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Bispectral index monitoring prevent awareness during total intravenous anesthesia： a prospective, randomized, double-blinded, multi-center controlled trial

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Chinese Medical Journal 2011年第22期124卷 3664-3669页

作者： ZHANG Chen XU liang MA Ya-qun SUN yan-xia li yan-hong ZHANG liang FENG Chun-sheng LUO Bing ZHAO Zhen-long GUO Jian-rong JIN Yao-jun WU Gang YUAN Wei YUAN Zhi-guo YUE Yun Department of Anesthesiology Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China

Background Awareness is a serious complication of general anesthesia. In China, the incidence of intraoperative awareness was 1% in patients undergoing total intravenous anesthesia （TIVA）. In this study, we compared the incidence of awareness between Bispectral index （BIS）-guided and routine TIVA protocol and evaluated the effect of BIS on preventing awareness. Methods A prospective, randomized, double-blinded, multicenter controlled trial was performed. Patients （〉18 years of age） undergoing TIVA were randomly divided into BIS-guided group （Group A, BIS was monitored and recommended to maintain between 40-60） and control group （Group B, BIS was monitored but the screen was covered）. The intraoperative BIS values were downloaded and the BIS trends of confirmed awareness cases were analyzed to determine whether light anesthesia existed. Results Of the total 5228 patients, 2919 patients were assigned to Group A and 2309 to Group B. Four cases of confirmed awareness （0.14%） were reported in the BIS-guided group and 15 （0.65%） in the control group （P=-0.002, OR=0.21, 95% confidence intervals： 0.07-0.63）. The incidence of possible awareness （0.14% vs. 0.26%, P=0.485） and dreaming （3.1% vs. 3.1%, P=0.986） was comparable between BIS-guided group and the control group. Among the 19 confirmed awareness cases, intraoperative BIS trends of six cases were downloaded and identified. Five of them showed signs of light anesthesia as BIS 〉60 and lasted 19-106 minutes, whereas one case had a stable BIS trend and the values were within 60 during the operation. Another five awareness cases were reviewed for anesthesia procedures, of which improper light anesthesia were confirmed. Conclusions BIS-guided TIVA （BIS was recommended to maintain between 40-60） decreased the risk of awareness compared with routine TIVA. The main reason for awareness was light anesthesia.

关键词： awareness complications general anesthesia monitoring, bispectral index

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卡前列甲酯栓与缩宫素治疗产后出血的比较

中国新药与临床杂志 1999年第5期18卷 303-305页

作者：姜金灵严利燕王玉梅中国人民武装警察部队青海省总队医院妇产科青海西宁810000 青海医学院青海西宁810001

目的 :探讨卡前列甲酯栓预防和治疗产后出血的疗效。方法 :对 40 0例正常足月妊娠阴道分娩者 ,随机分为卡前列甲酯栓组 30 0例和缩宫素组10 0例。卡前列甲酯栓组在胎儿娩出后向阴道内置入卡前列甲酯栓 1mg ;缩宫素组在胎儿前肩娩出后静... 详细信息

目的 :探讨卡前列甲酯栓预防和治疗产后出血的疗效。方法 :对 40 0例正常足月妊娠阴道分娩者 ,随机分为卡前列甲酯栓组 30 0例和缩宫素组10 0例。卡前列甲酯栓组在胎儿娩出后向阴道内置入卡前列甲酯栓 1mg ;缩宫素组在胎儿前肩娩出后静脉注射缩宫素 10IU。结果 :产后 2h平均出血量卡前列甲酯栓组为 138mL±s 2 6mL ,缩宫素组为 2 85mL± 60mL (P <0 .0 1)。产后出血发生率卡前列甲酯栓组为 4.0 % ,缩宫素组为 30 % (P <0 .0 1)。卡前列甲酯栓组不良反应轻微。结论 :卡前列甲酯栓预防和治疗产后出血是安全和有效的药物。

关键词：卡前列素缩宫素产后出血治疗

Clinic pathological features and prognosis of metaplastic breast carcinoma

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Journal of Hainan Medical University 2019年第15期25卷 30-34页

