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Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-Yu qu Guang-Yu Chen Meng-Zhou Xie yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

RolC基因的克隆及细胞分裂素在烟草中的过量表达

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Acta Botanica Sinica 1998年第3期40卷 211-215页

作者：贾燕涛麻密屈贵平潜忠兴林忠平中国科学院植物研究所

用ＰＣＲ方法从发根农杆菌（Ａｇｒｏｂａｃｔｅｒｉｕｍｒｈｉｚｏｇｅｎｅｓ）１６０１质粒中扩增出ｒｏｌＣ基因，并构建ＣａＭＶ３５Ｓ启动子驱动下的ｒｏｌＣ基因表达质粒ｐＣａＲ。以农杆菌介导的叶盘法，分别对野生型烟草（Ｎｉ... 详细信息

用ＰＣＲ方法从发根农杆菌（Ａｇｒｏｂａｃｔｅｒｉｕｍｒｈｉｚｏｇｅｎｅｓ）１６０１质粒中扩增出ｒｏｌＣ基因，并构建ＣａＭＶ３５Ｓ启动子驱动下的ｒｏｌＣ基因表达质粒ｐＣａＲ。以农杆菌介导的叶盘法，分别对野生型烟草（ＮｉｃｏｔｉａｎａｔａｂａｃｕｍＬ．ｃｖ．Ｗ３８）和已经异戊烯基转移酶基因（ｉｐｔ）转化的烟草进行了转化。Ｓｏｕｔｈｅｒｎｂｌｏｔ和ＲＮＡＤｏｔｂｌｏｔ分析表明，ｒｏｌＣ基因已转入烟草植株，并且可以正常表达。观察发现，经ｐＣａＲ转化的烟草，其形态特征与细胞分裂素过量表达时植株表现出的特征一致。用ＥＬＩＳＡ方法测定转基因烟草植株中激素含量，结果显示，单独转ｒｏｌＣ基因烟草和转ｒｏｌＣ和ｉｐｔ两个基因的烟草，细胞分裂素水平有不同程度的提高。转基因烟草表现多芽、节间距缩短等特征。

关键词： rolC 细胞分裂素烟草

基于RT-LAB的储能系统离网运行控制策略研究

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现代电力 2016年第6期33卷 33-36页

作者：朱观炜谭伟璞闫涛渠展展刘志波华北电力大学电气与电子工程学院北京102206 中国电力科学研究院北京100192

微网离网运行时,要求电压和频率稳定。针对风电和光伏的间歇性波动以及负载的频繁投切特性,微网需要储能系统平衡有功和无功功率。本文首先基于RT-LAB搭建了储能系统离网运行实验平台,然后在传统的V/f单环控制基础上,对比分析了电感电... 详细信息

微网离网运行时,要求电压和频率稳定。针对风电和光伏的间歇性波动以及负载的频繁投切特性,微网需要储能系统平衡有功和无功功率。本文首先基于RT-LAB搭建了储能系统离网运行实验平台,然后在传统的V/f单环控制基础上,对比分析了电感电流内环和电容电流内环两种双环控制方法,改进了传统的恒压恒频控制,该控制策略有更好的抗负载电流扰动特性。最后在matlab/simulink环境下进行了仿真,并且在RT-LAB平台上进行了半实物仿真验证,结果表明了提出控制策略的有效性。

关键词：微网离网运行储能系统恒压恒频半实物仿真

Defects‑Rich Heterostructures Trigger Strong Polarization Coupling in Sulfides/Carbon Composites with Robust Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 528-547页

作者： Jiaolong Liu Siyu Zhang Dan qu Xuejiao Zhou Moxuan Yin Chenxuan Wang Xuelin Zhang Sichen Li Peijun Zhang Yuqi Zhou Kai tao Mengyang Li Bing Wei Hongjing Wu Mengyang Li Bing Wei Hongjing Wu School of Physics Xidian UniversityXi’an 710071People’s Republic of China School of Advanced Materials and Nanotechnology State Key Discipline Laboratory of Wide Band Gap Semiconductor TechnologyXidian UniversityXi’an 710071People’s Republic of China School of Microelectronics Xidian UniversityXi’an 710071People’s Republic of China School of Telecommunication Engineering Xidian UniversityXi’an 710071People’s Republic of China MOE Key Laboratory of Material Physics and Chemistry Under Extraordinary School of Physical Science and TechnologyNorthwestern Polytechnical UniversityXi’an 710072People’s Republic of China The Ministry of Education Key Laboratory of Micro and Nano Systems forAerospace School of Mechanical EngineeringNorthwestern PolytechnicalUniversityXi’an 710072People’s Republic of China

