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Tumor necrosis factor: The key to hepatitis B viral clearance

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Cellular & Molecular Immunology 2018年第8期15卷 731-733页

作者： I-Tsu Chyuan Ping-Ning hsu Department of Internal Medicine Cathay General HospitalTaipeiTaiwanChina Graduate Institute of Clinical Medicine College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Graduate Institute of Immunology College of MedicineNational Taiwan UniversityTaipeiTaiwanChina Department of Internal Medicine National Taiwan University HospitalTaipeiTaiwanChina

The immunopathogenesis of hepatitis B virus(HBV)involves a complex interaction of innate and adaptive immune response associated with several ***,due to experimental limitations,very limited and even no activation of the innate immune response can be demonstrated in acute HBV *** role of innate immunity and the key innate effectors for HBV clearance is still *** is also not clear whether clinical use of TNF inhibitors in treating rheumatoid arthritis and other autoimmune disease patients with chronic HBV infection would affect viral ***,in a recent paper in Cell Mol Immunol,Chyuan et *** that under TNF-αblockade,HBV viral clearance was impaired with persistent elevated HBV viral load in a dose and temporal-dependent manner.1 It demonstrates that a deficiency of TNF-αreduces viral clearance and promotes HBV persistence in a mouse model,and the impairment of HBV clearance under anti-TNF-αoccurs at an early time point of HBV infection,suggesting that HBV may reactivate during therapy with TNF *** results together with previous reports support that TNF is a key innate cytokine required to clear HBV.2,3 It also provides evidence that therapy with TNF inhibitors may impair immune response to HBV clearance.

关键词： Immunol impaired immunity

Using 3D bioprinting to produce mini-brain

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Neural Regeneration Research 2017年第10期12卷 1595-1596页

作者： Hao-Wei Han Shan-hui hsu Institute of Polymer Science and Engineering National Taiwan UniversityTaipeiTaiwanChina Center of Tissue Engineering and 3D printing National Taiwan UniversityTaipeiTaiwanChina Institute of Cellular and System Medicine National Health Research InstitutesMiaoliTaiwanChina

Recent progresses in three-dimensional （3D） bioprinting technology accelerate the coming of the era of personalized medicine. With vari- ous printing approaches and materials developed, 3D bioprinting may have a broad range of medical applications, including the fabrication of delicate tissues/organs/or the clinical use in the future or for the es- tablishment of tissues in disease models. The principal advantages of 3D bioprinting are personalized design and precise fabrication, which are of critical importance for tissue engineering. To date, several types of biomimetic tissues, such as cartilage, skin, and vascular tissues have been fabricated by 3D bioprinting （Liaw and Guvendiren, 2017）.

关键词： Using 3D bioprinting to produce mini-brain ADSCs

Study on the Drift Effect of Potassium Ion Sensing Based on the Extended Gate Field Effect Transistor

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稀有金属材料与工程 2006年第A03期35卷 259-260页

作者： Jung-Chuan Chou Ching-Hsiang hsu Department of Electronic Engineering National Yunlin University of Science and TechnologyDouliouTaiwan 640China

The advantages of the extended gate field effect transistor (EGFET) compared with the ion sensitive field effect transistor (ISFET) are easy package,easy preservation,insensitive light effect,and better *** EGFET has above advantages,there are still some non-ideal effects such as drift etc..The drift behavior exists during the measurement process and results in the variation of the output voltage with *** can obtain the drift value by immersing EGFET into the pH solution for 12 hours and measure the rate of the output voltage versus time after S *** study analyzes the sensitivity, stability,and drift effect of the EGFET based on the structure of the ruthenium oxide/silicon (RuO_x/Si) wafer for measuring the potassium *** fabrication of the potassium ion sensor can be widely employed in medical detection.

