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A highly efficient humidity sensor based on lead(Ⅱ) coordination polymer via in-situ decarboxylation and hydrolysis synthesis

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Rare Metals 2022年第5期41卷 1652-1660页

作者： Hao Dong Le-Xi Zhang Heng Xu yan-yan yin Yi-Fei Liu Li-Jian Bie School of Materials Science and Engineering Tianjin Key Laboratory for Photoelectric Materials and DevicesKey Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)National Demonstration Center for Experimental Function Materials EducationTianjin University of TechnologyTianjin 300384China Department of Environmental Science and Engineering Nankai University Binhai CollegeTianjin 300270China

Function-oriented design of coordination polymers is emerging as an attracting topic to explore their practical applications, e.g., gas/humidity sensing. However,the successful synthesis of new coordination polymers showing splendid sensing property is an urgent need in fields of materials and sensors, yet still at the initial *** this contribution, a new one-dimensional(1D) coordination polymer with formula of [Pb(TAA)(BA)(H_(2)O)]_(n)(namedasPbL,HTAA = 3-thiopheneaceticacid,HBA = benzoic acid) has been successfully synthesized by a hydrothermal method, which involves in-situ synthesis of both decarboxylation and hydrolysis. As an impedimetric humidity sensing material, this coordination polymer exhibits excellent humidity sensing performance including high response, fast response, small hysteresis, and good repeatability. In the total relative humidity range(11%–97%) at room temperature, it is worth noting that the sensitivity of the humidity sensor is as high as 1.18×10^(4),the response time is only 2 s, and the max humidity hysteresis is as small as 1.8%. At last, we discussed the sensing mechanism using the alternating current(AC) impedance technique at various relative humidity.

关键词： Lead Coordination polymer In-situ synthesis Humidity sensor

H-bonding interactions enable a 3D pillared cobalt(Ⅱ) coordination polymer for touchless finger moisture detection

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Tungsten 2023年第1期5卷 109-117页

作者： Hao Dong Le-Xi Zhang Heng Xu yan-yan yin Xing-Bai Zhao Li-Jian Bie School of Materials Science and Engineering Tianjin Key Lab for Photoelectric Materials and DevicesKey Laboratory of Display Materials and Photoelectric Devices(Ministry of Education)National Demonstration Center for Experimental Function Materials EducationTianjin University of TechnologyTianjin 300384China Department of Environmental Science and Engineering Nankai University Binhai CollegeTianjin 300270China

Coordination polymers(CPs) are emerging as the next generation of macromolecule materials in many industrial and technological applications,***/humidity *** design of CP-based sensors with high performance and low cost is of significance,but this work is still in the infancy *** this contribution,a new one dimensional(1D) CP has been successfully synthesized by a simple solvent evaporation method at room temperature,namely [Co(DPP)(H_(2)O)_(2)]n·(TCA)2(H_(2)O)_(4)(named as Co-1,HTCA=3-thiophenezoic acid,DPP=1,3-di(4-pyridyl)propane).The Co-1 structure contains abundant H-bonding interactions,weaving it from 1D chain structure into three dimensional(3D) pillared-layer *** an impedimetric humidity sensing material,this CP exhibits short response time,small hysteresis,excellent repeatability,and good stability in the working range of 11%-97% relative humidity(RH).Furthermore,it also shows excellent performance in monitoring the moisture content of human finger *** analyzing the complex impedance spectra,the humidity sensing mechanism of Co-1 sensor was expounded at different RH ranges.

关键词： Cobalt Coordination polymer H-bonding interactions Humidity sensor Finger detection

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run Song Shiyi yin Jiannan Wu Junqiang yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao Jianjian Chu Tinglin Zhang Tong yin Yuankai Gu Wendanqi Liang Wenbo Ji Jianhua Zhuang yan Liu Jie Gao You yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

印度尼西亚2017年经济发展与2018年展望

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南宁职业技术学院学报 2018年第3期23卷 17-21页

作者：言银燕广西外国语学院东南亚语言文化学院广西南宁530222

印度尼西亚经济经历5年连续下滑后出现回暖,在2016年达到5.03%的增速。2017年印度尼西亚经济继续平稳发展,国内生产总值增长5.07%。印度尼西亚经济好转,得益于出口、投资的改善和国内消费的增长。同时,国家采取措施有效稳定物价,继续积... 详细信息

印度尼西亚经济经历5年连续下滑后出现回暖,在2016年达到5.03%的增速。2017年印度尼西亚经济继续平稳发展,国内生产总值增长5.07%。印度尼西亚经济好转,得益于出口、投资的改善和国内消费的增长。同时,国家采取措施有效稳定物价,继续积极推进基础设施建设等。但是,经济未来发展还受政府财政支出有限、国内消费未达预期水平、消费增长乏力、国内东西部地区发展不平衡,以及国内政治和国际环境不稳定因素的影响。

