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Impact of Annealing on the Melt Recrystallization of a-PDLA/α-PLLA Double-layered Films

Chinese Journal of Polymer Science 2024年第2期42卷 230-238,I0009页

作者： Yun-Peng Li Hao-Ran Shen shao-Juan Wang Hao Zhang Jian Hu rui Xin Xiao-Li Sun Shou-Ke yan Key Laboratory of rubber-Plastics Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plasticsQingdao University of Science&TechnologyQingdao266042China State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing100029China

Poly(lactic acid)(PLA) as a bio-based polymer with biodegradability and biocompatibility has attracted much attention. To manipulate its properties for different applications, regulation of crystal structure and crystalline morphology becomes an attractive research topic. In this work, the structure evolution of layered samples containing an amorphous poly(D-lactide)(PDLA) layer and a crystalline poly(L-lactide)(PLLA)layer with highly oriented edge-on α lamellar crystals after annealing at 150 ℃ or/and after melt-recrystallization has been studied by AFM, FTIR,and TEM combined with electron diffraction. The results demonstrate that melt recrystallization of the as-prepared sample leads to the formation of abundant randomly oriented PLA stereo-complex(PLA SC) crystals. Annealing at 150 ℃ results in the formation of a small amount of oriented PLA SC crystals at the interface. These PLA SC crystals show great impact on the recrystallization behavior of sample after melting at 190 ℃ and then crystallizing at 90 ℃. First, they impede the mutual diffusion of the overlying PDLA and underlying PLLA, and thus reduce their stereocomplexation ability as manifested by the decreased amount of PLA SC crystals. Second, they act as substrate to initiate the epitaxial crystallization of the overlying PDLA and underlying PLLA, which ensures the production of a highly oriented structure of PDLA and PLLA after melt recrystallization again.

关键词： Poly(L-lactide) Poly(D-lactide) Double layer Stereocomplex

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Human CD56+CD39+ dNK cells support fetal survival through controlling trophoblastic cell fate:immune mechanisms of recurrent early pregnancy loss

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National Science Review 2024年第6期11卷 129-145页

作者： Wentong Jia Liyang Ma Xin Yu Feiyang Wang Qian yang Xiaoye Wang Mengjie Fan yan Gu Ran Meng Jian Wang Yuxia Li Rong Li Xuan shao yan-Ling Wang State Key Laboratory of Stem cell and Reproductive Biology Key Laboratory of Organ Regeneration and ReconstructionInstitute of ZoologyChinese Academy of Sciences Beijing Institute for Stem Cell and Regenerative Medicine University of the Chinese Academy of Sciences NHC Key Lab of Reproduction Regulation Shanghai Engineering Research Center of Reproductive Health Drug and Devices Shanghai Institute for Biomedical and Pharmaceutical Technologies National Clinical Center for Obstetrics and Gynecology Peking University Third Hospital Department of Family Planning The Second Hospital of Tianjin Medical University Department of Prenatal Screening Haidian Maternal and Child Health Hospital

Decidual natural killer（dNK） cells are the most abundant immune cells at the maternal-fetal interface during early pregnancy in both mice and humans, and emerging single-cell transcriptomic studies have uncovered various human dNK subsets that are disrupted in patients experiencing recurrent early pregnancy loss（RPL） at early gestational stage, suggesting a connection between abnormal proportions or characteristics of dNK subsets and RPL pathogenesis. However, the functional mechanisms underlying this association remain unclear. Here, we established a mouse model by adoptively transferring human dNK cells into pregnant NOG（NOD/Shi-scid/IL-2Rγnull） mice, where human dNK cells predominantly homed into the uteri of recipients. Using this model, we observed a strong correlation between the properties of human dNK cells and pregnancy outcome. The transfer of dNK cells from RPL patients（dNK-RPL）remarkably worsened early pregnancy loss and impaired placental trophoblast cell differentiation in the recipients. These adverse effects were effectively reversed by transferring CD56+CD39+dNK *** studies revealed that CD56+CD39+dNK subset facilitates early differentiation of mouse trophoblast stem cells（m TSCs） towards both invasive and syncytial pathways through secreting macrophage colony-stimulating factor（M-CSF）. Administration of recombinant M-CSF to NOG mice transferred with dNK-RPL efficiently rescued the exacerbated pregnancy outcomes and fetal/placental development. Collectively, this study established a novel humanized mouse model featuring functional human dNK cells homing into the uteri of recipients and uncovered the pivotal role of M-CSF in fetal-supporting function of CD56+CD39+dNK cells during early pregnancy, highlighting that M-CSF may be a previously unappreciated therapeutic target for intervening RPL.

