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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： yan li Peng Hao Hongmei Duan Fei Hao Wen Zhao Yudan Gao Zhaoyang yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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两种不同药物预处理对子宫黏膜下肌瘤患者手术指标、宫颈扩张程度及不良反应的影响

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中国现代医学杂志 2017年第11期27卷 59-62页

作者：杨德红李燕茹云南省第一人民医院生殖妇科云南昆明650032 云南省交通中心医院妇产科云南昆明650042

目的研究米索前列醇和卡孕栓宫颈预处理方案对行宫腔镜手术子宫黏膜下肌瘤患者手术指标、宫颈扩张程度及不良反应的影响。方法选取2015年3月-2016年9月该院接受宫腔镜手术治疗前阴道放置卡孕栓软化宫颈的子宫黏膜下肌瘤患者92例作为实... 详细信息

目的研究米索前列醇和卡孕栓宫颈预处理方案对行宫腔镜手术子宫黏膜下肌瘤患者手术指标、宫颈扩张程度及不良反应的影响。方法选取2015年3月-2016年9月该院接受宫腔镜手术治疗前阴道放置卡孕栓软化宫颈的子宫黏膜下肌瘤患者92例作为实验组。同期选择78例放置米索前列醇软化宫颈的子宫黏膜下肌瘤患者作为对照组。比较组间的手术效果。结果实验组患者充分软化62例(67.39%),软化25例(27.17%),软化不良5例(5.43%),宫颈扩张程度优于对照组(P<0.05)。实验组患者的宫颈内口扩张宽度为(7.63±0.94)mm,高于对照组,手术时间为(28.41±8.69)min,术中出血量为(22.48±11.83)ml,低于对照组,差异有统计学意义(P<0.05)。实验组患者术后不良反应的发生率为4.35%,差异有统计学意义(P<0.05)。结论宫腔镜手术子宫黏膜下肌瘤患者术前阴道放置卡孕栓进行宫颈预处理效果良好,且术后不良反应较少,值得临床推广使用。

关键词：米索前列醇卡孕栓子宫黏膜下肌瘤宫腔镜

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Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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Nano-Micro Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang Nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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一次性力竭运动过程中大鼠“黑质-丘脑-皮层”通路神经元相干性及递质动态变化

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中国应用生理学杂志 2017年第3期33卷 204-211页

作者：胡琰茹刘晓莉乔德才北京师范大学体育与运动学院北京100875 中南大学体育教研部湖南长沙410083

目的:通过观察一次性力竭运动过程中大鼠"黑质-丘脑-皮层"通路核团间神经元电活动的相干性及各核团神经递质谷氨酸(Glu)和γ-氨基丁酸(GABA)的浓度,探讨运动疲劳发生过程中大鼠"黑质-丘脑-皮层"通路神经元电活动的可能机制。方法:40只雄... 详细信息

目的:通过观察一次性力竭运动过程中大鼠"黑质-丘脑-皮层"通路核团间神经元电活动的相干性及各核团神经递质谷氨酸(Glu)和γ-氨基丁酸(GABA)的浓度,探讨运动疲劳发生过程中大鼠"黑质-丘脑-皮层"通路神经元电活动的可能机制。方法:40只雄性Wistar大鼠,随机分为神经元电活动实时测定组、黑质网状部(SNr)神经元胞外神经递质实时测定组、丘脑腹外侧核(VL)神经元胞外神经递质实时测定组及皮层辅助运动区(SMA)神经元胞外神经递质实时测定组(n=10)。大鼠提供3级递增负荷跑台运动方案进行一次性力竭运动,通过自身对照,观察神经元电活动实时测定组大鼠SNr、VL及SMA神经元细胞在一次性力竭运动前、中、后神经元电活动的动态变化,同步、动态观察神经元胞外神经递质实时测定组大鼠一次性力竭运动前、中、后大鼠SNr、VL及SMA胞外Glu和GABA的浓度及其比值变化。结果:黑质网状部、丘脑腹外侧核局部场电与皮层脑电在力竭运动过程的不同阶段脑区之间神经元电活动,在0~30 Hz范围内均存在显著相干性。与安静状态相比较,自主运动期,大鼠黑质网状部神经元胞外Glu浓度、Glu/GABA比值均显著下降(P<0.05,P<0.01),GABA浓度则显著升高(P<0.05,P<0.01),而丘脑腹外侧核及皮层辅助运动区神经元胞外Glu浓度、Glu/GABA比值均显著升高(P<0.05,P<0.01),GABA浓度则显著下降(P<0.05,P<0.01);疲劳初期和力竭期,大鼠黑质网状部神经元胞外Glu浓度、Glu/GABA比值均显著升高(P<0.05,P<0.01),GABA浓度则显著下降(P<0.05,P<0.01),而丘脑腹外侧核及皮层辅助运动区神经元胞外Glu浓度、Glu/GABA比值均显著下降(P<0.05,P<0.01),GABA浓度则显著升高(P<0.05,P<0.01)。结论:大鼠在一次性力竭运动过程中"黑质-丘脑-皮层"通路各核团之间存在神经网络联系,该通路各核团神经递质Glu、GABA浓度的改变是导致其神经元电活动变化的因素之一。

