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Basonuclin 1 deficiency causes testicular premature aging: BNC1 cooperates with TAF7L to regulate spermatogenesis

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Journal of Molecular Cell Biology 2020年第1期12卷 71-83页

作者： Jing-Yi Li Yi-Feng Liu Hai-yan Xu Jun-Yu Zhang Ping-Ping Lv Miao-E Liu yan-yun ying Ye-Qing Qian Kun Li Cheng Li yun Huang Gu-Feng Xu Guo-Lian Ding Yu-Chan Mao Chen-Ming Xu Xin-Mei Liu Jian-Zhong Sheng Dan Zhang He-Feng Huang Key Laboratory of Reproductive Genetics(Ministry of Education)and Department of Reproductive Endocrinology Women's HospitalZhejiang University School of MedicineHangzhou 310006China International Peace Maternal and Child Health Hospital Shanghai Jiao Tong UniversityShanghai 200030China Department of Pathology&Pathophysiology Zhejiang University School of MedicineHangzhou 310000China

Basonuclin(BNC1)is expressed primarily in proliferative keratinocytes and gametogenic ***,its roles in spermatogenesis and testicular aging were not *** we discovered a heterozygous BNC1 truncation mutation in a premature ovarian insufficiency *** this study,we found that male mice carrying the truncation mutation exhibited progressively fertility loss and testicular premature ***-wide expression profiling and direct binding studies(by chromatin immunoprecipitation sequencing)with BNC1 in mouse testis identified several spermatogenesis-specific gene promoters targeted by BNC1 including kelch-like family member 10(Klhl1O),testis expressed 14(Tex14)9 and spermatogenesis and centriole associated 1(Spatcl).Moreover,biochemical analysis showed that BNC1 was associated with TATA-box binding protein-associated factor 7 like(TAF7L),a germ cell-specific paralogue of the transcription factor IID subunit TAF7,both in vitro and in testis,suggesting that BNC1 might directly cooperate with TAF7L to regulate *** truncation mutation disabled nuclear translocation of the BNC1/TAF7L complex,thus,disturbing expression of related genes and leading to testicular premature ***,expressions of Y-box-binding protein 2(YBX2),outer dense fiber of sperm tails 1(ODfl),and glyceraldehyde-3-phosphate dehydrogenase,spermatogenic(GAPDHS)were significantly decreased in the testis of men with non-obstructive *** present study adds to the understanding of the physiology of male reproductive aging and the mechanism of spermatogenic failure in infertile men.

关键词： testicular aging spermatogenesis BNC1 TAF7L gene mutation

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我国西部教育现状、影响因素与对策

特区经济 2005年第2期 116-117页

作者：杨应云湖南省衡阳市广播电视大学

一、目前西部地区教育发展现状与问题解放以来,特别是改革开放以来,西部地区教育事业发展很快,但因历史和经济等多种因素的影响,使教育投入不足,投入体制缺乏活力,造成西部教育落后、人才严重短缺,与东部相比,差距十分明显.有关资料表明... 详细信息

一、目前西部地区教育发展现状与问题解放以来,特别是改革开放以来,西部地区教育事业发展很快,但因历史和经济等多种因素的影响,使教育投入不足,投入体制缺乏活力,造成西部教育落后、人才严重短缺,与东部相比,差距十分明显.有关资料表明:西部地区每万名劳动者中,中专以上学历及初级以上职称人员仅92人,还不到东部地区的1/10.据第四次全国人口普查资料统计,西部不识字或识字很少的人口数占在业人口数比重为39.5%,高出全国平均水平8个百分点,高出东部地区11个百分点,西部90年代在业人口受教育年限仅相当于东部80年代水平.

