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Asian Journal of Andrology 2014年第1期16卷 101-106页

作者： yan-wei sha lu ding ping li Reproductive Medicine Center Maternal and Child Health Hospital of Xiamen Xiamen China

Kartagener＇s syndrome （KS） is an autosomal recessive genetic disease accounting for approximately 50% of the cases of primary ciliary dyskinesia （PCD）. As it is accompanied by many complications, PCD/KS severely affects the patient＇s quality of life. Therapeutic approaches for PCD/KS aim to enhance prevention, facilitate rapid definitive diagnosis, avoid misdiagnosis, maintain active treatment, control infection and postpone the development of lesions. In male patients, sperm flagella may show impairment in or complete absence of the ability to swing, which ultimately results in male infertility. Assisted reproductive technology will certainly benefit such patients. For PCD/KS patients with completely immotile sperm, intracytoplasmic sperm injection may be very important and even indispensable. Considering the number of PCD/KS susceptibility genes and mutations that are being identified, more extensive genetic screening is indispensable in patients with these diseases. Moreover, further studies into the potential molecular mechanisms of these diseases are required. In this review, we summarize the available information on various aspects of this disease in order to delineate the therapeutic objectives more clearly, and clarify the efficacy of assisted reproductive technology as a means of treatment for patients with PCD/KS-associated infertility.

关键词： assisted reproductive technology clinical diagnosis and treatment genetic mechanism Kartagener's syndrome malefertifity, primary ciliary dyskinesia

Genetic factors contributing to human primary ciliary dyskinesia and male infertility

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Asian Journal of Andrology 2017年第5期19卷 515-520页

作者： Zhi-Yong Ji yan-wei sha lu ding ping li The Center for Reproductive Medicine Xiamen Maternity and Child Care Hospital No. 10 Zhenhai Road Xiamen China

Primary ciliary dyskinesia （PCD） is an autosomal-recessive disorder resulting from the loss of normal ciliary function. Symptoms include neonatal respiratory distress, chronic sinusitis, bronchiectasis, situs inversus, and infertility. However, only 15 PCD-associated genes have been identified to cause male infertility to date. Owing to the genetic heterogeneity of PCD, comprehensive molecular genetic testing is not considered the standard of care. Here, we provide an update of the progress on the identification of genetic factors related to PCD associated with male infertility, summarizing the underlying molecular mechanisms, and discuss the clinical implications of these findings. Further research in this field will impact the diagnostic strategy for male infertility, enabling clinicians to provide patients with informed genetic counseling, and help to adopt the best course of treatment for developing directly targeted personalized medicine.

关键词： genetic factors Kartagener syndrome male infertility primary ciliary dyskinesia

First successful pregnancy outcome after intracytoplasmic sperm injection with short-tailed sperm from an infertile Han Chinese man

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Asian Journal of Andrology 2017年第5期19卷 613-614页

作者： yan-wei sha Qing Zhang lu ding ping li The Center for Reproductive Medicine Xiamen Maternity and Child Care HospitalXiamen Fujian Province China

Dear Editor, Short-tailed sperms are rarely encountered in clinical practice, but they make achieving fertilization difficult. We encountered a very rare case of an infertile man having short-tailed sperm. A 32-year-old Chinese farmer and his 27-year-old wife were referred to Xiamen Maternity and Child Care Hospital for a fertility evaluation.

关键词： clinical practice

A successful pregnancy by intracytoplasmic sperm injection using ejaculate sperm from an infertile man with 46, XX/46, XY true hermaphrodite

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Asian Journal of Andrology 2017年第6期19卷 721-722页

作者： yan-wei sha yan-Kun sha lu ding shao-Bin lin Zhi-Yong Ji Xu Wang Yue-Qiang Song ping li Center for Reproductive Medicine Xiamen Maternity and Child Care HospitalXiamen 361003 China Department of Nephrology First Affiliated Hospital ofLiaoning Medical University Jinzhou 121000 China.

