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Diagnosing Helicobacter pylori infection in vivo by novel endoscopic techniques

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World Journal of Gastroenterology 2014年第28期20卷 9314-9320页

作者： Rui Ji yan-qing li Department of Gastroenterology Shandong University Qilu Hospital

Infection with Helicobacter pylori(***)is a worldwide *** observation of *** infection in vivo would be helpful to obtain an immediate *** aim of this review is to describe recent advances in endoscopic technology and to review the available literature pertaining to its clinical application in *** *** visualization of *** infection is not always feasible using conventional ***,advanced endoscopic techniques have been developed with the aim of providing a precise and‘‘real-time’’endoscopic ***,new endoscopic techniques such as magnifying endoscopy,narrow band imaging,I-Scan,endocytoscopy and endomicroscopy help focus examination of the stomach to diagnose disease in a time-efficient manner,and the analysis of mucosal surface details is beginning to resemble histologic *** new detailed images have enabled endoscopists to observe microscopic structures,such as gastric pit patterns,microvessels and cell ***,endoscopic prediction of *** infection is possible by analysis of surface architecture of the mucosa,which influences the clinical *** endoscopic techniques might lead us to easier diagnosis and treatment of *** diseases.

关键词： Helicobacter pylori Diagnosis Gastrointestinal endoscopy

Interface energetics and engineering of organic heterostructures in organic photovoltaic cells

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Science China Chemistry 2016年第4期59卷 422-435页

作者： yan-qing li Qian-Kun Wang qing-Dong Ou Jian-Xin Tang Institute of Functional Nano & Soft Materials Collaborative Innovation Center of Suzhou Nano Science and TechnologyJiangsu Key Laboratory for Carbon-based Functional Materials & Devices Soochow University

The reliable information about interface energetics of organic materials, especially the energy level alignment at organic heterostructures is of pronounced importance for unraveling the photon harvesting and charge separation process in organic photovoltaic(OPV) cells. This article provides an overview of interface energetics at typical planar and mixed donor-acceptor heterostructures, perovskite/organic hybrid interfaces, and their contact interfaces with charge collection layers. The substrate effect on energy level offsets at organic heterostructures and the processes that control and limit the OPV operation are presented. Recent efforts on interface engineering with electrical doping are also discussed.

关键词： organic photovoltaic cell organic heterostructure energy level alignment substrate effect interface engineering

Quinolinyl Imidazolidin-2-imine Nickel Catalyzed Efficient Copolymerization of Norbornene with para-Chlorostyrene

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Chinese Journal of Polymer Science 2020年第9期38卷 941-949,I0005页

作者： yan-qing li Jian Zhou Ru Xiao Zheng-Guo Cai State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and EngineeringDonghua UniversityShanghai 201620China College of Biological and Chemical Engineering Guangxi University of Science and TechnologyLiuzhou 545006China

A series of novel quinolinyl imidazolidin-2-imine nickel complexes with different substituents on the imidazolidin-2-imine ligand were synthesized and *** complexes in the presence of methylaluminoxane(MAO)as a cocatalyst catalyzed the copolymerization of norbornene(N)and styrene(S)or para-chlorostyrene(CS)with high activity(up to 1070 kg·mol^-1·h^-1).The installation of sterically bulky substituents on the imidazolidine-2-imine ligand was effective for the increase of the molecular weight and the comonomer content,affording high molecular weight copolymers with tunable CS content(0.57 mol%-11.7 mol%),in which the existence of CI group can provide reaction site for the further functionalization of copolymers as well as the synthesis of graft or cross-linked *** linear relationship between the comonomer content and the glass transition temperature of the copolymers and the monomer reactivity ratios in the copolymerization indicated the formation of the expected functionalized cyclic olefin copolymers(COC).

关键词： Imidazolidin-2-imine ligand Nickel complex Norbornene para-Chlorostyrene Copolymerization

Flow pattern analysis of linear gradient flow distribution

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Applied Mathematics and Mechanics(English Edition) 2015年第1期36卷 81-106页

作者： Da-ming li Xiao-yu li yan-qing li R.J.FARAHANI School of Civil Engineering & Key Laboratory of Harbor & Ocean Engineering Ministry of Education Tianjin University Civil and Environmental Engineering Johns Hopkins University Civil Engineering The University of Adelaide

This paper uses the Oseen transformation to solve the differential equations governing motion of the vertical linear gradient flow distribution close to a wall surface. The Navier-Stokes equations are used to consider the inertia term along the flow direction. A novel contour integral method is used to solve the complex Airy function. The boundary conditions of linear gradient flow distribution for finite problems are determined. The vorticity function, the pressure function, and the turbulent velocity profiles are provided, and the stability of particle trajectories is studied. An Lx-function form of the third derivative circulation is used to to simplify the solution. Theoretical results are compared with the experimental measurements with satisfactory agreement.

