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Science China Mathematics 2011年第12期54卷 2651-2667页

作者： xi FuBao yin Gang Department of Mathematics Beijing Institute of Technology Beijing 100081 China Department of Mathematics Wayne State University Detroit MI48202 USA

This work focuses on a class of jump-diffusions with state-dependent switching. First, compared with the existing results in the literature, in our model, the characteristic measure is allowed to be a-finite. The existence and uniqueness of the underlying process are obtained by representing the switching component as a stochastic integral with respect to a Poisson random measure and by using a successive approximation method. Then, the Feller property is proved by means of introducing auxiliary processes and by making use of Radon-Nikodym derivatives. Furthermore, the irreducibility and all compact sets being petite are demonstrated. Based on these results, the uniform ergodicity is established under a general Lyapunov condition. Finally, easily verifiable conditions for uniform ergodicity are established when the jump-diffusions are linearizable with respect to the variable x （the state variable corresponding to the jump-diffusion component） in a neighborhood of the infinity, and some examples are presented to illustrate the results.

关键词： jump-diffusion sigma-finite characteristic measure state-dependent switching Feller property uniform ergodicity linearization

NK cell-based cancer immunotherapy: from basic biology to clinical application

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Science China(Life Sciences) 2015年第12期58卷 1233-1245页

作者： LI yang yin Jie LI Ting HUANG Shan yan Han LEAVENWORTH Jian Mei WANG xi Department of Cell Biology 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics Laboratory of Epigenetics in Development and Tumorigenesis Tianjin Research Center of Basic Medical Sciences Tianjin Key Laboratory of Medical Epigenetics Tianjin Medical University Department of Cancer Immunology and Virology Dana-Farber Cancer Institute Department of Microbiology and Immunobiology Division of Immunology Harvard Medical School

Natural killer(NK) cells, which recognize and kill target cells independent of antigen specificity and major histocompatibility complex(MHC) matching, play pivotal roles in immune defence against tumors. However, tumor cells often acquire the ability to escape NK cell-mediated immune surveillance. Thus, understanding mechanisms underlying regulation of NK cell phenotype and function within the tumor environment is instrumental for designing new approaches to improve the current cell-based immunotherapy. In this review, we elaborate the main biological features and molecular mechanisms of NK cells that pertain to regulation of NK cell-mediated anti-tumor activity. We further overview current clinical approaches regarding NK cell-based cancer therapy, including cytokine infusion, adoptive transfer of autologous or allogeneic NK cells, applications of chimeric antigen receptor(CAR)-expressing NK cells and adoptive transfer of memory-like NK cells. With these promising clinical outcomes and fuller understanding the basic questions raised in this review, we foresee that NK cell-based approaches may hold great potential for future cancer immunotherapy.

关键词： NK cell cancer cytokine infusion adoptive transfer immunotherapy

Microstructure and mechanical properties of CoCrNi-Mo medium entropy alloys:Experiments and first-principle calculations

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Journal of Materials Science & Technology 2021年第3期62卷 25-33页

作者： Ruobin Chang Wei Fang Jiaohui yan Haoyang Yu xi Bai Jia Li Shiying Wang Shijian Zheng Fuxing yin Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology Tianjin 300132China Research Institute for Energy Equipment Materials School of Materials Science and EngineeringHebei University of TechnologyTianjin 300132China School of Science Hebei University of TechnologyTianjin 300132China School of Materials Science and Engineering Changzhou UniversityChangzhou 213164China

The effect of Mo additions on the microstructures and mechanical properties of CoCrNi alloys was investigated,meanwhile,ab initio calculations are performed to quantitatively evaluate the lattice distortion and stacking fault energy(SFE).The yield strength,ultimate tensile strength,and elongation of(CoCrNi)_(97)Mo_(3)alloy are 475 MPa,983 MPa and 69%,*** yield strength is increased by~30%and high ductility is maintained,in comparison with CoCrNi *** the nano-twins and dislocations,the higher density of stacking faults is induced during the tensile deformation for(CoCrNi)_(97)Mo_(3)*** initio calculation results indicate the mean square atomic displacement(MSAD)and SFE value of(CoCrNi)_(97)Mo_(3)alloy is 42.6 pm^(2)and-40.4 mJ/m^(2)at 0 K,*** relationship between mechanical properties and MSAD,SFE for various multiple principal element alloys is discussed.

