectomies (OGD2) for the treatment of advanced gastric cancer (AGC).

关键词： D2 lymph node dissection Gastrectomy Gastric cancer Laparoscopy Meta-analysis

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城市经济发展与交通机动化的动态协整分析

系统工程 2015年第3期33卷 90-96页

作者：吴颖卢毅颜瑛长沙理工大学交通运输工程学院湖南长沙410004 湖南交通职业技术学院湖南长沙410132

基于北京市的数据,应用协整理论、VAR模型,Eviews6.0软件对北京市小汽车交通与城市经济发展,公共交通与政府公共交通投资之间的关系进行协整分析。分析表明小汽车交通与城市经济发展之间确实存在长期稳定均衡的协整关系,城市经济发展是... 详细信息

基于北京市的数据,应用协整理论、VAR模型,Eviews6.0软件对北京市小汽车交通与城市经济发展,公共交通与政府公共交通投资之间的关系进行协整分析。分析表明小汽车交通与城市经济发展之间确实存在长期稳定均衡的协整关系,城市经济发展是小汽车交通发展的Granger原因;以新的视角揭示出政府公共交通投资的增长并没有带来公共交通的理想发展,公共交通却是政府公共交通投资的Granger原因。一系列定量分析结果为在城市经济不断发展条件下,优化小汽车交通管理和机动化出行结构,改善交通拥堵,改善政府交通投资理念及策略,有效实施公交优先发展战略等提供了新的思路和理论依据。

关键词：交通机动化城市经济交通投资协整 Granger因果分析

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改良灌肠法治疗老年习惯性便秘的效果研究

中国实用护理杂志 2009年第15期25卷 22-24页

作者：晋运玲梁颖韫李晓燕王莹山东大学第二医院

目的探讨改良灌肠法解除老年习惯性便秘的疗效。方法将80例老年便秘患者按年龄及性别匹配的原则分为观察组和对照组各40例,观察组以改良式清洁灌肠法灌肠治疗,对照组以传统清洁灌肠法灌肠治疗。对2组患者灌肠液保留时间、解除便秘的排... 详细信息

目的探讨改良灌肠法解除老年习惯性便秘的疗效。方法将80例老年便秘患者按年龄及性别匹配的原则分为观察组和对照组各40例,观察组以改良式清洁灌肠法灌肠治疗,对照组以传统清洁灌肠法灌肠治疗。对2组患者灌肠液保留时间、解除便秘的排便次数及治疗后便秘复发率进行比较。结果观察组灌肠液保留时间长于对照组,解除便秘的排便次数少于对照组,治疗后便秘复发率低于对照组。结论改良灌肠法治疗老年习惯性便秘疗效优于传统清洁灌肠法。

关键词：灌肠便秘老年患者

Relationship Between Lodging Resistance and Chemical Contents in Culms and Sheaths of Japonica Rice During Grain Filling

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Rice science 2010年第4期17卷 311-318页

作者： ZHANG Feng-zhuan JIN Zheng-xun MA Guo-hui SHANG Wen-nan LIU Hai-ying Xu Mei-lan LIU yan Agricultural College Northeast Agricultural University Harbin 150030 China China National Hybrid Rice R ＆ D Center Changsha 41 O125 China Jilin Province Ping＇an Seeds Company Changchun 133000 China

To understand the relationship between lodging resistance and chemical component contents in culms and leaf sheaths of rice, the physical strength and maximum bearing capacity of culm, and the contents and amounts of potassium （K） silicon （Si） and soluble sugars in culms and leaf sheaths were investigated using four japonica rice varieties with different lodging resistance characteristics during grain filling. There were significant differences in the total amounts of K, Si and soluble sugars in culms and leaf sheaths among the tested rice varieties. The difference in the total amount of Si was greater than that of K or soluble sugars. The physical strength and maximum bearing capacity of culm continuously decreased from heading to ripening, with a rapid decrease at the dough stage. However, the contents and total amounts of K and Si in culms and the Si content in leaf sheaths gradually increased and an accumulation of K and Si in culms was exhibited, whereas the content and total amount of K and the total amount of Si in leaf sheaths gradually decreased and an exportation of K and Si in leaf sheaths was presented. The physical strength was positively and significantly correlated with the total amounts of K and Si in culms during grain filling except that at the heading stage, the total amount of soluble sugars in culms at the heading and milky stages, the total amounts of Si and soluble sugars in leaf sheaths at the heading stage, the total amount of K in leaf sheaths at the heading and milky stages, and the maximum bearing capacity during grain filling. It is suggested that the lodging resistance of japonica rice would be improved by increasing the amount of soluble sugars in plants at the early filling stage, and enhancing the amount of Si in plants during grain filling through topdressing Si fertilizer at the early filling stage.

关键词： japonica rice grain filling lodging resistance chemical component content dynamic change