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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Positron annihilation study of defect formation and evolution in matrix graphite under He ion irradiation

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Nuclear Science and Techniques 2025年第1期36卷 13-21页

作者： Hong-Xia Xu Jian-Dang Liu Bang-Jiao Ye Zi-wen Pan Jun Lin Jin-Liang Song Jian-Qing Cao Chao yan Ying-Ping Hao Jin-Xing Cheng Qing-Bo Wang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025China Beijing Institute of High Technology Beijing 100094China

The stability of matrix graphite under neutron irradiation and in corrosive environments is crucial for the safe operation of molten salt reactors(MSRs).Raman spectroscopy and a slow positron beam were employed to investigate the effects of He ion irradiation fluences and subsequent annealing on the microstructure and defects of the matrix *** ions with 500 keV energy and fluences ranging from 1.1×10^(15)ions∕cm^(2)to 3.5×10^(17)ions∕cm^(2)were used to simulate neutron irradiation at 300 *** samples with an irradiation fluence of 3.5×10^(16)ions∕cm^(2)were subjected to isochronal annealing at different temperatures(573 K,873 K and 1173 K)for 3 *** Raman results revealed that the D peak gradually increased,whereas the intrinsic G peak decreased with increasing irradiation *** the same irradiation fluence,the D peak gradually decreased,whereas the intrinsic G peak increased with increasing annealing *** positron beam analysis demonstrated that the density or size of irradiation defects(vacancy type)increased with higher irradiation fluence,but decreased rapidly with increasing annealing *** Raman spectral analysis of sample cross sections subjected to high irradiation fluences revealed the emergence of amorphization precisely at the depth where ion damage was most pronounced,whereas the surface retained its crystalline *** and positron annihilation analyses indicated that the matrix graphite exhibited good irradiation resistance to He ions at 300 ***,vacancy-type defects induced by He ion irradiation exhibit poor thermal stability and can be easily removed during annealing.

关键词： Graphite Positron annihilation Irradiation Raman spectrum

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不同形状超声乳化针头在扭动超声模式的应用

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国际眼科杂志 2015年第8期15卷 1441-1443页

作者：郭作锋史庆成周衍文沈阳爱尔眼视光医院白内障科中国辽宁省沈阳市110003

目的:通过与Infinity超声乳化针头对比,观察Centurion双重弯曲形状设计的超声乳化针头的临床效果。方法:前瞻性对照研究,将年龄相关性白内障患者132例132眼,随机分为两组,试验组66例66眼采用Centurion超声乳化针头,对照组66例66眼采用In... 详细信息

目的:通过与Infinity超声乳化针头对比,观察Centurion双重弯曲形状设计的超声乳化针头的临床效果。方法:前瞻性对照研究,将年龄相关性白内障患者132例132眼,随机分为两组,试验组66例66眼采用Centurion超声乳化针头,对照组66例66眼采用Infinity超声乳化针头,两组均用Centurion超声乳化仪在同一手柄下,利用相同参数下完成常规的超声乳化联合人工晶状体植入术。记录两组术中的累积消耗能量(cumulative dissipated energy,CDE),观察术后1wk,1mo的最佳矫正视力(best corrected visual acuity,BCVA)、角膜内皮密度(corneal endothelial cell density,CD)、中央角膜厚度(central corneal thickness,CCT)。采用独立样本t检验和χ2检验进行统计分析。结果:两组患者的CDE差异有统计学意义(P0.05)。结论:Centurion超声乳化针头能有效减少术中超声能量的释放,减少术后角膜内皮的损伤,对术后早期视力恢复更具有优势。

关键词：超声乳化白内障吸除术白内障累计消耗能量超声乳化针头

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Hypoxia-inducible factor 1-alpha and lactate dehydrogenase-A axis in metabolic changes and aggression in esophageal squamous-cell carcinoma

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 322-333页

作者： Xia Chen Hai-yan Liu Wu-Bi zhou Li-Li Zhang Jian Huang Da-Wei Bao Department of Pathology The Affiliated Huaian No.1 People's Hospital of Nanjing Medical UniversityHuai’an 223300Jiangsu ProvinceChina

BACKGROUND Esophageal squamous-cell carcinoma(ESCC)is a highly aggressive cancer,predominantly affecting populations in Eastern Asia and parts of *** pathogenesis is influenced by both genetic and environmental *** recent therapeutic advances,survival rates remain dismal,underscoring an urgent need for novel therapeutic *** To investigate the role of hypoxia-inducible factor 1-alpha(HIF1A)in the progression of ESCC and its impact on the metabolic enzyme lactate dehydrogenase A(LDHA),which is crucial for the glycolytic pathway in hypoxic tumor *** Utilizing transcriptomic data from multiple public databases,we analyzed differential gene expression and conducted gene ontology and transcription factor network *** regulatory impact of HIF1A on LDHA was specifically examined through integrative analysis with HIF1A ChIP-seq data and confirmed via siRNA-mediated knockdown experiments in ESCC cell *** Our findings reveal a significant upregulation of HIF1A in ESCC tissues,associated with poor ***1A directly regulates LDHA,enhancing glycolysis under hypoxic conditions and contributing to tumor *** of HIF1A in cell lines not only reduced LDHA expression but also altered key pathways related to cell cycle and *** The critical role of the HIF1A-LDHA axis in ESCC highlights its potential as a therapeutic target,underscoring the need for future clinical trials to validate the efficacy of HIF1A inhibitors in enhancing treatment outcomes.

