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Acquired immune thrombotic thrombocytopenic purpura(TTP)associated with inactivated COVID-19 vaccine CoronaVac

Frontiers of Medicine 2024年第4期18卷 744-751页

作者： Zhangbiao Long Suyu Jiang Honglei Xin Lu Zhang ruinan Lu Fengqi Liu Yong Xu Linv Wang Jun Wang Xuezhong Zhang Hui Liao Jinning Shi Xue yan Xiang Zhu ruonan shao Zijian Li Yilin Zhu Han yan Jiao Wu Chao Fang Xiaodong Xi Xiaofeng Shi Department of Hematology The First Affiliated Hospital of Anhui Medical UniversityHefei230022China Department of Hematology The Second Affiliated Hospital of Nanjing Medical UniversityNanjing210003China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing210029China Department of Hematology Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing210008China Department of Hematology The Affiliated Hospital of Nanjing University of Chinese MedicineThe First Clinical Medical College of Nanjing University of Chinese MedicineNanjing210009China Department of Hematology Zhongda Hospital of Southeast UniversityNanjing210044China Department of Hematology Nanjing First HospitalNanjing Medical UniversityNanjing210006China Department of Hematology The Air Force Hospital of Eastern Theater commandNanjing210016China Department of Hematology Jiangning Hospital Affiliated of Nanjing Medical UniversityNanjing211199China Department of Hematology Nanjing Hospital of Chinese MedicineNanjing210006China Department of Pharmacology School of Basic MedicineTongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseasesHuazhong University of Science and TechnologyThe Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei ProvinceWuhan430030China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China

Corona virus disease 2019(COVID-19)due to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has affected the whole *** thrombotic thrombocytopenic purpura(TTP)has been reported after administration of mRNA-or adenoviral vector-based COVID-19 vaccines,including ***2-S,BNT162b2,mRNA-1273,and ChAdOx1 ***,whether inactivated vaccines,such as CoronaVac,could cause TTP and whether the symptoms in TTPs caused by inactivated vaccines are different from previously reported cases are *** this study,two cases were *** cases developed TTP after the second CoronaVac vaccination shot,but not the *** demonstrated symptoms of fever,neurological abnormalities,renal dysfunction,thrombocytopenia,and *** patients achieved complete remission through several sessions of plasma exchanges and immune *** incidence of TTP in Nanjing area was *** number of patients with TTP was 12 in 2019,6 in 2020,16 in 2021,and 19 in *** the authors’knowledge,this report is the first report of TTP associated with inactivated COVID-19 vaccine(CoronaVac).The rarity and delayed onset may be due to the relatively milder immune response caused by the inactivated vaccines than mRNA-based *** plasma exchange is a vital treatment for CoronaVac-related TTP,similar to activated vaccine-related TTP.

关键词： thrombotic thrombocytopenia purpura(TTP) corona virus disease 2019(COVID-19) CoronaVac acute respiratory syndrome coronavirus 2(SARS-CoV-2) vaccine

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迭代奇异值方法在机械结构模态分离重构中的应用

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振动工程学报 2024年第2期37卷 210-217页

作者：罗治军田桂阎绍泽清华大学机械工程系摩擦学国家重点实验室北京100084 中国人民解放军96963部队博士创新工作站北京100084 陆军航空兵学院航电和兵器工程系北京101123

通过时频分解技术,将复杂的多模态信号分解成单模态成分,从而可以采用比较简单可靠的单模态识别方法对机械结构复杂模态信号进行参数辨识。经验小波变换(EWT)算法能有效解决模态分离问题,一些改进型EWT算法能有效克服噪声干扰,但是在模... 详细信息

