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Effects of combined antibiotics on nitrification, bacteria and antibiotic resistance genes in activated sludge: Insights from legacy effect of antibiotics

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Journal of Environmental Sciences 2023年第9期131卷 96-110页

作者： Zhong-Xing Zhang Xiao-yan Fan Xing li Yu-Xi Gao Jun-ru Zhao Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China

The effect of combined antibiotics exposure on nitrogen removal,microbial community assembly and proliferation of antibiotics resistance genes(ARGs)is a hotspot in activated sludge ***,it is unclear that how the historical antibiotic stress affects the subsequent responses of microbes and ARGs to combined *** this study,the effects of combined sulfamethoxazole(SMX)and trimethoprim(TMP)pollution on activated sludge under legacy of SMX or TMP stress with different doses(0.005-30 mg/L)were investigated to clarify antibiotic legacy *** activity was inhibited under higher level of combined exposure but a high total nitrogen removal(∼70%)*** on the full-scale classification,the legacy effect of past antibiotic stress had a marked effect on community composition of conditionally abundant taxa(CAT)and conditionally rare or abundant taxa(CRAT).Rare taxa(RT)were the keystone taxa in the microbial network,and the responses of hub genera were also affected by the legacy of antibiotic *** bacteria and genes were inhibited by the antibiotics and aerobic denitrifying bacteria(Pseudomonas,Thaurea and Hydrogenophaga)were enriched under legacy of high dose,as were the key denitrifying genes(napA,nirK and norB).Furthermore,the occurrences and co-selection relationship of 94 ARGs were affected by legacy ***,some shared hosts(eg.,Citrobacter)and hub ARGs(eg.,mdtD,mdtE and acrD)were ***,antibiotic legacy could affect responses of activated sludge to combined antibiotic and the legacy effect was stronger at higher exposure levels.

关键词： Antibiotics Antibiotic resistance genes(ARGs) Combined pollution Full-scale classification Legacy effect

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从教学技能掌握到教学素养发展:新时代好教师的核心追求

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黑龙江高教研究 2025年第1期43卷 22-30页

作者：单妍李志厚广东药科大学广东广州510006 广州华商学院广东广州511300 华南师范大学广东广州510631

教学素养是教育者经过专业学习和课堂教学实践培养和磨炼之后所表现出来的专业化教学素质与涵养,是教师专业所特有的内在素质和外在表现。它与教学技能、教学能力不同,在其基础上还包括教育信念、专业知能、教学眼光、通化意识、教育思... 详细信息

教学素养是教育者经过专业学习和课堂教学实践培养和磨炼之后所表现出来的专业化教学素质与涵养,是教师专业所特有的内在素质和外在表现。它与教学技能、教学能力不同,在其基础上还包括教育信念、专业知能、教学眼光、通化意识、教育思维、创新追求以及教育家精神等方面的素养。通过对教学素养与教学技能、教学能力异同的比较分析,探讨教育者教学素养发展的影响因素、形成条件、发展机制及其相关的问题,为有效促进新时代教师教学素养的发展以及新质教育力的探索提供有力参考。

关键词：教学技能教学能力教学素养教学创新新质教育力通化意识

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Memristive dynamics enabled neuromorphic computing systems

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Science China(Information Sciences) 2023年第10期66卷 5-19页

作者： Bonan yan Yuchao yanG ru HUANG Center for Brain Inspired Chips Institute for Artificial Intelligence Peking University Beijing Advanced Innovation Center for Integrated Circuits School of Integrated Circuits Peking University School of Electronic and Computer Engineering Peking University Center for Brain Inspired Intelligence Chinese Institute for Brain Research(CIBR)

The slowing down of transistor scaling and explosive growth for intelligence computing power emerge as the two driving factors for the study of novel devices and materials to pursue highly-efficient computing systems. Memristors, incorporating rich intrinsic dynamics, are a promising candidate for constructing efficient and scalable bio-inspired computing systems. In this progress report, we review the latest advances in novel types of memristors as well as their applications in implementing neuromorphic computing systems. This paper not only covers the memristive dynamics-enabled bionic computing systems but also discusses the memristive sensory systems that integrate sensing and computing. Eventually, device-circuit co-optimization methods are given to emphasize the trend of cross-layer co-design in this fast-evolving *** innovation in memristor devices mainly focuses on specialized computing hardware and yields superior computing and sensing efficiency. At last, we offer our insight into the trend of state-of-the-art research in memristive materials, devices, circuits, and systems.