关键词： recurrent pregnancy loss CD56+CD39+ dNK subset NOG mice adoptive transfer placental trophoblast cell fate M-CSF

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Neurokinin-2 receptor antagonist SR48968 induced necroptosis of myeloid leukemia cells by calcium overload-driven reactive oxygen species accumulation

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Genes & Diseases 2024年第5期11卷 33-35页

作者： Zhibin yan Xiangyu Hong Qihao Lin Leijie Wang Gang shao Chentao Ge ruilong Xia Caiyun Fu Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine College of Life Sciences and MedicineZhejiang Sci-Tech UniversityHangzhouZhejiang 310018China College of Life Sciences China Jiliang UniversityHangzhouZhejiang 310018China

Increasing evidence highlight tachykinin receptors as a prominent player in hematological *** previously revealed the proto-oncogenic role of neurokinin-1 receptor(NK-1R)in acute myeloid leukemia(AML),1 whereas the role of neurokinin-2 receptor(NK-2R)has not been ***,we found NK-2R was significantly up-regulated in AML patients in The Cancer Genome Atlas *** result was further confirmed in blood from AML patients and a range of human leukemia ***,we verified that blocking NK-2R by SR48968 markedly promoted cell death in human myeloid leukemia without cytotoxicity to normal ***,we uncovered that SR48968 induced cytotoxicity through necroptosis mediated by calcium overload-driven reactive oxygen species(ROS)*** summary,our results propose that NK-2R antagonist SR48968 may be used as a new therapeutic approach for myeloid leukemia.

关键词： myeloid antagonist markedly

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The relationship between compartment models and their stochastic counterparts:A comparative study with examples of the COVID-19 epidemic modeling

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Journal of Biomedical Research 2024年第2期38卷 175-188,I0016-I0018页

作者： Ziyu Zhao Yi Zhou Jinxing Guan yan yan Jing Zhao Zhihang Peng Feng Chen yang Zhao Fang shao Department of Biostatistics School of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Nanjing Hanwei Public Health Research Institute Co. LtdNanjingJiangsu 210005China China International Cooperation Center for Environment and Human Health Center for Global HealthNanjing Medical UniversityNanjingJiangsu 211166China The Center of Biomedical Big Data and the Laboratory of Biomedical Big Data Nanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Deterministic compartment models(CMs)and stochastic models,including stochastic CMs and agent-based models,are widely utilized in epidemic ***,the relationship between CMs and their corresponding stochastic models is not well *** present study aimed to address this gap by conducting a comparative study using the susceptible,exposed,infectious,and recovered(SEIR)model and its extended CMs from the coronavirus disease 2019 modeling *** demonstrated the equivalence of the numerical solution of CMs using the Euler scheme and their stochastic counterparts through theoretical analysis and *** on this equivalence,we proposed an efficient model calibration method that could replicate the exact solution of CMs in the corresponding stochastic models through parameter *** advancement in calibration techniques enhanced the accuracy of stochastic modeling in capturing the dynamics of ***,it should be noted that discrete-time stochastic models cannot perfectly reproduce the exact solution of continuous-time ***,we proposed a new stochastic compartment and agent mixed model as an alternative to agent-based models for large-scale population simulations with a limited number of *** model offered a balance between computational efficiency and *** results of this research contributed to the comparison and unification of deterministic CMs and stochastic models in epidemic ***,the results had implications for the development of hybrid models that integrated the strengths of both ***,the present study has provided valuable epidemic modeling techniques and their practical applications for understanding and controlling the spread of infectious diseases.

