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Effects of Central Administration of Glutamine and Alanine on Feed Intake and Hypothalamic Expression of Orexigenic and Anorexigenic Neuropetides in Broiler Chicks

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Journal of Integrative Agriculture 2012年第7期11卷 1173-1180页

作者： Khondowe Paul WANG Song-bo CHEN Sheng-feng YU Jian-jian ZHU Xiao-tong WANG Li-na GAO Ping XI Qian-yun ZHANG Yong-liang SHU Gang JIANG Qing-yan College of Animal Sciences South China Agricultural University Guangzhou 510642 P.R.China School of Natural Sciences Department of Biological Sciences University of Zambia PO. Box 32379 Lusaka Zambia

Different amino acids have been shown to affect feed intake when injected directly into the central nervous system of birds. In the present study, we investigated the effects of L-glutamine and L-alanine on feed intake and the mRNA expression levels of hypothalamic neuropeptides involved in feed intake regulation in broiler chicks. L-Glutamine or L- alanine was intra-cerebroventricularly （ICV） administered to 4-d-old broiler chicks and the feed intake were recorded at various time points. Quantitative PCR was performed to determine the hypothalamic mRNA expression levels of neuropeptide Y （NPY）, agouti related protein （AgRP）, pro-opiomelanocortin （POMC）, melanocortin receptor 4 （MC4R） and corticotropin releasing factor （CRF）. Our results showed that ICV administration of L-glutamine （0.55 or 5.5 pmol） significantly increased feed intake up to 2 h post-administration period and the hypothalamic NPY mRNA expression levels, while it markedly decreased hypothalamic POMC and CRF mRNA expression levels. In contrast, ICV administration of L-alanine （4 lamol） significantly decreased feed intake for the first 0.5 h post-administration period, and reduced the hypothalamic AgRP mRNA expression levels, while it remarkablely enhanced the mRNA expression levels of MC4R and CRF. These findings suggested that L-glutamine and L-alanine could act within the hypothalamus to influence feed intake in broiler chicks, and that both orexigenic and anorexigenic neuropeptide genes might contribute directly to these effects.

关键词： L-glutamine L-alanine intracerebroventricular (ICV) feed intake hypothalamus

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玉米的热分析研究

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粮食与油脂 2015年第12期28卷 53-55页

作者：严云西昌学院农业科学学院四川西昌615013

用SHMASZU DTG–60差热–热重分析仪器,在静态空气气氛条件下,对玉米进行了热分析研究,对影响热分析的各参数进行了条件的优化。结果表明,最佳的实验条件为升温速率10℃/min、样品的填充量2.72 mg且粒径为80目。通过热分析数据可知玉米... 详细信息

用SHMASZU DTG–60差热–热重分析仪器,在静态空气气氛条件下,对玉米进行了热分析研究,对影响热分析的各参数进行了条件的优化。结果表明,最佳的实验条件为升温速率10℃/min、样品的填充量2.72 mg且粒径为80目。通过热分析数据可知玉米粉的最佳分解温度为363.47℃,玉米皮的最佳分解温度为400.97℃。

关键词：玉米热分析差热-热重分析

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Targeted isolation of antitubercular cycloheptapeptides and an unusual pyrroloindoline-containing new analog,asperpyrroindotide A,using LC–MS/MS-based molecular networking

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Marine Life Science & Technology 2023年第1期5卷 85-93页

作者： Yi-Qian Han Qun Zhang Wei-Feng Xu yang Hai Rong Chao Cui-Fang Wang Xue-Mei Hou Mei-yan Wei Yu-Cheng Gu Chang-yun Wang Chang-Lun Shao Key Laboratory of Marine Drugs the Ministry of Education of ChinaSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China College of Food Science and Engineering Ocean University of ChinaQingdao 266003China Syngenta Jealott’s Hill International Research Centre BracknellBerkshire RG426EYUK Laboratory for Marine Drugs and Bioproducts Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China

