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XOR spin logic operated by unipolar current based on field-free spin-orbit torque switching induced by a lateral interface

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Rare Metals 2024年第8期43卷 3868-3875页

作者： yan-ru li Mei-Yin yang Guo-Qiang Yu Bao-Shan Cui Jin-Biao liu Yong-liang li Qi-Ming Shao Jun Luo Key Laboratory of Microelectronic Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences(IMECAS)Beijing 100029China University of Chinese Academy of Sciences(UCAS) Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory for Magnetism and Magnetic Materials of Ministry of Education Lanzhou UniversityLanzhou 730000China Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

Spin logics have emerged as a promising avenue for the development of logic-in-memory *** particular,the realization of XOR spin logic gates using a single spin-orbit torque device shows great potential for low-power stateful logic circuits in the next *** this study,we successfully obtained the XOR logic gate by utilizing a spin-orbit torque device with a lateral interface,which was created by local ion implantation in the Ta/Pt/Co/Ta Hall device exhibiting perpendicular magnetic *** angle of the lateral interface is set at 45°relative to the current direction,leading to the competition between symmetry breaking and current-driven Néel-type domain wall ***,the field-free magnetic switching reversed is realized by the same sign of current amplitude at this *** on this field-free magnetic switching behavior,we successfully proposed an XOR logic gate that could be implemented using only a single spin-orbit torque Hall *** study provides a potentially viable approach toward efficient spin logics and in-memory computing architectures.

关键词： Filed-free magnetic switching Spin-orbit torque XOR logic gate Lateral interface

Effects of Altered Intra-abdominal Pressure on the Upper Airway Collapsibility in a Porcine Model

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Chinese Medical Journal 2015年第23期128卷 3204-3210页

作者： Shu-lin Ren yan-ru li Ji-Xiang Wu Jing-Ying Ye Rachel Jen Department of General Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Otolaryngology Head and Neck Surgery Beijing Tsinghua Changgung Hospital Tsinghua University Beijing 102218 China Department of Medicine Respiratory Division University of British Columbia Vancouver BC Canada

Background： Obstructive sleep apnea is strongly associated with obesity, particularly abdominal obesity common in centrally obese males. Previous studies have demonstrated that intra-abdominal pressure （IAP） is increased in morbid obesity, and tracheal traction forces may influence pharyngeal airway collapsibility. This study aimed to investigate that whether IAP plays a role in the mechanism of upper airway （UA） collapsibility via IAP-related caudal tracheal traction. Methods： An abdominal wall lifting （AWL） system and graded CO2 pneumoperitoneum pressure was applied to four supine, anesthetized Guizhou miniature pigs and its effects on tracheal displacement （TD） and airflow dynamics of UA were studied. Individual run data in 3 min obtained before and after AWL and obtained before and after graded pneumoperitoneum pressure were analyzed. Differences between baseline and AWL/graded pneumoperitoneum pressure data of each pig were examined using a Student＇s t-test or analysis of variance. Results： Application of AWL resulted in decreased IAP and significant caudal TD. The average displacement amplitude was 0.44 mm （P 〈 0.001 ）. There were three subjects showed increased tidal volume （TV）（P 〈 0.01 ） and peak inspiratory airflow （P 〈 0.01 ）; however, the change of flow limitation inspiratory UA resistance （rua） was not significant. Experimental increased lAP by pneumoperitoneum resulted in significant cranial TD. The average displacement amplitude was 1.07 mm （P 〈 0.001） when lAP was 25 cmH2O compared to baseline. There were three subjects showed reduced rua while the TV increased （P 〈 0.01 ）. There was one subject had decreased TV and elevated rua （P 〈 0.001）. Conclusions： Decreased IAP significantly increased caudal TD, and elevated lAP significantly increased cranial TD. However, the mechanism of UA collapsibility appears primarily mediated by changes in lung volume rather than tracheal traction effect. TV plays an independent role in the mechanism of UA collapsibil