作者： Ping Zhou Bing lin yan-yan li Jian liu Department of Radiotherapy the First Affiliated Hospital of Hainan Medical CollegeNational Key Clinical SpecialistHaikou 571199China Guangxing Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine Hangzhou 310007China Department of Oncology the First Affiliated Hospital of Zhejiang UniversityNational Key Discipline of CancerZhejiang Provincial Key Laboratory of Integrative Medicine TherapyHangzhou 310003China

Objective:To investigate clinic pathological peculiarities and evaluate the prognosis of metaplastic breast ***:Patients with metaplastic breast carcinoma at the First Affiliated Hospital of Zhejiang University and Guangxing Hospital Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from 2008 to 2013 were retrospectively ***:A total of 73 female patients were reviewed,including 41 cases of purely epithelial type and 32 cases of mixed epithelial and mesenchymal *** tumor size was ***-three patients(58.8%)presented with lymph node metastasis,84.9%of cases were in advanced TNM stage,and 60.2%of cases were overexpressed by *** a median follow-up of 59 months,median overall survival and disease-free survival were 59.7 and 43.9 months,***-year overall survival rate was 45.2%and disease-free survival rate was 30.1%,and 76.7%of patients had recurrence or *** analysis showed that tumor size,lymph node,and radiotherapy were associated with overall survival and disease-free survival(P0.05).Conclusion:Metaplastic breast carcinoma is a rare malignant tumor with large tumor,high lymph node metastasis rate,staging relatively late,high local recurrence and distant metastasis *** treatment follows the principle of comprehensive treatment based on surgery,but the prognosis is *** size,lymph node,and radiotherapy treatment affect the *** of Ki-67 can be used as a potential diagnostic,therapeutic and prognostic indicator for metaplastic breast cancer.

关键词： Breast carcinoma Metaplasia Clinic pathological characteristics Prognosis

哈拉湖地区低频可控震源天然气水合物地球物理响应特征研究

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地球物理学报 2016年第11期59卷 4287-4296页

作者：田玉昆李桂林刘晖祝有海马彦彦李娟周惠王德润王林中国地质调查局非常规油气地质重点实验室北京100029 中国石油集团东方地球物理公司吐哈物探处新疆哈密839009 中国石油集团东方地球物理公司国际勘探事业部河北涿州072750

我国陆域天然气水合物主要分布于青藏高原和漠河地区.由于永久冻土层的存在,地震勘探很难获得高品质的资料,给天然气水合物勘探带来了诸多困难.为解决冻土层对地震信号的衰减问题,在哈拉湖地区采用低频可控震源进行地震资料采集试验,通... 详细信息

我国陆域天然气水合物主要分布于青藏高原和漠河地区.由于永久冻土层的存在,地震勘探很难获得高品质的资料,给天然气水合物勘探带来了诸多困难.为解决冻土层对地震信号的衰减问题,在哈拉湖地区采用低频可控震源进行地震资料采集试验,通过提高覆盖次数,获得了较高信噪比的地震资料.在高质量地震资料基础上,进行精细速度分析,获得了较准确的叠加速度谱资料;然后以层速度剖面为基础建立正演模型,开展天然气水合物地震正演模拟研究;最后利用叠后偏移地震数据进行地震属性分析.通过正演模拟和地震属性综合研究,总结了天然气水合物的地球物理响应特征,速度突变和空白反射带可作为哈拉湖地区陆域天然气水合物识别的敏感因素.

