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Geology, geochronology and geochemistry of large Duobaoshan Cu-Mo-Au orefield in NE China: Magma genesis and regional tectonic implications

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Geoscience Frontiers 2021年第1期12卷 265-292页

作者： wen-yan cai Ke-yong Wang Jian Li Li-juan Fu Chun-kit Lai Han-lun Liu College of Earth Sciences Jilin UniversityChangchun 130061China College of Geology and Mining Engineering Xinjiang UniversityUrumqi 830047China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Land and Resources of ChinaChangchun 130061China Technical Information Department Inner Mongolia Shandong Gold Geological Minerals Survey Co.Ltd.Chifeng 024000China Faculty of Science Universiti Brunei DarussalamGadongBrunei Darussalam

Duobaoshan is the largest porphyry-related Cu-Mo-Au orefield in northeastern(NE)Asia,and hosts a number of large-medium porphyry Cu(PCDs),epithermal Au and Fe-Cu skarn *** ages of these deposits,from the oldest(Ordovician)to youngest(Jurassic),have spanned across over 300 *** similar orefields of such size and geological complexity are found in NE Asia,which reflects its metallogenic uniqueness in forming and preserving porphyry-related *** this study,we explore the actual number and timing of magmatic/mineralization phases,their respective magma genesis,fertility,and regional tectonic connection,together with the preservation of *** present new data on the magmatic/mineralization ages(LA-ICP-MS zircon U-Pb,pyrite and molybdenite Re-Os dating),whole-rock geochemistry,and zircon trace element compositions on four representative deposits in the Duobaoshan orefield,i.e.,Duobaoshan PCD,Tongshan PCD,Sankuanggou Fe-Cu skarn,and Zhengguang epithermal Au deposits,and compiled published ones from these and other mineral occurrences in the *** terms of geochronology,we have newly summarized seven magmatic phases in the orefield:(1)Middle-Late Cambrian(506-491 Ma),(2)Early and Middle Ordovician(485-471 Ma and~462 Ma),(3)Late Ordovician(450-447 Ma),(4)Early Carboniferous and Late-Carboniferous to Early Permian(351-345 and 323-291 Ma),(5)Middle-Late Triassic(244-223 Ma),(6)Early-Middle and Late Jurassic(178-168 Ma and~150 Ma),and(7)Early Cretaceous(~112 Ma).Three of these seven major magmatic phases were coeval with ore formation,including(1)Early Ordovician(485-473 Ma)porphyry-type Cu-Mo-(Au),(2)Early-Middle Triassic(246-229 Ma)porphyry-related epithermal Au-(Cu-Mo),and(3)Early Jurassic(177-173 Ma)Fe-Cu skarn *** deposits in the orefield,notably Tongshan and Zhengguang,were likely formed by more than one mineralization *** terms of geochemistry,ore-causative granitoids in the orefield exhibit adakite-like or adakite-nor

关键词： Duobaoshan Cu-Mo-Au orefield(NE China) Porphyry Cu deposit Epithermal Au deposit Paleo-Asian Ocean Central Asian Orogenic Belt(CAOB)

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Genetic diversity and biogeography of red turpentine beetle Dendroctonus valens in its native and invasive regions

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Insect Science 2008年第4期15卷 291-301页

作者： yan-wen cai Xin-Yue Cheng Ru-Mei Xu Dong-Hong Duan Lawrence R. Kirkendall College of Life Sciences Beijing Normal University Beijing Forestry Office of Shanxi Province Taiyuan China Department of Zoology University of Bergen Bergen N-5007 Norway

Sequences of 479 bp region of the mitochondrial COI gene were applied to detect population genetic diversity and structure ofDendroctonus valens populations. By comparing the genetic diversity between native and invasive populations, it was shown that the genetic diversity of Chinese populations was obviously lower than that of native populations with both indices of haplotype diversity and Nei＇s genetic diversity, suggesting genetic bottleneck occurred in the invasive process of D. valens, and was then followed by a relatively quick population buildup. According to phylogenetic analyses of haplotypes, we suggested that the origin of the Chinese population was from California, USA. Phylogenetic and network analysis of native populations of D. valens revealed strong genetic structure at two distinct spatial and temporal scales in North America. The main cause resulting in current biogeographic pattern was supposedly due to recycled glacial events. Meanwhile, a cryptic species might exist in the Mexican and Guatemalan populations.