Dear Editor, True hermaphroditism is a condition in which the gonads, genital morphology, and sexuality simultaneously show both male and female characteristics （ovaries and testes） or in which both types of gonadal tissue exist in a single gonad （known as an ovariotestis）. True hermaphroditism associated with a chimeric or 46, XX/46, XY karyotype is extremely rare, and the genitalia of those affected can be characterized as female, male, or mixed.1-3 The cause of true hermaphroditism has not been determined because the condition is relatively rare and has a diverse phenotype.4

关键词： intracytoplasmic ejaculate hermaphrodite

Globozoospermic infertility associated with balanced DPY19L2 translocation/gene deletion at the chromosomal breakpoint

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Asian Journal of Andrology 2018年第2期20卷 210-211页

作者： yan-wei sha li-Bin Mei liang-Kai Zheng Rui-Hua Tian lu ding Zhi-Yong Ji Qing Zhang ping li Center for Reproductive Medicine Women and Children's Hospital of Xiamen Xiamen 361003 China Department of Pathology Women and Children's Hospita of Xiamen Xiamen 361003 China

We report here a rare case ofDPY19L2 gene deletion at chromosome 12 breakpoints caused by a 46, XY, t （4; 12）; （q27; qlS） balanced translocation. The patient eventually developed globozoospermia. A 32-year-old male had experienced infertility issues for 4 *** patient exhibited normal appearance, intelligence, and body type, with a height of 175 cm and a weight of 75 kg.

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Diagnosis of a Chinese man with 45,X/46,X,i（Y）（q10）/47,X,i（Y）（q10） ×2 mosaic Turner syndrome

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Asian Journal of Andrology 2018年第2期20卷 205-207页

作者： yan-wei sha lu ding Zhi-Yong Ji Yun-Sheng Ge Hui Kong Qing Zhang Yu-lin Zhou ping li Department of Reproductive Medicine Maternal and Child Health Hospital of Xiamen Xiamen 361005 China Genetics Laboratory Maternal and Child Health Hospital of Xiamen Xiamen 361005 China

Turner syndrome （TS）, characterized by the complete or partial absence of an X chromosome, is the only known viable chromosomal monosomy. It is one of the most common sex chromosome abnormalities in women, but it ca...

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Immunotherapy-based novel nanoparticles in the treatment of gastrointestinal cancer: Trends and challenges

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World Journal of Gastroenterology 2022年第37期28卷 5403-5419页

作者： Yi-Nan ding Ming Xue Qiu-sha Tang li-Jun Wang Hui-yan ding Han li Cheng-Cheng Gao wei-ping Yu Department of Pathophysiology College of MedicineSoutheast UniversityNanjing 210000Jiangsu ProvinceChina Department of Critical Care Medicine Zhongda HospitalSchool of MedicineSoutheast UniversityNanjing 210000Jiangsu ProvinceChina Department of Tuberculosis The Second Hospital of NanjingNanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina Department of Radiology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Medical School Southeast UniversityNanjing 210009Jiangsu ProvinceChina

Gastrointestinal cancer(GIC)is the most common cancer with a poor ***,surgery is the main treatment for ***,the high rate of postoperative recurrence leads to a low five-year survival *** recent years,immunotherapy has received much *** the only immunotherapy drugs approved by the Food and Drug Administration(FDA),immune checkpoint blockade(ICB)drugs have great potential in cancer ***,the efficacy of ICB treatment is greatly limited by the low immunogenicity and immunosuppressive microenvironment of ***,the targets of immunotherapy have expanded from ICB to increasing tumor immunogenicity,increasing the recruitment and maturation of immune cells and reducing the proportion of inhibitory immune cells,such as M2-like macrophages,regulatory T cells and myeloid-derived suppressor ***,with the development of nanotechnology,a variety of nanoparticles have been approved by the FDA for clinical therapy,so novel nanodrug delivery systems have become a research focus for anticancer *** this review,we summarize recent advances in the application of immunotherapy-based nanoparticles in GICs,such as gastric cancer,hepatocellular carcinoma,colorectal cancer and pancreatic cancer,and described the existing challenges and future trends.

