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Isolated gastric variceal bleeding related to non-cirrhotic portal hypertension following oxaliplatin-based chemotherapy:A case report

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World Journal of Gastroenterology 2022年第27期28卷 3524-3531页

作者： Xu Zhang yan-ying gao De-Zhao Song Bao-Xin Qian Department of Gastroenterology and Hepatology The Third Central Hospital of TianjinTianjin Key Laboratory of Extra-corporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin Institute of Hepatobiliary DiseaseTianjin 300000China Department of Interventional Radiology The Third Central Hospital of TianjinTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin Institute of Hepatobiliary DiseaseTianjin 300000China Department of Gastroenterology and Hepatology The Third Central Hospital of TianjinTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin Institute of Hepatobiliary DiseaseTianjin 300000China

BACKGROUND Sinusoidal obstruction syndrome has been reported after oxaliplatin-based chemotherapy,but liver fibrosis and non-cirrhotic portal hypertension(NCPH)are rarely *** SUMMARY Here,we describe the case of a 64-year-old woman who developed isolated gastric variceal bleeding 16 mo after completing eight cycles of oxaliplatin combined with capecitabine chemotherapy after colon cancer ***,splenomegaly and thrombocytopenia were not accompanied by variceal bleeding,which has been reported to have predictive value for gastric variceal ***,a liver biopsy showed fibrosis in the portal area,suggesting *** patient underwent endoscopic treatment and experienced no further *** It is necessary to guard against long-term complications after oxaliplatin-based *** splenic size and platelet level may not always accurately predict the occurrence of portal hypertension.

关键词： Non-cirrhotic portal hypertension Sinusoidal obstruction syndrome Isolated gastric varices Oxaliplatin chemotherapy Colon cancer Case report

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Hepatomegaly and jaundice as the presenting symptoms of systemic light-chain amyloidosis: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 550-556页

作者： Xu Zhang Fei Tang yan-ying gao De-Zhao Song Jing Liang Department of Gastroenterology and Hepatology The Third Central Hospital of TianjinTianjin 300170China Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases Artificial Cell Engineering Technology Research CenterTianjin Institute of Hepatobiliary DiseaseTianjin 300170China Department of Interventional Radiology The Third Central Hospital of TianjinTianjin 300170China

BACKGROUND Light chain(AL)amyloidosis is a plasma cell dyscrasia characterized by the pathologic production and extracellular tissue deposition of fibrillar proteins derived from immunoglobulin AL fragments secreted by a clone of plasma cells,which leads to progressive dysfunction of the affected *** two most commonly affected organs are the heart and kidneys,and liver is rarely the dominant affected organ with only 3.9%of cases,making them prone to misdia-gnosis and missed *** SUMMARY A 65-year-old woman was admitted with a 3-mo history of progressive jaundice and marked ***,based on enhanced computed tomography scan and angiography,Budd-Chiari syndrome was considered and balloon dilatation of significant hepatic vein stenoses was ***,addi-tional diagnostic procedures,including liver biopsy and bone marrow-exami-nation,revealed immunoglobulin kapa AL amyloidosis with extensive liver involvement and hepatic vascular *** disease course was progre-ssive and fatal,and the patient eventually died 5 mo after initial presentation of *** AL amyloidosis with isolated liver involvement is very rare,and can be easily misdiagnosed as a vascular disease.

关键词： Jaundice Hepatomegaly Liver amyloidosis Kappa light chain Pseudo-Budd-Chiari syndrome Case report

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Unexplained hyperammonemia and encephalopathy in the emergency department:Abernethy malformation in elderly patients

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World Journal of Emergency Medicine 2023年第1期14卷 69-71页

作者： yan-ying gao Qing Tang yan-cun Liu Xiao-he Liu Bao-xin Qian yan-fen Chai Li-jun Wang Department of Hepatology the Third Central Hospital of TianjinTianjin Institute of Hepatobiliary DiseaseTianjin 300170China Department of Emergency Medicine Tianjin Medical University General HospitalTianjin 300052China

Congenital extrahepatic portosystemic shunt(CEPS),also known as Abernethy malformation,is a rare disorder characterized by the partial or complete diversion of portal blood into systemic *** is classified into two types:typeⅠis an end-to-side portocaval shunt,whereas typeⅡis a side-to-side shunt,diverting blood from the portal vein to the inferior vena cava(IVC)(Figure 1).[1]