关键词： compartment models agent-based models compartment-agent mixed models comparative study COVID-19

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Prevalence and Risk Factors of Stroke in Inpatients with Type 2 Diabetes Mellitus in China

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Current Medical Science 2024年第4期44卷 698-706页

作者： Zuo-ling XIE Chen-chen WANG Xi HUANG Zheng WANG Hai-yan SHANGGUAN shao-hua WANG Department of Endocrinology the Affiliated ZhongDa Hospital of Southeast UniversityNanjing210009China School of Medicine Southeast UniversityNanjing210009China

Objective The prevalence and the cluster characteristics of risk factors of stroke were assessed in a Chinese diabetic *** Clinical data of 30693 inpatients who were diagnosed with type 2 diabetes mellitus(T2DM)and admitted between 2013 and 2018 were retrospectively *** age-standardized prevalence of stroke was estimated using the 2010 Chinese population census data,and risk factors were analyzed by multiple imputation and *** The crude and standardized prevalence rates of stroke in patients with T2DM were 34.4%and 21.5%,respectively,and 85.2%of the stroke patients had ischemic *** half of the patients who experienced stroke had clusters of more than 4 risk *** with no-risk-factor clustering,the risk of stroke significantly increased 3-4 times in the presence of more than 4 risk-factor clusters(P<0.001).Hypertension was the most common major risk factor for ischemic stroke[odds ratio(OR),2.34;95%confidence interval(CI),2.18-2.50]and hemorrhagic stroke(OR,3.68;95%CI 2.95-4.59;P<0.001).Moreover,a 1-standard-deviation increase in fasting blood glucose(FBG)was significantly negatively correlated with ischemic stroke risk,and the same change in FBG was significantly associated with an 8%increased risk of hemorrhagic *** The prevalence of stroke in patients with T2DM is rather high,and the clustering of risk factors is associated with the development of stroke in T2DM *** factors differ in different stroke *** risk factors for a specific high-risk group is necessary.

关键词： type 2 diabetes mellitus stroke prevalence risk factor cluster

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Cooperative activation of sodium channels for downgrading the energy efficiency in neuronal information processing

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Chinese Physics B 2024年第5期33卷 758-763页

作者：严浩然颜家琦俞连春邵玉峰 School of Physical Science and Technology Lanzhou Center for Theoretical PhysicsLanzhou UniversityLanzhou 730000China Key Laboratory of Theoretical Physics of Gansu Province and Key Laboratory of Quantum Theory and Applications of MoELanzhou UniversityLanzhou 730000China Department of Neuroscience AnatomyHistologyand EmbryologyKey Laboratory of Preclinical Study for New Drugs of Gansu ProvinceSchool of Basic Medical SciencesLanzhou UniversityLanzhou 730000China

The Hodgkin–Huxley model assumes independent ion channel activation,although mutual interactions are common in biological *** raises the problem why neurons would favor independent over cooperative channel *** this study,we evaluate how cooperative activation of sodium channels affects the neuron’s information processing and energy *** of the stochastic Hodgkin–Huxley model with cooperative activation of sodium channels show that,while cooperative activation enhances neuronal information processing capacity,it greatly increases the neuron’s energy *** a result,cooperative activation of sodium channel degrades the energy efficiency for neuronal information *** discovery improves our understanding of the design principles for neural systems,and may provide insights into future designs of the neuromorphic computing devices as well as systematic understanding of pathological mechanisms for neural diseases.

关键词： energy efficiency ion channel noise action potential generation neuronal dynamics

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A comprehensive aerodynamic-thermalmechanical design method for fast response turbocharger applied in aviation piston engines

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Propulsion and Power Research 2024年第2期13卷 145-165页

作者： Yu Zhou Yue Song Shuai Zhao Xueyu Li Longtao shao Huansong yan Zheng Xu Shuiting Ding Research Institute of Aero-Engine Beihang UniversityBeijing 100083China Aircraft/Engine Integrated System Safety Beijing Key Laboratory Beijing 100083China School of Energy and Power Engineering Beihang UniversityBeijing 100083China School of Transportation Science and Engineering Beihang UniversityBeijing 100083China AVIC Nanjing Engineering Institute of Aircraft Systems Nanjing 210000China Hangzhou International Innovation Institute Beihang UniversityHangzhou 311115China Civil Aviation University of China Tianjin 300300China