关键词： linear gradient distribution flow contour integral stability analysis Airyfunction Oseen transformation

An Association between Immunosenescence and CD4^+CD25^+ Regulatory T Cells: A Systematic Review

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Biomedical and Environmental Sciences 2010年第4期23卷 327-332页

作者： liNG WANG yan XIE li-JING ZHU TING-TING CHANG yan-qing MAO JIE li Clinical Immunology Laboratory The First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu China

Objective Age-related increment of the prevalence of CD4^＋CD25^＋ regulatory T （Treg） cells were described controversially, and whether such changes explain immune dysfunction in the elderly is still unclear. The aim of this systematic review is to evaluate the role of the Tregs in immunosenescence. Methods Medline and manual searches were performed to identify all published epidemiological and animal studies investigating the efficacy of the association between immunosenescence and Treg cells. Results It was founded that the frequency, phenotypic characteristics, and number/function of Tregs were altered significantly with aging. Medical conditions in individuals with advanced ageas well as apoptosis intensity of Treg cells had an impact on the accumulation of Tregs which in turn could deteriorate cytotoxic activity of CD8＋ T and NK cells and production of IL-2. The range of immune cells that could be suppressed by Treg cells was quite wide and covered CD4^＋CD25^＋ T cells, NK cells, dendritic cells and even monocytes. These changes were observed both in humans and experimental animals. Besides, it was believed that frequency of Tregs increased with age and was accompanied by intensified suppressive activity for Tregs in patients, for example, with Alzheimer disease （AD） and Parkinson disease （PD）. The impaired condition of CD4＋ T cells, so-called immunosenescence, rendered transplant recipients less responsive to an allogeneic kidney graft, an effect that was limited to transplant recipients who were aged over 60 years. Conclusions Treg cells are associated with immunosenescence. All these changes contribute to the aging-related decline of immune responses and lead to the higher risk of immune-mediated diseases, cancer or infections in aged individuals.

关键词： Aging Immunosenescence CD4^+CD25^+ T cell Treg Case-control studies Cohort studies Cross-sectional studies

Classification of histological severity of Helicobacter pylori-associated gastritis by confocal laser endomicroscopy

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World Journal of Gastroenterology 2010年第41期16卷 5203-5210页

作者： Peng Wang Rui Ji Tao Yu Xiu-li Zuo Chang-qing li Zhen li yan-qing li Cheng-Jun Zhou Department of Gastroenterology Shandong University Qilu Hospital Jinan 250012 Shandong Province China Peng Wang Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Qilu Hospital Shandong University China Department of Pathology Shandong University Qilu HospitalJinan 250012Shandong ProvinceChina

AIM: To classify the histological severity of Helicobacter pylori (H. pylori) infection-associated gastritis by confocal laser endomicroscopy (CLE). METHODS: Patients with upper gastrointestinal symptoms or individuals who were screened for gastric cancer were enrolled in this study. Histological severity of H. pylori infection-associated gastritis was graded according to the established CLE criteria. Diagnostic value of CLE for histo-logical gastritis was investigated and compared with that of white light endoscopy (WLE). Targeted biopsies from the sites observed by CLE were performed. RESULTS: A total of 118 consecutive patients with H. pylori infection-associated gastritis were enrolled in this study. Receiver operating characteristic curve analysis showedthat the sensitivity and specifi city of CLE were 82.9% and 90.9% for the diagnosis of H. pylori infection, 94.6% and 97.4% for predicting gastric normal mucosa, 98.5% and 94.6% for predicting histological active inflammation, 92.9% and 95.2% for predicting glan-dular atrophy, 98.6% and 100% for diagnosing intes-tinal metaplasia, respectively. Post-CLE image analysis showed that goblet cells and absorptive cells were the two most common parameters on the CLE-diagnosed intestinal metaplasia (IM) images (P < 0.001). More his-tological lesions of the stomach could be found by CLE than by WLE (P < 0.001). CONCLUSION: CLE can accurately show the histological severity of H. pylori infection-associated gastritis. Mapping IM by CLE has a rather good diagnostic accuracy.