关键词： memrsitor memristive dynamics artificial synapse artificial neuron neuromorphic computing

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以顺铂为基础的髂内动脉灌注化疗在宫颈癌治疗中的作用

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西北国防医学杂志 2007年第6期28卷 419-421页

作者：李妍芹乔如丽刘志杰赵汝珠兰州军区兰州总医院妇产科甘肃兰州730050

目的：探讨以顺铂为基础的髂内动脉灌注化疗在宫颈癌治疗中的作用。方法：112例中晚期宫颈癌患者，双侧髂内动脉插管，以DDP为基础，辅以BLM、MMC和PYM等灌注化疗，最后以明胶海绵颗粒栓塞。结果：本组病例临床症状均有改善；Ⅰb2‖Ⅱb2... 详细信息

目的：探讨以顺铂为基础的髂内动脉灌注化疗在宫颈癌治疗中的作用。方法：112例中晚期宫颈癌患者，双侧髂内动脉插管，以DDP为基础，辅以BLM、MMC和PYM等灌注化疗，最后以明胶海绵颗粒栓塞。结果：本组病例临床症状均有改善；Ⅰb2‖Ⅱb27例化疗后行手术治疗，完整切除病灶；巨块型癌80．4％（41／51）肿块缩小超过50％，3～4周后92．2％（47／51）宫颈外形可见；颈管型缩小超过50％病例占66．7％（10／15）；97．8％（45／46）溃疡型癌合并出血治疗后出血即刻停止；盆腔疼痛缓解率100％，下肢水肿缓解率100％。结论：以顺铂为基础的髂内动脉灌注化疗对中晚期宫颈癌有非常好的近期疗效，可作为提高治愈率和长期缓解率的常规治疗手段。

关键词：宫颈癌化疗栓塞,治疗性治疗效果

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A Distributed Phase Shifter Using Bi_(1.5)Zn_(1.0)Nb_(1.5)O_(7)/Ba_(0.5)Sr_(0.5)TiO_(3) Thin Films

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Chinese Physics Letters 2013年第7期30卷 251-253页

作者： li ru-Guan JIANG Shu-Wen GAO li-Bin li yan-Rong State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 610054

We report the demonstration of a monolithic phase shifter employing Bi_(1.5)Zn_(1.0)Nb_(1.5)O_(7)/Ba_(0.5)Sr_(0.5)TiO_(3)(BST)thin films on sapphire *** BST and BZN thin films are successively deposited by radio-frequency magnetron sputtering.A distributed phase shifter with a coplanar-waveguide transmission line periodically loaded with the BZN/BST capacitors is *** return loss of the circuit is better than-13 dB from 1 to 12 GHz,and it provides 65°phase shift with an insertion loss of-4 dB at 12 *** results show that BZN/BST thin films are promising candidate dielectrics for rf/microwave tunable applications.

关键词： (3) BST phase

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Coated sodium butyrate ameliorates high‑energy and low‑protein diet induced hepatic dysfunction via modulating mitochondrial dynamics, autophagy and apoptosis in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1190-1206页

作者： Sasa Miao Tianming Mu ru li yan li Wenyan Zhao Jiankui li Xinyang Dong Xiaoting Zou Key Laboratory of Animal Feed and Nutrition of Zhejiang Province Key Laboratory of Animal Nutrition and Feed Science(Eastern of China)Ministry of Agriculture and Rural AffairsThe Key Laboratory of Molecular Animal NutritionMinistry of EducationCollege of Animal SciencesZhejiang UniversityHangzhou 310058China.

