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Probing granular inhomogeneity of a particle-emitting source by imaging two-pion Bose–Einstein correlations

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Nuclear Science and Techniques 2021年第2期32卷 81-89页

作者： Li-Ya Li Peng ru Ying hu School of Mathematics and Economics Hubei University of EducationWuhan 430205HubeiChina Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China

Using the source imaging technique in two-pion interferometry,we study the image of the hydrodynamic particle-emitting source with the HIJING initial conditions for relativistic heavy-ion collisions on an event-by-event *** is shown that the initial-state fluctuations may give rise to bumpy structures of the medium during hydrodynamical evolution,which affects the two-pion emission space and leads to a visible two-tiered shape in the source function imaged using the two-pion Bose–Einstein *** two-tiered shape can be understood within a similar but more analytic granular source model and is found to be closely related to the introduced quantity n,which characterizes the granular inhomogeneity of the *** fitting the imaged source function with a granular source parametrization,we extract the granular inhomogeneity of the hydrodynamic source,which is found to be sensitive to both the Gaussian smearing width of the HIJING initial condition and the centrality of the collisions.

关键词： Heavy-ion collision Bose-Einstein correlations Imaging technique

Memristive dynamics enabled neuromorphic computing systems

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Science China(Information Sciences) 2023年第10期66卷 5-19页

作者： Bonan yan Yuchao yanG ru huANG Center for Brain Inspired Chips Institute for Artificial Intelligence Peking University Beijing Advanced Innovation Center for Integrated Circuits School of Integrated Circuits Peking University School of Electronic and Computer Engineering Peking University Center for Brain Inspired Intelligence Chinese Institute for Brain Research(CIBR)

The slowing down of transistor scaling and explosive growth for intelligence computing power emerge as the two driving factors for the study of novel devices and materials to pursue highly-efficient computing systems. Memristors, incorporating rich intrinsic dynamics, are a promising candidate for constructing efficient and scalable bio-inspired computing systems. In this progress report, we review the latest advances in novel types of memristors as well as their applications in implementing neuromorphic computing systems. This paper not only covers the memristive dynamics-enabled bionic computing systems but also discusses the memristive sensory systems that integrate sensing and computing. Eventually, device-circuit co-optimization methods are given to emphasize the trend of cross-layer co-design in this fast-evolving *** innovation in memristor devices mainly focuses on specialized computing hardware and yields superior computing and sensing efficiency. At last, we offer our insight into the trend of state-of-the-art research in memristive materials, devices, circuits, and systems.

关键词： memrsitor memristive dynamics artificial synapse artificial neuron neuromorphic computing

Design and Aerodynamic Analysis of Dragonfly-like Flapping Wing Micro Air Vehicle

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Journal of Bionic Engineering 2022年第2期19卷 343-354页

作者： yanjuan hu Weiwei ru Qiang Liu Zhanli Wang School of Mechatronic Engineering Changchun University of TechnologyChangchun 130012China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun 130022China

Dragonflies have naturally high flying ability and flight maneuverability,making them more adaptable to harsh ecological *** this paper,a flapping wing bionic air vehicle with three-degrees-of-freedom is designed and manufactured by simulating the flight mode of ***,the body structure of dragonfly was analyzed,and then the design scheme of flapping wing micro air vehicle was proposed based on the flight motion characteristics and musculoskeletal system of *** optimizing the configuration and using Adams to do kinematic simulation,it is shown that the designed structure can make the wings move in an“8”shape trajectory,and the motion in three directions can maintain good consistency,with good dynamic *** on CFD simulation method,we analyzed that the wing has the conditions to achieve flight with good aerodynamic performance at the incoming flow speed of 5 m s^(-1)and frequency of 4 Hz,and studied the effects of angle of attack and flutter frequency on the aerodynamic performance of the ***,the force measurement test of the aircraft prototype is carried out using a force balance and a small wind *** test results show that the prototype can provide the average lift of 3.62 N and the average thrust of 2.54 N,which are in good agreement with the simulation results.