关键词： biogeography genetic diversity invasive species mitochondrial DNA redturpentine beetle

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STOP1 regulates CCX1-mediated Ca^(2+)homeostasis for plant adaptation to Ca^(2+)deprivation

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Journal of Integrative Plant Biology 2024年第10期66卷 2126-2139页

作者： wen Hao Tian wen yan cai Chun Quan Zhu Ya Li Kong Xiao Chuang Cao Lian Feng Zhu Jia Yuan Ye Jun Hua Zhang Shao Jian Zheng State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China College of Environmental and Resource Sciences Zhejiang A&F UniversityHangzhou 311300China State Key Laboratory of Plant Environmental Resilience College of Life ScienceZhejiang UniversityHangzhou 310058China

Calcium(Ca)is essential for plant growth and stress adaptation,yet its availability is often limited in acidic soils,posing a major threat to crop *** the intricate mechanisms orchestrating plant adaptation to Ca deficiency remains ***,we show that the Ca deficiency-enhanced nuclear accumulation of the transcription factor SENSITIVE TO PROTON RHIZOTOXICITY 1(STOP1)in Arabidopsis thaliana confers tolerance to Ca deprivation,with the global transcriptional responses triggered by Ca deprivation largely impaired in the stop1 ***,STOP1 activates the Ca deprivation-induced expression of CATION/Ca^(2+)EXCHANGER 1(CCX1)by directly binding to its promoter region,which facilitates Ca^(2+)efflux from endoplasmic reticulum to cytosol to maintain Ca ***,the constitutive expression of CCX1 in the stop1 mutant partially rescues the Ca deficiency phenotype by increasing Ca content in the *** findings uncover the pivotal role of the STOP1-CCX1 axis in plant adaptation to low Ca,offering alternative manipulating strategies to improve plant Ca nutrition in acidic soils and extending our understanding of the multifaceted role of STOP1.

关键词： Ca deficiency Ca homeostasis CCX1 STOP1 transcriptional response

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China Life Sciences 2025年第1期68卷 116-129页

作者： Jiangpeng Wu Siyu Xia wenting Ye yan Sun Jing cai Fubing Yu Haiping wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Isolation,characterization and identification of rats oligodendrocyte precursor cells in vitro

Isolation,characterization and identification of rats oligod...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Li-yan WANG,wen-Qin cai,Peng-hui CHEN Department of Neurobiology,the Third Military Medical University,Chongqing 400038

Oligodendrocyte progenitor cells(OPCs,NG2 glia) are a major glial population in the developing as well as mature central nervous system(CNS).In addition to their well established oligodendrocyte progenitor role,OPCs have been shown to actively participate in CNS *** of OPCs has revealed differences in proliferative capacity,migratory ability,growth factor responses,and vulnerability to damage or *** is necessary to develop a simplified method for generating large quantities of highly purified OPCs for understanding their biology and function. OPCs were prepared from forebrains of postnatal day 0-2 rats and purified by using the shaking method as previously described with some *** OPCs were generated from primary mixed glial cultures by orbital shaker and further purified by differential adhesion,and finally cultured in chemically defined serum-free medium,with appended neurotrophin 2(N2),platelet-derived growth factor(PDGF-AA),basic fibroblast growth factor(bFGF).The identity of OPCs was determined by both immunostaining and electrophysiological *** 95%of the separated cells were OPCs, as assessed by immunostaining with anti- NG2 *** and microglia accounted for less than 5%of total *** majority of OPCs had a small cell body and a bipolar morphology with unbranched *** exhibited a moderate input resistance,delayed rectifier K currents(IK) could be antagonized partly by TEA-C1 and CsCl,small tetrodotoxin (TTX) sensitive Na currents that failed to generate typical action potentials,and a small inflection on the rising phase of the depolarization elicited by positive current *** results suggest that separation and purification by shaking and differential adhesion and chemically defined medium are suitable and effective to obtain highly purified OPCs. Physiological recordings from OPCs revealed that they possessed unique properties that distinct from neuron,astrocyte, oligoden