关键词：力竭运动大鼠 “黑质-丘脑-皮层”通路相干性神经递质

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High-energy-density lithium manganese iron phosphate for lithium-ion batteries: Progresses, challenges, and prospects

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Journal of Energy Chemistry 2025年第1期100卷 1-17页

作者： Bokun Zhang Xiaoyun Wang Shuai Wang yan li libo Chen Handong Jiao Zhijing Yu Jiguo Tu State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing Research Institute for Intelligent Wearable Systems The Hong Kong Polytechnic University Institute of Advanced Structure Technology Beijing Institute of Technology

The soaring demand for smart portable electronics and electric vehicles is propelling the advancements in high-energy–density lithium-ion *** manganese iron phosphate (liMnxFe1-xPO4) has garnered significant attention as a promising positive electrode material for lithium-ion batteries due to its advantages of low cost,high safety,long cycle life,high voltage,good high-temperature performance,and high energy *** liMnxFe1-xPO4has made significant breakthroughs in the past few decades,there are still facing great challenges in poor electronic conductivity and li-ion diffusion,manganese dissolution affecting battery cycling performance,as well as low tap *** review systematically summarizes the reaction mechanisms,various synthesis methods,and electrochemical properties of liMnxFe1-xPO4to analyze reaction processes accurately and guide material ***,the main challenges currently faced are concluded,and the corresponding various modification strategies are discussed to enhance the reaction kinetics and electrochemical performance of liMnxFe1-xPO4,including multi-scale particle regulation,heteroatom doping,surface coating,as well as microscopic morphology ***,in view of the current research challenges faced by intrinsic reaction processes,kinetics,and energy storage applications,the promising research directions are *** importantly,it is expected to provide key insights into the development of high-performance and stable liMnxFe1-xPO4materials,to achieve practical energy storage requirements.

关键词： Semiconductor doping

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang liu Tingting li Chengcheng Gai Danqing Xin Yijing Zhao yan Song Yahong Cheng Tong li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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高背压+引射器+抽汽供热方式下热网调节特性分析

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汽轮机技术 2024年第2期66卷 133-137页

作者：武云跃马素霞闫利如太原理工大学电气与动力工程学院太原030024

分析一次热网调节方式的调节特性并获得最佳的一次热网调节方式在供热期对能源节约利用至关重要。基于某2×350MW热电机组高背压+引射器+抽汽梯级供热系统,研究比较了供热初末寒期与寒期各3种调节方式的经济特性,给出了不同环境温度下... 详细信息

分析一次热网调节方式的调节特性并获得最佳的一次热网调节方式在供热期对能源节约利用至关重要。基于某2×350MW热电机组高背压+引射器+抽汽梯级供热系统,研究比较了供热初末寒期与寒期各3种调节方式的经济特性,给出了不同环境温度下所需要乏汽量及抽汽量;并以机组发电量与循环泵耗电量的净电量最佳为目标量化了不同环境温度段的最优供热调节方式。结果表明:整个供热期调节方式的相对流量比越大,总乏汽量利用越多,抽汽总量越少;初末寒期:环境温度为-3℃~1℃、2℃~3℃、4℃~5℃3个阶段对应的最优热网调节方式分别为相对流量比为1、0.84、0.7的质调节。寒期:环境温度为-11℃~-4℃,质调节最优且平均净电量优于质量综合调节约3.087MW、优于量调+质调约4.75MW,-14℃~-12℃3种调节方式净电量几乎相同。

关键词：热电机组高背压+引射器+抽汽调节特性相对流量比净电量

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高职教师队伍建设的博弈分析

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南京工业职业技术学院学报 2009年第3期9卷 62-64页

作者：颜立茹南京工业职业技术学院资产管理处江苏南京210046

针对高职院校教师队伍建设的各种模式,运用博弈论的研究方法对其得益进行了分析,为建设一支高效运转和良性循环的高等职业教师队伍提供了一定的理论依据。

关键词：教师队伍建设模式博弈

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A Bayesian expectation maximization algorithm for state estimation of intelligent vehicles considering data loss and noise uncertainty

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Science China Technological Sciences 2025年

作者： yan WANG Feng TIAN Jianqiang WANG Keqiang li Department of Industrial and Systems Engineering The Hong Kong Polytechnic University School of Vehicle and Mobility Tsinghua University

Sideslip angle, yaw rate, and vehicle velocity are essential for intelligent vehicle control. Since these vehicle states are not measured directly, some Kalman-based approaches have been developed to estimate these states using in-vehicle sensors. However, the existing studies seldom account for the influence of sensor data loss on estimation accuracy. In addition,the process and measurement noise change during the estimation process because of the various driving conditions. To address these problems, an expectation-maximization robust extended Kalman filter (EMREKF) is proposed. Firstly, a robust extended Kalman filter (REKF) is developed to deal with the impact of missing measurements. Then, an improved expectation maximization (EM) algorithm that considers data loss is presented to update the noise parameter of the REKF dynamically. Finally,the improved EM is fused with the REKF to form the EMREKF to estimate vehicle state. The experimental results demonstrate that the EMREKF outperforms EKF, REKF, and maximum correntropy criterion EKF for various degrees of data loss and the proposed algorithm has a strong adaptive ability to different driving conditions.

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang li Xingping Quan Jinfen Chen yan Han li yang Manfei Zhou Greta Seng Peng Mok ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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