Limited by the poor transient response performance of turbochargers,the dynamic performance of aviation piston engines tends to *** a bid to enhance the turbocharger’s acceleration capabilities,this study scrutinizes various factors impacting its *** on the operational principles and transient response process of the turbocharger,three types of in-ertiadnamely,aerodynamic inertia(ADI),thermal inertia(TI),and mechanical inertia(MI)d are identiﬁed and addressed for *** begin,this paper pioneers the innovative deﬁnition of a method for evaluating the transient response performance of the *** method incor-porates the introduction of an ADI parameter,inspired by the deﬁnition of ***,a thin-walled volute design with a low Biot number and a lightweight turbine impeller is introduced to reduce the turbocharger’s TI and *** simulation results of theﬂowﬁeld distribution within the volute and diffuser demonstrate the comprehensive design method’s effectiveness in improving gas pressure and temperature distributions in these ***,the pressure distributionﬂuctuation in the constant moment-of-momentum volute(CMV)is 62.8%lower than that in the constant velocity moment volute(CVMV).The low-TI thin-walled volute not only en-hances the turbocharger’s response speed but also reduces its weight by approximately 40%.The impact of three types of inertia on the engine’s response speed is quantiﬁed as follows:ADI(94%)>MI(5%)>TI(1%).This conclusion has been veriﬁed through test results of both the turbocharger and the *** design method not only signiﬁcantly improves the turbo-charger’s response performance but also offers valuable insights for the optimal design of other blade mechanical systems.

关键词： Turbocharger Fast response design method Aerodynamic inertia Thermal inertia Mechanical inertia

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LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation

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Science China(Life Sciences) 2024年第3期67卷 488-503页

作者： Xiao Fan Fangzhou Liu Xiang Wang Ying Wang Yu Chen Chengyu Shi Xinwan Su Manman Tan Qingfeng yan Jinrong Peng Jianzhong shao yan Xiong Aifu Lin MOE Laboratory of Biosystem Homeostasis and Protection College of Life SciencesZhejiang UniversityHangzhou 310058China Key Laboratoryof Cancer Prevention and Intervention China National Ministry of EducationHangzhou 310009China Cancer Center Zhejiang UniversityHangzhou 310058China Key Laboratory for Cell and Gene Engineering of Zhejiang Province Hangzhou 310058China Department of Central Laboratory the First People's Hospital of HuzhouHuzhou 313000China Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006China MOE Key Laboratory for Molecular Animal Nutrition College of Animal SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310000China Breast Center of the First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China International School of Medicine International Institutes of MedicineThe 4th Affiliated Hospital of Zhejiang University School of MedicineYiwu 322000China

Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully elucidated. Here, we report that the long non-coding RNA(lncRNA) LncFASA increases the susceptibility of triple-negative breast cancer(TNBC) to ferroptosis. As a tumor suppressor, LncFASA drives the formation of droplets containing peroxiredoxin1(PRDX1), a member of the peroxidase family, resulting in the accumulation of lipid peroxidation via the SLC7A11-GPX4 axis. Mechanistically, LncFASA directly binds to the Ahpc-TSA domain of PRDX1, inhibiting its peroxidase activity by driving liquid-liquid phase separation, which disrupts intracellular ROS homeostasis. Notably, high LncFASA expression indicates favorable overall survival in individuals with breast cancer, and LncFASA impairs the growth of breast xenograft tumors by modulating ferroptosis. Together, our findings illustrate the crucial role of this lncRNA in ferroptosis-mediated cancer development and provide new insights into therapeutic strategies for breast cancer.