通过时频分解技术,将复杂的多模态信号分解成单模态成分,从而可以采用比较简单可靠的单模态识别方法对机械结构复杂模态信号进行参数辨识。经验小波变换(EWT)算法能有效解决模态分离问题,一些改进型EWT算法能有效克服噪声干扰,但是在模态重构时,滤波器彼此重叠、临近模态互相干扰,会不可避免地出现重构模态失真。本文针对模态分离重构问题展开研究,分析了EWT算法在模态分离重构中面临的重构失真问题,提出了基于迭代截断奇异值分解(ITSVD)方法的改进算法,并在仿真信号和含结合面机械结构模型振动响应信号上进行了应用。结果表明,所提ITSVD⁃EWT算法能够更好地实现机械结构模态分离重构。

关键词：参数辨识经验模态分解机械结构经验小波变换迭代截断奇异值分解

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Pit density reduction for AlN epilayers grown by molecular beam epitaxy using Al modulation method

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Chinese Physics B 2024年第10期33卷 95-101页

作者： Huan Liu Peng-Fei shao Song-Lin Chen Tao Tao Yu yan Zi-Li Xie Bin Liu Dun-Jun Chen Hai Lu Rong Zhang Ke Wang Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Hefei National Laboratory Hefei 230088China Xiamen University Xiamen 361005China

We have investigated homoepitaxy of AlN films grown by molecular beam epitaxy on AlN/sapphire templates byadopting both the continuous growth method and the Al modulation epitaxy(AME)growth *** continuous growthmethod encounters significant challenges in controlling the growth *** the precise Al/N=1.0 ratio is difficult toachieve,either the excessive Al-rich or N-rich growth mode *** contrast,by adopting the AME growth method,sucha difficulty has been effectively *** manipulating the supply time of the Al and nitrogen sources,we were able toproduce AlN films with much improved surface *** first step of the AME method,only supplying Al atoms,is important to wet the surface and the Al adatoms can act as a *** of the initial Al supply time caneffectively reduce the pit density on the grown AlN *** pits density dropped from 12 pits/μm^(2)to 1 pit/μm^(2)andthe surface roughness reduced from 0.72 nm to 0.3 nm in a 2×2μm^(2)area for the AME AlN film homoepitaxially grownon an AlN template.

关键词： Al modulation epitaxy molecular beam epitaxy AlN pits

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Risk factors and predictive model of cerebral edema after road traffic accidents-related traumatic brain injury

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Chinese Journal of Traumatology 2024年第3期27卷 153-162页

作者： Di-You Chen Peng-Fei Wu Xi-yan Zhu Wen-Bing Zhao Shi-Feng shao Jing-ru Xie Dan-Feng Yuan Liang Zhang Kui Li Shu-Nan Wang Hui Zhao Institute for Traffic Medicine Daping HospitalArmy Medical UniversityChongqing400042China Department of Radiology Daping HospitalArmy Medical UniversityChongqing400042China Chongqing Key Laboratory of Traffic Injury and Vehicle Ergonomics Chongqing400042China Wound Trauma Medical Center State Key Laboratory of TraumaBurns and Combined InjuryInstitute of Surgery ResearchDaping HospitalArmy Medical UniversityChongqing.400042China

Purpose:Cerebral edema(CE)is the main secondary injury following traumatic brain injury(TBI)caused by road traffic accidents(RTAs).It is challenging to be predicted *** this study,we aimed to develop a prediction model for CE by identifying its risk factors and comparing the timing of edema occurrence in TBI patients with varying levels of ***:This case-control study included 218 patients with TBI caused by *** cohort was divided into CE and non-CE groups,according to CT results within 7 *** data,imaging data,and clinical data were collected and *** variables that follow normal distribution were presented as mean±standard deviation,those that do not follow normal distribution were presented as median(Q1,Q3).Categorical variables were expressed as *** Chi-square test and logistic regression analysis were used to identify risk factors for *** curve fitting was performed to predict the time to secondary CE in TBI patients with different levels of *** efficacy of the model was evaluated using the receiver operator characteristic ***:According to the study,almost half(47.3%)of the patients were found to have *** risk factors associated with CE were bilateral frontal lobe contusion,unilateral frontal lobe contusion,cerebral contusion,subarachnoid hemorrhage,and abbreviated injury scale(AIS).The odds ratio values for these factors were 7.27(95%confidence interval(CI):2.08-25.42,p=0.002),2.85(95%CI:1.11-7.31,p=0.030),2.62(95%CI:1.12-6.13,p=0.027),2.44(95%CI:1.25-4.76,p=0.009),and 1.5(95%CI:1.10-2.04,p=0.009),*** also observed that patients with mild/moderate TBI(AIS≤3)had a 50%probability of developing CE 19.7 h after injury(χ^(2)=13.82,adjusted R2=0.51),while patients with severe TBI(AIS>3)developed CE after 12.5 h(χ^(2)=18.48,adjusted R2=0.54).Finally,we conducted a receiver operator characteristic curve analysis of CE time,which showed an area under the curve of 0

