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Use of pre-, pro- and synbiotics in patients with acute pancreatitis:A meta-analysis

World Journal of Gastroenterology 2010年第31期16卷 3970-3978页

作者： Ming-Ming Zhang Ping yang Xiao-Ting Wu yan-rong lu Zhi-Hui Yi Gastroenterological Surgery Center West China Hospital Sichuan University Chengdu 610041 Sichuan Province China Key Laboratory of Transplantation Engineering and Immunology the Ministry of Health China Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

AIM: To assess the clinical outcomes of pre-, pro-and synbiotics therapy in patients with acute pancreatitis. METHODS: The databases including Medline, Embase, the Cochrane Library, Web of Science and Chinese Biomedicine Database were searched for all relevant randomized controlled trials that studied the effects of pre-, pro- or synbiotics in patients with acute pancreatitis. Main outcome measures were postoperative infections, pancreatic infections, multiple organ failure (MOF), systemic inflammatory response syndrome (SIRS), length of hospital stay, antibiotic therapy and mortality. RESULTS: Seven randomized studies with 559 acute pancreatic patients were included. Pre-, pro-or synbiot-ics treatment showed no influence on the incidence of postoperative infections [odds ratios (OR) 0.30, 95% conf idence interval (CI): 0.09-1.02, P = 0.05], pancre- atic infection (OR 0.50, 95% CI: 0.12-2.17, P = 0.36), MOF (OR 0.88, 95% CI: 0.35-2.21, P = 0.79) and SIRS (OR 0.78, 95% CI: 0.20-2.98, P = 0.71). There were also no signif icant differences in the length of antibiotic therapy (OR 0.75, 95% CI: 0.50-1.14, P = 0.18) and the mortality (OR 0.75, 95% CI: 0.25-2.24, P = 0.61). However, Pre-, pro-or synbiotics treatment was associ- ated with a reduced length of hospital stay (OR -3.87, 95% CI: -6.20 to -1.54, P = 0.001). When stratifying for the severity of acute pancreatitis, the main results were similar. CONCluSION: Pre-, pro-or synbiotics treatment shows no significant influence on patients with acute pancreatitis. There is a lack of evidence to support the use of probiotics/synbiotics in this area.

关键词： Probiotics Synbiotics Prebiotics Nutrition support Acute pancreatitis

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Growth inhibition of high-intensity focused ultrasound on hepatic cancer in vivo

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World Journal of Gastroenterology 2005年第28期11卷 4317-4320页

作者： Xiu-Jie Wang Shu-Lan Yuan yan-rong lu Jie Zhang Bo-Tao Liu Wen-Fu Zeng Yue-Ming He Yu-Rui FU Division of Experimental Oncology Key Laboratory of Biotherapy of Human Diseases of Ministry of Education PR China West China Hospital Sichuan University. Chengdu 610041. Sichuan Province. China Mianyang Electronic Equipment Factory Mianyang 621000 Sichuan ProvinceChina

AIM： To investigate the damaging effect of high-intensity focused ultrasound （HIFU） on cancer cells and the inhibitory effect on tumor growth. METHODS： Hurine H22 hepatic cancer cells were treated with HIFU at the same intensity for different lengths of time and at different intensities for the same length oftime in vitro, the dead cancer cells were determined by trypan blue staining. Two groups of cancer cells treated with HIFU at the lowest and highest intensity were inoculated into mice. Tumor masses were removed and weighed after 2 wk, tumor growth in each group was confirmed pathologically.RESULTS： The death rate of cancer cells treated with HIFU at 1 000 W/cm^2 for 0.5, 1, 2, 4, 8, and 12 s was 3.11±1.21%, 13.37±2.56%, 38.84±3.68%, 47.22±5.76%,87.55±7.32%, and 94.33±8.11%, respectively. A positive relationship between the death rates of cancer cells and the length of HIFU treatment time was found （r = 0.96,P〈0.01）. The death rate of cancer cells treated with HIFU at the intensity of 100, 200, 400, 600, 800, and 1 000 W/cm^2 for 8 s was 26.31±3.26%, 31.00±3.87%, 41.97±5.86%,72.23±8.12%, 94.90±8.67%, and 99.30±9.18%, respectively. A positive relationship between the death rates of cancer cells and the intensities of HIFU treatment was confirmed （r= 0.98, P〈0.01）. The cancer cells treated with HIFU at 1 000 W/cm^2 for 8 s were inoculated intomice ed into. The tumor inhibitory rate was 90.35% compared to the control （P〈0.01）. In the experimental group inoculated with the cancer cells treated with HIFU at 1 000 W/cm^2 for 0.5 s, the tumor inhibitory rate was 22.9% （P〈0.01）. By pathological examination, tumor growth was confirmed in 8 out of 14 mice （57.14%, 8/14） inoculated with the cancer cells treated with HIFU at 1 000 W/cm^2 for 8 s, which was significantly lower than that in the control （100%, 15/15, P〈O.05）.CONCluSION： HIFU is effective on killing or damage of H22 hepatic cancer cells in vitro and on inhibiting tumor growth in mice ex vivo.