关键词： Gastrointestinal cancer Gastric cancer Hepatocellular carcinoma Colorectal cancer Pancreatic cancer Immunotherapy-based novel nanoparticles

Observation of ^(186m)Ta

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Nuclear Science and Techniques 2006年第1期17卷 16-20页

作者： XU yan-Bing ding Hua-Jie ZHANG Sheng-Dong YUAN Shuang-Gui yanG wei-Fan lu Xi-Ting WANG Xian-Yi ZHAO li-Min WANG ping-Zhi li Heng-Yuan Institute of Modern Physics the Chinese Academy of Sciences Lanzhou 730000 China China Institute of Atomic Energy Beifing 102413 China School of Physics Peking University Beijing 100871 China

Unreported tantalum isomer 186mTa has been produced through the reaction 186W(n,p) by irradiation of natW with 14 MeV neutrons. The activity of 186mTa and 186Ta was measured using HPGe detectors and several X-γ as well as γ-γ coincidence arrangements. The 186mTa has been identified by means of measuring known γ rays from 186Ta β-decay. The half-life of 186mTa has been determined to be (1.5±0.1) min.

关键词： ^186mTa 中子反应 β衰变钽同分异构体

Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing in vitro Fertilization and Embryo Transfer: A Large Retrospective Cohort Study

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Biomedical and Environmental Sciences 2021年第2期34卷 130-138页

作者： GAI Xiao yan CHI Hong Bin ZENG lin CAO Wen li CHEN li Xue ZHANG Chen lu Ming NING Lan ding CHANG Chun ZHANG wei Xia liU ping li Rong SUN Yong Chang QIAO Jie Department of Respiratory and Critical Care Medicine Peking University Third HospitalBeijing 100191China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China National Clinical Research Center for Obstetrics and Gynecology Beijing 100191China Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Tuberculosis Department Beijing Geriatric HospitalBeijing 102699China Information Center Peking University Third HospitalBeijing 100191China

Objective Prior pulmonary tuberculosis(PTB) on chest X-ray(CXR) was commonly found in infertile patients receiving examinations before in vitro fertilization and embryo transfer(IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after *** We conducted a retrospective cohort study of 14,254 infertile patients who had received IVFET at Peking University Third Hospital in 2017. Prior PTB was defined as the presence of signs suggestive of old or inactive PTB on CXR, with or without a clinical TB history. Patients who had prior PTB on CXR but had not received a clinical diagnosis and anti-TB therapy were included for analysis. live birth,clinical pregnancy, and miscarriage rates were compared between the untreated PTB and non-PTB *** The untreated PTB group had significantly lower clinical pregnancy(31.7% vs. 38.1%) and live birth(23.8% vs. 30.6%) rates than the non-PTB group(both P live birth rate [odds ratio(OR), 0.80;95% confidence interval(CI), 0.66–0.98;P = 0.028] in all patients and for increased miscarriage(OR, 4.19;95% CI,1.69–10.39;P = 0.002) and decreased live birth(OR, 0.45;95% CI, 0.24–0.83;P = 0.011) rates in patients with unexplained *** Untreated PTB was associated with adverse pregnancy outcomes after IVF-ET, especially in patients with unexplained infertility, highlighting the clinical significance of PTB in this specific patient population.

关键词： Tuberculosis Embryo transfer In vitro fertilization Infertility Pregnancy outcome

Somatosensory disinhibition in patients with paroxysmal kinesigenic dyskinesia

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Chinese Medical Journal 2012年第5期000卷 838-842页

作者： wei Hua SUN Ying CHEN Hai WANG De-quan li li-ping ding yan liU Ai-hua lu Chang-feng WANG Yu-ping Department of Neurology Xuanwu Hospital Capital MedicalUniversity Beijing 100053 China Department of Neurology Tongren Hospital Capital MedicalUniversity Beijing 100730 China

Background Paroxysmal kinesigenic dyskinesia （PKD） is characterized by recurrent brief episodes of chorea and dystonia induced by sudden movement. Whether the central nervous system is hyper- or hypoexcitable in PKD remains undetermined. The aim of our study was to compare the somatosensory evoked potential （SEP） recovery cycle, a marker of somatosensory system excitability, in PKD patients and controls.

关键词： paroxysmal kinesigenic dyskinesia somatosensory evoked potentials recovery cycle paired stimulation