关键词：天然气水合物低频可控震源冻土区纵波速度地震属性哈拉湖地区

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新辅助放化疗对局部进展期直肠癌的疗效观察

西安交通大学学报（医学版） 2018年第3期39卷 442-446页

作者：闫燕丽马晓薇谭黎邵帅刘嘉欣任娟西安交通大学第一附属医院肿瘤放疗科陕西西安710061

目的探讨新辅助放化疗对局部进展期直肠癌的疗效及其安全性。方法收集2014年3月至2017年3月在西安交通大学第一附属医院接受治疗的32例局部进展期直肠癌患者,根据是否行新辅助放化疗分为观察组和对照组。观察组16例患者接受术前新辅助... 详细信息

目的探讨新辅助放化疗对局部进展期直肠癌的疗效及其安全性。方法收集2014年3月至2017年3月在西安交通大学第一附属医院接受治疗的32例局部进展期直肠癌患者,根据是否行新辅助放化疗分为观察组和对照组。观察组16例患者接受术前新辅助放化疗后行手术治疗,对照组16例患者不接受新辅助放化疗而直接行手术治疗。结果观察组16例患者接受新辅助放化疗后完全缓解(CR)2例,部分缓解(PR)10例,疾病稳定(SD)4例,总缓解率(CR+PR)为75%(12/16);1例患者新辅助放化疗后达到CR拒绝手术而未行手术治疗,余15例患者均接受手术治疗,术中探查发现肠道水肿1例,肠道粘连7例,均未影响手术治疗。观察组患者保肛率(56.25%,9/16)显著高于对照组(18.75%,3/16),差异有统计学意义(χ2=4.800,P=0.028);观察组患者局部复发率为0%(0/16)、远处转移率为12.50%(2/16),对照组局部复发率为18.75%(3/16)、远处转移率为31.25%(5/16),两组比较差异无统计学意义(χ2=2.133、0.667,P=0.144、0.414)。观察组患者术后并发症(肠梗阻、吻合口瘘、切口裂开等)及放化疗不良反应(胃肠道反应、骨髓抑制及肛周皮肤反应等)的发生率与对照组相比,差异均无统计学意义(P>0.05)。结论在不增加术后并发症及放化疗不良反应的情况下,新辅助放化疗可明显提高局部进展期直肠癌患者的保肛率,从而改善患者远期预后及生存质量,具有很高的临床应用价值,值得进一步推广应用。

关键词：局部进展期直肠癌新辅助放化疗疗效

Can patients with mild non-neoplastic lesions diagnosed at baseline screening be safely exempt from surveillance: evidence from multicenter community-based cohorts

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Science China life Sciences 2025年第1期 263-271页

作者： Siyi He Zhiyi Zhang Guohui Song Zhenhai Wang Chunyun Dai Shipeng yan Kun Jiang Bingbing Song He li Maomao Cao Dianqin Sun Fan yang Xinxin yan Shaoli Zhang Yi Teng Qianru li Changfa Xia Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Gastroenterology Gansu Wuwei Tumor Hospital Cixian Cancer Institute linzhou Cancer Hospital Center for Disease Control and Prevention of Sheyang County Department of Cancer Prevention and Control Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University Luoshan Center for Disease Control and Prevention Office for Cancer Control and Research Affiliated Cancer Hospital of Harbin Medical University

Surveillance recommendations for gastric cancer（GC） in current guidelines focused on advanced precancerous lesions and were based on precise diagnosis of severity/extent of baseline lesions. We aimed to develop a less endoscopy-related equipment-dependent risk-stratification tool, and assessed whether mild-precursor-lesion patients can be safely exempt from surveillance. In the multicenter communitybased cohort, 75,051 participants receiving baseline endoscopy were enrolled during 2015–2017 and followed-up until 2021. Cumulative incidence rates（CIRs） of GC for precancerous-conditions were calculated by Kaplan-Meier method and compared by Log-rank tests. Mixedeffects Cox regression models were used to detect potential factors for progression towards GC. A risk score was calculated as counts of selected factors. An independent cohort, including 26,586 participants was used for external validation. During a median follow-up of 6.25 years, CIRs of GC were 0.302%, 0.436%, and 4.756% for normal group, non-neoplastic（atrophic gastritis/intestinal metaplasia） and neoplastic lesions（low-grade/high-grade dysplasia）, respectively(Ptrendlimited vegetable consumption, were selected for risk-stratification. High-risk patients（≥3 risk factors） with non-neoplastic lesions showed higher GC risks（adjusted HR=7.73, 95%CI: 4.29–13.92）, and their four-year CIR reached the one-year CIR of neoplastic lesions. Further categorizing non-neoplastic lesions by histological grade, both patients with moderate-to-severe lesions（aHR=3.07, 95%CI: 1.67–5.64） and high-risk patients with mild lesions（aHR=7.29, 95%CI: 3.58–14.86） showed higher risks. Consistent trends were observed in validation cohort. High-risk mild-precursor-lesion patients should receive surveillance within 3–5 years after baseline screening. Our study provides evidence on supplementing current guideline recommendations.

