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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-yan Sun Lingyun Nie Jing Zhang Xue Fang Hongmei Luo Chuanhai Fu Zhiyi wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第1期 369-376页

作者： Song-Meng Wang Hao Nian yan-Fang Wang Li-Shuo Zheng Yu-Tao Zheng Yi-wei Dong Liping Huang Xiaoping Wang wei Jiang Liu-Pan yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan Qi wei Hong yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

A Wind Tunnel Experimental Study on the Wake Characteristics of a Horizontal Axis Wind Turbine

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Journal of Thermal Science 2025年第1期 145-158页

作者： GUO Xingduo LI Yinran LI Rennian MA Yulong wei kui College of Energy and Power Engineering Lanzhou University of Technology Key Laboratory of Fluid Machinery and Systems Gansu Provincial Technology Centre for Wind Turbines

The characteristics of wind turbine wakes are influenced by multiple factors,including the atmospheric boundary layer(ABL) wind and wind turbine operating conditions(e.g.,tip speed ratio and yaw angle).In this study,two types of ABL winds with different velocity gradients and turbulence intensities are generated in a wind tunnel through configurations of spires,baffles,and various numbers of roughness elements.A wind turbine with a rotor diameter of 0.8 m and a hub height of 0.6 m is tested under varying tip speed ratios,yaw angles,and ABL wind *** results indicate that the streamwise velocity deficit in the near-wake region becomes more pronounced with an increase in the tip speed ratio,while the far-wake velocity deficit remains largely unaffected by changes in the tip speed *** the yaw angle increases,the wake deflection becomes more prominent and the wake narrows;the offset of the wake center at various downstream positions grows linearly,reaching a maximum value of approximately half the rotor ***,the turbulence level and influence range in the wake region are reduced when the turbine is *** ABL wind conditions,high turbulence intensity in the incoming flow accelerates wake recovery,and the Reynolds stress at different lateral positions tends to become consistent with increasing longitudinal ***,turbulence has a significant impact on the meandering characteristics of the wind turbine wake,with greater fluctuations in the wake center observed under higher turbulence ***,this study provides insights that could inform the optimal operation of wind farms.

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Properties of oxide coating on the surface of ZrH_(1.8) prepared by microarc oxidation with different positive voltages

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Rare Metals 2013年第2期32卷 169-173页

作者： Guo-Qing yan wei-Dong Chen Xue-kui Zhong Shu-Fang yan School of Materials Science and Engineering Inner Mongolia University of Technology

Zirconia coatings as hydrogen permeation barriers were formed on disktype ZrHj.s substrate speci mens in phosphate solution system by microarc oxidation technique. Influence of positive voltage on hydrogen per meation barriers on the surface of zirconium hydride was investigated as the main factor. The thickness of total oxide layer increased from 42.5 to 55.0 ~tm the increase of positive voltage increasing from 325 up to 425 V. The permeation reduction factor （PRF） was observed under different voltages, which increased with the increasing positive voltages. The phase structure of oxide layer was monoclinic Zr02 and tetragonal ZrO1.88. No reduction reaction occured in the process of hydrogen escaping, and it indicates that hydrogen permeation through oxide layer is restricted.

关键词： Zirconium hydride Hydrogen permeationbarrier Oxide layers Microarc oxidation technique

Selective detection of mercury(II) and methylmercury(II) via coordinationinduced emission of a small-molecule probe

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Science China Chemistry 2016年第12期59卷 1651-1657页

作者： yan yang Zhiyi Yao wei Li kui Chen Lei Liu Hai-Chen Wu Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety Institute of High Energy Physics Chinese Academy of Sciences College of Chemical Engineering Beijing Institute of Petro-chemical Technology

Mercury is one of the major toxic pollutants and has many adverse effects on human health. The main mercury species in the environment or in living organisms are inorganic mercuric ion （Hg2＋） and organic methylmercury （CH3Hg＋）. Detection of the two mercury ions is a particularly active topic in the molecular sensing field during the past decade. However, efficient sensors that can sensitively detect and discriminate the two species are rare. In this work, we adopt the concept of restriction of intramolecular rotations which is the basis of aggregation induced emission, and design a molecular probe with pyridyl group as the chelating unit and 1,8-naphthalimide as the fluorescent unit for the detection of both Hg2＋ and CH3Hg＋. When the probe is free in solution, it exhibits weak fluorescence because free intramolecular rotations of the 1,8-naphthalimide moieties non-radiatively annihilate its excited state. However, upon coordination with Hg2＋ or CH3Hg＋, the rotation of 1,8-naphthalimide moieties would be restricted due to the chelation between 1,8-naphthalimide and Hg2＋ or CH3Hg＋, leading to significantly enhanced fluorescent emission. The response induced by Hg2＋ is much stronger than CH3Hg＋; but for specific detection of CH3Hg＋, we introduced a T-rich DNA fragment which could completely mask Hg2＋ in solution. Furthermore, we have employed the sensor for confocal imaging of rig2＋ and CH3Hg＋in immobilized cells. We expect the probe design tactics can be generally useful for sensing many other analytes.