关键词： Road traffic accident Traumatic brain injury Cerebral edema Risk factors Time window

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PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis ina Temporal Manner

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Research 2024年第1期2023卷 33-48页

作者： Fangqian Wang Yuxiao Ye Zengjie Zhang Wangsiyuan Teng Hangxiang Sun Xupeng Chai Xingzhi Zhou Jiayu Chen Haochen Mou Yinwang Eloy Xiaoqiang Jin Liang Chen Zhenxuan shao yan Wu Yue Shen An Liu Peng Lin Jianwei Wang Xiaohua Yu Zhaoming Ye Department of Orthopedic Surgery the Second Affiliated HospitalZhejang University School of MedicineHangzhou CityZhejiang ProvincePR China Orthopedics Research Institute of Zhejang University Hangzhou CityZhejiang ProvincePR China Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou CityZhejiang ProvincePR China School of Material Science and Engineering University of New South WalesSydney 2052Australia

Platelet-derived growth factor-BB(PDGF-BB)/platelet-derived growth factor receptor-β(PDGFR-β)pathway is conventionally considered as an important pathway to promote osteogenesis;however,recent study suggested its role during osteogenesis to be *** the differential functions of this pathway during 3 stages of bone healing,we hypothesized that temporal inhibition of PDGF-BB/PDGFR-βpathway could shift the proliferation/differentiation balance of skeletal stem and progenitor cells,toward osteogenic lineage,which leads to improved bone *** first validated that inhibition of PDGFR-βat late stage of osteogenic induction effectively enhanced differentiation toward *** effect was also replicated invivo by showing accelerated bone formation when block PDGFR-βpathway at late stage of critical bone defect healing mediated using ***,we found that such PDGFR-βinhibitor-initiated bone healing was also effective in the absence of scaffold implantation when administrated ***,timely inhibition of PDGFR-βblocked extracellular regulated protein kinase 1/2 pathway,which shift proliferation/differentiation balance of skeletal stem and progenitor cell to osteogenic lineage by upregulating osteogenesis-related products of Smad to induce *** study offered updated understanding of the use of PDGFR-βpathway and provides new insight routes of action and novel therapeutic methods in the field of bone repair.

关键词： healing sized implantation

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菊糖的提取及纯化

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天然产物研究与开发 2002年第1期14卷 65-69页

作者：严慧如黄绍华余迎利南昌大学食品科学与工程系南昌330047

菊糖是一种水溶性的功能性天然多糖 ,可用热水从菊芋中提取。本实验对菊糖的提取工艺进行了研究 ,比较了提取温度、固液比、提取次数、提取时间四个因素对提取率的影响 ,并采用正交设计法优化提取条件 ,确定了最佳的提取工艺。

关键词：菊糖提取纯化

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Gas exchange optimization in aircraft engines using sustainable aviation fuel:A design of experiment and genetic algorithm approach

Energy and AI

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Energy and AI 2024年第3期17卷 261-280页

