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The impact of water quality on the formation of halogenated benzoquinones and the adsorption efficiency by activated carbon

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Journal of Environmental Sciences 2024年第1期135卷 693-702页

作者： Yongjing Wang song Gao Xinyu yan songtao Wang Ruolin Zhang yan Zhou Lianhai Ren Cheng Li State Environmental Protection Key Laboratory of Food Chain Pollution Control Beijing Technology and Business UniversityBeijing 100048China Institute of Scientific and Technical Information of China Beijing 100038China Institute of Quality Standard and Testing Technology Beijing Academy of Agriculture and Forestry SciencesBeijing 100097China Key Laboratory of Cleaner Production and Integrated Resource Utilization of China National Light Industry Beijing Technology and Business UniversityBeijing 100048China

Halogenated benzoquinones(HBQs)could cause bladder cancer,but there were few related studies on the generation and *** this study,the impact of different precursors,pH,bromide concentration,and algae-derived organic matters on the formation of HBQs and the removal efficiency by activated carbon were *** was found that the chlorination of bisphenol A produced the most 2,6-dichloro-1,4-benzoquinone(2,6-DCBQ),reaching 14.86μg/L at 1 hr,followed by tyrosine,2-chlorophenol,P-hydroxybenzoic acid,trichlorophenol,and *** production of 2,6-DCBQ increased first and then decreased from 0 to 36 hr(chlorination doses 0-20 mg/L),indicating that HBQs were unstable in ***(THMs)were detected during chlorination,and the concentration increased with prolongation of reaction time.2,6-DCBQ production decreased and 2,6-dibromo-1,4-benzoquinone(2,6-DBBQ)production increased with increment bromide concentration and the bromide promoted the formation of *** production of 2,6-DCBQ decreased with increase of pH,and the maximum production was 141.38μg/L at pH of *** aeruginosa,Chlorella algae cells,and intracellular organic matters(IOM)could be chlorinated as potential precursors for *** most amount of 2,6-DCBQ was generated from algae cells of Microcystis aeruginosa,followed by Chlorella algae cells,Microcystis aeruginosa IOM,and Chlorella *** study compared the removal efficiency of HBQs by granular activated carbon(GAC)and columnar activated carbon(CAC)under different carbon doses and initial concentrations of *** was found that the removal efficiency by GAC(80.1%)was higher than that by CAC(51.8%),indicating that GAC has better control for HBQs.

关键词： HBQS DBPS Drinking water Algae derived organic matters Activated carbon

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SHR-A1811(antibody-drug conjugate)in advanced HER2-mutant non-small cell lung cancer:a multicenter,open-label,phase 1/2 study

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3483-3492页

作者： Ziming Li Zhengbo song Wei Hong Nong yang Yongsheng Wang Hong Jian Zibin Liang Sheng Hu Min Peng yan yu yan Wang Zicong Jiao Kaijing Zhao Ke song You Li Wei Shi Shun Lu Shanghai Lung Cancer Center Shanghai Chest HospitalShanghai Jiaotong University School of MedicineShanghai 200030China Phase I Clinical Trial Ward Zhejiang Cancer HospitalHangzhou 310000China Department of Thoracic Oncology Zhejiang Cancer HospitalHangzhou 310000China Department of Lung&Gastrointestinal Oncology Hunan Cancer HospitalChangsha 410031China Thoracic Oncology Ward/Cancer Center West China Hospital of Sichuan UniversityChengdu 610041China Department of Thoracic Oncology The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 51900China Department of Medical Oncology Hubei Cancer HospitalWuhan 43000China Department of Oncology Renmin Hospital of Wuhan UniversityWuhan 430200China Department of Thoracic Medicine Harbin Medical University Cancer HospitalHarbin 150081China Department of Medical Oncology Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Geneplus-Beijing CoLtd.Beijing 102206China Jiangsu Hengrui Pharmaceuticals Co.Ltd.Shanghai 200120China