关键词： Medium entropy alloys Severe lattice distortion Stacking fault energy Single phase Mechanical properties Ab initio calculations High entropy alloys

Stochastic Liénard Equations with State-Dependent Switching

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Acta Mathematicae Applicatae Sinica 2015年第4期31卷 893-908页

作者： Fu-bao xi G.yin School of Mathematics Beijing Institute of Technology Department of Mathematics Wayne State University

This work focuses on stochastic Lienard equations with state-dependent switching. First, the existence and uniqueness of a strong solution are obtained by successive construction method. Next, strong Feller property is proved by introducing certain auxiliary processes and using the Radon-Nikodym derivatives and truncation arguments. Based on these results, positive Harris recurrence and exponential ergodicity are obtained under the Foster-Lyapunov drift conditions. Finally, examples using van der Pol equations are presented for illustrations, and the corresponding Foster-Lyapunov functions for the examples are constructed explicitly.

关键词： stochastic Li6nard equation state-dependent switching strong Feller property positive Harrisrecurrence exponential ergodicity

Synthesis and Characterization of a Novel Copoly(aryl ether ketone) Containing 4, 4'-Biphenyl-bis[4-phthalazin-1(2H)-one] Moiety

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Chinese Chemical Letters 2003年第2期14卷 145-146页

作者： Shao yin ZHANG xi Gao JIAN Shu De xiAO Jin yan WANG Jie ZHANG Department of Polymer Science and Materials Dalian University of TechnologyDalian 116012

A new monomer of 4, 4-biphenyl-bis[4-phthalazin-1(2H)-one] was synthesized from biphenyl and phthalic anhydride, and a novel copoly(aryl ether ketone) (PPEK) was synthesized from 2, 2-bis(4-hydroxyphenyl)-propane (BPA), 4, 4'-biphenyl-bis-[4-phthalazin-1(2H)-one], 4, 4- difluorodiphenylketone (DFK). The monomer and copolymer were characterized by FT-IR and 1H-NMR. DSC and TGA were used to the novel polymer.

关键词： Poly(aryl ether ketone) 4,4'-biphenyl-bis[4-phthalazin-1(2H)-one] 2,2-bis(4-hydroxy- phenyl)-propane(BPA).

Diverse and variable sex determination mechanisms in vertebrates

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Science China(Life Sciences) 2018年第12期61卷 1503-1514页

作者： xi-yin Li Jian-Fang Gui State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology College of Modern Agriculture Sciences University of Chinese Academy of Sciences The Innovative Academy of Seed Design Chinese Academy of Sciences

Sex is prevalent in nature and sex determination is one of the most fundamental biological processes, while the way of initiating female and male development exhibits remarkable diversity and variability across vertebrates. The knowledge on why and how sex determination mechanisms evolve unusual plasticity remains limited. Here, we summarize sex determination systems,master sex-determining genes and gene-regulatory networks among vertebrates. Recent research advancements on sex determination system transition are also introduced and discussed in some non-model animals with multiple sex determination mechanisms. This review will provide insights into the origin, transition and evolutionary adaption of different sex determination strategies in vertebrates, as well as clues for future perspectives in this field.

关键词： sex determination sex-determining gene sex chromosome sex transition sex differentiation sex control breeding

Long noncoding RNA protein-disulfide isomerase-associated 3 regulated high glucose-induced podocyte apoptosis in diabetic nephropathy through targeting miR-139-3p

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World Journal of Diabetes 2024年第2期15卷 260-274页

作者： yin-xi He Ting Wang Wen-xian Li yan-xia Chen Department of Orthopaedic Trauma The Third Hospital of ShijiazhuangShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology The First Hospital of ZhangjiakouZhangjiakou 075000Hebei ProvinceChina

BACKGROUND Podocyte apoptosis plays a vital role in proteinuria pathogenesis in diabetic nephropathy(DN).The regulatory relationship between long noncoding RNAs(lncRNAs)and podocyte apoptosis has recently become another research hot spot in the DN *** To investigate whether lncRNA protein-disulfide isomerase-associated 3(Pdia3)could regulate podocyte apoptosis through miR-139-3p and revealed the underlying *** Using normal glucose or high glucose(HG)-cultured podocytes,the cellular functions and exact mechanisms underlying the regulatory effects of lncRNA Pdia3 on podocyte apoptosis and endoplasmic reticulum stress(ERS)were *** Pdia3 and miR-139-3p expression were measured through quantitative real-time polymerase chain *** cell viability was detected through the cell counting kit-8 colorimetric *** podocyte apoptosis rate in each group was measured through flow *** interaction between lncRNA Pdia3 and miR-139-3p was examined through the dual luciferase reporter ***,western blotting was performed to detect the effect of lncRNA Pdia3 on podocyte apoptosis and ERS via *** The expression of lncRNA Pdia3 was significantly downregulated in HG-cultured ***,lncRNA Pdia3 was involved in HG-induced podocyte ***,the dual luciferase reporter assay confirmed the direct interaction between lncRNA Pdia3 and *** Pdia3 overexpression attenuated podocyte apoptosis and ERS through miR-139-3p in HG-cultured *** Taken together,this study demonstrated that lncRNA Pdia3 overexpression could attenuate HG-induced podocyte apoptosis and ERS by acting as a competing endogenous RNA of miR-139-3p,which might provide a potential therapeutic target for DN.