作者： Zheng Xu Jinze Pei Shuiting Ding Longfei Chen Shuai Zhao Xiaowei Shen Kun Zhu Longtao shao Zhiming Zhong Huansong yan Farong Du Xueyu Li Pengfei yang Shenghui Zhong Yu Zhou Hangzhou International Innovation Institute Beihang UniversityHangzhou311115China Research Institute of Aero-Engine Beihang UniversityBeijing102206China Civil Aviation University of China Tianjin300300China Aircraft/Engine Integrated System Safety Beijing Key Laboratory Beijing100083China Aero Engine Academy of China Beijing101304China School of Energy and Power Engineering Beihang UniversityBeijing100083China AVIC Chengdu Aircraft Design and Research Institute Chengdu610091China AVIC Nanjing Engineering Institute of Aircraft Systems Nanjing211106China School of Transportation Science and Engineering Beihang UniversityBeijing100083China Faculty of Science and Engineering University of Nottingham Ningbo ChinaNingbo315100China

The poppet valves two-stroke(PV2S)aircraft engine fueled with sustainable aviation fuel is a promising option for general aviation and unmanned aerial vehicle propulsion due to its high power-to-weight ratio,uniform torque output,and flexible valve ***,its high-altitude gas exchange performance remains unexplored,presenting new opportunities for optimization through artificial intelligence(AI)*** study uses validated 1D+3D models to evaluate the high-altitude gas exchange performance of PV2S aircraft *** valve timings of the PV2S engine exhibit considerable flexibility,thus the Latin hypercube design of experiments(DoE)methodology is employed to fit a response surface model.A genetic algorithm(GA)is applied to iteratively optimize valve timings for varying *** optimization process reveals that increasing the intake duration while decreasing the exhaust duration and valve overlap angles can significantly enhance high-altitude gas exchange *** optimal valve overlap angle emerged as 93°CA at sea level and 82°CA at 4000 m *** effects of operating parameters,including engine speed,load,and exhaust back pressure,on the gas exchange process at varying altitudes are further *** higher engine speed increases trapping efficiency but decreases the delivery ratio and charging efficiency at various *** effect is especially pronounced at elevated *** increase in exhaust back pressure will significantly reduce the delivery ratio and increase the trapping *** study demonstrates that integrating DoE with AI algorithms can enhance the high-altitude performance of aircraft engines,serving as a valuable reference for further optimization efforts.

关键词： Poppet valves two-stroke Design of experiment Genetic algorithm optimization Heavy fuel aircraft engine High altitude gas exchange performance

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金属疲劳损伤全寿命过程及工程应用综述

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塑性工程学报 2024年第4期31卷 117-130页

作者：彭艳张伟李如俊李玉雪邵为义燕山大学起重机械关键技术全国重点实验室河北秦皇岛066004 燕山大学国家冷轧板带装备及工艺工程技术研究中心河北秦皇岛066004 燕山大学机械工程学院河北秦皇岛066004

金属疲劳损伤过程复杂,不同载荷类型与服役环境下金属疲劳损伤机理、变形特性和破坏模式存在较大差异。将疲劳损伤全寿命过程按照循环寿命周次划分为超高周、高周、低周和裂纹扩展4个类别,根据变形响应特性和变形机理特征阐述了各类别... 详细信息

金属疲劳损伤过程复杂,不同载荷类型与服役环境下金属疲劳损伤机理、变形特性和破坏模式存在较大差异。将疲劳损伤全寿命过程按照循环寿命周次划分为超高周、高周、低周和裂纹扩展4个类别,根据变形响应特性和变形机理特征阐述了各类别疲劳损伤的研究现状及发展趋势,涉及宏观尺度、微细观尺度和宏细微观多尺度理论体系。同时结合工程实际案例,以轧辊和燕尾榫作为代表性构件,分析其疲劳损伤行为与影响因素,探讨了目前疲劳理论在工程实践中的应用及挑战,旨在为金属疲劳损伤全寿命理论体系的完善和关键部件健康质量管控提供理论依据和技术指导。

关键词：金属疲劳全寿命多尺度工程实践

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6种代谢产物与特应性皮炎的因果关联:双向双样本孟德尔随机化研究