Background Fatty liver hemorrhagic syndrome(FLHS),a fatty liver disease in laying hens,poses a grave threat to the layer industry,stemming from its ability to trigger an alarming plummet in egg production and usher in acute mortality among laying *** evidence suggests that the onset and progression of fatty liver was closely related to mitochondria *** butyrate was demonstrated to modulate hepatic lipid metabolism,alle-viate oxidative stress and improve mitochondrial dysfunction in vitro and mice ***,there is limited existing research on coated sodium butyrate(CSB)to prevent FLHS in laying hens,and whether and how CSB exerts the anti-FLHS effect still needs to be *** this experiment,the FLHS model was induced by administering a high-energy low-protein(HELP)diet in laying *** objective was to investigate the effects of CSB on alleviating FLHS with a focus on the role of CSB in modulating mitochondrial *** A total of 288 healthy 28-week-old Huafeng laying hens were arbitrarily allocated into 4 groups with 6 replicates each,namely,the CON group(normal diet),HELP group(HELP diet),CH500 group(500 mg/kg CSB added to HELP diet)and CH750 group(750 mg/kg CSB added to HELP diet).The duration of the trial encompassed a period of 10 *** The result revealed that CSB ameliorated the HELP-induced FLHS by improving hepatic steatosis and patho-logical damage,reducing the gene levels of fatty acid synthesis,and promoting the mRNA levels of key enzymes of fatty acid *** reduced oxidative stress induced by the HELP diet,upregulated the activity of GSH-Px and SOD,and decreased the content of MDA and *** also mitigated the HELP diet-induced inflammatory response by blocking TNF-α,IL-1β,and F4/*** addition,dietary CSB supplementation attenuated HELP-induced activation of the mitochondrial unfolded protein response(UPRmt),mitochondrial damage,and decline of ATPase *** diet decreased th

关键词： Autophagy Coated sodium butyrate Laying hens lipid metabolism Mitochondria

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Persistent alterations in gray matter in COVID-19 patients experiencing sleep disturbances:a 3-month longitudinal study

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Neural Regeneration Research 2025年第10期20卷 3013-3024页

作者： Kaixuan Zhou Gaoxiong Duan Ying liu Bei Peng Xiaoyan Zhou lixia Qin lingyan liang Yichen Wei Qingping Zhang Xiaocheng li Haixia Qin Yinqi Lai Yian Lu yan Zhang Jiazhu Huang Jinli Huang Yinfei Ouyang Bolin Bin Mingming Zhao Jun liu Jianrong yang Demao Deng Guangxi Key Laboratory of Special Biomedicine School of MedicineGuangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology the People’s Hospital of Guangxi Zhuang Autonomous RegionGuangxi Academy of Medical SciencesNanningGuangxi Zhuang Autonomous RegionChina Department of Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina Department of Radiology The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Guangxi Clinical Research Center for Sleep Medicine the People’s Hospital of Guangxi Zhuang Autonomous RegionNanningGuangxi Zhuang Autonomous RegionChina

Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 *** studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase *** a result,little is known about the pathophysiology of sleep disturbances in the acute phase of *** address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this *** COVID-19 patients with sleep disturbances were included in a longitudinal *** found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain *** cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index ***,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy *** 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep *** findings indicate that the sleep disturbances patients had altered morphology in the cortical an

关键词： brain structure cortical gray matter volume cortical surface area cortical thickness hippocampus magnetic resonance imaging Pittsburgh Sleep Quality Index severe acute respiratory syndrome coronavirus 2 infections sleep disturbances sub-cortical volume

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Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei Yi Taikang li Mingwei Chen Jiayun Chen Ge Song Chuanbin yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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Peficitinib suppresses diffuse-type tenosynovial giant cell tumor by targeting TYK2 and JAK/STAT signaling

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Science China life Sciences 2025年