关键词：印度尼西亚经济发展平稳增长增长前景

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方法标准验证实验数据中离群值的识别

中国环境监测 2017年第5期33卷 167-175页

作者：李玉武任立军闫岩殷惠民国家环境分析测试中心北京100029

对方法标准验证实验中测量数据进行合格性审核,对于后续方法精密度计算是一个重要环节。文献中识别离群值的Grubbs法、Dixon法等经典方法有时不能满足要求。探讨了用稳健统计法识别离群值的可行性。基于2套文献数据和XRF方法标准验证实... 详细信息

对方法标准验证实验中测量数据进行合格性审核,对于后续方法精密度计算是一个重要环节。文献中识别离群值的Grubbs法、Dixon法等经典方法有时不能满足要求。探讨了用稳健统计法识别离群值的可行性。基于2套文献数据和XRF方法标准验证实验精密度测量数据,对Grubbs法、Dixon法、Mandel h检验法、质控指标法和稳健统计法(四分位法、迭代法、合格数据范围判定法)进行了比较。结果表明:稳健统计法可有效识别离群值。但四分位法存在过度"检出"现象。综合考虑多种方法识别结果有利于提高离群值判定结论的可靠性。对于个别难以判断的情形,可借助质控指标、技术要求以及数据是否剔除对实验室间标准偏差的影响进行取舍。

关键词：方法标准验证离群值识别稳健统计法 X射线荧光光谱法

Effects of AST and AS-I on intracellular calcium concentration of cells in senescent rats treated by hydrocortisone

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Effects of AST and AS-I on intracellular calcium concentrati...

第十五届国际药理学大会

作者： Yu-You Yao Wei-Ping Li. yan-yan yin. Dong-Mei liu Yu-Ling Wang (Dept of pharmacology Anhui Medical University Hefei 230032)

＜正＞ To explore the effects of Astragalosides （AST） and Astragals Saponin I （AS - I） on intracellular calcium concentration （[Ca2 + ]i） in senescent rats treated by hydrocortisone. The [Ca2 + ]i was measured by using double wavelength fluorescence spectrophotometer in thymocytes and hippocampus neurons intrasynaptosomes from mice. The results showed that [Ca2 + ]i in senescent thymus and hippocampus sitrasynaptosomes was significantly higher than [ Ca2 + ] i of adult thymus and hippocamal intrasynaptosomes. The high level [Ca2+ ]i of hippocampus caused memory impairment in senescent mice. When treated with AST or AS - I. the [ Ca2+ ] i in two kind cells decreased. Dexamamethasone （ DEX）. BayK8644,KCl and Glutamete （Glu） all elevated [Ca2+ ]i of thymocytes of neonate （7 days rats） and hippocampal neurons of fatal rats in vitro. When treated with AST or AS - I. the [ Ca2+ ]i in cultured thymocytes and hippocampus neurons stimulated by DEX,BayK8644,KC1 and Glu decreased.

关键词： AST AS-I DEX Glu Glucocorticoid

来源： cnki会议评论

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莫索尼定治疗难治性高血压

中国新药与临床杂志 2004年第12期23卷 907-908页

作者：龚艳艳尹中君上海第二医科大学附属瑞金医院心内科

目的 :评价莫索尼定对难治性高血压的疗效及安全性。方法 :6 8例难治性高血压病人 ,男性38例 ,女性 30例 ,年龄 (5 4±s 14 )a ,在原有用药基础上加用莫索尼定 0 .2mg ,po ,qd ;若 2wk以上血压≥ 18.7/ 12kPa ,剂量增至 0 .4mg ,po ,qd ... 详细信息

目的 :评价莫索尼定对难治性高血压的疗效及安全性。方法 :6 8例难治性高血压病人 ,男性38例 ,女性 30例 ,年龄 (5 4±s 14 )a ,在原有用药基础上加用莫索尼定 0 .2mg ,po ,qd ;若 2wk以上血压≥ 18.7/ 12kPa ,剂量增至 0 .4mg ,po ,qd ;于治疗前后进行 2 4h动态血压监测。结果 :治疗后偶测血压 [SBP和DBP分别为 (2 1.6± 1.6 )kPavs(18.1± 1.1)kPa ,(13.3± 0 .9)kPavs (11.3±0 .4 )kPa]及 2 4h动态血压均较治疗前明显降低(P <0 .0 5 ) ;不良反应轻微。结论 :莫索尼定治疗难治性高血压降压疗效确切。

关键词：高血压抗高血压药药物疗法血压监测,便携式莫索尼定