关键词：西部地区中国教育状况教育投入办学体制办学经费

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重庆市居民健康服务需求程度及差异化分析

现代预防医学 2019年第24期46卷 4453-4456+4466页

作者：王政严云鹰重庆市渝中区教师进修学院重庆医科大学公共卫生与管理学院

目的了解居民对健康服务的需求程度,为政府优化健康服务供给政策提供思路借鉴。方法在重庆市抽取8个区县共1 120名居民进行问卷调查,采用SPSS 22.0软件进行聚类分析、秩和检验和有序多分类logistic回归分析。结果居民对健康服务的需求... 详细信息

目的了解居民对健康服务的需求程度,为政府优化健康服务供给政策提供思路借鉴。方法在重庆市抽取8个区县共1 120名居民进行问卷调查,采用SPSS 22.0软件进行聚类分析、秩和检验和有序多分类logistic回归分析。结果居民对健康服务的需求程度从强到弱分为5类,需求度最高类型:健康保障服务;需求度较高类型:医院服务、基层医疗卫生服务和专业公共卫生服务;需求度一般类型:社会健康服务、体育健身服务、健康咨询服务和健康保险服务;需求度较弱类型:健康相关零售服务和健康相关租赁服务;需求度最弱类型:健康教育服务。所有不同社会特征的调查对象需求第1位次均为健康保障服务,但第2位次却有所不同:低收入居民对医院服务(OR=1.225,95%CI:0.820～1.829)和基层医疗卫生服务(OR=1.556,95%CI:1.042～2.323)的需求较高;初中学历的居民对专业公共卫生服务(OR=1.639,95%CI:1.039～2.586)的需求较高;60岁以下(OR=3.438,95%CI:2.059～5.743)、高学历(OR=0.442,95%CI:0.228～0.858)的居民对体育健身服务的需求较高。结论健康保障服务是重庆市居民最迫切需要的类型,未来应针对不同人群特征供给差异化健康服务,通过加强居民健康教育和提升健康素养水平来培育多元化健康服务需求。

关键词：健康服务需求健康保障体育健身健康教育

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政策工具视角下我国公立医院改革政策分析

中国医院管理 2020年第8期40卷 9-13页

作者：严云鹰陈菲重庆医科大学公共卫生与管理学院·医学与社会发展研究中心·国民健康社会风险预警协同创新中心重庆400016

科学设计和正确选择政策工具是推动公立医院改革进程的基本途径.研究以我国2009—2018年政府层面出台的公立医院改革相关政策文件为对象,基于基本政策工具和改革系统维度构建二维分析框架,利用内容分析法进行条目编码分类以及频数统计,... 详细信息

科学设计和正确选择政策工具是推动公立医院改革进程的基本途径.研究以我国2009—2018年政府层面出台的公立医院改革相关政策文件为对象,基于基本政策工具和改革系统维度构建二维分析框架,利用内容分析法进行条目编码分类以及频数统计,剖析我国公立医院改革政策体系存在的问题与不足,为优化公立医院改革政策体系提供参考.

关键词：政策工具公立医院改革内容分析

2008-2012年南宁市7岁以下儿童手足口病流行病特征分析

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现代预防医学 2015年第18期42卷 3276-3279页

作者：周永东颜云盈广西南宁市妇幼保健院儿科

目的分析2008-2012年南宁市7岁以下儿童手足口病流行特征,为制定手足口病重点人群防控措施提供依据。方法收集2008-2012年7岁以下儿童手足口病疫情资料和实验室检测结果,进行描述性流行病学分析。结果2008-2012年南宁市7岁以下儿童共报... 详细信息

目的分析2008-2012年南宁市7岁以下儿童手足口病流行特征,为制定手足口病重点人群防控措施提供依据。方法收集2008-2012年7岁以下儿童手足口病疫情资料和实验室检测结果,进行描述性流行病学分析。结果2008-2012年南宁市7岁以下儿童共报告手足口病144 252例。年平均发病率为485.08/万,重症率为0.66%,死亡率为1.98/10万。西乡塘区年均发病率最高为857.30/万,横县(195.61/万)最低。4-7月为发病高峰,男性发病高于女性,以散居儿童和幼托儿童为主,占96.85%。病原学监测以EV-71和Cox A-16隔年交替流行为主。结论南宁市7岁以下儿童手足口病实际发病率、重症率和死亡率比以往报告均明显增高,而病死率较低。做好高发人群,高发季节和高发地区的防控工作尤为重要。