关键词： Abdominal Obesity Intra-abdominal Pressure Lung Volume Obstructive Sleep Apnea Trachea Traction

Fidgetin knockdown and knockout influences female reproduction distinctly in mice

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The Journal of Biomedical Research 2022年第4期36卷 269-279页

作者： Cong-Rong li ruo-Lei Wang Shi-Ya Xie yan-ru li Lei-Lei Gao Zhi-Xia yang Dong Zhang State Key Lab of Reproductive Medicine Nanjing Medical UniversityNanjingJiangsu 211166China Animal Core Facility Nanjing Medical UniversityNanjingJiangsu 211166China

Microtubule-severing proteins(MTSPs),are a family of proteins which use adenosine triphosphate to sever *** have been shown to play an important role in multiple microtubule-involved cellular *** member of this family,fidgetin(FIGN),is also involved in male fertility;however,no studies have explored its roles in female *** this study,we found mouse fidgetin is rich within oocyte zona pellucida(ZP)and is the only MTSP member to do *** also appears to interact with all three ZP *** findings prompted us to propose that fidgetin might prevent *** from in vitro maturation oocytes analysis showed that fidgetin knockdown did cause *** then deleted all three fidgetin isoforms with CRISPR/Cas9 technologies;however,female mice remained healthy and with normal *** all mouse MTSPs,only the mRNA level of fidgetin-like 1(FIGNL1)significantly ***,we assert that fidgetin-like 1 compensates fidgetin's roles in fidgetin knockout female mice.

关键词： mouse fidgetin knockdown knockout female reproduction

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia yang Qian-ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Revealing and predicting the long-term biomechanical response of orthokeratology by developing a patient-specific computational model

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 156-168页

作者： Yifeng li Zhuoran yang Ziming yan Huibin Shi Zhanli liu Kaijie Wang Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Orthokeratology(OK) is widely used for effective myopia correction and control. However, the incomplete understanding of its biomechanical mechanisms makes OK lens fitting rely heavily on clinician judgment, complicating accurate predictions of treatment outcomes. In this paper, we performed clinical experiments and numerical analysis to study corneal deformation modes and long-term changes in central corneal thickness. Clinical experiments were conducted on 194 Chinese myopic patients under OK treatment for 3 months. Based on the experimental data, a patient-specific computational biomechanical model for OK was established and validated. Specifically, the anisotropic mechanical properties of the cornea were incorporated into the model to describe the significant difference between its shear modulus(29.5 kPa) and tensile modulus(768.4 kPa). Additionally, a viscohyperelastic material model with a prolonged corneal relaxation time of 5.6 h was developed to capture the long-term deformation response. The results show that corneal thickness reduction in OK is primarily due to out-of-plane shear deformation,influenced by the cornea's low shear resistance. Modeling the extended corneal relaxation time is crucial for predicting long-term biomechanical responses. The computational model effectively captures long-term changes in central corneal thickness, potentially improving OK lens fitting accuracy.

关键词： orthokeratology computational biomechanical model long-term viscoelasticity myopia correction

Systemic investigation of natural flavonoids as Nrf2 activators:SAR analysis,mechanism of action,and inhibition of oxidative stress

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Systemic investigation of natural flavonoids as Nrf2 activat...