Further insights on the secondary metabolites of a soft coral-derived fungus Aspergillus versicolor under the guidance of MS/MS-based molecular networking led to the isolation of seven known cycloheptapeptides,namely,asperversiamides A–C(1–3)and asperheptatides A–D(4–7)and an unusual pyrroloindoline-containing new cycloheptapeptide,asperpyrroindotide A(8).The structure of 8 was elucidated by comprehensive spectroscopic data analysis,and its absolute configuration was determined by advanced Marfey’s *** semisynthetic transformation of 1 into 8 was successfully achieved and the reaction conditions were ***,a series of new derivatives(10−19)of asperversiamide A(1)was semi-synthesized and their anti-tubercular activities were evaluated against Mycobacterium tuberculosis *** preliminary structure−activity relationships revealed that the serine hydroxy groups and the tryptophan residue are important to the activity.

关键词： Marine natural product MS/MS-based molecular networking Cycloheptapeptides Semi-synthesis Anti-tubercular activity

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Evaluation of oxaliplatin and tigio combination therapy in locally advanced gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1709-1716页

作者： Teng Wang Li-yun Zhang Department of Gastroenterology Xianyang HospitalYan’an UniversityXianyang 712000Shaanxi ProvinceChina

BACKGROUND Locally advanced gastric cancer(LAGC)is a common malignant *** recent years,neoadjuvant chemotherapy has gradually become popular for the treatment of *** To investigate the efficacy of oxaliplatin combined with a tigio neoadjuvant chemotherapy regimen vs a conventional chemotherapy regimen for *** Ninety patients with LAGC were selected and randomly divided into control and study groups with 45 patients in each group,according to the numerical table *** control group was treated with conventional chemotherapy,and the study group was treated with oxaliplatin combined with tigio-neoadjuvant *** primary outcome measures were the clinical objective response rate(ORR)and surgical resection rate(SRR),whereas the secondary outcome measures were safety and Karnofsky Performance Status *** The ORR in the study group was 80.00%,which was significantly higher than that of the control group(57.78%).In the study group,SRR was 75.56%,which was significantly higher than that of the control group(57.78%).There were 15.56%adverse reactions in the study group and 35.56%in the control *** differences were statistically significant between the two *** The combination of oxaliplatin and tigio before surgery as neoadjuvant chemotherapy for patients with LAGC can effectively improve the ORR and SRR and is safe.

关键词： Locally advanced gastric cancer Oxaliplatin and tigio Neoadjuvant chemotherapy Surgical resection rate Objective response rate Clinical efficacy

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X-ray-activated long persistent phosphors featuring strong UVC afterglow emissions

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Light(Science & Applications) 2018年第1期7卷 222-232页

作者： yan-Min yang Zhi-Yong Li Jun-ying Zhang Yue Lu Shao-Qiang Guo Qing Zhao Xin Wang Zi-Jun Yong Hong Li Ju-Ping Ma Yoshihiro Kuroiwa Chikako Moriyoshi Li-Li Hu Li-yan Zhang Li-Rong Zheng Hong-Tao Sun College of Physics Science and Technology Hebei University071002 BaodingChina College of Chemistry Chemical Engineering and Materials ScienceSoochow University215123 JiangsuChina Department of Physics Beihang University100191 BeijingChina Department of Physical Science Hiroshima UniversityHigashihiroshimaHiroshima 739-8526Japan Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences201800 ShanghaiChina Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of Sciences100049 BeijingChina