关键词： oligodendrocyte progenitor cells isolation purification

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浅谈过隧道型900t架桥机20‰大坡道桥间转移

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山西建筑 2008年第8期34卷 161-162页

作者：温艳才中铁三局线桥分公司

为了保证架桥工程的顺利开展,结合过隧道型900 t架桥机20‰大坡道桥间转移施工实践,分析了大坡道桥间转移的重点和难点,详细介绍了桥间转移的施工工序,为类似工程提供了参考依据。

关键词：架桥机施工工序稳定性吊梁

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人脸识别技术的应用风险及其法律规制

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哈尔滨学院学报 2022年第6期43卷 67-71页

作者：颜文彩福州大学法学院福建福州350108

近年来人脸识别技术的应用日渐广泛,但该技术在带来便利的同时也伴随风险,包括侵犯基本权利、附带安全隐患、侵权后难以补救及救济。我国《个人信息保护法》虽已初步建立了个人信息保护的基本法律框架,但仍不够完善和细化。应借鉴美国... 详细信息

近年来人脸识别技术的应用日渐广泛,但该技术在带来便利的同时也伴随风险,包括侵犯基本权利、附带安全隐患、侵权后难以补救及救济。我国《个人信息保护法》虽已初步建立了个人信息保护的基本法律框架,但仍不够完善和细化。应借鉴美国、欧盟的法律实践经验,结合我国实际情况,从人脸识别技术的应用范围、应用过程、侵权后的救济等三方面入手完善规制措施。

关键词：人脸识别技术应用风险侵权救济

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An autonomous dynamic recovery technology for autonomous underwater vehicles based on unmanned surface vehicles

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Science China Technological Sciences 2025年

作者： Yueying WANG Yiqi SHI Guanghui wen Huaicheng yan School of Mechatronic Engineering and Automation Shanghai University Department of Systems Science School of Mathematics Southeast University School of Information Science and Engineering East China University of Science and Technology

Autonomous underwater vehicles (AUVs) have attracted considerable attention due to their vast potential applications, such as offshore oil exploration, underwater rescue, military reconnaissance, and marine scientific...

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Effective factors of CD monitoring technique based on the narrow-band electrical power detection

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Optoelectronics Letters 2006年第5期2卷 364-368页

作者： LI yan JING wen-cai SU Jin-long ZHANG Yi-mo ZHOU Ge ZHANG Jin JIA Da-gong ZHANG Hong-xia DONG Hai College of Precision Instrument ＆ Opto-electronics Engineering Tianjin University Tianjin 300072 P. R. China Key Laboratory of Opto-electronics Information and Technical Science （Tianjin University） Ministry of Education Tianjin 300072 China Laboratory of Optical Fiber Communication C Tianjin University） Tianjin 300072 China

Chromatic Dispersion （CD） monitoring technique based on narrow-band electrical power detecting is one of the cost-effective and simple CD monitoring techniques, while the performance of this method is debased by factors such as bandwidth and center frequency of the detected frequency band, self-phase modulation （SPM） ,light source chirps and optical fiber losses. The CD-electrical power curve is simulated to investigate the effects of the factors above mentioned. Theoretical analysis shows that in single-channeled fiber link,the effect of SPM is small enough （≤0. 003% ） to be ignored,while the chirps and the losses must be taken into account ; the bandwidth of the detected frequency band would better be less than 2π× GHz;the selected central frequency is related to the shape of the original pulse,a central frequency of 12 GHz is chosen in a 4.0 Gbit/s system,and 5GHz is chosen in a 10 Gbit/s system. A testing system is established. The experimental results agree well with the theoretical analysis.

关键词：色散监听技术带宽功率检测

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