作者： Shan Lu Chenxi Cao Wenjia Zhang Jiayi li Jingli yang Zisheng Huang Zhijun Wu Baitao liu Hongjie Huang Haijun Wang Yongjian Wang Dingge liu Zhihua Zhang Kaiping liu Gang yang Xi Gong Hui Dai Yingjia li Erdan Dong Xin Zhang yan Zhang Haihe Laboratory of Cell Ecosystem Institute of Cardiovascular Diseases The First Affiliated Hospital of Dalian Medical University Institute of Cardiovascular Sciences School of Basic Medical Sciences Peking University Health Science Center Department of Cardiology and Institute of Vascular Medicine Peking University Third HospitalState Key Laboratory of Vascular Homeostasis and Remodeling Peking University Department of Sports Medicine Peking University Third Hospital Institute of Sports Medicine of Peking University Beijing Key Laboratory of Sports Injuries Engineering Research Center of Sports Trauma Treatment Technology and Devices Ministry of Education State Key Laboratory of Membrane Biology Institute of Molecular Medicine College of Future Technology Peking University Peking University Health Science Centre Peking University Department of Immunology School of Basic Medical Sciences NHC Key Laboratory of Medical Immunology Peking University Research Center for Cardiopulmonary Rehabilitation University of Health and Rehabilitation Sciences Qingdao Hospital (Qingdao Municipal Hospital) School of Health and Life Sciences University of Health and Rehabilitation Sciences Research Unit of Medical Science Research Management/Basic and Clinical Research of Metabolic Cardiovascular Diseases Chinese Academy of Medical Sciences

Diffuse-type tenosynovial giant cell tumor(dTGCT) is a destructive but rare benign proliferative synovial neoplasm. Although surgery is currently the main treatment modality for dTGCT, the recurrence risk is up to 50%. Therefore, there is a great need for effective drugs against dTGCT with minor side effects. The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling plays a central role in rheumatoid arthritis(RA), a disease with similar characteristics as dTGCT, but its function in dTGCT remains *** fibroblast-like synoviocytes(FLS) and macrophages were isolated from 10 synovial tissue samples from dTGCT patients for the screening and validation of the five clinically approved JAK inhibitors to treat RA against dTGCT. Cell viability, cell death, inflammation and the activity of the JAK family members of cultured dTGCT FLS(both 2-D and 3-D) and macrophages were investigated for the efficacy of the JAK inhibitors. Here, we found that similar to RA, JAK/STAT signaling was markedly activated in the dTGCT synovium. Of the 5 JAK inhibitors, peficitinib was shown to have the most potency in addressing some of the pathological responses of dTGCT FLS and *** potency of peficitinib was much higher than pexidartinib, which is the only FDA-approved drug for dTGCT. Mechanistically, peficitinib inhibited tyrosine kinase 2(TYK2), a JAK family member necessary for the pathological progression of dTGCT FLS and macrophages. In summary, we not only revealed JAK/STAT(especially TYK2) signaling as the major mechanism underlying dTGCT, but also identified peficitinib as a promising drug against dTGCT.

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Analysis on MAV/UAV cooperative combat based on complex network

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Defence Technology（防务技术） 2020年第1期16卷 150-157页

作者： Jie-ru Fan Dong-guang li ru-peng li Yue Wang Beijing Institute of Technology BeijingChina Beijing Electro-mechanical Engineering Institute BeijingChina Beijing Institute of Electronic System Engineering BeijingChina

A formation model of manned/unmanned aerial vehicle(MAV/UAV) collaborative combat can qualitatively and quantitatively analyze the synergistic ***,there is currently no effective and appropriate model construction method or theory,and research in the field of collaborative capability evaluation is basically *** to the actual conditions of cooperative operations,a new MAV/UAV collaborative combat network model construction method based on a complex network is *** analyzing the characteristic parameters of the abstract network,the index system and complex network are ***,a method for evaluating the synergistic effect of the cooperative combat network is *** method provides assistance for the verification and evaluation of MAV/UAV collaborative combat.

关键词： Complex network Stochastic network MAV/UAV collaborative combat Evaluation

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