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Effects of Prior Antiplatelet Therapy on the Prognosis of Primary Intracerebral Hemorrhage： A Meta-analysis

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Chinese Medical Journal 2017年第24期130卷 2969-2977页

作者： Hal-Han Yu Chao Pan Ying-Xin Tang Na liu Ping Zhang yang Hu Ye Zhang Qian Wu Hong Deng Gai-Gai li yan-yan li Hao Nie Zhou-Ping Tang Department of Neurology Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 China

Background：Antiplatelet therapy （APT） was prevalently being used in the prevention of vascular disease,but the influence of prior APT on the prognosis of patients with intracerebral hemorrhage （ICH） remains *** meta-analysis was to explore the effects of prior APT on the prognosis of patients with primary ***：PubMed and Embase were searched to identify the eligible *** studies comparing the mortality of ICH patients with or without prior APT were *** quality of these studies was evaluated by the Newcastle-Ottawa quality assessment *** adjusted or unadjusted odds ratio （OR） for mortality between ICH patients with and without prior APT were pooled with 95% confidence interval （95% CI） as the effect of this ***：Twenty-two studies fulfilled the inclusion criteria and exhibited high *** pooled OR was 1.37 （95% CI：1.13-1.66,P =0.001） for univariate analysis and 1.41 （95% CI：1.05-1.90,P =0.024） for multivariate *** meta-regression indicated that for each 1-day increase in the time of assessment,the adjusted OR for the mortality of APT patients decreased by 0.0049 （95% CI：0.0006-0.0091,P =0.026） as compared to non-APT ***：Prior APT was associated with high mortality in patients with ICH that might be attributed primarily to its strong effect on early time.

关键词： Antiplatelet Therapy: Intracerebral Hemorrhage: Meta-analysis: Outcome

Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong liu Haorun li yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Nanorods

Sensitive detection of SARS-CoV-2 spike protein based on electrochemical impedance spectroscopy of Fe_(3)O_(4)@SiO_(2)–Au/GCE biosensor

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Advanced Sensor and Energy Materials

Advanced Sensor and Energy Materials 2023年第3期2卷 9-17页

作者： Xun-Hai You Yao liu yan-yan li Bing Zhao Yong yang Rohan Weerasooriya Xing Chen Key Lab of Aerospace Structural Parts Forming Technology and Equipment of Anhui Province Institute of Industry and Equipment TechnologyHefei University of TechnologyHefei 230009PR China School of Materials Science and Engineering Hefei University of TechnologyHefei 230009PR China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009PR China State Key Laboratory of High-Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050PR China National Centre for Water Quality Research National Institute of Fundamental StudiesKandy20000Sri Lanka

Highly contagious COVID-19 disease is caused by a novel severe acute respiratory syndrome coronavirus 2(SARSCoV-2),which poses a serious threat to global public ***,the development of a fast and reliable method for the detection of SARS-CoV-2 is an urgent research *** Fe3O4@SiO2–Au is enriched with a variety of functional groups,which can be used to fabricate a sensitive electrochemical biosensor by biofunctionalization with angiotensin-converting enzyme 2(ACE2).Accordingly,we developed a novel electrochemical sensor by chemically modifying a glassy carbon electrode(GCE)with Fe3O4@SiO2–Au nanocomposites(hereafter Fe_(3)O_(4)@SiO_(2)–Au/GCE)for the rapid detection of S-protein spiked SARS-CoV-2 by electrochemical impedance spectroscopy(EIS).The new electrochemical sensor has a low limit detection(viz.,4.78 pg/mL)and a wide linear dynamic range(viz.,0.1 ng/mL to 10μg/mL)for detecting the EIS response signal of *** robust Fe_(3)O_(4)@SiO_(2)–Au/GCE biosensor has high selectivity,stability,and reproducibility for the detection of Sprotein with good recovery of saliva samples.

关键词： SARS-CoV-2 spike protein Fe_(3)O_(4)@SiO_(2)-Au nanocomposites Electrochemical biosensor Electrochemical impedance spectroscopy

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting li Chengcheng Gai Danqing Xin Yijing Zhao yan Song Yahong Cheng Tong li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO2 and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao yang Jia li Xiaojin Han yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal Chemistry Chinese Academy of Science University of Chinese Academy of Science Shenyang University of Chemical Technology

Photoelectrocatalytic coupling CO2and volatile organic compounds （VOCs） is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO2and the competitive hydrogen evolution of ***,a modified g-C3N4/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol *** revealed by in-situ characterizations and density functional theory calculations,CO2and HCHO were absorbed at Zn site and N site,***,*CO generated from CO2and HCHO was converted to*CH3O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH3O in electrocatalysis *** from the“*CO+*CH3O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO2and HCHO simultaneously driven by light and electricity.

关键词： Ethanol

Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang li Xingping Quan Jinfen Chen yan Han li yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong yang Haochen Shen Xiaoming Xiao Zhichao li Qi Zhou Wei yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： Ultraviolet photoelectron spectroscopy

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真空变压吸附提纯合成气中CO的实验与模拟

高校化学工程学报 2016年第5期30卷 1027-1035页

作者：周言阎海宇李冬冬张东辉天津大学化工学院化学工程研究所化学工程联合国家重点实验室天津300354

采用自制的载铜活性炭为吸附剂,实验验证了CO高吸附选择性和吸附固定床数学模型的准确性。通过数值模拟研究了多塔真空变压吸附(VPSA)提纯合成气(28.2%CO/46.9%H_2/2.3%CH_4/1.2%CO_2/21.4%N_2)(V)中CO的工艺流程。15塔数值计算结果可获... 详细信息

采用自制的载铜活性炭为吸附剂,实验验证了CO高吸附选择性和吸附固定床数学模型的准确性。通过数值模拟研究了多塔真空变压吸附(VPSA)提纯合成气(28.2%CO/46.9%H_2/2.3%CH_4/1.2%CO_2/21.4%N_2)(V)中CO的工艺流程。15塔数值计算结果可获得99.5%(V)CO纯度和95.0%CO回收率,同时吸附剂产率高达3.36 mol CO×kgads-1×h-1,而单位能耗低至0.107 k Wh×Nm^(-3) feed。最后,系统考察了操作参数对CO吸附分离性能的影响规律。参数分析研究结果表明,解吸真空度和产品气流量都不宜过大以保证较高产品纯度和较低单位能耗,而产品纯度和回收率受进料流量和置换流量的变化波动较大,应在满足分离要求下选择最佳的进料和置换条件以获得较高的CO回收价值,从而为指导工业合成气尾气提纯CO工艺以及后续氢气纯化工艺装置的设计和调优提供了基本的操作参数。

关键词：载铜活性炭合成气变压吸附参数分析