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Rare Metals 2022年第4期41卷 1202-1209页

作者： Yao-Min Li Li-hui Meng yan-ru hu Tian-Tian Zhang Zheng-Nan Su Zhi-Yuan Ouyang Wen-Chao Li Jiang-Ling Wan Qing-Zhi Wu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing and Biomedical Materials and Engineering CentreWuhan University of TechnologyWuhan 430070China National Engineering Research Centre for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China

FePt nanoparticles(NPs)have attracted a great deal of attention in biomedical applications due to their excellent superparamagnetic property and anticancer activity,which display promising potential as the MRI/CT contrast imag-ing agent for cancer detection and *** this study,the suppression mechanism induced by FePt NPs on U251 cells is *** U251 cells are co-cultured with FePt NPs at different concentrations,and the intra-cellular oxidative stress was studied by detecting the activities of various redox enzymes and expression of several apoptosis-related *** cell viability assay shows that the highest suppression on the proliferation of glioma U251 cells is 10.5%±5.6%after treatment with 5μg·ml^(-1)FePt NPs for 24 *** this case,the LDH release remarkably *** cytometry and fluorescence assay show that FePt NPs promote the apoptosis and G0/G1 phase arrest of U251 cells.

关键词： nanoparticles U251 stress

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MSCT在空腔脏器穿孔定位中的价值

中国医学影像技术 2010年第6期26卷 1126-1128页

作者：阎玉明张兰慧闫如虎安徽中医学院第一附属医院影像中心安徽合肥230031

目的探讨MSCT在空腔脏器穿孔定位诊断中的价值。方法回顾性分析17例空腔脏器穿孔患者的临床资料。结果 17例患者中,胃、十二指肠穿孔11例,空、回肠穿孔2例,结肠穿孔3例,子宫穿孔1例。CT表现为腹腔内游离气体、腹腔积液、穿孔部位周围脂... 详细信息

目的探讨MSCT在空腔脏器穿孔定位诊断中的价值。方法回顾性分析17例空腔脏器穿孔患者的临床资料。结果 17例患者中,胃、十二指肠穿孔11例,空、回肠穿孔2例,结肠穿孔3例,子宫穿孔1例。CT表现为腹腔内游离气体、腹腔积液、穿孔部位周围脂肪间隙模糊及原发病变的征象。结论 MSCT扫描对确定空腔脏器穿孔、判断穿孔部位有重要的临床价值。

关键词：空腔脏器穿孔气腹体层摄影术,X线计算机

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-ru He Fei Ding Hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi Ji Chaoyi yang Xuerui Pang Yibing yan Yue Wu Zhi Geng Wenjie hu Panpan hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao hu Dong-Yi yan Ke-hui Zhang Di Zhang Xi-Mao Cui Xiao-hua Jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi hu rui Wang Hanyue Zhang Xiou Wang Sijia Zhou Bo Ma yan Luan Xin Wang Xinlin Chen Zhichao Zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

基于Au纳米颗粒/还原氧化石墨烯C-反应蛋白免疫传感器的研制

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分析测试学报 2017年第3期36卷 349-354页

作者：张茜夏介仁李德蕾张坤蕾白茹燕胡蓉杨云慧云南师范大学化学化工学院云南昆明650500

采用还原氧化石墨烯-金纳米颗粒(RGO-Au NPs)作为免疫传感器的固定基质,将C-反应蛋白(CRP)抗体固定在玻碳电极表面,用蒽醌二羧酸作为标记物,制成夹心型的CRP免疫传感器。在最优实验条件下,通过示差脉冲伏安法对CRP的含量进行检测。该传... 详细信息

采用还原氧化石墨烯-金纳米颗粒(RGO-Au NPs)作为免疫传感器的固定基质,将C-反应蛋白(CRP)抗体固定在玻碳电极表面,用蒽醌二羧酸作为标记物,制成夹心型的CRP免疫传感器。在最优实验条件下,通过示差脉冲伏安法对CRP的含量进行检测。该传感器在0.25~100 ng/m L范围内具有良好的线性关系,检出限为0.08 ng/m L,线性系数为0.997。该传感器为C-反应蛋白的检测提供了一种新的手段。

关键词：夹心型免疫传感器 C-反应蛋白(CRP) 还原氧化石墨烯电化学

聚桂醇泡沫硬化剂治疗下肢静脉曲张中两种不同注射途径的比较研究

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介入放射学杂志 2014年第5期23卷 392-396页

作者：张万高闫如虎纵慧敏王前程陈大庆徐允鹏安徽中医药大学第一附属医院介入中心合肥230031

目的比较两种不同途径注射1％聚桂醇泡沫剂治疗大隐静脉曲张的临床效果。方法2010年12月-2012年12月收治诊断明确的下肢静脉曲张患者80例，随机分为X线透视下直接穿刺曲张静脉远心端注射1％聚桂醇泡沫剂（顺行组，40例）及经近心端穿刺... 详细信息

