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Meroterpenoids Possessing Diverse Rearranged Skeletons with Anti-inflammatory Activity from the Mangrove-Derived Fungus Penicillium sp. HLLG-122

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Chinese Journal of Chemistry 2023年第19期41卷 2507-2517页

作者： Yu-Yue Qin Wan-Shan Li Xuan Zhang Zhang-Xin Yu Xiao-Bao Li Han-Yi Chen yan-ru lv Chang-Ri Han Guang-Ying Chen Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education and Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical EngineeringHainan Normal UniversityHaikouHainan571158 China Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province Hainan Vocational University of Science and TechnologyHaikouHainan571126 China

Fifteen new meroterpenoids, littoreanoids A—O (1—15), including three rearranged skeleton meroterpenoids (1—3), were isolated from the mangrove-derived fungus Penicillium sp. HLLG-122. Compound 1 was a novel berkeleyacetal-derived meroterpenoid featuring an unusual spirocyclic 2-oxaspiro[5.5]undeca-4,7-dien-3-one moiety. Compound 2 possessed an unusual 6/6/6/6/6 pentacyclic system with a novel 1-hydroxy-7,7-dimethyl-2-oxabicyclo[2.2.2]octan-5-yl acetate moiety. Compound 3 was an unusual 6/7/6/5/6/5/4 polycyclic systems containing a β-lactone ring. The structures and absolute configurations of new compounds were elucidated by HRESIMS, NMR spectroscopy, single crystal X-ray diffraction analysis, and electronic circular dichroism calculations. The plausible biosynthetic pathways of 1—3 were also proposed. Compounds 6 and 11 exhibited anti-inflammatory effects with IC_(50) values of 30.41 and 19.02 μmol/L, respectively. The bioactive compound 11 was selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments. Compound 11 could suppress the levels of TNF-α and IL-6, and down-regulate the protein expression of iNOS and COX-2 in RAW 264.7 cells.

关键词： Penicillium sp Terpenoids Structural elucidation Anti-inflammatory activities Conformation analysis Natural products

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Pretreatment levels of circulating endothelial cells on efficacy of first-line therapy in patients with advanced non-small cell lung cancer

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TMR Cancer 2020年第4期3卷 137-143页

作者： Yu-Hua Cao yan-ru lv yan-Rong Hao Xiao-Yun Mo Guo-Sheng Feng Lu Huang Xiao-Dan Chen Shan Gao Shui Lu People's Hospital of Guangxi Zhuang Autonomous Region clinical cancer centerchemotherapy No.1 departmentNanning 530021China People's Hospital of Guangxi Zhuang Autonomous Region Scientific research departmentNanning 530021China

Background:Elevated levels of circulating endothelial cells might reflect significant vascular damage and *** studies have shown that circulating endothelial cells levels are related to therapeutic responses of tumors,and thus,could be used as an indicator to predict the efficacy of tumor *** purpose of this study was to investigate the correlation and impact of endothelial cells with and on the efficacy of first-line therapy(platinum-based or tyrosine kinase inhibitor drugs treatments)for advanced non-small-cell lung ***:We analyzed 45 inpatients who met the inclusion criteria of diagnosis with inoperable non-small-cell lung cancer stages III and IV,in the People’s Hospital of Guangxi Zhuang Autonomous Region from January 2019 to January *** flow cytometry technique was adopted to detect pretreatment levels of circulating endothelial cells in peripheral blood of patients with advanced non-small-cell lung *** pretreatment peripheral blood was collected to analyze the relations of circulating endothelial cells with different clinical characteristics and ***:The level of pretreatment circulating endothelial cells was significantly correlated with the efficacy of treatment(Prum carcinoembryonic antigen(P>0.05).The comparison between the groups of response(complete response+partial response)and nonresponse(stable disease+progressive disease)showed a significant difference in circulating endothelial cells *** with low levels of circulating endothelial cells,a high level of circulating endothelial cells led to a poor efficacy(P<0.05).Conclusion:The level of pretreatment circulating endothelial cells significantly correlated with the efficiency of first-line therapy for non-small-cell lung *** with low level of circulating endothelial cells,high level of circulating endothelial cells

关键词： Circulating endothelial cells Non-small-cell lung cancer First-line therapy Efficacy

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需求导向的高职课程改革探索

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山东商业职业技术学院学报 2011年第6期11卷 63-66页

作者：杨彦如吕倩娜北京电子科技职业学院北京100029

高职课程是高等职业教育的灵魂和载体,是实现实用性人才和良好公民培养的桥梁。高职课程改革不仅要满足社会需求,而且要满足人的发展需求。课程应该因需而设,体现行业和岗位群需求,突出实践课程,注重基础课程和专业课程的融合,重视项目... 详细信息

高职课程是高等职业教育的灵魂和载体,是实现实用性人才和良好公民培养的桥梁。高职课程改革不仅要满足社会需求,而且要满足人的发展需求。课程应该因需而设,体现行业和岗位群需求,突出实践课程,注重基础课程和专业课程的融合,重视项目教学;要体现人文关怀,重视隐性课程和选修课的开展,充分利用多媒体等,重视学生个性的培养。课程设置和实施的改革必然带来评价的变革,教师素质要求的提高等。