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西安交通大学学报（医学版） 2024年第5期45卷 801-808页

作者：魏艳孙妍王丽娟邵帅郑焱西安交通大学第一附属医院皮肤科陕西西安710061 空军军医大学第一附属医院皮肤科陕西西安710032

目的采用双向双样本孟德尔随机化(MR)分析来研究代谢产物与特应性皮炎(AD)之间的因果关系。方法从全基因组关联研究(GWAS)的汇总数据中提取与代谢产物相关的单核苷酸多态性(SNP)位点作为工具变量(IV)。使用R软件中的TwoSampleMR包对6种... 详细信息

目的采用双向双样本孟德尔随机化(MR)分析来研究代谢产物与特应性皮炎(AD)之间的因果关系。方法从全基因组关联研究(GWAS)的汇总数据中提取与代谢产物相关的单核苷酸多态性(SNP)位点作为工具变量(IV)。使用R软件中的TwoSampleMR包对6种代谢物与AD之间的因果关联进行分析。所采用的主要方法包括逆方差加权法(IVW)、MR Egger和加权中位数法。使用Cochran’Q统计量进行异质性检验,MR Egger截距检验水平多效性,使用“留一法”进行敏感性分析。结果IVW分析结果显示,抗坏血酸(OR=0.861,95%CI:0.751~0.987)、花生四烯酸(OR=0.363,95%CI:0.193~0.683)、可的松(OR=0.447,95%CI:0.221~0.906)与AD的发生呈负相关;尿苷(OR=3.473,95%CI:1.043~11.562)、5-羟色胺(OR=1.896,95%CI:1.007~3.571)及2-羟基戊二酸(OR=2.158,95%CI:1.186~3.924)与AD的发生呈正相关,差异均具有统计学意义。结论遗传学预测的代谢产物与AD风险增加具有因果关联,但尚无显著证据支持AD与上述6种代谢产物之间的因果关系。

关键词：特应性皮炎(AD) 孟德尔随机化(MR) 因果关联代谢产物逆方差加权法(IVW)

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Acute primary angle closure during the Omicron outbreak

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1337-1343页

作者： Dong Fang Wang-Ting Li Jia Liang Lu Chen Ning-Xin Dou Hui-yan Zheng Can-Feng Huang Ting Xie Yi-Jing Zhuang Peng-Feng Li Xing-Xing Mao shao-Chong Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Key Laboratory of OphthalmologyShenzhen 518040Guangdong ProvinceChina

AIM:To investigate Omicron’s impact on clinical presentation of acute primary angle closure(APAC)in ***:A consecutive case series with historical controls was conducted at Shenzhen Eye Hospital,the largest specialized hospital in Shenzhen,*** records from a two-month period during the Omicron pandemic(December 1,2022,to January 31,2023)were compared with records from two control groups(12/2018–1/2019 and 12/2021–1/2022)before *** with APAC were included,and the prevalence of APAC and demographic characteristics in Omicron-infected and noninfected patients were ***:Seventy-one(23.43%)out of 303 patients were diagnosed with APAC in the pandemic cohort,which was 2.98 and 2.61 times higher than that in control cohorts(7.87%in 2019,8.96%in 2022,P<0.001).The pandemic cohort has significantly higher Omicron-infected rate(78.87%vs 0 vs 0;P<0.001),lower proportion of glaucoma history(16.90%vs 42.86%vs 41.67%,P=0.005),higher surgical rate(95.77%vs 83.33%vs 78.57%,P=0.024),higher total medical costs and larger pupil diameter(5.63±0.15 vs 4.68±0.15 vs 4.69±0.22 mm,P<0.01).In 83%Omicron-infected patients,ocular symptoms appeared within 3d after systemic symptoms *** multivariate analysis,Omicron infection(P<0.001)was the only independent predictor of pupil ***:In the Omicron epidemic in China,there is an increase of prevalence and severity of APAC,particularly focusing on the first 3d following infection.

关键词： Omicron acute primary angle closure ocular symptoms

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