关键词： HIFU Uver cancer Growth inhibition

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Expression of miRNA-140 in Chondrocytes and Synovial Fluid of Knee Joints in Patients with Osteoarthritis

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Chinese Medical Sciences Journal 2016年第4期31卷 207-212页

作者： Hai-bo Si Yi Zeng Zong-ke Zhou Fu-xing Pei yan-rong lu Jing-qiu Cheng Bin Shen Department of Orthopedics West China HospitalSichuan University Key Laboratory of Transplant Engineering and Immunology Regenerative Medicine Research CentreWest China HospitalSichuan University

Objective To investigate the expression of miRNA-140 in chondrocytes and synovial fluid of osteoarthritis(OA) patients, and explore the relationship between the miRNA-140 expression and OA severity. Methods This study enrolled 30 OA patients who underwent total knee arthroplasty for chondrocytes sampling and 30 OA patients who underwent intra-articular injection for synovial fluid sampling. All OA patients were grouped into mild [Kellgren and Lawrence(KL) grade 1-2], moderate(KL grade 3) and severe(KL grade 4), with 10 in each subgroups for each sampling purposes. 7 non-OA patients and 10 patients with knee injury were collected for cartilage and synovial fluid sampling respectively as control groups. Chondrocytes were isolated from the cartilage tissue and cultured in vitro. Quantitative real time PCR for miRNA-140 in chondrocytes and synovial fluid were performed, and the U6 sn RNA was used as internal control. The expression difference of miRNA-140 among groups and correlation between the expression and the KL grade of OA were analysed using one-way ANOVA and Spearman test respectively. Results The expression of miRNA-140 in chondrocytes of knees in OA patients was reduced than that in normal knees, and the between-group difference was statistically significant(F=305.464, Pluid of both normal knees and OA knees, its relative expression level was reduced in synovial fluid of OA group compared with normal group, and the between-group difference was statistically significant as well(F=314.245, Pluid were negatively correlated with the KL grade of OA(r=-0.969, Plusion miRNA-140 could be detected in chondrocytes and synovial fluid of OA patients, and its expression was negatively correlated with the severity of OA.

关键词： microRNA-140 osteoarthritis chondrocytes synovial fluid

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu yan-Ping Guo yan-Mei lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(PluSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

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液相色谱测定有机胺固化剂中的水杨酸含量

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热固性树脂 2018年第2期33卷 65-68页

作者：陈德胜闫锦荣陆绍宁何朝霞罗炎桂林电子科技大学材料科学与工程学院

建立了高压液相色谱测定有机胺固化剂中水杨酸含量的方法。优化后的高压液相色谱条件为：C18柱（4.6 mm×250 mm,5μm）,20μL进样量,214 nm UV检测波长,乙腈（A流动相）-三乙胺/磷酸/水缓冲液（B流动相,p H=6.35）梯度洗脱。在测试范围... 详细信息

建立了高压液相色谱测定有机胺固化剂中水杨酸含量的方法。优化后的高压液相色谱条件为：C18柱（4.6 mm×250 mm,5μm）,20μL进样量,214 nm UV检测波长,乙腈（A流动相）-三乙胺/磷酸/水缓冲液（B流动相,p H=6.35）梯度洗脱。在测试范围内,紫外吸收强度与水杨酸溶液浓度呈良好线性关系,线性回归系数为0.999 7,加标回收率符合85%~115%的规范。

关键词：有机胺固化剂高效液相色谱水杨酸加标回收率

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High Fe‑Loading Single‑Atom Catalyst Boosts ROS Production by Density Effect for Efficient Antibacterial Therapy

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Nano-Micro Letters 2025年第2期17卷 187-203页

作者： Si Chen Fang Huang Lijie Mao Zhimin Zhang Han Lin Qixin yan Xiangyu lu Jianlin Shi Department of Cardiology Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityShanghai 200092People’s Republic of China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050People’s Republic of China Shanghai Frontiers Science Center of Nanocatalytic Medicine School of MedicineTongji UniversityShanghai 200092People’s Republic of China