A dose-escalation and expansion,phase 1/2 study(***,NCT04818333)was conducted to assess the novel antibodydrug conjugate SHR-A1811 in pretreated HER2-altered advanced non-small cell lung cancer(NSCLC).Here,we report results from the phase 1 *** who had previously failed or were intolerant to platinum-based chemotherapy were enrolled and received SHR-A1811 intravenously at doses of 3.2 to 8.0 mg/kg every 3 *** escalation followed a Bayesian logistic regression model that included overdose control,with subsequent selection of tolerable levels for dose ***,63 patients were enrolled,including 43 receiving a recommended dose for expansion of 4.8 mg/*** patients had HER2-mutant ***-limiting toxicity occurred in one patient in the 8.0 mg/kg dose ***≥3 treatment-related adverse events occurred in 29(46.0%)*** patient in the 6.4 mg/kg cohort died due to interstitial lung *** of April 11,2023,the 4.8 mg/kg cohort showed an objective response rate of 41.9%(95%Cl 27.0-57.9),and a disease control rate of 95.3%(95%Cl 84.2-99.4).The median duration of response was 13.7 months,with 13 of 18 responses *** median progression-free survival was 8.4 months(95%CI 7.1-15.0).SHR-A1811 demonstrated favourable safety and clinically meaningful efficacy in pretreated advanced HER2-mutantNSCLC.

关键词： SHR HER2 doses

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Boundary Regularity of Isometries Between Infinitely Flat Complex Domains

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1375-1387页

作者： Jin song LIU Fei TAO Hong yu WANG Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190P.R.China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China Beijing International Center for Mathematical Research Peking UniversityBeijing 100871P.R.China School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China Key Laboratory of Mathematics and Information Networks(Beijing University of Posts and Telecommunications) Ministry of EducationBeijing 100876P.R.China

In this paper we prove that isometries with respect to the Kobayashi metric between certain domains having boundary points at which the boundary is infinitely flat extend continuously to the *** strategy is to reestab... 详细信息

关键词： Boundary extension Kobayashi metric isometries

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三元相关性量子行为粒子群优化算法研究

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通信学报 2015年第3期36卷 207-214页

作者：吴涛陈曦严余松成都信息工程学院计算机学院四川成都610225 西南民族大学计算机科学与技术学院四川成都610041 西南交通大学计算机科学与技术学院四川成都610031

为了提高QPSO算法的收敛性能,在对随机因子进行分析的基础上提出了三元相关性QPSO(TC-QPSO,ternary correlation QPSO)算法。该算法使用正态Copula函数建立了粒子对自身经验信息、群体共享信息以及粒子当前位置与群体平均最好位置的距... 详细信息

为了提高QPSO算法的收敛性能,在对随机因子进行分析的基础上提出了三元相关性QPSO(TC-QPSO,ternary correlation QPSO)算法。该算法使用正态Copula函数建立了粒子对自身经验信息、群体共享信息以及粒子当前位置与群体平均最好位置的距离信息之间的内在认知和联系,并利用Cholesky平方根公式给出了三元相关因子的生成方法。对测试函数的仿真结果证明,当三元相关因子u与r1或r2之间存在负线性相关关系时,TC-QPSO算法可以获得比标准QPSO算法更好的优化性能。

关键词：粒子群优化量子粒子群优化量子势阱正态Copula函数收敛

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Stability of water yield in watersheds

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Science China Earth Sciences 2024年第2期67卷 483-496页

作者： yu yan Zhiyong LIU Xiaohong CHEN Liyan HUANG Center for Water Resources and Environment School of Civil EngineeringSun Yat-Sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519082China