关键词：手足口病儿童流行病学防控

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基于优先序的健康服务产业供给选择路径研究

中国卫生政策研究 2018年第7期11卷 49-53页

作者：严云鹰陈菲雷雪孙月重庆医科大学公共卫生与管理学院医学与社会发展研究中心国民健康社会风险预警协同创新中心重庆400016

目的:为满足居民对健康服务需求的多元化趋势,基于优先序视角探寻健康服务产业供给选择路径,为政府优化健康产业结构提供思路借鉴。方法:采用自行设计的调查问卷,对全国34个城市的1 187名居民进行调查,通过卡方检验、Pearson和Spearman... 详细信息

目的:为满足居民对健康服务需求的多元化趋势,基于优先序视角探寻健康服务产业供给选择路径,为政府优化健康产业结构提供思路借鉴。方法:采用自行设计的调查问卷,对全国34个城市的1 187名居民进行调查,通过卡方检验、Pearson和Spearman相关分析法进行统计分析,建立需求度与满意度二维耦合模型对供给优先顺序进行类别划分。结果:居民对健康服务产业的需求度与满意度均较高,其中居民需求度和满意度耦合值最高的是健康保障服务产业,其次是基层医疗卫生服务产业、专业公共卫生服务产业等9项产业,健康教育服务产业得分最低。结论:基于模型将11项健康服务产业亚类划分为三类供给路径。I类为最急需供给产业类型,应最优先供给;Ⅱ类为需求型供给产业类型,在条件具备的基础上应大力发展;Ⅲ类为培育型供给产业类型,需要培育市场需求后合理发展。

关键词：健康服务产业需求度满意度优先序路径选择

Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous Zinc‑(Dual)Halogen Batteries

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Nano-Micro Letters 2025年第3期17卷 121-137页

作者： Chengwang Zhou Zhezheng Ding Shengzhe ying Hao Jiang yan Wang Timing Fang You Zhang Bing Sun Xiao Tang Xiaomin Liu School of Textiles and Clothing School of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071ShandongPeople’s Republic of China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW 2007Australia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanPeople’s Republic of China

Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical ***,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical ***,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal *** double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active *** employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling *** work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries

Unveiling an ancient whole-genome duplication event in Stentor,the model unicellular eukaryotes

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Science China Life Sciences 2025年

作者： Weibo Zheng Chao Li Zhaorui Zhou Xiao Chen Michael Lynch ying yan School of Life Sciences Ludong University Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity Ocean University of China Biodesign Center for Mechanisms of Evolution Arizona State University Marine College Shandong University

Whole-genome duplication(WGD) events are widespread across eukaryotes and have played a significant role in moulding the genetic architectures of diverse organisms. In the present study, the newly sequenced genome of a giant ciliated protist, Stentor roeselii, provides an opportunity for the analysis of the collinearity and retention of reciprocal best-hit genes between two Stentor species. As a main result, we have unveiled a previously undetected ancient WGD event shaping the genome of its congener, Stentor coeruleus, a model protist used in cytological and evolutionary studies. Genomes of two congeners, S. coeruleus and S. roeselii, are compared and analyzed, revealing that:(i)the former exhibits a much higher retention rate of colinear-gene pairs(28%) than does S. roeselii, and in S. coeruleus, 75% of genes that have a RBH hit in S. roeselii, have paralogs with high amino-acid identity, consistent with a WGD event in the lineage leading to S. coeruleus;(ii) the S. roeselii genome possesses extremely short intergenic regions, implying that the lengths of intergenic regions are under strong selection;(iii) the unique characteristics of introns may have been shaped in the common ancestor of heterotrichs;(iv) gene families that play a role in activities of multiple protein kinases and voltage-gated ion channels expanded rapidly in the ancestor of both taxa, possibly relating to the remarkable regenerative ability in Stentor. This study offers new insights into the evolutionary dynamics of ciliate genomes,with implications for understanding of the processes underlying the evolution of genomic complexity.

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T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren ying Liu Juntang yan Congai Chen yanhui He Yuyu Shi Fafeng Cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells