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Sulforaphane,an NRF2 agonist,alleviates ferroptosis in acute liver failure by regulating HDAC6 activity

Journal of Integrative Medicine 2023年第5期21卷 464-473页

作者： yan-qiong zhang Chun-xia Shi Dan-mei zhang Lu-yi zhang Lu-wen Wang Zuo-jiong Gong Department of Infectious Diseases Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

Objective Acute liver failure(ALF)is characterized by severe liver dysfunction,rapid progression and high mortality and is difficult to *** have found that sulforaphane(SFN),a nuclear factor E2-related factor 2(NRF2)agonist,has anti-inflammatory,antioxidant and anticancer effects,and has certain protective effects on neurodegenerative diseases,cancer and liver *** paper aimed to explore the protective effect of SFN in ALF and it possible mechanisms of *** Lipopolysaccharide and D-galactosamine were used to induce liver injury in vitro and in ***2 agonist SFN and histone deacetylase 6(HDAC6)inhibitor ACY1215 were used to observe the protective effect and possible mechanisms of SFN in ALF,*** viability,lactate dehydrogenase(LDH),Fe2+,glutathione(GSH)and malondialdehyde(MDA)were *** expression of HDAC6,NRF2,glutathione peroxidase 4(GPX4),acyl-CoA synthetase long-chain family member 4(ACSL4)and solute carrier family 7 member 11(SLC7A11)were detected by Western blotting and *** Our results show that NRF2 was activated by ***,Fe2+,MDA and ACSL4 were downregulated,while GSH,GPX4 and SLC7A11 were upregulated by SFN in vitro and in vivo,indicating the inhibitory effect of SFN on ***,HDAC6 expression was decreased in the SFN group,indicating that SFN could downregulate the expression of HDAC6 in *** using the HDAC6 inhibitor,ACY1215,SFN further reduced HDAC6 expression and inhibited ferroptosis,indicating that SFN may inhibit ferroptosis by regulating HDAC6 *** SFN has a protective effect on ALF,and the mechanism may include reduction of ferroptosis through the regulation of HDAC6.

关键词： Acuteliverfailure Sulforaphane NRF2 HDAC6 Ferroptosis

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Network Pharmacology-based Approaches Capture Essence of Chinese Herbal Medicines

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Chinese Herbal Medicines 2016年第2期8卷 107-116页

作者： yan-qiong zhang Xia Mao Qiu-yan Guo Na Lin Shao Li Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences MOE Key Laboratory of Bioinformatics and Bioinformatics Division TNLIST Department of Automation Tsinghua University

Traditional Chinese Medicine（TCM）, a crucial component of the current medical system, has been extensively used in clinical practice due to its valuable therapeutic efficacy, and its potentials as an important source of new pharmacophores. TCM is characterized by holistic theory, which emphasizes maintaining the balance of the patient＇s whole body using herbal formulae（fangji in Chinese） composed of mixtures of herbs with multiple bioactive ingredients. Because of the complex nature of these formulae, it is necessary to develop systematic methods to identify their bioactive ingredients and to clarify their mechanisms of action. With the rapid progress in bioinformatics, systems biology, and polypharmacology, ＂network pharmacology＂, which shifts the ＂one target, one drug＂ paradigm to the ＂network target, multi-component＂ strategy, has attracted the attention because it can not only reveal the underlying complex interactions between a herbal formula and cellular proteins but detect the influence of their interactions on the function and behavior of the system. Growing evidence shows that the network pharmacology strategy can be a powerful approach to modern research on TCM. The present paper focuses on the basis of network pharmacology and the recent progress in its methodology, illustrates its utility in screening bioactive ingredients and elucidating the mechanisms of action of TCM herbal formulae, analyzes its limitations and problems, and discusses its development direction and application prospects.