关键词： potassium ion extended gate field effect transistor RuO_x/Si wafer sensitivity drift

A unified model with a generalized gauge symmetry and its cosmological implications

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Chinese Physics C 2015年第10期39卷 68-76页

作者： Jong-Ping hsu Kazuo O.Cottrell Department of Physics University of Massachusetts Dartmouth

A unified model is based on a generalized gauge symmetry with groups [Sg3c]color×（SU2×U1）X[U1b×U11]. It implies that all interactions should preserve conservation laws of baryon number, lepton number, and electric charge, etc. The baryonie U1b, leptonie U11 and color SU3o gauge transformations are generalized to involve nonintegrable phase factors. One has gauge invariant fourth-order equations for massless gauge fields, which leads to linear potentials in the [U1b × U11] and color [SUao] sectors. We discuss possible cosmological implications of the new baryonie gauge field. It can produce a very small constant repulsive force between two baryon galaxies （or between two anti-baryon galaxies）, where the baryon force can overcome the gravitational force at very large distances and leads to an accelerated cosmic expansion. Based on conservation laws in the unified model, we discuss a simple rotating dumbbell universe with equal amounts of matter and anti-matter, which may be pictured as two gigantic rotating clusters of galaxies. Within the gigantic baryonie cluster, a galaxy will have an approximately linearly accelerated expansion due to the effective force of constant density of all baryonie matter. The same expansion happens in the gigantic anti-baryonic cluster. Physical implications of the generalized gauge symmetry on charmonium confining potentials due to new SUac field equations, frequency shift of distant supernovae Ia and their experimental tests are discussed.

关键词： unified model nonintegrable phase factors conservation laws cosmology accelerated expansion

STRUCTURAL EVOLUTION IN BIORENEWABLE SOY BASED POLYURETHANES

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Chinese Journal of Polymer Science 2009年第4期27卷 447-454页

作者： Deepa Puthanparambil Casey Kimball Shaw Ling hsu Polymer Science and Engineering Department and Materials Research Science and Engineering Center University of MassachusettsAmherstMA 01003USA Douglas McKinnon Hall Williston Northampton AcademyEasthamptonMA 01027USA Invited lecture presented at the International Symposium on Polymer Physics

Spectroscopic studies have revealed that the amount of polyureas formed and the kinetics of their formation in soy based polyurethane systems are considerably different from traditional systems employing ethylene oxide-propylene oxide (EO-PO) based *** aggregation of polyureas was characterized by the hydrogen bonds formed utilizing FTIR *** study offered the opportunity to assign the previously undefined infrared *** structural transformation is reflected in the segmental rel...

关键词： Spectroscopy Miscibility Polyurethanes

On the Regularity for Stationary Harmonic Maps

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Acta Mathematica Sinica,English Series 2008年第2期24卷 223-226页

作者： De Liang hsu Jia Yu LI Department of Mathematics Shanghai Jiaotong University Shanghai 200030 P. R. China Institute of Mathematics Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 P. R. China

We prove a compactness theorem for k-indexed stationary harmonic maps, and show a regularity theorem for this kind of maps which says that the singular set of a k-indexed stationary harmonic map is of Hausdorff dimens... 详细信息

关键词： k-indexed stationary harmonic map stable stationary harmonic map blowing up Morse index

A comparative study of seismic provisions between International Building Code 2003 and Uniform Building Code 1997

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Earthquake Engineering and Engineering Vibration 2006年第1期5卷 49-60页

作者： Wenshen Pong Zu-hsu Lee Anson Lee School of Engineering San Francisco State University San Francisco CA 94132 USA Department of Management and Information Systems Montclair State University Montclair NJ 07043 USA

This study focuses on the comparison of the Uniform Building Code （UBC） 1997 and International Building Code （IBC） 2003 in relation to the seismic design and analysis of special steel moment resisting frame buildings （SMRF）. This paper formulates a numerical study of a steel SMRF building, studied in four different situations, namely： as an office building in San Francisco; as an office building in Sacramento; as an essential facility in San Francisco, and as an essential facility in Sacramento. The analytical results of the model buildings are then compared and analyzed taking note of any significant differences. This case study explores variations in the results obtained using the two codes, particularly the design base shear and drift ratios as they relate to different locations and occupancy use. This study also proves that IBC 2003 is more stringent for the redundancy factor under design category E for the SMRF building, and drift limits for essential facilities.