关键词： Dragonfy Flapping wing micro air vehicle Three-degrees-of-freedom Aerodynamic performance

Limits on sequential sharing of nonlocal advantage of quantum coherence

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 26-35页

作者： Ming-Liang hu Jia-ru Wang Heng Fan School of Science Xi’an University of Posts and TelecommunicationsXi’an 710121China Institute of Physics Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

Sequential sharing of nonlocal correlation is inherently related to its *** address the question as to how many observers can share the nonlocal advantage of quantum coherence(NAQC)in a(d×d)-dimensional state,where d is a prime or a power of a *** first analyze the trade-off between disturbance and information gain of the general d-dimensional unsharp *** in a scenario where multiple Alices perform unsharp measurements on one party of the state sequentially and independently and a single Bob measures coherence of the conditional states on the other party,we show that at most one Alice can demonstrate NAQC with *** limit holds even when considering the weak measurements with optimal pointer *** results may shed light on the interplay between nonlocal correlations and quantum measurements on high-dimensional systems and the hierarchy of different quantum correlations.

关键词： quantum coherence quantum correlation unsharp measurement

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内皮细胞特异性骨形态发生蛋白2对血管新生的影响:生物信息学分析和实验验证

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中国组织工程研究 2025年第1期29卷 103-110页

作者：燕茹王凯茹张飞燕贾绍斌丛广志宁夏医科大学总医院心内科宁夏回族自治区银川市750004 宁夏医科大学总医院医学研究院宁夏回族自治区银川市750004 宁夏医科大学总医院心血管病研究所宁夏回族自治区银川市750004

背景:血管新生是心血管疾病的主要干预靶点,骨形态发生蛋白2具有调控血管新生作用,但内皮细胞特异性骨形态发生蛋白2对血管新生的调控作用不清楚。目的:探讨内皮细胞特异性骨形态发生蛋白2对血管新生的影响。方法:(1)生物信息学分析:通... 详细信息

背景:血管新生是心血管疾病的主要干预靶点,骨形态发生蛋白2具有调控血管新生作用,但内皮细胞特异性骨形态发生蛋白2对血管新生的调控作用不清楚。目的:探讨内皮细胞特异性骨形态发生蛋白2对血管新生的影响。方法:(1)生物信息学分析:通过Panglao DB公共基因表达数据库单细胞转录组荟萃分析观察骨形态发生蛋白2细胞群表达丰度和定位。血管新生小鼠和内皮(心内膜)过表达骨形态发生蛋白2小鼠转录组测序数据集探索内皮细胞骨形态发生蛋白2对血管新生信号通路的调控作用。(2)体内实验验证:建立小鼠后肢缺血模型,对比模型小鼠患侧与健侧缺血后肢7,14和21 d血流灌注情况,免疫荧光和免疫组织化学染色评估小鼠骨形态发生蛋白2和CD31的表达定位情况。(3)体外实验验证:体外培养人脐静脉内皮细胞,分为对照组、缺氧组和骨形态发生蛋白2抑制剂(Noggin蛋白)干预组,培养24 h,观察各组内皮细胞血管新生情况。结果与结论:(1)内皮细胞是表达骨形态发生蛋白2的重要细胞亚群,在血管新生内皮细胞和骨形态发生蛋白2过表达内皮细胞转录组再分析均发现骨形态发生蛋白2表达明显升高,血管新生通路明显激活。(2)缺血7 d小鼠新生血管周围骨形态发生蛋白2阳性血管明显增加(P<0.05),缺血2周骨形态发生蛋白2阳性血管明显减少(P<0.001)。(3)体外培养人脐静脉内皮细胞,缺氧干预后,内皮细胞迁移能力和血管出芽明显增加,血管新生因子血管内皮生长因子和血小板衍生生长因子的表达明显升高,Noggin明显减少了缺氧诱导的内皮细胞血管新生(P<0.001),并下调血管内皮生长因子和血小板衍生生长因子的表达(P<0.01)。(4)结果证实,内皮细胞特异性骨形态发生蛋白2具有调控血管新生作用,靶向性内皮细胞骨形态发生蛋白2可望改善血管新生。

关键词：内皮细胞骨形态发生蛋白2 血管新生单细胞RNA测序批量RNA测序信号通路后肢缺血模型成管实验

Alloy anodes for sodium-ion batteries

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Rare Metals 2021年第2期40卷 272-289页

作者： Shu-Min Zheng yan-ru Tian Ya-Xia Liu Shuang Wang Chao-Quan hu Bao Wang Kai-Ming Wang State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Nanjing IPE(Institute of Process Engineering)Institute of Green Manufacturing Industry Nanjing211135China School of Fashion Beijing Institute of Fashion TechnologyBeijing100029China School of Science University of Science and Technology LiaoningAnshan114051China