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我国生物制品的注册历程分析

中国新药杂志 2018年第21期27卷 2584-2587页

作者：刘志磊张彦彦李小芳国家药品监督管理局药品审评中心北京100022 沈阳药科大学亦弘商学院北京100027 泰州医药园区新药申报服务中心泰州225300

自1985年至今,在生物制品发展过程中,历版重要法规和文件不断修订,包括历年版《药品注册管理办法》,也包括《中华人民共和国药典》,这是我国生物制品注册监管理念不断更新、技术评价标准不断完善的体现。在国家政策的引导下,生物制品审... 详细信息

自1985年至今,在生物制品发展过程中,历版重要法规和文件不断修订,包括历年版《药品注册管理办法》,也包括《中华人民共和国药典》,这是我国生物制品注册监管理念不断更新、技术评价标准不断完善的体现。在国家政策的引导下,生物制品审评审批更加严格,创新程度不断提高,低水平重复逐渐减少。本文以时间轴为顺序,结合历年获批上市的生物制品情况,分析部分重要法规修订对生物制品注册的影响。

关键词：生物制品注册法规

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38例患者感染丝状真菌的临床调查

中国消毒学杂志 2017年第7期34卷 650-652,656页

作者：张乐研闫丽红杨蕙解放军第107医院山东烟台264002 青岛大学附属医院

目的了解住院患者感染丝状真菌临床分布特点,为真菌感染防控提供参考。方法采用回顾性调查方法,对某医院住院患者送检标本丝状真菌检测结果进行调查与分析。结果调查确认38例丝状真菌感染,有50%菌株分离自痰液标本,表明呼吸道感染占主导... 详细信息

目的了解住院患者感染丝状真菌临床分布特点,为真菌感染防控提供参考。方法采用回顾性调查方法,对某医院住院患者送检标本丝状真菌检测结果进行调查与分析。结果调查确认38例丝状真菌感染,有50%菌株分离自痰液标本,表明呼吸道感染占主导;其次是耳内和眼角膜感染,分别占28.95%和13.16%。丝状真菌感染病例主要集中于呼吸科、高干科、眼科及耳鼻喉科。检出的菌种为曲霉菌属和毛霉菌,以及部分链格孢菌和镰刀霉菌等。结论丝状真菌感染涉及感染部位和病原种类较多,诊治难度大,应加强丝状真菌感染的诊治和防控技术培训。

关键词：侵袭性真菌丝状真菌感染防控

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延庆县中小学校健康教育开课情况调查

中国健康教育 2006年第4期22卷 322-322,304页

作者：闫丽艳北京市延庆县疾病预防控制中心北京延庆102100

目的了解延庆县中小学校健康教育课的开课情况及影响健康教育课质量的相关因素,为制订学校健康教育课实施办法提供依据。方法采取随机抽样的方法抽取小学11所、初中9所、高中1所,对其抽取的学生和家长进行问卷调查;并对全县所有中小学... 详细信息

目的了解延庆县中小学校健康教育课的开课情况及影响健康教育课质量的相关因素,为制订学校健康教育课实施办法提供依据。方法采取随机抽样的方法抽取小学11所、初中9所、高中1所,对其抽取的学生和家长进行问卷调查;并对全县所有中小学校的领导和从事健康教育授课工作的保健教师进行问卷调查。结果中小学健康教育课的总体开课率为92.5%,健康教育课本使用版本不一,师资力量也存在很大差异,学生获得健康知识的渠道和形式也不尽相同。结论各级各类学校没有统一的健康教育课程设置及相关规定,不利于学生健康知识获得。

关键词：学校健康教育调查学生