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Combined ATAC-seq,RNA-seq,and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster(Crassostrea ariakensis)

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Zoological Research 2024年第1期45卷 201-214页

作者： Biao Wu Xi Chen Jie Hu Zhen-Yuan Wang yan Wang Da-You Xu Hao-Bing Guo Chang-Wei shao Li-Qing Zhou Xiu-Jun Sun Tao Yu Xiao-Mei Wang yan-Xin Zheng Guang-Yi Fan Zhi-Hong Liu State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdaoShandong 266071China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266426China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai 201306China Changdao Enhancement and Experiment Station Chinese Academy of Fishery SciencesYantaiShandong 265800China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China

Glycogen serves as the principal energy reserve for metabolic processes in aquatic shellfish and substantially contributes to the flavor and quality of *** Jinjiang oyster(Crassostrea ariakensis)is an economically and ecologically important species in *** the present study,RNA sequencing(RNA-seq)and assay for transposase-accessible chromatin using sequencing(ATAC-seq)were performed to investigate gene expression and chromatin accessibility variations in oysters with different glycogen *** identified 9483 differentially expressed genes(DEGs)and 7215 genes with significantly differential chromatin accessibility(DCAGs)were obtained,with an overlap of 2600 genes between ***,a significant proportion of these genes were enriched in pathways related to glycogen metabolism,including“Glycogen metabolic process”and“Starch and sucrose metabolism”.In addition,genome-wide association study(GWAS)identified 526 single nucleotide polymorphism(SNP)loci associated with glycogen *** loci corresponded to 241 genes,63 of which were categorized as both DEGs and *** study enriches basic research data and provides insights into the molecular mechanisms underlying the regulation of glycogen metabolism in ***.

关键词： Crassostrea ariakensis Glycogen Transcriptome ATAC GWAS

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Clinical study of neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio in hypertriglyceridemia-induced acute pancreatitis and acute biliary pancreatitis with persistent organ failure

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1647-1659页

作者： Mu-Sen Xu Jia-Le Xu Xin Gao shao-Jian Mo Jia-Yu Xing Jia-Hang Liu yan-Zhang Tian Xi-Feng Fu The Third Hospital of Shanxi Medical University Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalTaiyuan 030032Shanxi ProvinceChina Department of Environmental Health School of Public HealthShanxi Medical UniversityTaiyuan 030032Shanxi ProvinceChina

BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various *** categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and *** A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were *** patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 *** collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital *** The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP *** the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥***,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥***,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP *** NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.

关键词： Acute pancreatitis Gallstone Hypertriglyceridemia Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Persistent organ failure

Cyclic Dinucleotide Self-Assembled Nanoparticles as a Carrier-Free Delivery Platform for STING-Mediated Cancer Immunotherapy

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CCS Chemistry 2024年第1期6卷 177-195页

作者： Lang Zhao shao-Hua Zhuo Tian-yang Wang Jun-Jun Wu Jing-Yun Su Wen-Hao Li Bo-Dou Zhang yan-Mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain Disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CDNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy ***,CDNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CDNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CDNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CDN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CDNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CDN NPs promote cellular uptake of CDNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific T-cell *** also demonstrate that the use of CDN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CDN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy

球形双曲色散超材料腔的多重窄带回音廊模式及透明显示应用

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物理学报 2024年第2期73卷 59-68页

作者：李艳任思萌褚博燕汝江于群星孙辉邵立钟发成郑州航空工业管理学院材料学院郑州450046

本文提出并设计了一种用于提高彩色透明显示性能的球形双曲色散超材料(HMM)腔.该腔由介质/银层交替包裹银核组成,具有深度亚波长性质,并支持和银层数目相同的同阶回音廊模式.这些模式能够将电磁波能量高度局域在不同介质壳层内,从而降... 详细信息

本文提出并设计了一种用于提高彩色透明显示性能的球形双曲色散超材料(HMM)腔.该腔由介质/银层交替包裹银核组成,具有深度亚波长性质,并支持和银层数目相同的同阶回音廊模式.这些模式能够将电磁波能量高度局域在不同介质壳层内,从而降低欧姆损耗,减小共振线宽.针对5层银/介质交替包裹形成的HMM腔,详细分析了结构参数对回音廊模式的调谐作用.发现仅改变最外层介质或银层厚度,几乎不影响TM1,2和TM1,3模式的共振位置,但对TM1,1模式的共振位置及3个模式的强度产生明显调谐.通过优化HMM腔,在红绿蓝波段实现三重窄带共振,且在三重共振位置均具有偶极辐射特点,能够将散射光限制在和入射光夹角为-45°—+45°范围内.该HMM腔不仅支持红绿蓝三重窄带共振,并具有宽的散射角,可应用于实现高透明度、高亮度和宽视角的全彩透明显示.

关键词：双曲色散超材料腔米氏散射回音廊模式透明显示器

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Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A

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Virologica Sinica 2024年第4期39卷 685-693页

作者： yanyan Dong Enze shao Siwei Li ruiqi Wang Dan Wang Lixin Wang Hong yang Yingxia He Tian Luan yang Chen Yao Wang Lexun Lin yan Wang Zhaohua Zhong Wenran Zhao Department of Cell Biology Harbin Medical UniversityHarbin 150081China Department of Microbiology Harbin Medical UniversityHarbin 150081China

Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated *** B coxsackievirus(CVB)is one of the leading causative pathogens of viral myocarditis,which primarily affects children and young *** to the lack of vaccines,the development of antiviral medicines is crucial to controlling CVB infection and the progression of *** this study,we investigated the antiviral effect of baicalein,a flavonoid extracted from Scutellaria *** results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected *** addition,significant reductions in viral protein 3D,viral RNA,and viral particles were observed in CVB3-infected cells treated with *** found that baicalein exerted its inhibitory effect in the early stages of CVB3 *** also suppressed viral replication in the myocardium and effectively alleviated myocarditis induced by CVB3 *** study revealed that baicalein exerts its antiviral effect by inhibiting the activity of caspase-1 and viral protease *** together,our findings demonstrate that baicalein has antiviral activity against CVB3 infection and may serve as a potential therapeutic option for the myocarditis caused by enterovirus infection.