Sodium-ion batteries(SIBs)have emerged as one of the most promising candidates for next-generation energy storage systems because sodium is abundant in *** practical application of SIBs critically depends on developing robust electrode materials with high specific capacity and long cycling life,developing suitable anode materials is even more ***-type anodes are attractive for their high gravimetric and volumetric specific capacities,demonstrating great potential for high-energy SIBs,however,huge volume swelling hampered their practical *** the encouraging breakthroughs on alloy anodes for SIBs,herein,we present a review of the up-to-date progress and works carried out with alloy-based anode materials for *** review the synthetic strategies and their detailed electrochemical *** particular,we extensively reveal the important roles of alloy-based anodes in the development of *** progress of alloy-type anodes and their compounds for sodium storage is *** efforts to enhance the electrochemical performance of the alloy-based anode materials are ***,we proposed multi-component alloys/high-entropy alloys(HEAs)as further research directions for alloy-based anodes.

关键词： Alloy-based anodes High-entropy alloy Multi-component alloy Sodium-ion battery

Adipose-derived stem cell therapy shows promising results for secondary lymphedema

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World Journal of Stem Cells 2020年第7期12卷 612-620页

作者： Li-ru hu Jian Pan State Key Laboratory of Oral Diseases West China College of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina

Lymphedema is mainly identified by progressive soft tissue swelling in impaired lymphatic *** lymphedema attributed to cancer therapy,parasite infection,and trauma remains a serious global *** with lymphedema suffer swelling,pain,and fatigue,with the dysfunction of the deformed extremities reducing the quality of life and increasing the risk of infection and ***-derived stem cells(ADSCs)possess prominent regenerative potential to differentiate into multilineage cells,and produce various lymphangiogenic factors,making ADSC therapy a promising approach for *** development of lymphedema consists of local inflammation,the fibrosis of lymphatic vessels,and the deposition of adipose *** animal models do not mimic the chronic inflammation environment,therefore suitable models are required in further *** signal pathways and molecular mechanisms in physiological and pathological lymphagiogenesis remain *** previous animal and human trials,ADSC therapy reduced edema in varying degrees.A larger number of trials with larger samples and longer follow-up periods are required to verify the efficiency and feasibility of ADSC *** are of easy availability and immune exemption,making them a candidate for lymphedema *** ADSCs enhance malignant characteristics or trigger the malignant change deserves further exploration and study before ADSC therapy can be made widely available.

关键词： Secondary lymphedema Adipose-derived stem cells Lymphangiogenesis Stem cells Cell therapy Lymphatic regeneration

C反应蛋白/白蛋白比值对2型糖尿病合并急性心肌梗死患者远期不良心脑血管事件的预测价值研究

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中国全科医学 2025年第6期28卷 705-712页

作者：马娟马盛宗燕茹马学平贾绍斌宁夏医科大学总医院心血管内科宁夏回族自治区银川市750000 宁夏回族自治区人民医院妇产科宁夏回族自治区银川市750000

背景急性心肌梗死(AMI)是威胁全球公众健康的主要原因之一。虽然已有相应的再灌注治疗策略,但AMI相关的主要不良心脑血管事件(MACCEs)仍然是全世界人口死亡的原因之一。尤其合并糖尿病的AMI患者,因冠状动脉病变复杂,病变程度严重,尽早... 详细信息