2型糖尿病的冠心病患者临床和冠状动脉病变特点分析

中国化学会第十二届全国天然有机化学学术会议

作者： Ming-Xing Zhou Xue-Yi Wu yan-ru li Dong-Mei Ren Xiao-Ning Wang Lan Xiang Hong-Xiang Lou Tao Shen Key Lab of Chemical Biology (MOE) School of Pharmaceutical SciencesShandong University

Oxidative stress plays a critical role in the pathogenesis of many human *** of nuclear factor E2-related factor 2(Nrf2) effectively counteracts oxidative stress in human *** are capable of maintaining intracellular redox homeostasis via the activation of Nrf2,and thus potentially preventive effects against oxidative stress-related *** this study,a natural flavonoid library was established and tested for their potential Nrf2 inducing effect using NAD(P)H:quinone reductase(QR) *** on QR inducing effect of flavonoids,their structure-activity relationship(SAR) on Nrf2 induction was summarized,and twenty-four compounds were found to be potential Nrf2 ***,twenty flavonoids were firstly identified to be potential activators of Nrf2-mediated defensive ***,the methoxyl-substituted dihydroflavone,(2 S)-5,6,7,3’,4’-pentamethoxyflavanone(PMF),was further investigated for its capability on the Nrf2 activation and prevention against oxidative insults in human lung epithelial *** results indicated that:(ⅰ) PMF activated Nrf2 and its downstream genes,NAD(P)H:quinone oxidoreductase(NQO1) and γ-glutamylcysteine synthetase(γ-GCS),and enhanced the stabilization of Nrf2 through inhibiting ubiquitination of Nrf2 protein.(ⅱ)Inhibition of PI3 K,p38 MAPK,PKC and PERK by specific kinase inhibitors suppressed PMF-induced activation of Nrf2-mediated cytoprotective response.(ⅲ) PMF also displayed potential interruptive effect on Nrf2-Keapl protein-protein interaction(PPI).(ⅳ) PMF conferred Nrf2-dependent protection against sodium arsenite [As(Ⅲ)]-and cigarette smoke extract(CSE)-induced cytotoxicity in lung epithelial cells in ***,we conclude that PMF is a novel Nrf2 activator with potential prevention against oxidative insults in human lung tissue.

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中国全科医学 2006年第6期9卷 460-462页

作者：闫丽儒哈尔滨医科大学附属第四医院黑龙江省哈尔滨市150001

目的探讨2型糖尿病(DM)合并冠心病患者临床及冠状动脉病变的特点。方法分析经冠状动脉造影诊断的伴有DM(229例)和不伴有DM(793例)的冠心病患者的临床表现和造影结果。结果与非DM的冠心病患者相比,DM合并冠心病患者存在有更多的心血管危... 详细信息

目的探讨2型糖尿病(DM)合并冠心病患者临床及冠状动脉病变的特点。方法分析经冠状动脉造影诊断的伴有DM(229例)和不伴有DM(793例)的冠心病患者的临床表现和造影结果。结果与非DM的冠心病患者相比,DM合并冠心病患者存在有更多的心血管危险因素高血压、血清三酰甘油异常、女性吸烟,且无症状心肌缺血者比例高。在冠状动脉病变特点方面,DM合并冠心病患者的冠状动脉血管病变支数构成、病变类型构成、小血管病变、弥漫性血管病变的发生率与非DM的冠心病患者间差别均有显著性意义(P<0.01)。结论合并DM与不合并DM的冠心病患者临床及冠状动脉病变有显著差异,前者多支冠状动脉病变、C型病变发生率高,冠状动脉病变分布于小血管多且病变复杂。

关键词：冠心病糖尿病,2型冠状血管造影术

Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu liu Xiandeng li Mi li Xian Wu Xiaohui Huang Ajing Xu yan liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Manufacture the conducting polymer with light

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Science China Chemistry 2025年第01期 8-9页

作者： yang li Tianyu li yan Ji Baoguang liu College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications

Poly(3,4-ethylenedioxythiophene) (PEDOT), heralded as the “king” of conducting polymers, is esteemed in bioelectronics for its mixed electronic and ionic conductivity, mechanical properties compatible with biological tissues, tunable healing ability and stability in diverse environments [1]. Based on additive manufacturing of three-dimensional structures,PEDOT realizes the implementation in the efficient production of flexible bioelectronics, the construction of intricate electrode-neural implantations, and the development of smart brain-computer-interfaces [2].

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