关键词： Baicalein Coxsackievirus B(CVB) Myocarditis 2A protease Caspase-1

Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

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World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting yang Kang Chao Xia Zhu Xue-Ding Wang Sumyuet Chan yan-Ping Guan Jing Mao Pan Li shao-Xing Guan Wen Xie Xiang Gao Min Huang School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte countrug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

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结肠镜检查肠道准备研究热点的可视化分析

世界华人消化杂志 2023年第14期31卷 605-614页

作者：邵艳茹郑桃花单信芝李姗姗康梅青岛大学护理学院山东省青岛市266000 青岛大学附属医院消化内科山东省青岛市266000 青岛大学附属医院服务管理部山东省青岛市266000 青岛大学附属医院神经外科重症监护室山东省青岛市266000

背景肠道准备是结肠镜检查前的必要环节,其研究主题较为分散.掌握肠道准备的研究现状及发展趋势,对于疾病研究和实际临床工作具有重要的价值,而目前该领域采用文献计量学的形式对此进行归纳和总结的研究是缺乏的.目的了解结肠镜检查前... 详细信息

背景肠道准备是结肠镜检查前的必要环节,其研究主题较为分散.掌握肠道准备的研究现状及发展趋势,对于疾病研究和实际临床工作具有重要的价值,而目前该领域采用文献计量学的形式对此进行归纳和总结的研究是缺乏的.目的了解结肠镜检查前肠道准备相关研究在国内外的研究热点和发展趋势,以为研究者及临床工作者提供指导价值.方法检索建库至2022-09-10中国知网(CNKI)、万方、维普、中国生物医学文献数据库(CBM)、Web of Science核心数据集中与肠道准备主题相关的文献,采用CiteSpace 6.1.R3软件对年发文量、国家、机构、发文作者、关键词及聚类、文献共被引情况进行可视化分析.结果共分别纳入中、英文文献2340篇、2674篇,年发文量均呈逐年上升趋势,国际上最高产作者为Hassan Cesare,最高产国家为美国、韩国、英国等,国内最高产作者为孟小芬、张媛媛、钮美娥,最高产机构为苏州大学第一附属医院、中国人民解放军总医院、西安交通大学附属第二医院,研究热点为肠道准备质量、肠道准备方案的研究、特殊人群的肠道准备.结论国内外肠道准备相关的研究具备一定研究基础,国内研究能紧跟国际研究热点,但国际间、团队间合作仍需加强,未来应扩大基于更广泛人群的、更契合大数据时代发展的肠道准备相关研究产出,以为临床提供更高质量的研究证据.

关键词：结肠镜肠道准备 Citespace 可视化研究热点

Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning Li Yong Wang Chun Li Xu Chen Xue-Feng Zhang Nan Nan Tan Yi-Qin Hong Ming-yan shao Bing-Hua Tang Dong-Qing Guo School of Life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

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激光诱导击穿光谱技术对水稻产地识别研究

光谱学与光谱分析 2024年第6期44卷 1553-1558页

作者：宋少忠符少燕刘园园齐春艳李景鹏高勋吉林工程技术师范学院数据科学与人工智能学院吉林长春130052 长春理工大学物理学院吉林长春130022 吉林省农业科学院水稻研究所吉林长春130033 中国科学院东北地理与农业生态研究所吉林长春130102

水稻是中国主要粮食作物,而水稻品质与其生长的外部环境如土壤特性、气候、日照时间和灌溉水等环境息息相关,高品质水稻的产地区域面积有一定地域限制,因此水稻可看成为是一个明显的地理标志物。市场常出现一些假冒或者贴牌的知名优质... 详细信息

水稻是中国主要粮食作物,而水稻品质与其生长的外部环境如土壤特性、气候、日照时间和灌溉水等环境息息相关,高品质水稻的产地区域面积有一定地域限制,因此水稻可看成为是一个明显的地理标志物。市场常出现一些假冒或者贴牌的知名优质水稻出售,损害了水稻品牌,降低了消费者的水稻品质保障,并且扰乱了市场稳定性,因此对于水稻产地快速识别技术的需求十分迫切。利用LIBS结合机器学习算法,对吉林省5个产地(大安、公主岭、前郭、松原、洮儿河)的水稻进行产地识别,建立了主成分分析(PCA)算法分别结合Bagged Trees、Weighted KNN、Quadratic SVM和Coarse Gaussian SVM共四种机器学习算法的水稻产地识别模型。实验选取了5个水稻产地共450组在200~900 nm的LIBS数据,对水稻LIBS光谱数据采用卷积平滑(S-G平滑)进行降噪和特征谱线归一化预处理,对水稻LIBS光谱数据进行主成分分析,实现了水稻产地具有较好的聚类空间集群分布,但部分水稻产地存在空间重叠。采用5倍交叉验证,采用PCA-Bagged Trees、PCA-Weighted KNN、PCA-Quadratic SVM和PCA-Coarse Gaussian SVM共四种机器学习模型,水稻产地的识别精度均达到91.8%以上,并且PCA-Quadratic SVM模型的识别精度高达97.3%。结果表明结合LIBS技术和机器学习算法能够高精度和高效率实现水稻产地的识别。

关键词：激光诱导击穿光谱机器学习算法水稻产地识别识别精度

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