关键词： bioactive ingredient Chinese herbal medicine molecular mechanism network pharmacology network target

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Copulatory pattern and behavior in a semi-captive population of Eld＇s deer

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Current Zoology 2011年第3期57卷 284-292页

作者： Zhigao ZENG yan-Ling SONG qiong zhang Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

Male copulatory patterns, female multiple copulation and male post-copulatory guarding were studied in Eld＇s deer Cervus eldi in Datian National Nature Reserve, China. Mating behavior in 18 females and 11 males from a group of 61 semi-captive Eld＇s deer were observed. The majority （55.8%） of copulations occurred between 15：00-19：00 h. The ejaculatory mount was preceded by an average of 5.1 prior mounts. Successful copulation consisted of a single thrust with ejaculation during one intromission, with no lock. This copulatory pattern is classified as pattern No. 15 （no lock, no intravaginal thrusting, single intromission, and multiple ejaculation） and No. 16 （no lock, no intravaginal thrusting, single intromission, and single ejaculation） under Dewsbury＇s scheme （1972） and as No. 16 （no lock, no thrusting, single and brief intromission） under Dixson＇s classification （1998）. Copulation frequency was 1.5 ± 0.9 times for males/females with the same female/male per day. The duration of the final mount, which included ejaculation, was brief （3.4±1.3 s）, and ejaculation usually terminated copulation. Eleven females copulated more than once in this study： three of them copulated with several males （multi-male copulations） and the remainder copulated with a single male （repeated copulations）. Our results indicate that some female Eld＇s deer may seek multiple copulations to be a strategy to improve the genetic quality of their offspring or to avoid harassment. Post-copulatory guarding of females by males followed all copulations, with dominant males guarding for significantly longer than subordinate males. Dominant males appear to be more effective at post-copulatory guarding than subordinate males. Subordinate males engaged in a quicker pre-copulatory phase to improve their chances of finishing copulation before being forced to accede to dominant males [Current Zoology 57 （3）： 284-292, 2011].

关键词： Cervus eldi Copulatory pattern Female multiple copulation Post-copulatory guarding Dominant male Subordinate male

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Hes1,an important gene for activation of hepatic stellate cells,is regulated by Notch1 and TGF-β/BMP signaling

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World Journal of Gastroenterology 2015年第3期21卷 878-887页

作者： Kai zhang yan-qiong zhang Wen-Bing Ai Qing-Ting Hu Qiao-Juan zhang Lin-yan Wan Xiao-Lian Wang Chang-Bai Liu Jiang-Feng Wu Medical College China Three Gorges University the Second College of Clinical Medical Science China Three Gorges University Institute of Molecular Biology Medical CollegeChina Three Gorges University

AIM:To determine the role of Notch1 and Hes1 in regulating the activation of hepatic stellate cells(HSCs) and whether Hes1 is regulated by transforming growth factor(TGF)/bone morphogenetic protein(BMP) ***:Immunofluorescence staining was used to detect the expression of desmin,glial fibrillary acidic protein and the myofibroblastic marker α-smooth muscle actin(α-SMA) after freshly isolated,normal rat HSCs had been activated in culture for different numbers of days(0,1,3,7 and 10 d).The expression of α-SMA,collagen1α2(COL1α2),Notch receptors(Notch1-4),and the Notch target genes Hes1 and Hey1 were analyzed by reverse transcriptase-polymerase chain *** reporter assays and Western blot were used to study the regulation of α-SMA,COL1α1,COL1α2 and Hes1 by NICD1,Hes1,CA-ALK3,and CA-ALK5 in HSC-T6 ***,the effects of inhibiting Hes1 function in HSC-T6 cells using a Hes1 decoy were also ***:The expression of Notch1 and Hes1 m RNAs was significantly down-regulated during the culture of freshly isolated *** HSC-T6 cells,Notch1 inhibited the promoter activities of α-SMA,COL1α1 and COL1α*** the other hand,Hes1 enhanced the promoter activities of α-SMA and COL1α2,and this effect could be blocked by inhibiting Hes1 function with a Hes1 ***,co-transfection of pc DNA3-CAALK3(BMP signaling activin receptor-like kinase 3) and pc DNA3.1-NICD1 further increased the expression of Hes1 compared with transfection of either vector alone in HSC-T6 cells,while pc DNA3-CA-ALK5(TGF-β signaling activin receptor-like kinase 5) reduced the effect of NICD1 on Hes1 ***:Selective interruption of Hes1 or maintenance of Hes1 at a reasonable level decreases the promoter activities of α-SMA and COL1α2,and these conditions may provide an anti-fibrotic strategy against hepatic fibrosis.

