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Comparative efficacy and safety of cognitive enhancers for treating vascular cognitive impairment: systematic review and Bayesian network meta-analysis

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Neural Regeneration Research 2019年第5期14卷 805-816页

作者： Bo-ru Jin Hua-yan liu Department of Neurology First Affiliated Hospital China Medical University

Objective: To assess and compare the clinical efficacy and safety of cognitive enhancers(donepezil, galantamine, rivastigmine, and memantine) on cognition, behavior, function, and global status in patients with vascular cognitive *** sources: The initial literature search was performed with PubMed, EMBASE, the Cochrane Methodology Register, the Cochrane Central Register of Controlled Trials, and Cumulative Index to Nursing & Allied Health(CINAHL) from inception to January 2018 for studies regarding donepezil, galantamine, rivastigmine, and memantine for treatment of vascular cognitive *** selection: Randomized controlled trials on donepezil, galantamine, rivastigmine, and memantine as monotherapy in the treatment of vascular cognitive impairment were included. A Bayesian network meta-analysis was conducted. Outcome measures: Efficacy was assessed by changes in scores of the Alzheimer's Disease Assessment Scale, cognitive subscale, Mini-Mental State Examination, Neuropsychiatric Inventory scores and Clinician's Interview-Based Impression of Change Scale Plus Caregiver's Input, Activities of Daily living, the Clinical Dementia Rating scale. Safety was evaluated by mortality, total adverse events(TAEs), serious adverse events(SAEs), nausea, vomiting. diarrhea, or cerebrovascular accidents(CVAs). Results: After screening 1717 citations, 12 randomized controlled trials were included. Donepezil and rivastigmine(mean difference(e) = –0.77, 95% confidence interval(CI): 0.25–1.32; MD = 1.05, 95% CI: 0.18–1.79) were significantly more effective than placebo in reducing Mini-Mental State Examination scores. Donepezil, galantamine, and memantine(MD = –1.30, 95% CI: –2.27 to –0.42; MD = –1.67, 95% CI: –3.36 to –0.06; MD = –2.27, 95% CI: –3.91 to –0.53) showed superior benefits on the Alzheimer's Disease Assessment Scale–cognitive scores compared with placebo. Memantine(MD = 2.71, 95% CI: 1.05–7.29) improved global status(Clinician's Interview-Based Impres

关键词： nerve regeneration vascular cognitive impairment vascular dementia pharmacotherapy cholinesterase inhibitors donepezil galantamine rivastigmine memantine systematic review Bayesian network meta-analysis neural regeneration

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肾外夹角对外生型肾乏脂肪血管平滑肌脂肪瘤与肾透明细胞癌的鉴别诊断价值

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临床放射学杂志 2025年第1期44卷 133-137页

作者：张小梅李娜赵艳王滔乐山市人民医院放射医学科 614000

目的探讨肾外夹角对外生型肾乏脂肪血管平滑肌脂肪瘤(AMLmf)与肾透明细胞癌(ccRCC)的鉴别诊断价值。方法回顾性分析经手术和病理证实的ccRCC患者55例共56个病灶,AMLmf患者20例共22个病灶,通过形态学分析两组肿瘤差异,测量肿瘤的肾外夹... 详细信息

目的探讨肾外夹角对外生型肾乏脂肪血管平滑肌脂肪瘤(AMLmf)与肾透明细胞癌(ccRCC)的鉴别诊断价值。方法回顾性分析经手术和病理证实的ccRCC患者55例共56个病灶,AMLmf患者20例共22个病灶,通过形态学分析两组肿瘤差异,测量肿瘤的肾外夹角并定量分析两组间的差异。结果假包膜、劈裂征及“冰激凌蛋筒征”对AMLmf与ccRCC的鉴别有统计学差异(P<0.05);两组肿瘤的肾外较大夹角及较小夹角值间差异有统计学意义。受试者工作特征(ROC)曲线分析显示肾外较大夹角、肾外较小夹角、劈裂征、“冰激凌蛋筒征”及假包膜鉴别AMLmf与ccRCC的曲线下面积(AUC)值分别为0.925、0.983、0.638、0.727、0.731,五种指标联合的AUC值为0.996,明显高于单一指标。结论肾外夹角、假包膜、劈裂征及“冰激凌蛋筒征”有助于AMLmf与ccRCC的鉴别诊断,联合五种影像学特征的诊断效能更高。