关键词： Esophageal squamous-cell carcinoma Hypoxia-inducible factor 1-alpha Lactate dehydrogenase A Metabolic reprogramming Therapeutic target

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角膜屈光术后人工晶状体度数计算的临床观察

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国际眼科杂志 2016年第2期16卷 339-342页

作者：郭作锋史庆成周衍文沈阳爱尔眼视光医院中国辽宁省沈阳市110003

目的:探讨角膜近视屈光术后白内障患者的人工晶状体度数的计算方法,观察初步的临床效果。方法:回顾性分析2013-03/2015-06于我院行白内障手术同时伴有角膜近视屈光手术史的患者14例23眼。根据患者既往角膜手术方式分为LASIK(laser in si... 详细信息

目的:探讨角膜近视屈光术后白内障患者的人工晶状体度数的计算方法,观察初步的临床效果。方法:回顾性分析2013-03/2015-06于我院行白内障手术同时伴有角膜近视屈光手术史的患者14例23眼。根据患者既往角膜手术方式分为LASIK(laser in situ keratomileusis)组9例15眼,RK(radial keratotomy)组5例8眼。将每例患者的角膜地形图中央2.5mm最低点曲率值,带入SRK-T公式,按照预留-1.00^-1.50D选择人工晶状体度数,完成常规的白内障超声乳化联合人工晶状体植入术。术后随访3mo,观察术后视力、矫正视力和屈光状态。计算出术后人工晶状体计算公式的预测屈光误差,分别与***网站上的Shammas公式和Barrett True K公式进行比较,观察其应用效果,采用独立样本t检验进行统计分析。结果:LASIK组和RK组相比,两组患者术后3mo的裸眼视力(LogM AR)分别是0.15±0.11、0.21±0.16,术后屈光度分别是-0.43±1.04、-1.52±1.01D,SRK-T公式预测屈光误差分别是-0.71±0.80、0.43±0.99,LASIK组均优于RK组且两组间差异均有统计学意义(P0.05)。结论:应用研究方法的术后屈光状态均为轻度近视,适用于因近视行角膜屈光手术的白内障患者进行人工晶状体度数的选择,此方法对于LASIK手术史患者的人工晶状体度数预测性更佳。

关键词：白内障人工晶状体计算公式屈光手术角膜曲率

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Corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 143-156页

作者： Meng-zhen ZHU Jing-lei MIAO Xiong-wen zhou Er-lin ZHANG Zhi-lin LIU Hai-lin yanG State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China The Third Xiangya Hospital Central South UniversityChangsha 410013China Department of Prosthodontics Centre of StomatologyXiangya HospitalCentral South UniversityChangsha 410008China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China Light Alloy Research Institute College of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China

The corrosion resistance and antibacterial properties of Ti−3Cu alloy prepared by selective laser melting were evaluated using electrochemical experiments and a variety of antibacterial *** is found that the charge transfer resistance of Ti−3Cu alloy was 4.89×10^(5)Ω∙cm^(2),which was doubled the data obtained by CP-Ti *** antibacterial rates of Ti−3Cu alloy against *** and *** were 45.0%and 54.5%.And the antibacterial rates increased with the prolongation of cultivation time,reaching up to 62.8%and 68.6%,*** in-situ nano Ti_(2)Cu precipitates were homogeneously distributed in the matrix of the Ti−3Cu alloy,which was the key reason of increasing the corrosion ***,the microscale electric fields between theα-Ti matrix and the Ti_(2)Cu was responsible for the enhancement of the antibacterial properties.