关键词： malformation shunt patients

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Treatment efficacy of radiof requency ablation of 338 patients with hepatic malignant tumor and the relevant complications

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World Journal of Gastroenterology 2005年第40期11卷 6395-6401页

作者： Min-Hua Chen Wei yang Kun yan Wen gao ying Dai yan-Bin Wang Xiao-Peng Zhang Shan-Shan Yin Departmentof Ultrasound Peking University School of Oncology 52 Fu-cheng Rd Haidian District Beijing 100036 China

AIM： To investigate the treatment efficacy of radiofrequency ablation （RFA） of hepatic malignant tumor and the relevant complications. METHODS： A total of 338 patients with 763 hepatic tumors underwent ultrasound-guided RFA （565 procedures）. There were 204 cases of hepatic cellular carcinoma （HCC） with 430 tumors, the mean largest diameter was 4.0 cm. Of them, 48 patients （23.5%） were in stages Ⅰ-Ⅱ （UICC Systems） and 156 （76.5%） in stages Ⅲ-Ⅳ There were 134 cases of metastatic liver carcinoma （MLC）, with 333 metastases in the liver, the mean diameter was 4.1 cm, the liver metastases of 96 patients （71.6%） came from gastrointestinal tract. Ninety-three percent of the 338 patients were treated using the relatively standard protocol. Crucial attention must be paid to monitor the abnormal changes in ultrasound images as well as the vital signs of the patients to find the possible hemorrhage and peripheral structures injury in time. The tumors were considered as ablated completely, if no viability was found on enhanced CT within 24 h or at 1 mo after RFA. These patients were followed up for 3-57 too. RESULTS： The ablation success rate was 93.3% （401/430 tumors） for HCC and was 96.7% （322/333 tumors） for MLC. The local recurrence rate for HCC and MLC was 7.9% （34/430 tumors） and 10.5% （351333 tumors）, respectively. A total of 137 patients （40.5%） underwent 2-11 times of repeated ablations because of tumor recurrence or metastasis. The 1st, 2nd, and 3rd year survival rate was 84.6%, 66.6%, and 63.1%, respectively; the survival rate from 48 patients of I-II stage HCC was 93.7%, 80.4%, and 80.4%, respectively. The major complication rate in this study was 2.5% （14 of 565 procedures）, which consisted of 5 hemorrhages, i colon perforation, 5 injuries of adjacent structures, 2 bile leakages, and 1 skin burn. CONCLUSION： RFA, as a minimally invasive local treatment, has become an effective and relatively safe alternativefor the patients of hepatic malignant tumor, even of advanc

关键词： Radiofrequency ablation Liver neoplasms Survival Complication Ultrasonography

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肥胖成因的解释--基于食物奖赏研究的视角

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心理科学进展 2017年第3期25卷 452-462页

作者：韩艳舍英高笑西南大学心理学部重庆400715 西南大学认知与人格教育部重点实验室重庆400715

肥胖的形成和发展受生物、心理和社会因素的共同作用,其中食物奖赏对肥胖的产生有重要的作用。食物是一种自然奖赏,它指机体天生对食物的渴望和依赖。食物奖赏包括"wanting"、"liking"以及"learning&reinforcement"三个成分,每个成分由... 详细信息

肥胖的形成和发展受生物、心理和社会因素的共同作用,其中食物奖赏对肥胖的产生有重要的作用。食物是一种自然奖赏,它指机体天生对食物的渴望和依赖。食物奖赏包括"wanting"、"liking"以及"learning&reinforcement"三个成分,每个成分由相应的神经通路表征。食物奖赏调控机体的摄食行为并以此调控体重变化。目前,关于肥胖与食物奖赏关系的理论模型主要有刺激—敏感化理论、奖赏过度理论以及奖赏不足理论。采用横断面设计、前瞻研究设计和纵向被试内重复测量设计,使用食物图片线索和直接给予美味奶昔的技术方法,人类脑成像研究从不同侧面为以上三个理论模型提供了证据。除此之外,食物奖赏还受基因的调控。目前,研究者关注较多的是多巴胺D2受体基因Taq IA rs1800497的多态性和FTO基因rs9939609的多态性对食物奖赏及体重改变的调控。

关键词：肥胖食物奖赏 fMRI TaqIA FTO

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Visualizing charge transfer and nuclear quantum effects in the hydrogen bond network of water

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Science China Chemistry 2025年

作者： ying gao Haotian Wang Bin Zhang Department of Chemistry School of Science Tianjin University

Water, one of the most common and important solvents on earth, is widely used in biology, physics, chemistry, and other fields [1]. The hydrogen bond interactions between water molecules form a highly dynamic and syne...