关键词：体层摄影术 X线计算机肾外夹角肾乏脂肪血管平滑肌脂肪瘤肾透明细胞癌

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Advances of Electrochemical and Electrochemiluminescent Sensors Based on Covalent Organic Frameworks

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Nano-Micro Letters 2024年第2期16卷 395-422页

作者： Yue Cao ru Wu yan‑yan Gao yang Zhou Jun‑Jie Zhu Key Laboratory for Organic Electronics and Information Displays(KLOEID)and Institute of Advanced Materials(IAM) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023People’s Republic of China

Covalent organic frameworks(COFs),a rapidly developing category of crystalline conjugated organic polymers,possess highly ordered structures,large specific surface areas,stable chemical properties,and tunable pore *** the first report of boroxine/boronate ester-linked COFs in 2005,COFs have rapidly gained popularity,showing important application prospects in various fields,such as sensing,catalysis,separation,and energy *** them,COFs-based electrochemical(EC)sensors with upgraded analytical performance are arousing extensive *** this review,therefore,we summarize the basic properties and the general synthesis methods of COFs used in the field of electroanalytical chemistry,with special emphasis on their usages in the fabrication of chemical sensors,ions sensors,immunosensors,and ***,the emerged COFs in the electrochemiluminescence(ECL)realm are thoroughly covered along with their preliminary ***,final conclusions on state-of-the-art COFs are provided in terms of EC and ECL sensors,as well as challenges and prospects for extending and improving the research and applications of COFs in electroanalytical chemistry.

关键词： Covalent organic frameworks Electrochemistry Electrochemiluminescence Sensors

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Grid authentication from identity-based cryptography without random oracles

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The Journal of China Universities of Posts and Telecommunications 2008年第4期15卷 55-59页

作者： ZHENG yan WANG Hai-yan WANG ru-chuan College of Computer Science Nanjing University of Posts and Telecommunications Nanjing 210003 China

As a critical component of grid security, secure and efficient grid authentication needs to be well addressed. However, the most widely accepted and applied grid authentication is based on public key infrastructure （PKI） and X.509 certificates, which make the system have low processing efficiency and poor anti-attack capability. To accommodate the challenge of grid authentication, this article aims at designing a secure and efficient method for grid authentication by employing identity-based cryptography （IBC）. Motivated by a recently proposed secure and efficient identity-based encryption （IBE） scheme without random oracles, an identity-based signature （IBS） scheme is first proposed for the generation of private key during grid authentication. Based on the proposed IBS and the former IBE schemes, the structure of a novel grid authentication model is given, followed by a grid authentication protocol described in detail. According to the theoretical analysis of the model and the protocol, it can be argued that the new system has improved both the security and efficiency of the grid authentication when compared with the traditional PKI-based and some current IBC-based models.

关键词： grid authentication security IBC scheme

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Effects of medium fluid cavitation on fluctuation characteristics of magnetic fluid seal interface in agricultural centrifugal pump

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International Journal of Agricultural and Biological Engineering 2021年第6期14卷 85-92页

作者： Zhenggui li Wangxu li Qifan Wang ru Xiang Jie Cheng Wei Han Zhaoqiang yan Key Laboratory of Fluid and Power Machinery Ministry of EducationXihua UniversityChengdu 610039China Huaneng Gansu Hydropower Development Co. LtdLanzhou 730000China School of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Zigong Zhaoqiang Sealing Products Industrial Co. LtdZigong 643000SichuanChina