The hydrological system of a watershed is intricately influenced by both underlying characteristics and climate *** the variability in water yield is essential for effective water resources management and water security in the context of changing *** this study,we adopted the Budyko framework and leveraged simulations from the CMIP6 model to investigate the compensation effects of climate and underlying characteristics on watershed water *** on Taylor expansion and Budyko framework,we estimated the sensitivity of watershed water yield to climate and underlying characteristics(the first-and second-order partial derivatives).By combining external watershed characteristics(e.g.,water yield ratios and underlying characteristics)with internal sensitivity coefficients,this study further used vine copula and principal component analysis to quantify the stability of watershed water *** findings show:(1)Water-yield changes related to underlying characteristics could be offset by climate-related water-yield changes across all climate zones,maintaining the water yield ratio steady(i.e.,the compensation effects).(2)However,global watersheds will turn more sensitive to underlying characteristics and less sensitive to climate variation in the *** climate-and underlying-related sensitivities increase in watersheds with arid climates.(3)The stability of watershed water yield will gradually diminish in the *** 1901–1950to 2051–2100,the global stability of 280 watersheds drops from 0.054 to 0.021(i.e.,stability index identified by the joint probability).Particularly,the largest change in stability of water yield reaches-0.347±0.18 in arid *** semi-arid,semihumid,and humid regions,the changes are-0.039±0.010,-0.028±0.005,and-0.005±0.002,*** findings provide a reference for the future sustainable water resources development under climate change,highlighting the vulnerability of the water resources in ari

关键词： Hydrological system stability Compensation effects on water yield Sensitivities Budyko-Fu decomposition framework Global watersheds

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Association between operative position and postoperative nausea and vomiting in patients undergoing laparoscopic sleeve gastrectomy

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2088-2095页

作者： Zhao-Peng Li yan-Cheng song Ya-Li Li Dong Guo Dong Chen yu Li Department of Gastrointestinal Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266033Shandong ProvinceChina Department of Operation Room The Affiliated Hospital of Qingdao UniversityQingdao 266033Shandong ProvinceChina

BACKGROUND Bariatric surgery is one of the most effective ways to treat morbid obesity,and postoperative nausea and vomiting(PONV)is one of the common complications after bariatric *** present,the mechanism of the high incidence of PONV after weight-loss surgery has not been clearly explained,and this study aims to investigate the effect of surgical position on PONV in patients undergoing bariatric *** To explore the effect of the operative position during bariatric surgery on *** Data from obese patients,who underwent laparoscopic sleeve gastrectomy(LSG)in the authors’hospital between June 2020 and February 2022 were divided into 2 groups and retrospectively *** logistic regression analysis and the t-test were used to study the influence of operative position on *** There were 15 cases of PONV in the supine split-leg group(incidence rate,50%)and 11 in the supine group(incidence rate,36.7%)(P=0.297).The mean operative duration in the supine split-leg group was 168.23±46.24 minutes and 140.60±32.256 minutes in the supine group(P<0.05).Multivariate analysis revealed that operative position was not an independent risk factor for PONV(odds ratio=1.192,95%confidence interval:0.376-3.778,P=0.766).CONCLUSION Operative position during LSG may affect PONV;however,the difference in the incidence of PONV was not statistically *** position should be carefully considered for obese patients before surgery.

关键词： Postoperative nausea and vomiting Bariatric surgery Laparoscopic sleeve gastrectomy Operative positions Obesity

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Advances of graphdiyne-supported metal catalysts in thermocatalytic reactions

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Nano Research 2024年第4期17卷 2223-2233页

作者： Jia yu Yida yang yuliang Li Changyan Cao Weiguo song Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular SciencesLaboratory of Molecular Nanostructures and NanotechnologyInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular SciencesLaboratory of organic solidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

Supported metal catalysts are widely used in the modern chemical *** electronic interaction between supports and active components is of great significance for heterogeneous ***(GDY),a new type of carbon allotrope with sp-hybridized carbon atoms,πconjugate structure,and electron transmission capability,is a promising candidate as catalyst *** years have witnessed the rapid progress of GDY-supported metal catalysts for different catalysis *** that most processes in the current chemical industry are thermocatalytic reactions,we herein give an overview about the advances and particular characteristics of GDY-supported catalysts in these *** geometric structure and electronic properties of GDY are first ***,the synthesis methods for GDY-supported metal catalysts and their applications in thermocatalytic reactions are discussed,in which the effect of electronic interaction on catalytic performance is ***,the current challenges and future directions of GDY-supported metal catalysts for thermocatalysis are *** is expected that this review will enrich our understanding of the advances of GDY as a superior support for metal catalysts in thermocatalytic reactions.