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慢性肝衰竭患者预后的影响因素

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世界华人消化杂志 2008年第29期16卷 3343-3346页

作者：高艳颖韩涛阚志超天津市第三中心医院消化内科天津市300170

目的:探讨影响慢性肝衰竭患者预后的独立危险因素,并建立预测模型.方法:选择天津市第三中心医院2002-05/2007-03行人工肝治疗的慢性肝功能衰竭,且病例资料完整的患者228例,对其临床资料进行回顾性分析.使用Logistic回归分析筛选影响预... 详细信息

目的:探讨影响慢性肝衰竭患者预后的独立危险因素,并建立预测模型.方法:选择天津市第三中心医院2002-05/2007-03行人工肝治疗的慢性肝功能衰竭,且病例资料完整的患者228例,对其临床资料进行回顾性分析.使用Logistic回归分析筛选影响预后的独立危险因素,根据筛选出的独立危险因素建立适合我国慢性肝衰竭患者的预测模型.结果:影响慢性肝衰竭患者预后的独立危险因素有Child-Pugh评分、血钠值、酪氨酸、是否有胆酶分离、是否合并肝癌、间接胆红素及白细胞.228例慢性肝衰竭患者中大于9.5分者的病死率72.18%,小于9.5分者的病死率13.68%,两组比较有显著性差异(P<0.05).患者早期的病死率为13.68%,中期的病死率68.91%,晚期的病死率为100%,三组比较有显著性差异(P<0.05).结论:本研究建立的LOG模型对慢性肝衰竭患者的预后有很好的预测性.

关键词：慢性肝衰竭预后的预测因子 Logistic回归 LOG模型

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Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang Jianfeng Zheng Guoyu Wang Yifei gao Yatao yang Jia Li Xiaojin Han yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou ying Mo Biao Zheng Miaomiao Han Qin Zhong Wenwen yang Peng gao Lezhi yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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Electrode/Electrolyte Optimization‑Induced Double‑Layered Architecture for High‑Performance Aqueous Zinc‑(Dual)Halogen Batteries

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Nano-Micro Letters 2025年第3期17卷 121-137页

作者： Chengwang Zhou Zhezheng Ding Shengzhe ying Hao Jiang yan Wang Timing Fang You Zhang Bing Sun Xiao Tang Xiaomin Liu School of Textiles and Clothing School of Chemistry and Chemical EngineeringQingdao UniversityQingdao 266071ShandongPeople’s Republic of China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyUltimoNSW 2007Australia School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007HenanPeople’s Republic of China

Aqueous zinc-halogen batteries are promising candidates for large-scale energy storage due to their abundant resources,intrinsic safety,and high theoretical ***,the uncontrollable zinc dendrite growth and spontaneous shuttle effect of active species have prohibited their practical ***,a double-layered protective film based on zinc-ethylenediamine tetramethylene phosphonic acid(ZEA)artificial film and ZnF2-rich solid electrolyte interphase(SEI)layer has been successfully fabricated on the zinc metal anode via electrode/electrolyte synergistic *** ZEA-based artificial film shows strong affinity for the ZnF2-rich SEI layer,therefore effectively suppressing the SEI breakage and facilitating the construction of double-layered protective film on the zinc metal *** double-layered architecture not only modulates Zn2+flux and suppresses the zinc dendrite growth,but also blocks the direct contact between the metal anode and electrolyte,thus mitigating the corrosion from the active *** employing optimized metal anodes and electrolytes,the as-developed zinc-(dual)halogen batteries present high areal capacity and satisfactory cycling *** work provides a new avenue for developing aqueous zinc-(dual)halogen batteries.

关键词： Zn metal anodes Double-layered protective film Electrode/electrolyte optimization Aqueous zinc-(dual)halogen batteries

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