The fluctuation law of magnetic fluid seal interface of an agricultural centrifugal pump is theoretically unknown;the pressure and velocity fluctuations are crucial factors that cause interface *** this study,the pressure and velocity fluctuations of the sealing interface on an agricultural centrifugal pump during cavitation were investigated based on the methods of Ansys CFX numerical calculation and experimental *** results demonstrated that at the same flow rate,the pressure fluctuation amplitude of the sealing interface decreased gradually from the shaft surface to the bottom of the polar *** different flow rates,the amplitude of the pressure fluctuation decreased with an increase in the flow *** cavitation of the medium aggravated the impact and water hammer of the liquid,leading to the occurrence of the jitter phenomenon in the sealing interface to accelerate the fluctuation frequency of the axial velocity of the sealing liquid,which accelerated the emulsification of the magnetic *** law can provide a reference for the design of magnetic fluid sealing devices for agricultural centrifugal pumps.

关键词： centrifugal pump magnetic liquid sealing device medium cavitation interface fluctuations

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Effect of applied stress on r'-rafting behavior in a Ni-based singlecrystal superalloy:experiments and finite element analysis

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Journal of Iron and Steel Research International 2019年第3期26卷 259-267页

作者： Yuan-chao Yu Yi ru Yong Shang yan-ling Pei Shu-suo li Sheng-kai Gong School of Materials Science and Engineering Beihang University Beijing 100191 China

The effect of applied tensile stress on the r'-rafting behavior for a Ni-based single-crystal superalloy with more negative misfit was *** conducting interrupted creep tests at high temperature,it indicated that the increase in the applied stress accelerates the r'-rafting(directional coarsening of yr phase).In the early stage of rafting,the r'-cubes start interconnecting at the ends of the parallel-to-applied-stress r'-*** distributions of misfit stress,coherent strain and strain energy density of the r/r'phases are then calculated by finite element *** calculation results show that the rafting acceleration is mainly ascribed to the reduced strain energy density in the parallel-to-applied-stress r'-channel that is driven from the couple interaction of external load and misfit *** dislocation network formation,resulting from the misfit-induced increase in resolved shear stress,also contributes to the r'-rafting.

关键词： Ni-based superalloy High lattice misfit Rafting Finite element analysis Misfit stress Strain energy density

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Enhancing cycle stability of li metal anode by using polymer separators coated with Ti-containing solid electrolytes

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Rare Metals 2021年第6期40卷 1357-1365页

作者： Zhao yan Hong-Yi Pan Jun-yang Wang ru-Song Chen Quan li Fei Luo Xi-Qian Yu Hong li Beijing Advanced Innovation Center for Materials Genome Engineering Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Tianmulake Excellent Anode Materials Co. Ltd.Liyang 213300China yangtze River Delta Physics Research Center Co. Ltd.Liyang 213300China

The employment of lithium metal anode in rechargeable lithium batteries has been hindered by the safety concerns which are associated with the uncontrolled lithium dendrite growth and the unceasing side reactions with liquid *** this work,we report that the use of Ti-containing solid electrolyte-coated separators can greatly enhance the cycle performances of lithium metal anode in cells using liquid *** detailed morphologic studies indicate that more uniform lithium deposition is achieved in cells using Ti-containing solid electrolyte-coated separators than that using Al_(2)O_(3)-coated separators,which is likely due to the modified anode and electrolyte interfacial properties induced by the reactive nature of Ti-containing solid electrolytes with metallic *** work demonstrates an effective strategy to enhance the homogeneity of lithium deposition,which leads to the stable cycling of lithium metal anode in rechargeable lithium-ion batteries.

关键词： lithium metal anode lithium batteries Solid electrolyte Separator

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HYDRODYNAMIC INTERACTIONS BETWEEN TWO BODIES

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Journal of Hydrodynamics 2007年第6期19卷 784-785页

作者： CHENG li Wu De-ming Xu Yu-ru Wang yan-ying li Ji-de Zhang liang Ding Yong College of Shipbuilding Engineering Harbin Engineering University Harbin 150001 China Harbin Engineering University （member of CAE Harbin Engineering University） Chairman Dalian University of Technology