关键词： long non-coding RNA peroxiredoxin liquid-liquid phase separation ferroptosis breast cancer

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Spatiotemporal evolution and future simulation of land use/land cover in the Turpan-Hami Basin,China

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Journal of Arid Land 2024年第10期16卷 1303-1326页

作者： CHEN Yiyang ZHANG Li yan Min WU Yin DONG Yuqi shao Wei ZHANG Qinglan Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing100094China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China University of Chinese Academy of Sciences Beijing 100094China Xinjiang Uygur Autonomous Region Natural Resources Planning and Research Institute Urumqi 830011China School of Geomatics and Marine Information Jiangsu Ocean UniversityLianyungang 222001China College of Geomatics and Geoinformation Guilin University of TechnologyGuilin 541004China

The Turpan-Hami(Tuha)Basin in Xinjiang Uygur Autonomous Region of China,holds significant strategic importance as a key economic artery of the ancient Silk Road and the Belt and Road Initiative,necessitating a holistic understanding of the spatiotemporal evolution of land use/land cover(LULC)to foster sustainable planning that is tailored to the region's unique resource ***,existing LULC classification methods demonstrate inadequate accuracy,hindering effective regional *** this study,we established a two-level LULC classification system(8 primary types and 22 secondary types)for the Tuha *** employing Landsat 5/7/8 imagery at 5-a intervals,we developed the LULC dataset of the Tuha Basin from 1990 to 2020,conducted the accuracy assessment and spatiotemporal evolution analysis,and simulated the future LULC under various scenarios via the Markov-Future Land Use Simulation(Markov-FLUS)*** results revealed that the average overall accuracy values of our LULC dataset were 0.917 and 0.864 for the primary types and secondary types,*** with the seven mainstream LULC products(GlobeLand30,Global 30-meter Land Cover with Fine Classification System(GLC_FCS30),Finer Resolution Observation and Monitoring of Global Land Cover PLUS(FROM_GLC PLUS),ESA Global Land Cover(ESA_LC),Esri Land Cover(ESRI_LC),China Multi-Period Land Use Land Cover Change Remote Sensing Monitoring Dataset(CNLUCC),and China Annual Land Cover Dataset(CLCD))in 2020,our LULC data exhibited dramatically elevated overall accuracy and provided more precise delineations for land features,thereby yielding high-quality data backups for land resource analyses within the *** 2020,unused land(78.0%of the study area)and grassland(18.6%)were the dominant LULC types of the basin;although cropland and construction land constituted less than 1.0%of the total area,they played a vital role in arid land development and primarily situated within oases that form the urban co

关键词： land use/land cover(LULC) future simulation manual interpretation Markov-Future Land Use Simulation(Markov-FLUS)model Turpan-Hami(Tuha)Basin Xinjiang

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Astronomical Knowledge Entity Extraction in Astrophysics Journal Articles via Large Language Models

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Research in Astronomy and Astrophysics 2024年第6期24卷 140-155页

作者： Wujun shao rui Zhang Pengli Ji Dongwei Fan Yaohua Hu Xiaoran yan Chenzhou Cui Yihan Tao Linying Mi Lang Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Data Center Beijing 100101China Research Institute of Artificial Intelligence Zhejiang LabHangzhou 311100China Guilin University Guangxi 541006China Xidian University Xi’an 710126China

Astronomical knowledge entities,such as celestial object identifiers,are crucial for literature retrieval and knowledge graph construction,and other research and applications in the field of *** methods of extracting knowledge entities from texts face numerous challenging obstacles that are difficult to ***,there is a pressing need for improved methods to efficiently extract *** study explores the potential of pre-trained Large Language Models(LLMs)to perform astronomical knowledge entity extraction(KEE)task from astrophysical journal articles using *** propose a prompting strategy called PromptKEE,which includes five prompt elements,and design eight combination prompts based on *** select four representative LLMs(Llama-2-70B,GPT-3.5,GPT-4,and Claude 2)and attempt to extract the most typical astronomical knowledge entities,celestial object identifiers and telescope names,from astronomical journal articles using these eight combination *** accommodate their token limitations,we construct two data sets:the full texts and paragraph collections of 30 *** the eight prompts,we test on full texts with GPT-4and Claude 2,on paragraph collections with all *** experimental results demonstrate that pre-trained LLMs show significant potential in performing KEE tasks,but their performance varies on the two data ***,we analyze some important factors that influence the performance of LLMs in entity extraction and provide insights for future KEE tasks in astrophysical articles using ***,compared to other methods of KEE,LLMs exhibit strong competitiveness in multiple aspects.

关键词： astronomical databases:miscellaneous virtual observatory tools methods:data analysis

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