Defects-rich heterointerfaces integrated with adjustable crystalline phases and atom vacancies,as well as veiled dielectric-responsive character,are instrumental in electromagnetic *** methods,however,constrain their delicate ***,an innovative alternative is proposed:carrageenan-assistant cations-regulated(CACR)strategy,which induces a series of sulfides nanoparticles rooted in situ on the surface of carbon *** unique configuration originates from strategic vacancy formation energy of sulfides and strong sulfides-carbon support interaction,benefiting the delicate construction of defects-rich heterostructures in M_(x)S_(y)/carbon composites(M-CAs).Impressively,these generated sulfur vacancies are firstly found to strengthen electron accumulation/consumption ability at heterointerfaces and,simultaneously,induct local asymmetry of electronic structure to evoke large dipole moment,ultimately leading to polarization coupling,i.e.,defect-type interfacial ***“Janus effect”(Janus effect means versatility,as in the Greek two-headed Janus)of interfacial sulfur vacancies is intuitively confirmed by both theoretical and experimental investigations for the first ***,the sulfur vacancies-rich heterostructured Co/Ni-CAs displays broad absorption bandwidth of 6.76 GHz at only 1.8 mm,compared to sulfur vacancies-free CAs without any dielectric *** defects-rich heterostructures,this one-pot CACR strategy may steer the design and development of advanced nanomaterials,boosting functionality across diverse application domains beyond electromagnetic response.

关键词： Defects-rich heterointerfaces Sulfides Polarization coupling Electromagnetic wave absorption

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Small modifications of endo-functionalized cavities lead to large changes in molecular interaction in water

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Science China Chemistry 2025年第01期 369-376页

作者： Song-Meng Wang Hao Nian yan-Fang Wang Li-Shuo Zheng Yu-tao Zheng Yi-Wei Dong Liping Huang Xiaoping Wang Wei Jiang Liu-Pan yang Department of Chemistry Southern University of Science and Technology School of Chemistry and Pharmaceutical Sciences State Key Laboratory for Chemistry and Molecular Engineering of Medicinal ResourcesGuangxi Normal University School of Pharmaceutical Science Hengyang Medical School University of South China

Studying molecular recognition in aqueous environments is crucial for understanding biological processes. Herein, we present a series of N-doped endo-functionalized anthracene-based cavities by introducing inward-directed pyridine units. The subtle modifications can significantly affect the binding properties of these receptors, which is similar to the mutations in biological systems. Combining theoretical calculations and molecular recognition experiments demonstrated that these “mutations” have an impact on the hydrophobicity and charge distribution of the hosts, consequently significantly influencing molecular *** is crucial for understanding the intricate mechanisms of molecular-level interactions in biological receptors.

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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui qu Xiangbing Wu Wei Wu Ying Wang yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

Martensitic transformation,shape memory effect and superelasticity of Ti-xZr-(30-x)Nb-4Ta alloys

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Rare Metals 2019年第10期38卷 965-970页

作者： Wen-tao qu Hao Gong Jun Wang Yong-Sheng Nie yan Li School of Mechanical Engineering Xi'an Shiyou UniversityXi’an 710065China School of Materials Science and Engineering Beihang UniversityBeijing 100191China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing 100191China Lanzhou Seemine SMA Co.Ltd Lanzhou 730010China

Martensitic transformations,mechanical properties,shape memory effect and superelasticity of Ti-xZr-(30-x)Nb-4Ta(x=15,16,17 and 18;at%) alloys were investigated.X-ray diffraction(XRD),optical microscopy(OM) and transmission electron microscopy(TEM) results indicated that the Ti-16Zr-14Nb-4Ta,Ti-17Zr-13Nb-4Ta and Ti-18Zr-12Nb4Ta alloys were mainly composed of α″-martensite,while the Ti-15Zr-15Nb-4Ta alloy was characterized by predominant p *** reverse martensitic transformation temperatures increased when Nb was replaced by Zr,indicating stronger p-stabilizing effect for the *** Ti-15Zr-15Nb-4Ta alloy displayed superelasticity during tensile deformation with a recovery strain of 3.51%.For the other three alloys with higher Zr content,the martensitic reorientation occurred during tensile deformation,resulting in shape memory recovery upon subsequent *** maximum shape memory effect was 3.46% in the Ti-18Zr-12Nb-4Ta alloy.

关键词： Ti-Zr alloys Martensitic transformation Shape memory effect Superelasticity

Selberg's Normal Density Theorem for Automorphic L-Functions for GL_m

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Acta Mathematica Sinica,English Series 2007年第10期23卷 1903-1908页

作者： yan qu Department of Mathematics Shandong University Ji'nan 250100 P. R. China

Let π be an irreducible unitary cuspidal representation of GLm（AQ） with m ≥ 2, and L（s, Tr） the L-function attached to π. Under the Generalized Riemann Hypothesis for L（s,π）, we estimate the normal density of primes in short intervals for the automorphic L-function L（s, π）. Our result generalizes the corresponding theorem of Selberg for the Riemann zeta-function.

关键词： automorphic L-functions generalized Riemann Hypothesis normal density