关键词： Uniform Building Code 1997 International Building Code 2003 building periods special moment resisting frame redundancy factor

Influence of the Boreal Summer Intraseasonal Oscillation on Extreme Temperature Events in the Northern Hemisphere

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Journal of Meteorological Research 2018年第4期32卷 534-547页

作者： Yifei DIAO Tim LI Pang-Chi hsu Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environmental ChangeCollaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science &Technology International Pacific Research Center and Department of Atmospheric Sciences School of Ocean and Earth Science and Technology University of Hawaii

The impact of the boreal summer intraseasonal oscillation （BSISO） on extreme hot and cool events was investig-ated, by analyzing the observed and reanalysis data for the period from 1983 to 2012. It is found that the frequency of the extreme events in middle and high latitudes is significantly modulated by the BSISO convection in the tropics, with a 3-9-day lag. During phases 1 and 2 when the BSISO positive rainfall anomaly is primarily located over a northwest-southeast oriented belt extending from India to Maritime Continent and a negative rainfall anomaly ap- pears in western North Pacific, the frequency of extreme hot events is 40% more than the frequency of non-extreme hot events. Most noticeable increase appears in midlatitude North Pacific （north of 40°N） and higher-latitude polar region. Two physical mechanisms are primarily responsible for the change of the extreme frequency. First, an upper-tropo-spheric Rossby wave train （due to the wave energy propagation） is generated in response to a negative heating anom-aly over tropical western North Pacific in phases 1 and 2. This wave train consists of a strong high pressure anomaly center northeast of Japan, a weak low pressure anomaly center over Alaska, and a strong high pressure anomaly cen-ter over the western coast of United States. Easterly anomalies to the south of the two strong midlatitude high pres-sure centers weaken the climatological subtropical jet along 40°N, which is accompanied by anomalous subsidence and warming in North Pacific north of 40°N. Second, an enhanced monsoonal heating over South Asia and East Asia sets up a transverse monsoonal overturning circulation, with large-scale ascending （descending） anomalies over trop-ical Indian （Pacific） Ocean. Both the processes favor more frequent extreme hot events in higher-latitude Northern Hemisphere. An anomalous atmospheric general circulation model is used to confirm the tropical heating effect.

关键词： boreal summer intraseasonal oscillation extreme hot events extreme cool events Rossby wave train monsoonal circulation

Beyond the Rex: an innovative meso-intrahepatic portal vein bypass for late-onset extrahepatic portal vein occlusion after living donor liver transplantation

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 662-668页

作者： Chee-Chien Yong hsu-ting Yen Yu-Fan Cheng Leona Bettina Dungca Raymond Joseph De Vera Itsuko Chih-Yi Chen Chao-Long Chen Department of Surgery Liver Transplantation CenterKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung Department of Cardiovascular Surgery Liver Transplantation CenterKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung Department of Diagnostic Radiology Liver Transplantation CenterKaohsiung Chang Gung Memorial HospitalChang Gung University College of MedicineKaohsiung

The Meso-Rex bypass(MRB)is recognized as an effective treatment for portal hypertension secondary to extrahepatic portal vein occlusion(EHPVO)both in the pediatric and adult population,within or outside the context of liver *** is the preferred surgical treatment in most centers because not only does it addresses the portal hypertension,but also restores physiologic portal hepatopetal ***,the Rex recess,the landmark for this technique,may not be safely accessible in some *** present a 22-year-old male who underwent living donor liver transplant(LDLT)for neonatal *** presented with variceal bleeding due to EHPVO at 13 years after *** endoscopic,radiologic,and surgical interventions were employed to address the recurrent gastrointestinal bleeding,but results have been *** performed a meso-intrahepatic portal vein bypass(MIPVB),an innovative alternative to the MRB,for this patient with extensive post-operative adhesions,perihilar collaterals,and cavernous *** creation in patients where the Rex recess is inaccessible is technically *** with a multidisciplinary team approach,meticulous preoperative planning,and close follow-up,the authors have demonstrated that it is a safe and feasible option for patients with late-onset EHPVO after liver transplantation.

关键词： Meso-Rex bypass(MRB) portal vein occlusion liver transplantation(LT)