Phosphors emitting visible and near-infrared persistent luminescence have been explored extensively owing to their unusual properties and commercial interest in their applications such as glow-in-the-dark paints,optical information storage,and in vivo ***,no persistent phosphor that features emissions in the ultraviolet C range(200–280 nm)has been known to exist so ***,we demonstrate a strategy for creating a new generation of persistent phosphor that exhibits strong ultraviolet C emission with an initial power density over 10 milliwatts per square meter and an afterglow of more than 2 *** characterizations coupled with first-principles calculations have revealed that structural defects associated with oxygen introduction-induced anion vacancies in fluoride elpasolite can function as electron traps,which capture and store a large number of electrons triggered by Xray ***,we show that the ultraviolet C afterglow intensity of the yielded phosphor is sufficiently strong for *** discovery of this ultraviolet C afterglow opens up new avenues for research on persistent phosphors,and it offers new perspectives on their applications in terms of sterilization,disinfection,drug release,cancer treatment,anti-counterfeiting,and beyond.

关键词： ultraviolet fluoride visible

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异型铜带连续挤压过程的数值模拟研究

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塑性工程学报 2008年第4期15卷 142-145页

作者：运新兵宋宝韫赵颖大连交通大学材料科学与工程学院大连116028

利用DEFORM-3D软件对异型铜带的连续挤压扩展成形过程进行三维有限元数值模拟,分析金属的流动规律、速度、应力、应变分布。模拟结果表明,采用常规连续挤压工装模具结构会在产品横截面上产生很大的速度差,中间流速快,两边流速慢。通过... 详细信息

利用DEFORM-3D软件对异型铜带的连续挤压扩展成形过程进行三维有限元数值模拟,分析金属的流动规律、速度、应力、应变分布。模拟结果表明,采用常规连续挤压工装模具结构会在产品横截面上产生很大的速度差,中间流速快,两边流速慢。通过对模腔结构的优化设计,使金属流动趋于均匀。在TLJ400连续挤压机上进行了异型铜带的连续挤压工艺试验,试验结果与数值模拟结果吻合良好。

关键词：异型铜带连续挤压扩展成形数值模拟

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工程结构优化设计的混合遗传算法

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四川大学学报（工程科学版） 2005年第4期37卷 15-19页

作者：李艺张延年阎运起东北大学资源与土木工程学院辽宁沈阳110004 JamesCookUniv.

根据工程实际,充分考虑规范规定的约束条件和各项技术标准要求,建立了工程结构优化设计模型。为了改善遗传算法在迭代过程中经常出现未成熟收敛、振荡、随机性太大和迭代过程缓慢等缺点,提出一种离散变量结构优化设计的三等分割算法,并... 详细信息

根据工程实际,充分考虑规范规定的约束条件和各项技术标准要求,建立了工程结构优化设计模型。为了改善遗传算法在迭代过程中经常出现未成熟收敛、振荡、随机性太大和迭代过程缓慢等缺点,提出一种离散变量结构优化设计的三等分割算法,并与标准遗传算法结合成混合遗传算法。对25杆框架结构优化设计,结果表明,这种混合遗传算法的收敛特性得到很好的改善,即发挥了三等分割算法省时、局部搜索能力强的特点,又发挥了遗传算法全局性好的特点,是有效的工程结构优化设计方法。

关键词：离散变量结构优化遗传算法混合遗传算法

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黑河干流纤毛虫群落组成及其对水质的响应

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生态学杂志 2017年第5期36卷 1350-1356页

作者：宁应之烟郑杰孙静陈凌云西北师范大学生命科学学院兰州730070

为了解淡水纤毛虫群落对河流水质变化的响应及将淡水纤毛虫群落特征作为评价水质的一个重要参数,于2013年2月至2014年1月,选取黑河干流流域作为研究区域,分不同季节采集水样对其纤毛虫群落组成和理化指标进行分析。结果表明:从上游地区... 详细信息