关键词：高职课程改革社会需求人的需求

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多模态互动法在初中英语阅读教学中的应用

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英语教师 2025年第1期 91-94页

作者：吕妍江苏省苏州工业园区星汇学校江苏苏州215000

介绍多模态互动法。阐述多模态互动法在初中英语阅读教学中的应用意义,即让学生“悦”读、“会”读。结合教学实例,分析多模态互动法在初中英语阅读教学中的应用流程,即读前以图像、句子等呈现单词、短语的含义,读中以多种媒介助力学生... 详细信息

介绍多模态互动法。阐述多模态互动法在初中英语阅读教学中的应用意义,即让学生“悦”读、“会”读。结合教学实例,分析多模态互动法在初中英语阅读教学中的应用流程,即读前以图像、句子等呈现单词、短语的含义,读中以多种媒介助力学生深度阅读,读后以多模态互动助力学生迁移阅读成果。实践证明,在初中英语阅读教学中应用多模态互动法,不仅能提升学生的深度阅读能力,还能培养学生的英语学科核心素养。

关键词：初中英语多模态互动法阅读教学

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浮游藻类物候遥感监测研究进展

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湖泊科学 2025年第1期37卷 1-13页

作者：严照江房冲宋开山王翔宇吕云峰中国科学院东北地理与农业生态研究所长春130102 长春师范大学地理科学学院长春130032

浮游藻类广泛分布于海洋和内陆水体生态系统中,其生长和发育过程具有明显的时空异质性,对气候变化的响应也极为复杂。藻类物候描述了其在长期适应气候、水质和人类干预等因素下的周期性变化,从而形成一种与环境条件相适应的生长发育节... 详细信息

浮游藻类广泛分布于海洋和内陆水体生态系统中,其生长和发育过程具有明显的时空异质性,对气候变化的响应也极为复杂。藻类物候描述了其在长期适应气候、水质和人类干预等因素下的周期性变化,从而形成一种与环境条件相适应的生长发育节律。它主要包括藻类的出现时间、增长高峰以及减少或消亡的时间等特征。遥感技术通过高时空分辨率持续获取叶绿素a浓度数据(浮游藻类生物量的表征参数),实现对藻类物候的长期监测。本文详细地回顾了近年来遥感藻类物候监测和提取方法的进展,指出目前存在的问题与不足,并对未来的发展趋势进行展望。首先,回顾了现有卫星遥感提供大范围时空连续的藻类生长信息。其次,总结了浮游藻类物候阶段的监测,以及估计藻类特定物候阶段的方法。同时,介绍了用于遥感时间序列估算藻类物候的常用数据处理方法,探讨了浮游藻类物候特性的变化趋势。最后,探索了可能影响藻类物候变化的因素和驱动机制。基于以上分析,本文指出未来藻类物候遥感的研究应重点关注:(1)开发并验证适用于不同水域环境的通用算法,结合机器学习等智能算法改进物候模型,提高物候监测精度和算法的业务化应用水平;(2)结合数值模型和生态系统动态模型,深入研究浮游藻类物候背后的驱动机制。

关键词：藻类物候叶绿素a 海洋和内陆水体

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Application of neutrophil-lymphocyte ratio and red blood cell distribution width in diabetes mellitus complicated with heart failure

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World Journal of Diabetes 2024年第6期15卷 1226-1233页

作者： Jie Pang Lin-yan Qian Ping lv Xiao-ru Che Heart Center Department of Cardiovascular MedicineZhejiang Provincial People’s Hospital(The Affiliated People’s Hospital)Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Accumulating clinical evidence has shown that diabetes mellitus(DM)is a serious risk factor for cardiovascular disorders and an important factor for adverse cardiovascular *** To explore the value of the combined determination of the neutrophil-lymphocyte ratio(NLR)and red blood cell distribution width(RDW)in the early diagnosis and prognosis evaluation of DM complicated with heart failure(HF).METHODS We retrospectively analyzed clinical data on 65 patients with type 2 DM(T2DM)complicated with HF(research group,Res)and 60 concurrent patients with uncomplicated T2DM(control group,Con)diagnosed at Zhejiang Provincial People’s Hospital between January 2019 and December *** NLR and RDW values were determined and comparatively analyzed,and their levels in T2DM+HF patients with different cardiac function grades were *** receiver operating characteristic(ROC)curves were plotted to determine the NLR and RDW values(alone and in combination)for the early diagnosis of *** correlation between NLR and RDW with the presence or absence of cardiac events was also *** Higher NLR and RDW levels were identified in the Res vs the Con groups(P<0.05).The NLR and RDW increased gradually and synchronously with the deterioration of cardiac function in the Res group,with marked differences in their levels among patients with grade II,III,and IV HF(P<0.05).ROC curve analysis revealed that NLR combined with RDW detection had an area under the curve of 0.915,a sensitivity of 76.9%,and a specificity of 100%for the early diagnosis of ***,HF patients with cardiac events showed higher NLR and RDW values compared with HF patients without cardiac *** NLR and RDW were useful laboratory indicators for the early diagnosis of DM complicated with HF,and their joint detection was beneficial for improving diagnostic ***,NLR and RDW values were directly proportional to patient outcomes.