On the basis of model tests, potential flow theory, and viscous Computational Fluid Dynamics （CFD） method, the hydrodynamic interactions between two underwater bodies were investigated to determine the influencing factors, changing rule, interaction mechanism, and appropriate methods describing them. Some special phenomena were discovered in two series of near-wall interaction experiments. The mathematical model and predicting methods were presented for interacting forces near wall, and the calculation results agreed well with the experimental ones. From the comparisons among numerical results with respect to nonviscosity, numerical results with respect to viscosity, and measured results, data on the influence of viscosity on hydrodynamic interactions were obtained. For hydrodynamic interaction related to multi-body unsteady motions with six degrees of freedom that is difficult to simulate in tests, numerical predictions of unsteady interacting forces were given.

关键词： hydrodynamic interactions UUV unsteady flow wall effect panel method model test Kutta condition

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Plastic bronchitis associated with Botrytis cinerea infection in a child:A case report

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World Journal of Clinical Cases 2020年第20期8卷 5019-5024页

作者： yan-ru liu Tao Ai Department of Pediatric Respiratory Medicine Chengdu Women’s and Children’s Central HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731Sichuan ProvinceChina

BACKGROUND Plastic bronchitis(PB)frequently occurs in children after the surgical repair of congenital cardiac defects or in the presence of inflammatory or allergic diseases of the *** epidemiological data of this condition are still *** SUMMARY A 5-year-old boy,with a clear medical history,presented to our hospital with persistent cough and pneumonia with segmental atelectasis on chest computerized *** showed no significant improvement after 1 wk of amoxicillin-clavulanate potassium *** casts were extracted using flexible *** examination of the dendritic cast confirmed the diagnosis of type I *** cinerea was detected by next-generation sequencing of the bronchoalveolar lavage *** the removal of the airway obstruction and fluconazole treatment,the patient recovered and was discharged 14 d after admission without the recurrence of *** Botrytis cinerea pneumonia should be considered in children with PB who still have prolonged cough and atelectasis after a regular course of antibiotic *** bronchoscopy and etiological examination should be performed in a timely manner to determine the diagnosis,clear the airway obstruction,and target etiological treatment.

关键词： Bronchial casts Botrytis cinerea Pneumonia Children Case report

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Recent progress on photoactive nonprecious transition-metal complexes

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Science China Chemistry 2025年第1期 46-95页

作者： Zhong-liang Gong Hong-Jie Zhang yan Cheng Jianxun liu Yuhan Ai Yaqin li Zhihui Feng Qiong Zhang Shaolong Gong Yong Chen Chang-Jiang Yao Yuan-Yuan Zhu liang-Jin Xu Yu-Wu Zhong CAS Key Laboratory of Photochemistry Institute of Chemistry Chinese Academy of Sciences State Key Laboratory of Structural Cemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences School of Chemistry and Chemical Engineering Anhui Key Laboratory of Advanced Catalytic Materials and Reaction EngineeringHefei University of Technology State Key Laboratory of Explosion Science and Safety Protection School of Mechatronical Engineering Beijing Institute of Technology College of Chemistry and Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic Materials Wuhan University School of Chemistry and Chemical Engineering Anhui University Key Laboratory of Photochemical Conversion and Optoelectronic Materials & CAS-HKU Joint Laboratory on New Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Photoactive complexes of nonprecious transition metals, mainly including those in the first-row and partially the second-row of the Periodic table of elements, have received increasing attention in view of their low cost and long-term sustainability. They are recognized as promising alternatives to noble transition metal complex congeners that have been extensively studied in optoelectronic devices, artificial photosynthesis, photocatalysis, biodiagnostics, and therapeutics, etc. This review is devoted to a comprehensive summary on the classical and recent advances on photoactive nonprecious transition metal complexes, including photoactive Zr, V, Cr, Mo, and W complexes, Mn complexes and hybrids, Fe, Co, Ni, and Cu complexes, and Zn and Cd complexes and hybrids. A particular focus is given on the molecular design, modulation of photophysical and photochemical properties, and applications of the representative and lately-developed nonprecious metal complexes. In addition, a perspective on the future development in this field is provided at the end of this review.

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