关键词： mercury methylmercury coordination-induced emission fluorescence enhancement selectivity

Gut microbiota-derived metabolites as key mucosal barrier modulators in obesity

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World Journal of Gastroenterology 2021年第33期27卷 5555-5565页

作者： yan-Xia wei kui-yang Zheng Yu-Gang Wang Laboratory of Infection and Immunity Jiangsu Key Laboratory of Immunity and MetabolismDepartment of Pathogenic Biology and ImmunologyXuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina

A significant breakthrough in the field of obesity research was the demonstration that an obese phenotype could be manipulated by modulating the gut *** important next step is to elucidate a human-relevant"map"of microbiota-host interactions that regulate the metabolic health of the *** improved understanding of this crosstalk is a prerequisite for optimizing therapeutic strategies to combat *** mucosal barrier dysfunction is an important contributor to metabolic diseases and has also been found to be involved in a variety of other chronic inflammatory conditions,including cancer,neurodegeneration,and *** mechanistic basis for intestinal barrier dysfunction accompanying metabolic disorders remains poorly *** the molecular and cellular modulators of intestinal barrier function will help devise improved strategies to counteract the detrimental systemic consequences of gut barrier *** in the composition and function of the gut microbiota,i.e.,dysbiosis,are thought to drive obesity-related pathogenesis and may be one of the most important drivers of mucosal barrier *** effects of the microbiota on the host are mediated by microbiota-derived *** this review,we focus on several relatively well-studied microbial metabolites that can influence intestinal mucosal homeostasis and discuss how they might affect metabolic *** design and use of microbes and their metabolites that are locally active in the gut without systemic side effects are promising novel and safe therapeutic modalities for metabolic diseases.

关键词： Obesity Metabolic diseases Microbiota Mucosal homeostasis Gut Microbial metabolites

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基于干涉和实时前馈实现三个量子节点的纠缠

原子与分子物理学报 2025年第4期42卷 113-120页

作者：刘艳红陈伟李雁翔太原师范学院物理系晋中030619 太原师范学院计算机科学与技术学院晋中030619 山西北方机械制造有限责任公司太原030009

纠缠多个空间分离的远程量子节点是构建量子信息网络的基础,不仅如此,多量子节点间的纠缠亦可应用于分布式量子计算和量子精密测量等,实现更高纠缠度的多量子节点间纠缠势在必行.文中基于干涉和实时前馈,借助于腔增强通过采用受激拉曼... 详细信息

纠缠多个空间分离的远程量子节点是构建量子信息网络的基础,不仅如此,多量子节点间的纠缠亦可应用于分布式量子计算和量子精密测量等,实现更高纠缠度的多量子节点间纠缠势在必行.文中基于干涉和实时前馈,借助于腔增强通过采用受激拉曼散射机制实现三个远距离原子系综的纠缠.该方案中只需要三套腔增强原子系统,光学谐振腔增强了光和原子之间的相互作用,使得通过受激拉曼散射产生的斯托克斯光场和反斯托克斯光场的效率得到提高,实现了高纠缠度的光与原子纠缠.在此前提下,基于斯托克斯光场的干涉和实时前馈实现三个远程原子节点间的纠缠.这种方法可以扩展到更大规模,甚至更加复杂的量子信息网络中,从而在量子信息科学中具有潜在的应用.

关键词：原子系综纠缠干涉实时前馈受激拉曼散射

Stability and Collective Excitation of Two-Dimensional BECs with Two-and Three-Body Interactions in an Anharmonic Trap

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Communications in Theoretical Physics 2009年第3期51卷 433-440页

作者： YONG Wen-Mei wei Xiu-Fang ZHOU Xiao-yan XUE Ju-kui College of Physics and Electronics Engineering Northwest Normal University Lanzhou 730070 China College of Science Gansu Agricultural University Lanzhou 730070 China Department of Physics Lanzhou City University Lanzhou 730070 China

The stability and collective excitation of Bose-Einstein condensates with both two- and three-body interactions in a two-dimensional anhaxmonic trap （i.e., harmonic plus quartic trap） are investigated. By using the variational method, the influence of the three-body interaction and the anharmonicity on the stability axe discussed in detail. It is found that the anhaxmonicity of the trap and the three-body interaction have significant effect on the stability and collective excitations of the system.

关键词： Bose Einstein condensates stability anharmonicity three-body interaction