目的比较两种不同途径注射1％聚桂醇泡沫剂治疗大隐静脉曲张的临床效果。方法2010年12月-2012年12月收治诊断明确的下肢静脉曲张患者80例，随机分为X线透视下直接穿刺曲张静脉远心端注射1％聚桂醇泡沫剂（顺行组，40例）及经近心端穿刺置管注入1％聚桂醇泡沫剂（逆行组，40例）两组。记录两组患者的手术时间、术后恢复时间、硬化剂用量、治疗并发症、是否补充治疗及随访结果。结果两组治疗后3～6个月的临床总体疗效差异无统计学意义（P〉0．05）；顺行组治疗前临床-病因-解剖-病理分级（CEAP）分数为3．70±0．63，治疗后为0．88±1．18：逆行组治疗前CEAP分数为3．73±0．59，治疗后为0．88±1．27，两组治疗前后比较差异均有统计学意义（P〈0．05），但组间比较差异无统计学意义（P〉0．05）；但在手术时间、术后恢复时间、硬化剂用量、需要补充治疗人次等方面差异有统计学意义。结论采用X线透视引导下顺行和逆行两种方法注射聚桂醇泡沫硬化剂治疗下肢静脉曲张总体疗效相当，各有优缺点，应根据不同患者情况采取个体化治疗方案。

关键词：静脉曲张聚桂醇泡沫硬化治疗 X线透视引导

Effects of Ti_(0.5)Al_(0.5)N coatings on the protecting against oxidation for titanium alloys

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Rare Metals 2010年第2期29卷 154-161页

作者： ru Qiang hu Shejun Laboratory of Quantum Information Technology School of Physics and Telecommunication Engineering South China Normal University Guangzhou 510006 China Department of Mathematics and Physics Wuyi University Jiangmen 529020 China

Ti0.5Al0.5N coatings were deposited on TC11（Ti-6.5Al-3.5Mo-1.5Zr-0.3Si） and silicon substrates using a cathode arc ion-plating *** microstructure, composition, phase structure, and oxidation-resistance of the alloys and nitride coatings were investigated by scanning electron microscopy, X-ray diffraction, transmission electron microscopy, Auger electron spectroscopy, and thermal *** results show that the oxidation resistance of the titanium alloy is relatively limited;the compound structures of Ti mixed with Al oxides are formed during the heating *** phases of the Ti0.5Al0.5N coatings are composed of a TiN solid solution *** oxidation kinetics obeys the parabolic *** the oxidation process, the selective oxidation of Al occurs, thus protecting the underlying coating and substrate.

关键词： titanium alloy TiAlN oxidation resistance ion plating

Effect of vegetation on soil bacteria and their potential functions for ecological restoration in the hulun Buir Sandy Land,China

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Journal of Arid Land 2020年第3期12卷 473-494页

作者： yan ru FENG Wei yanchi Research Station School of Soil and Water ConservationBeijing Forestry UniversityBeijing 100083China Engineering Research Center of Forestry Ecological Engineering of the Ministry of Education Beijing Forestry UniversityBeijing 100083China

To date,much of research on revegetation has focused on soil microorganisms due to their contributions in the formation of soil and soil remediation ***,little is known about the soil bacteria and their functions respond to the diverse vegetational types in the process of vegetation *** of dominated vegetation,i.e.,Artemisia halodendron Turcz Ex Bess,Caragana microphylla Lam.,Hedysarum fruticosum *** Pinus sylvestris *** bacterial community structures and their potential functions in the hulun Buir Sandy Land,China were determined using high-throughput 16S rRNA gene sequencing and phylogenetic investigation of communities by reconstruction of unobserved states(PICruSt)in *** the dominant phyla of soil bacterial community among different types of vegetation,including Proteobacteria,Actinobacteria,Acidobacteria,Bacteroidetes and Firmicutes,were similar,the relative abundance of these dominant groups significantly differed,indicating that different types of vegetation might result in variations in the composition of soil bacterial *** addition,functional genes of bacterial populations were similar among different types of vegetation,whereas its relative abundance was significantly *** carbon fixation genes showed a high relative abundance in ***,*** carbon decomposition genes in ***,suggesting the variations in carbon cycling potential of different types of *** of assimilatory nitrate reduction genes was the highest in ***,*** nitrate reduction and nitrate reductase genes in ***,indicating higher nitrogen gasification loss and lower nitrogen utilization gene functions in *** structures and functional genes of soil bacterial community showed marked sensitivities to different plant species,presenting the potentials for regulating soil carbon and nitrogen cycling.

关键词： bacterial taxonomic composition functional gene vegetational type soil carbon and nitrogen 16S rRNA