关键词： selective laser melting Ti−3Cu alloy microstructure corrosion resistance antibacterial properties

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Electronic structure,elasticity,magnetism of Mn_(2)XIn(X=Fe,Co)full Heusler compounds under biaxial strain:First-principles calculations

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Chinese Physics B 2025年第1期34卷 438-449页

作者： Shiran Gao Chengyang Zhao Xinzhuo Zhang wen Qiao Shiming yan Ru Bai Tiejun zhou School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

The electronic structure,elasticity,and magnetic properties of the Mn_(2)XIn(X=Fe,Co)full-Heusler compounds are comprehensively investigated via first-principles *** calculated elastic constants indicate that both Mn_(2)FeIn and Mn_(2)Co In possess *** the optimal lattice constants,the magnetic moments are found to be 1.40μB/*** Mn_(2)FeIn and 1.69μB/*** Mn_(2)*** the biaxial strain ranging from-2%to 5%,Mn_(2)FeIn demonstrates a remarkable variation in the spin polarization,spanning from-2%to 74%,positioning it as a promising candidate for applications in spintronic *** of the electronic structure reveals that the change in spin polarization under strain is due to the shift of the spin-down states at the Fermi ***,under biaxial strain,the magnetic anisotropy of Mn_(2)FeIn undergoes a transition of easy-axis *** second-order perturbation theory and electronic structure analysis,the variation in magnetic anisotropy with strain can be attributed to changes of d-orbital states near the Fermi surface.

关键词： magnetic anisotropy biaxial strain electronic band structure mechanical properties

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Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 291-298页

作者： Tian-Hao Guo Sheng-Wei Hong wen-Jian Zhu Yi-Fan Hui wen-Li Qiu yan Wu Xuan Li Fei Ke Liu Li Hai-Bo Cheng Institute of Health and Regimen Jiangsu Open UniversityNanjing 210036Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Pathology Jiangsu Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine)Nanjing 210029Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer *** patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to *** recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including *** present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of *** SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as *** patient has been receiving a combination treatment of Western and Traditional Chinese *** assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its *** patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies *** the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced *** This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.

关键词： Colorectal cancer Colorectal liver metastasis Drug resistance Immunotherapy Anti-programmed death-1 Case report

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Electro-optic tuning in ferroelectric capacitor with photonic crystal nanobeam cavity

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Science China(Information Sciences) 2025年第2期68卷 393-394页

作者： Tongtong WANG Yong ZHANG Danyang YAO Zhi JIANG Dongxin TAN Jie wen Qiyu yanG Xuetao GAN yan LIU Yue HAO Genquan HAN State Key Discipline Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University Key Laboratory of Light Field Manipulation and Information Acquisition Ministry of Industry and Information TechnologyShaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical University Hangzhou Institute of Technology Xidian University

Silicon photonics has provided a platform for the convergency of photonic devices and electronic circuits, facilitating the development of optical telecommunications and optical interconnects on chip [1]. As the basic building block of optical communication systems, electro-optic tuning is expected to be more compact, high bandwidth, energy efficient, and allow for CMOS-compatible fabrication in the future [2]. Resonator-based electro-optic tuning has attracted more and more interest due to the small footprint, enhanced light-matter interactions and high energy efficiency. Compared with microring and microdisk resonators, photonic crystal nanobeam cavities(PCNBCs) realize higher quality factors, stronger light-matter interactions, ultrasmall mode volume and a much larger free spectral range(FSR) [3].

关键词： Hysteresis

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Breaking Solvation Dominance Effect Enabled by Ion-Dipole Interaction Toward Long-Spanlife Silicon Oxide Anodes in Lithium-Ion Batteries

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Nano-Micro Letters 2025年第4期17卷 367-380页

作者： Shengwei Dong Lingfeng Shi Shenglu Geng yanbin Ning Cong Kang yan Zhang Ziwei Liu Jiaming Zhu Zhuomin Qiang Lin zhou Geping Yin Dalong Li Tiansheng Mu Shuaifeng Lou State Key Laboratory of Space Power-Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China School of Marine Science and Technology Harbin Institute of Technology at WeihaiWeihai 264200People’s Republic of China Chongqing Research Institute of HIT Chongqing 401135People’s Republic of China

Micrometer-sized silicon oxide(SiO)anodes encounter challenges in large-scale applications due to significant volume expansion during the alloy/de-alloy ***,an innovative deep eutectic electrolyte derived from succinonitrile is introduced to enhance the cycling stability of SiO *** functional theory calculations validate a robust ion-dipole interaction between lithium ions(Li^(+))and succinonitrile(SN).The cosolvent fluoroethylene carbonate(FEC)optimizes the Li^(+)solvation structure in the SN-based electrolyte with its weakly solvating *** dynamics simulations investigate the regulating mechanism of ion-dipole and cation-anion *** unique Li^(+)solvation structure,enriched with FEC and TFSI^(-),facilitates the formation of an inorganic-organic composite solid electrolyte interphase on SiO ***-CT further detects the inhibiting effect on the SiO volume *** a result,the SiO|LiCoO_(2) full cells exhibit excellent electrochemical performance in deep eutectic-based *** work presents an effective strategy for extending the cycle life of SiO anodes by designing a new SN-based deep eutectic electrolyte.

关键词： Lithium-ion batteries Micrometer-sized silicon oxide Ion-dipole interaction Long-term cycling

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