为了解淡水纤毛虫群落对河流水质变化的响应及将淡水纤毛虫群落特征作为评价水质的一个重要参数,于2013年2月至2014年1月,选取黑河干流流域作为研究区域,分不同季节采集水样对其纤毛虫群落组成和理化指标进行分析。结果表明:从上游地区到下游地区,水中总氮含量(TN)、化学需氧量(COD)、生物需氧量(BOD)和溶氧量(DO)差异显著,总磷含量TP与pH值相对稳定。水质条件的改变使得河流中纤毛虫群落多样性指数、丰富度指数与均匀度指数显著下降(P<0.05),而污生指数显著上升(P<0.05)。这表明纤毛虫群落的组成变化能够敏感地表征水质的变化情况。冗余分析显示,黑河干流纤毛虫群落的变化很好地响应了河流水质的变化情况,根据生物学指标,将黑河干流水质评价为轻度至中度污染,显示出生物学评价在河流水质评价方面存在相当的潜力。

关键词：纤毛虫生物学评价理化指标冗余分析

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Characterization and Differentiation into Adipocytes and Myocytes of Porcine Bone Marrow Mesenchymal Stem Cells

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Journal of Integrative Agriculture 2014年第4期13卷 837-848页

作者： DU Min-qing HUANG Yue-qin LU Nai-Sheng SHU Gang ZHU Xiao-tong WANG Li-na GAO Ping XI Qian-yun ZHANG Yong-liang WANG Song-bo JIANG Qing-yan College of Animal Sciences South China Agricultural University

Bone marrow mesenchymal stem cells （BMSCs） could differentiate into various cell types including adipocytes and myocytes, which had important scientific significance not only in the field of tissue regeneration, but also in the field of agricultural science. In an attempt to exhibit the characterization and differentiation into adipocytes and myocytes of porcine BMSCs, we isolated and purified porcine BMSCs by red blood cell lysis method and percoll gradient centrifugation. The purified cells presented a stretched fibroblast-like phenotype when adhered to the culture plate. The results of flow cytometry analysis and immunofluorescence staining demonstrated that the isolated cells were positive for mesenchymal surface markers CD29, CD44 and negative for hematopoietic markers CD45 and the adhesion molecules CD31. Cells were induced to differentiate into adipocytes with adipogenic medium containing insulin, dexamethasone, oleate and octanoate. Oil Red O staining demonstrated that the porcine BMSCs successfully differentiated to adipocytes. Moreover, the findings of real-time PCR and Western blotting indicated that the induced cells expressed adipogenic marker genes （PPAR-y, C/EBP-c~, perilipin, aP2） mRNA or proteins （PPAR-3,, perilipin, aP2）. On the other hand, porcine BMSCs were induced into myoctyes with myogenic medium supplemented with 5-azacytidine, basic fibroblast growth factor, chick embryo extract and horse serum. Morphological observation by hochest 33342 staining showed that the induced cells presented as multi-nucleus muscular tube structure. And myogenic marker genes （Myf5, desmin） mRNA or proteins （MyfS, MyoD, myogenin, desmin） were found in the induced cells. In addition, the results of immunofluorescence staining revealed that myogenic marker （Myf5, MyoD, myogenin, desmin, S-MyHC） proteins was positive in the induced cells. Above all, these results suggested that the isolated porcine BMSCs were not only consistent with the characterization of mesenchyma

关键词： porcine bone marrow mesenchymal stem cell adipocyte myocyte

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“十三五”国家科技创新规划指标的相关统计问题研究

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中国软科学 2017年第11期 1-7页

作者：赵彦云中国人民大学应用统计科学研究中心北京100872

"十三五"国家科技创新规划使用了12个指标。为了更好地在国家层次和地区层次科学有效推行"十三五"国家科技创新规划指标的监测与考核,本文研究了每个指标的统计问题,包括统计的科学依据和方法要点,以及分析应用的基本理论,也探索了进一... 详细信息

"十三五"国家科技创新规划使用了12个指标。为了更好地在国家层次和地区层次科学有效推行"十三五"国家科技创新规划指标的监测与考核,本文研究了每个指标的统计问题,包括统计的科学依据和方法要点,以及分析应用的基本理论,也探索了进一步深入完善的发展理论问题。

关键词：科技创新规划指标政策统计

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