关键词： Neutrophil-lymphocyte ratio Red blood cell distribution width Type 2 diabetes Heart failure Early diagnosis

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Dynamic modeling and damage analysis of debris cloud fragments produced by hypervelocity impacts viaimage processing

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Frontiers of Information Technology & Electronic Engineering 2022年第4期23卷 555-570页

作者： ru ZENG yan SONG Weizhen lv Department of Control Science and Engineering University of Shanghai for Science and TechnologyShanghai200093China

It is always a challenging task to model the trajectory and make an efficient damage estimation of debris clouds produced by hypervelocity impact(HVI)on thin-plates due to the difficulty in obtaining high-quality fragment images from *** improve the damage estimation accuracy of HVIs on a typical double-plate Whipple shield configuration,we investigate the distributive characteristic of debris clouds in successive shadowgraphs using image processing techniques and traditional numerical *** aim is to extract the target movement parameters of a debris cloud from the acquired shadowgraphs using image processing techniques and construct a trajectory model to estimate the damage with desirable *** HVI experiments,eight successive frames of fragment shadowgraphs are derived from a hypervelocity sequence laser shadowgraph imager,and four representative frames are selected to facilitate the subsequent feature ***,using image processing techniques,such as denoising and segmentation techniques,special fragment features are extracted from successive *** on the extracted information,image matching of debris is conducted and the trajectory of debris clouds is modeled according to the matched debris.A comparison of the results obtained using our method and traditional numerical methods shows that the method of obtaining hypervelocity impact experimental data through image processing will provide critical information for improving numerical ***,an improved estimation of damage to the rear wall is presented based on the constructed *** proposed model is validated by comparing the estimated damage to the actual damage to the rear wall.

关键词： Debris clouds Hypervelocity impact Image processing Damage estimation

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Existence of Positive Periodic Solutions for Nonautonomous Predator-prey Systems with Discrete and Continuously Distributed Delays

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Acta Mathematicae Applicatae Sinica 2007年第1期23卷 39-48页

作者： yan lv Wei lv Jian-hua Sun Department of Mathematics Nanjing University Nanjing 210008 China Department of Mathematics Xi'an Jiao Tong University Xi'an 710049 China

By using the continuation theorem of coincidence degree theory, the sufficient conditions to guarantee the existence of positive periodic solutions are established for nonautonomous predator-prey systems with discrete... 详细信息

关键词： Predator-prey system time delay positive periodic solution Fredholm operator coincidence degree

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Control of chiral-optical activities by magnetic field based on the transformation of achiral binary crystals into chiral ternary crystals

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Science China Chemistry 2024年第7期67卷 2300-2305页

作者： Zhiyan Chen yan lv Wei Qin College of Physics Qingdao UniversityQingdao 266071China School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shandong Linuo Photovoltaic Hi-Tech Co. Ltd.Jinan 250100China

Multicomponent self-assembled chiral systems have attracted great attention due to their promising application in the area of spin-photonics and *** this work,through introducing an achiral third component into an achiral binary crystal,a chiral organic ternary crystal is fabricated,where both pronounced chiral-optical coupling and magnetic field dependence of chiral-optical activities are *** transformation of achiral structure into chiral structure generates a significant effect on the polarized state of light and the electron spin resonance ***,the coupling between circularly polarized photon and spin is observed in chiral ternary crystal with pronounced chiral orbit,where obvious magnetic field-transmissivity loop is ***,temperature could increase the magnitude of lattice parameters to lead to a larger helix radius to increase the chiral orbit ***,this work indicates that the further exploration of photon-chiral orbit-spin interactions in organic chiral ternary crystals is promising.

关键词： organic chiral ternary crystals chiral orbit chiral-optical activities magnetic field

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Structure-aware fusion network for 3D scene understanding

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Chinese Journal of Aeronautics 2022年第5期35卷 194-203页

作者： Haibin yan Yating lv Venice Erin LIONG School of Automation Beijing University of Posts and TelecommunicationsBeijing 100876China Interdisciplinary Graduate School Nanyang Technological UniversitySingapore 639798Singapore

In this paper,we propose a Structure-Aware Fusion Network(SAFNet)for 3D scene *** 2D images present more detailed information while 3D point clouds convey more geometric information,fusing the two complementary data can improve the discriminative ability of the *** is a very challenging task since 2D and 3D data are essentially different and show different *** existing methods first extract 2D multi-view image features and then aggregate them into sparse 3D point clouds and achieve superior ***,the existing methods ignore the structural relations between pixels and point clouds and directly fuse the two modals of data without *** address this,we propose a structural deep metric learning method on pixels and points to explore the relations and further utilize them to adaptively map the images and point clouds into a common canonical space for *** experiments on the widely used ScanNetV2 and S3DIS datasets verify the performance of the proposed SAFNet.

关键词： 3D point clouds Data fusion Structure-aware 3D scene understanding Deep metric learning

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