关键词： graphdiyne metal catalysts thermocatalytic reactions heterogeneous catalysis

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Comparison of models to predict air infiltration rate of buildings with different surrounding environments

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Building Simulation 2024年第6期17卷 1007-1021页

作者： Shu Zheng Xiujiao song Lin Duanmu yu Xue Xudong yang Department of Building Science Tsinghua UniversityBeijing100084China School of Civil Engineering Dalian University of TechnologyDalian116024China Shanxi Research Institute for Clean Energy Tsinghua UniversityTaiyuan030032China

The air infiltration rate of buildings strongly influences indoor environment and energy *** this study,several traditional methods for determining the air infiltration rate were compared,and their accuracy in different scenarios was ***,a method combining computational flow dynamics(CFD)with the Swami and Chandra(S-C)model was developed to predict the influence of the surrounding environment on the air infiltration *** buildings in Dalian,China,were selected:one with a simple surrounding environment and the other with a complex surrounding environment;their air infiltration rates were *** test results were used to validate the accuracy of the air infiltration rate solution models in different urban *** the building with a simple environment,the difference between the simulation and experimental results was 0.86%–22.52%.For the building with a complex environment,this difference ranged from 17.42%to 159.28%.We found that most traditional models provide accurate results for buildings with simple surrounding and that the simulation results widely vary for buildings with complex *** results of the method of combining CFD with the S-C model were more accurate,and the relative error between the simulation and test results was 10.61%.The results indicate that the environment around the building should be fully considered when calculating the air infiltration *** results of this study can guide the application of methods of determining air infiltration rate.

关键词： air infiltration rate models CFD simulation building surrounding air infiltration rate test

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Laparoscopic anatomical liver resection of segment 7 using a sandwich approach to the right hepatic vein (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 217-220页

作者： song-Feng yu Wei-Chen Zhang Jun yu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Full laparoscopic liver resection has been performed widely since it was introduced in the early *** has been expanded from initial for partial resection of the anterolateral segments to non-restriction of area of the liver[1–3].Anatomical liver resec-tion is considered to have potential superiority than non-anatomic resection in terms of tumor prognosis,thus it is more often rec-ommended in the treatment of hepatocellular carcinoma[4,5].Recently,laparoscopic segmental liver resection according to the Couinaud classification has been widely performed due to its ad-vantages in minimal invasiveness and tumor prognosis.

关键词： resection liver hepatic

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Exploiting demand-side heterogeneous flexible resources in risk management of power system frequency

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Science China(Technological Sciences) 2024年第5期67卷 1612-1627页

作者： YAO yu song YongHua YE ChengJin DING Yi ZHAO yuMing College of Electrical Engineering Zhejiang UniversityHangzhou310027China State Key Laboratory of Internet of Things for Smart City University of MacaoMacao SAR519000China Shenzhen Power Supply Bureau Co. Ltd.Shenzhen518051China

More demand-side flexible resources(DFRs)are participating in the frequency regulation of renewable power systems,whose heterogeneous characteristics have a significant impact on the system frequency ***,selecting suitable DFRs poses a formidable challenge for independent system operators(ISO).In this paper,a reserve allocation methodology for heterogeneous DFRs is proposed to manage the risk of power system ***,a performance curve is developed to describe the cost,capacity,and response speed of ***,a clustering method for multiple distributed DFRs is conducted to calculate the aggregated performance curves and uncertainty ***,the frequency security criterion considering DFRs’performance is constructed,whose linearity makes it can be easily coupled into the system scheduling model and ***,a risk management model for DFRs considering frequency-chance-constraint is proposed to make a trade-off between cost and frequency ***,the model is transformed into mixed integer second-order cone programming(MISOCP)and solved by the commercial *** proposed model is validated by the IEEE 30 and IEEE 118 bus systems.

关键词： demand-side heterogenous flexible resources risk management of power system frequency performance curve aggregation method mixed integer second-order cone programming

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