关键词： Long noncoding RNAs Diabetic nephropathy Podocyte apoptosis Endoplasmic reticulum stress Competing endogenous RNA

Boosting cationic and anionic redox activity of Li-rich layered oxide cathodes via Li/Ni disordered regulation

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Journal of Energy Chemistry 2025年第1期100卷 533-543页

作者： Zewen Liu Zhen Wu Hao Wang Xudong Zhang Yuanzhen Chen Yongning Liu Shengwu Guo Shenghua Chen yanli Nan yan Liu State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University School of Materials Science and Engineering Xi'an University of Architecture and Technology Hefei Advanced Computing Center Operation Management Corp Ltd Network Information Center Xi'an Jiaotong University

Lithium-rich layered oxides （LLOs） are increasingly recognized as promising cathode materials for nextgeneration high-energy-density lithium-ion batteries （LIBs）.However,they suffer from voltage decay and low initial Coulombic efficiency （ICE） due to severe structural degradation caused by irreversible O ***,we introduce a three-in-one strategy of increasing Ni and Mn content,along with Li/Ni disordering and TM–O covalency regulation to boost cationic and anionic redox activity simultaneously and thus enhance the electrochemical activity of *** target material,Li1.2Ni0.168Mn0.558Co0.074O2（L1）,exhibits an improved ICE of 87.2%and specific capacity of 293.2 mA h g-1and minimal voltage decay of less than 0.53 m V cycle-1over 300 cycles at 1C,compared to Li1.2Ni0.13Mn0.54Co0.13O2（Ls）(274.4 mA h g-1for initial capacity,73.8%for ICE and voltage decay of 0.84 mV/cycle over 300 cycles at 1C).Theoretical calculations reveal that the density of states （DOS） area near the Fermi energy level for L1 is larger than that of Ls,indicating higher anionic and cationic redox reactivity than ***,L1 exhibits increased O-vacancy formation energy due to higher Li/Ni disordering of 4.76%（quantified by X-ray diffraction Rietveld refinement） and enhanced TM–O covalency,making lattice O release more difficult and thus improving electrochemical *** increased Li/Ni disordering also leads to more Ni2+presence in the Li layer,which acts as a pillar during Li+de-embedding,improving structural *** research not only presents a viable approach to designing low-Co LLOs with enhanced capacity and ICE but also contributes significantly to the fundamental understanding of structural regulation in high-performance LIB cathodes.

关键词： Ice

SYMMETRICAL SISF IN DEFORMED Ni_3Al AND ITS FORMATION MECHANISM

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Acta Metallurgica Sinica(English Letters) 1992年第2期5卷 76-81页

作者： yan Wen xi′an Institute of Technology,xi′an,China xi'an Inst of Technology Xi'an China

The symmetrical superlattice intrinsic stacking faults(SISFs)formed on {111} planes are the predominant crystal defects in polycrystalline Ni_3AI after slight deformation at room temper- *** formation of this kind of SISF is resulted from the dipoles which are distributed on the neighboring {111} planes after reorientation,dissociation and annihilation under applied stress.

关键词： deformed Ni_3Al symmetrical stacking fault formation mechanism

NUMERICAL SIMULATIONS OF NONLINEAR WAVE TRANSFORMATION AROUND WAVE-PERMEABLE STRUCTURE

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Journal of Hydrodynamics 2005年第6期17卷 699-703页

作者： Li xi yan Yi-xin Department of Ocean Engineering Hohai University Nanjing 210098 China

The problem of wave partial/full reflection and transmission by wave-permeable structure is approached by solving the shape-related function with focus on the understanding of wave attenuation. 2D depth averaged Boussinesq type wave equations are given with new damping item in simulating the nonlinear wave transmission through wave-permeable structure. 1D wave equation is examined to give the analytical expression of the absorbing coefficient, and is compared with laboratory data in flume to calibrate the coefficients, and the expression is applied directly in modified Boussinesq type equations. Compared with wave basin data for various incident wave conditions, the accurate predictions of combined diffraction refraction effects in simulating nonlinear wave going through wave-permeable breakwater in the engineering application can be obtained. It shows that wave-permeable breakwaters with proper absorbing effects can be used as an effective alternative to massive gravity breakwaters in reduction of wave transmission in shallow water.

关键词： Boussinesq equations wav-absorbing coeffieient wave permeable breakwaters