关键词： Hes1 Notch1 TGF-β/BMP Hepatic stellate cells Hepat

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自重构机器人系统自修复的拓扑空间及运动规则描述

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上海交通大学学报 2009年第3期43卷 490-493页

作者：费燕琼张鑫徐磊上海交通大学机械与动力工程学院上海200240

针对一种新颖的同构式模块化自重构机器人系统,研究了一种基于图论的数学描述方法,以表示每个模块的空间位置及连接状态,进而表达全局拓扑结构;受有限状态机的启发,分析了自重构机器人系统模块的基本运动,提出了该网格型自重构模块化机... 详细信息

针对一种新颖的同构式模块化自重构机器人系统,研究了一种基于图论的数学描述方法,以表示每个模块的空间位置及连接状态,进而表达全局拓扑结构;受有限状态机的启发,分析了自重构机器人系统模块的基本运动,提出了该网格型自重构模块化机器人的模块运动规则,为研究自修复算法提供了理论基础.

关键词：自重构机器人模块拓扑空间运动规则

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai qiong Wu Yushan Chen Zhen Wei Yufei Mei yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang yanyu zhang yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan Chen Hongxia Deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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UPLC-Q-TOF/MS在烘焙食品中羧甲基赖氨酸和羧乙基赖氨酸检测中的应用

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分析测试学报 2017年第3期36卷 297-304页

作者：林钦郑小严陈纯戴明周燕琼张英福建省产品质量检验研究院福建福州350002 浙江大学生物系统工程与食品科学学院浙江杭州310058

建立了烘焙食品中羧甲基赖氨酸(CML)和羧乙基赖氨酸(CEL)的UPLC-Q-TOF/MS检测方法。烘焙食品经脱脂、还原、沉淀蛋白、酸水解释放出CML和CEL,使用FMOC-Cl柱前衍生和HLB小柱固相萃取净化后,采用UPLC-Q-TOF/MS检测。CML和CEL在1~700 ng/m ... 详细信息

建立了烘焙食品中羧甲基赖氨酸(CML)和羧乙基赖氨酸(CEL)的UPLC-Q-TOF/MS检测方法。烘焙食品经脱脂、还原、沉淀蛋白、酸水解释放出CML和CEL,使用FMOC-Cl柱前衍生和HLB小柱固相萃取净化后,采用UPLC-Q-TOF/MS检测。CML和CEL在1~700 ng/m L浓度范围内均呈良好的线性关系,线性回归系数r>0.999。CML和CEL的检出限均为0.1 mg/kg;回收率为94.4%~108.3%;相对标准偏差(RSD,n=6)为0.4%~6.2%。该方法定性、定量准确,灵敏度高,能很好地应用于烘焙食品中CML和CEL的检测。

关键词：超高效液相色谱-四极杆-飞行时间质谱仪烘焙食品羧甲基赖氨酸羧乙基赖氨酸

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Copulatory pattern and behavior in a semi-captive population of Eld's deer

Copulatory pattern and behavior in a semi-captive population...

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第七届全国野生动物生态与资源保护学术研讨会

作者： Zhi-Gao ZENG yan-Ling SONG and qiong zhang (Key Laboratory of Animal Ecology and Conservation Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China)

Male copulatory patterns,female multiple copulation and male post-copulatory guarding were studied in Eld’s deer Cervus eldi in Datian National Nature Reserve,*** behavior in 18 females and 11 males from a group of 61 semi-captive Eld’s deer were *** majority(55.8%) of copulations occurred between 15:00-19:00 *** ejaculatory mount was preceded by an average of 5.1 prior *** copulation consisted of a single thrust with ejaculation during one intromission,with no *** copulatory pattern is classified as pattern No.15(no lock,no intravaginal thrusting,single intromission,and multiple ejaculation)and No.16(no lock,no intravaginal thrusting,single intromission,and single ejaculation)under Dewsbury’s scheme(1972)and as No.16 (no lock,no thrusting,single and brief intromission)under Dixson’s classification(1998).Copulation frequency was 1.5±0.9 times for males/ females with the same female/male per *** duration of the final mount,which included ejaculation,was brief(3.4±1.3 s),and ejaculation usually terminated *** females copulated more than once in this study:three of them copulated with several males(multi-male copulations)and the remainder copulated with a single male(repeated copulations). Our results indicate that some female Eld’s deer may seek multiple copulations to be a strategy to improve the genetic quality of their offspring or to avoid ***-copulatory guarding of females by males followed all copulations,with dominant males guarding for significantly longer than subordinate *** males appear to be more effective at post-copulatory guarding than subordinate *** males engaged in a quicker pre-copulatory phase to improve their chances of finishing copulation before being forced to accede to dominant males.

关键词： Cervus eldi copulatory pattern female multiple copulation post-copulatory guarding dominant male subordinate male

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