关键词： Confocal laser endomicroscopy Helicobacter pylori Gastritis Classif ication Histology

Magnified and enhanced computed virtual chromoendoscopy in gastric neoplasia: A feasibility study

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World Journal of Gastroenterology 2013年第26期19卷 4221-4227页

作者： Chang-qing li Ya li Xiu-li Zuo Rui Ji Zhen li Xiao-Meng Gu Tao Yu qing-qing Qi Cheng-Jun Zhou yan-qing li Department of Gastroenterology Shandong University Qilu Hospital Department of Pathology Shandong University 2nd Affiliated Hospital

AIM: To evaluate the feasibility of a new computed virtual chromoendoscopy (CVC) device (M i-scan) in the diagnosis of gastric neoplasia. METHODS: Patients with superficial lesions no larger than 1.0 cm found during high definition endoscopy were included. Those with advanced or obviously protruded or depressed lesions, lesions larger than 1.0 cm and/or lesions which were not amenable to observation by zoom function were excluded. The endoscopist was required to give the real-time descriptions of surface pit patterns of the lesions, based on surface pattern classification of enhanced magnification endoscopy. According to previous reports, types Ⅰ-Ⅲ represent nonneoplastic lesions, and types Ⅳ-Ⅴ represent neoplastic lesions. Diagnosis with M i-scan and biopsy was performed before histopathological diagnosis. Magnified images of gastric lesions with and without enhancement were collected for further analysis. The diagnostic yield of real-time M i-scan and effects on magnification image quality by tone enhancement (TE), surface enhancement (SE) and color enhancement (CE) were calculated. The selected images were sent to another endoscopist. The endoscopist rated the image quality of each lesion at 3 levels. Ratings of image quality were based on visualization of pit pattern, vessel and demarcation line. RESULTS: One hundred and eighty-three patients were recruited. Five patients were excluded for advanced gastric lesions, 1 patient was excluded for poor preparation and 2 patients were excluded for superficial lesions larger than 1.0 cm; 132 patients were excluded for no lesions found by high definition endoscopy. In the end, 43 patients with 43 lesions were included. Histopathology revealed 10 inflammation, 14 atrophy, 10 metaplasia, 1 low grade dysplasia (LGD), 5 high grade dysplasia (HGD) and 3 cancers. For 7 lesions classified into type Ⅰ, histopathology revealed 6 atrophy and 1 metaplasia; for 10 lesions classified into type Ⅱ, histopathology revealed 2 inflammatio

关键词： Computed virtual chromoendoscopy i-scan Gastric neoplasia Diagnosis

Dynamic measurement of beam divergence angle of different fields of view of scanning lidar

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Chinese Physics B 2021年第2期30卷 304-307页

作者： qing-yan li Shi-Yu yan Bin Zhang Chun-Hui Wang National Key Laboratory of Tunable Laser Technology Harbin Institute of TechnologyHarbin 150001China

The laser beam divergence angle is one of the important parameters to evaluate the quality of the laser *** can not only accurately indicate the nature of the beam divergence when the laser beam is transmitted over a long distance,but also objectively evaluate the performance of the laser *** present,lidar has received a lot of attention as a core component of environment awareness ***-electromechanical system(MEMS)micromirror has become the first choice for three-dimensional imaging lidar because of its small size and fast scanning ***,due to the small size of the MEMS micromirror,the lidar scanning system has a small field of view(FOV).In order to achieve a wide range of scanning imaging,collimating optical system and wide-angle optical system are generally added to the ***,due to the inherent properties of the optical lens,it is impossible to perfect the imaging,so the effects of collimating and expanding the beam will be different at different *** article aims to propose a measurement system that dynamically measures the divergence angles of MEMS scanning lidar beams in different fields of view to objectively evaluate the performances of scanning lidar systems.

关键词： laser divergence angle lidar CCD different fields of view(FOV)

Smoc2 potentiates proliferation of hepatocellular carcinoma cells via promotion of cell cycle progression

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World Journal of Gastroenterology 2016年第45期22卷 10053-10063页

作者： Jing-Ran Su Jing-Hua Kuai yan-qing li Department of Gastroenterology Laboratory of Translational Gastroenterology Shandong University Qilu Hospital Department of Gastroenterology Shandong University Qilu Hospital of Shandong University (Qingdao)

AIM To determine the influence of Smoc2 on hepatocellular carcinoma(HCC) cell proliferation and to find a possible new therapeutic target for preventing HCC *** We detected expression of Smoc2 in HCC tissues and corresponding non-tumor liver(CNL) tissues using PCR, western blot, and immunohistochemistry methods. Subsequently, we down-regulated and upregulated Smoc2 expression using siR NA and lentivirus transfection assay, respectively. Then, we identified the effect of Smoc2 on cell proliferation and cell cycle using CCK-8 and flow cytometry, respectively. The common cell growth signaling influenced by Smoc2 was detected by western blot assay. RESULTS The expression of Smoc2 was significantly higher in HCC tissues compared with CNL tissues. Overexpression of Smoc2 promoted HCC cell proliferation and cell cycle progression. Down-regulation of Smoc2 led to inhibition of cell proliferation and cell cycle progression. Smoc2 had positive effect on ERK and AKT *** Smoc2 promotes the proliferation of HCC cells through accelerating cell cycle progression and might act as an anti-cancer therapeutic target in the future.

关键词： Smoc2 Hepatocellular carcinoma Cell cycle Proliferation