The current single-atom catalysts(SACs)for medicine still suffer from the limited active site ***,we develop a synthetic method capable of increasing both the metal loading and mass-specific activity of SACs by exchanging zinc with *** constructed iron SACs(h^(3)-FNC)with a high metal loading of 6.27 wt%and an optimized adjacent Fe distance of~4 A exhibit excellent oxidase-like catalytic performance without significant activity decay after being stored for six months and promising antibacterial ***,a“density effect”has been found at a high-enough metal doping amount,at which individual active sites become close enough to interact with each other and alter the electronic structure,resulting in significantly boosted intrinsic activity of single-atomic iron sites in h^(3)-FNCs by 2.3 times compared to low-and medium-loading ***,the overall catalytic activity of h^(3)-FNC is highly improved,with mass activity and metal mass-specific activity that are,respectively,66 and 315 times higher than those of commercial Pt/*** addition,h^(3)-FNCs demonstrate efficiently enhanced capability in catalyzing oxygen reduction into superoxide anion(O_(2)·^(−))and glutathione(GSH)*** in vitro and in vivo assays demonstrate the superior antibacterial efficacy of h^(3)-FNCs in promoting wound *** work presents an intriguing activity-enhancement effect in catalysts and exhibits impressive therapeutic efficacy in combating bacterial infections.

关键词： Nanocatalytic medicine Single-atom catalysts Reactive oxygen species(ROS) High metal loading Oxidase catalysis

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矿物解理/断裂规律与晶面间距的弱相关性及证明

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岩石矿物学杂志 2024年第4期43卷 931-937页

作者：王纪镇张佳祺闫荣禄陈友良李甲伟西安科技大学化学与化工学院陕西西安710054

应用密度泛函理论、断裂键理论和晶体化学性质,定量研究了矿物解理/断裂的晶体化学机制以及与晶面间距(或面网间距)的关系。归纳发现,矿物常见解理/断裂面并不总是与晶面间距最大的晶面相对应,体现为弱相关性。理论计算结果表明,矿物常... 详细信息

应用密度泛函理论、断裂键理论和晶体化学性质,定量研究了矿物解理/断裂的晶体化学机制以及与晶面间距(或面网间距)的关系。归纳发现,矿物常见解理/断裂面并不总是与晶面间距最大的晶面相对应,体现为弱相关性。理论计算结果表明,矿物常见解理/断裂面对应于表面能最低的晶面,而表面能与面网密度及晶面原子平均断裂键数τ正相关。晶面间距与面网密度正相关,意味着当晶面间距大的晶面成为常见解理/断裂面时,需通过降低晶面原子平均断裂键数τ值以降低表面能。然而,通过分析发现,晶面间距与晶面原子平均断裂键数τ的关联性差,从而使得晶面间距与矿物解理/断裂规律无直接关联性。本文的研究结果能够为矿物解理/断裂规律以及表面性质研究提供理论借鉴。

关键词：晶面间距矿物解理/断裂表面能断裂键参数弱相关性

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Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

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Alterations of plasma aspartic acid,asparagine and glycine in major depressive disorder

Alterations of plasma aspartic acid,asparagine and glycine i...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Xin-yan FU,Yun-rong lu,Juan-Li WU,Ai-Min BAO~* Department of Neurobiology Key laboratory of Medical Neurobiology of Ministry of Health of China Zhejiang Province key Laboratory of Neurobiology,Zhejiang University School of Medicine,Hangzhou 310058,China

＜正＞Objective Several experimental and human studies indicate a role for the amino acid transmitters in the pathogenesis of mood *** measurement of neurotransmitters has significant potential as a clinical *** neurotransmitter testing is relatively non-invasive and therefore the desired method to analyze nervous system *** present study was carried out to evaluate the changes of plasma levels of excitatory amino acid neurotransmitters aspartic acid（Asp）,amino acid Asparagine（Asn） and the inhibitory neurotransmitter Glycine（Gly）, together with their correlations,in major depressive disorder（MDD）.Methods Plasma samples were collected from 15 patients who were for the first time diagnosed as MDD（9 male and 6 female subjects,aged 32-64 years） and 14 healthy control subjects（7 male and 7 female subjects,aged 30-65 years）.Plasma of 6 MDD patients（5 males and 1 female subject） was also collected after 2 months of antidepressant *** plasma levels of amino acids were determined by high performance liquid chromatography（HPLC）.Results（1） Significantly lower concentrations of plasma Asp and Gly were observed in MDD compared with ***,no significant differences were observed in the plasma level of Asn.（2） There was a significant positive correlation between plasma levels of Gly and of Asp in the control group,but not in MDD *** the MDD group,both before and after treatment,the plasma levels of Gly were significantly positively correlated with plasma levels of Asn.（3） MDD patients did not show significant differences in plasma Asp,Asn and Gly levels before or after antidepressant treatment of 2 months. Conclusion The lower plasma levels of Asp and Gly may serve as a trait-biomarker for MDD in clinical practice,a new finding that deserves further studies for *** relationship with cerebrospinal fluid levels is also under investigation.

关键词： aspartic acid asparagine glycine depression

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