背景急性心肌梗死(AMI)是威胁全球公众健康的主要原因之一。虽然已有相应的再灌注治疗策略,但AMI相关的主要不良心脑血管事件(MACCEs)仍然是全世界人口死亡的原因之一。尤其合并糖尿病的AMI患者,因冠状动脉病变复杂,病变程度严重,尽早发现和判断该部分患者远期预后相对困难,因此寻找相对简便、易获得的实验室指标,有利于为2型糖尿病(T2DM)合并AMI患者经皮冠状动脉介入(PCI)术后MACCEs的预测提供依据。目的探讨血清C反应蛋白(CRP)/白蛋白(Alb)比值(CAR)对T2DM合并AMI患者PCI术后远期MACCEs的预测价值。方法纳入2014—2019年就诊于宁夏医科大学总医院心血管内科1683例T2DM合并AMI患者为研究对象,收集患者的一般临床资料与检查结果。对所有患者进行电话或门诊随访,以全因死亡、非致死性心肌梗死、再发不稳定型心绞痛、非致死性脑卒中、新发心力衰竭或心力衰竭加重再入院、再次血运重建作为MACCEs。根据患者随访期间是否发生MACCEs分为MACCEs组(508例)和非MACCEs组(1175例)。采用单因素及多因素Logistic回归分析探讨T2DM合并AMI患者MACCEs事件的影响因素。采用Kaplan-Meier法绘制患者的生存曲线,生存曲线的比较采用Log-rank检验。采用受试者工作特征(ROC)曲线分析CAR对T2DM合并AMI患者远期发生MACCEs的预测效能,使用净重分类改善指标(NRI)和综合判别指数(IDI)评价CAR对T2DM合并AMI患者预后评估的改善效果。结果1683例患者中508例(30.18%)患者发生MACCEs。多因素Logistic回归分析显示高血压病[OR(95%CI)=1.994(1.142~3.483)]、冠状动脉植入支架长度[OR(95%CI)=1.031(1.002~1.062)]、CRP[OR(95%CI)=0.950(0.915~0.986)]、Alb[OR(95%CI)=0.933(0.880~0.989)]及CAR[OR(95%CI)=5.582(1.705~18.277)]是T2DM合并AMI患者PCI术后发生MACCEs的影响因素(P<0.05)。根据CAR中位表达水平(0.86),将患者分为CAR<0.86组和CAR≥0.86组,Log-rank检验结果显示,CAR≥0.86组MACCEs发生率高于CAR<0.86组(52.68%与22.92%;χ^(2)=65.65,P<0.001)。ROC曲线显示CAR预测T2DM合并AMI患者发生MACCEs的ROC曲线下面积为0.728(95%CI=0.702~0.754),最佳截断值为0.576,灵敏度为0.617,特异度为0.747。在基线模型基础上,与CRP、Alb相比,CAR能明显改善对患者发生MACCEs的预测效果(NRI=0.377,IDI=0.166,C指数=0.690;P<0.05)。结论CAR是T2DM合并AMI患者PCI术后远期MACCEs发生风险的有效预测指标。

关键词：心肌梗死糖尿病,2型主要不良心脑血管事件 C反应蛋白白蛋白预测

Effect of etanercept on refractory systemic-onset juvenile idiopathic arthritis

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World Journal of Pediatrics 2016年第1期12卷 96-102页

作者： Xiao hu Fang Yuan Jian Zhang Lei Yin Bi-ru Li yan-Liang Jin Department of Rheumatology Shanghai Children's Medical CenterShanghai Jiaotong UniversitySchool of MedicineShanghaiChina

Background:Treatment of systemic-onset juvenile idiopathic arthritis(So-JIA)is challenging,and the effi cacy of injectable recombinant human tumor necrosis factor type 1 receptor-antibody fusion protein(etanercept)on So-JIA has been ***:We retrospectively studied 12 patients with refractory systemic juvenile arthritis treated with etanercept at our hospital in the past 5 *** 12 patients were divided into a corticosteroid-dependent group(n=7)and an ineffective group(n=5)on the basis of their responses to treatment before the administration of *** was added to the treatment without substantially changing the original regimens in general,and doses,and signs of efficacy including alleviation or resolution of symptoms such as high fever,infl ammatory arthropathy,eruption rash,hydrohymenitis,as well as changes in the levels of laboratory infl ammatory markers such as the white blood cell count,erythrocyte sedimentation rate,levels of C-reactive protein and serum ferritin were ***:Etanercept was withdrawn after the first dose from one patient in the corticosteroid-dependent group because of a systemic allergic rash,and was also withdrawn from one patient in the ineffective group after 2 months of treatment owing to ineffi cacy;the remaining 10 patients completed the entire treatment protocol,at which point etanercept was *** that time,clinical symptoms and laboratory infl ammatory markers of the remaining patients were within the normal range and the mean dose of prednisone was 0.18 mg/kg per day,an 81%decrease from the mean dose at *** present,the corticosteroid has been discontinued and only methotrexate maintenance treatment is used in 3 patients;the other 7 patients are treated with prednisone and methotrexate maintenance *** of the 10 patients are in a medicated remission with no ***:In the treatment of patients with refractory So-JIA,the principles of individual ther

关键词： etanercept juvenile idiopathic arthritis systemic-onset therapy