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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan yang Zhi-Cheng Zhang qi Dai Xiao-yan Bao Lin-Jie Wu Ya-Xin qin Xin Tan Xiao-yan Sun Xu-Fang Ying Zhi-qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong yan Ting Liang Jia Jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

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新型酯键型α-猪去氧胆酸分子钳的设计合成

四川大学学报（自然科学版） 2002年第5期39卷 925-928页

作者：李玲牟其明鄢琦杨祖幸陈淑华四川大学化学学院成都610064

以α 猪去氧胆酸为spacer ,苯衍生物为arm设计合成了一类新型的酯键型分子钳 ,其结构均经1HNMR ,IR 。

关键词：酯键型设计 α-猪去氧胆酸合成分子钳结构表征苯衍生物手性分子识别性能

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KDD中知识的自动评价系统

计算机科学 2003年第11期30卷 29-31,52页

作者：綦艳霞杨炳儒北京控制工程研究所软件中心北京100080

1.引言在知识发现过程中,通过挖掘算法产生大量的模式,例如斯坦福大学对一个有3万条记录的调查数据库中使用关联规则的发现算法,产生了2万多条的规则[1],而大多数规则是显而易见和毫无意义的.

关键词： KDD 系统自动评价

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彩色数字图像量化的一种新算法

上海交通大学学报 1999年第11期33卷 1402-1405页

作者：严京旗杨新杜朝晖施鹏飞上海交通大学图象处理与模式识别研究所上海200030

分析比较了基于方差最小标准和基于最大类内距离最小标准的彩色图像量化算法．方差最小算法着重于最小化整幅图像量化前后的总方差；最大类内距离最小算法着重于减少类内任意点与其代表点的最大距离．文中提出了一种结合两种标准的新算... 详细信息

分析比较了基于方差最小标准和基于最大类内距离最小标准的彩色图像量化算法．方差最小算法着重于最小化整幅图像量化前后的总方差；最大类内距离最小算法着重于减少类内任意点与其代表点的最大距离．文中提出了一种结合两种标准的新算法，在限制类内点与其类代表点最大距离的同时，尽量降低整幅图像量化前后的总误差．经验证。

关键词：图像处理矢量量化彩色图像数字图像处理

cetuximab alone treat metastatic esophageal carcinoma:a case report

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cetuximab alone treat metastatic esophageal carcinoma:a case...

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

2009年浙江省放射肿瘤治疗学学术年会

作者： Department of Radiation Oncology,Sir Run Run Shaw Hospital,Medical College of Zhejiang University Hangzhou(310016) China XU Jing SUN Xiao-nan ZHU yan-hong yang qi-chu Hu Jian-bin

Esophageal cancer is the sixth most frequent cause of cancer death worldwide.1 Most patients with esophageal cancer in Asian contries have squamous cell carcinoma(SCC),while most of those in Western countries have *** improvements in surgical techniques and perioperative management,and despite the addition of chemotherapy and radiotherapy to surgery,the prognosis remains poor.2,3 Therefore,for esophageal SCC patients,better therapies are very much *** this paper,we report the excellent response achieved by using cetuximab,a novel EGFR antibody,in a patient with recurrent metastatic esophageal cancer. The use of cetuximab and similar molecular targeted therapies in esophageal cancers is discussed.

关键词： esophageal cancer squamous cell carcinoma cetuximab

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong Guan Xiaolan qi Wei Hong yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

豆浆中风味物质形成、与蛋白的互作机制及生物法改善豆浆风味的研究进展

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食品科学 2025年第2期46卷 280-289页

作者：高宇齐宝坤廖一闫世长李杨黄雨洋东北农业大学食品学院黑龙江哈尔滨150030 哈尔滨商业大学食品工程学院黑龙江哈尔滨150028

豆浆作为一种营养丰富的植物基蛋白饮品,在全球范围内受到消费者的喜爱。然而,其特有的不良风味往往影响消费者的接受度,限制了豆浆产品的市场推广。本文探讨豆浆中风味物质的形成机理、这些风味物质与豆浆中的蛋白质之间的相互作用机... 详细信息

豆浆作为一种营养丰富的植物基蛋白饮品,在全球范围内受到消费者的喜爱。然而,其特有的不良风味往往影响消费者的接受度,限制了豆浆产品的市场推广。本文探讨豆浆中风味物质的形成机理、这些风味物质与豆浆中的蛋白质之间的相互作用机制以及通过生物方法改善豆浆风味的研究进展。通过无脂氧合酶大豆品种的开发、酶处理和微生物发酵等生物方法,可以有效地改善豆浆的风味,同时保持其营养价值。最后对未来改善豆浆风味的研究方向做出展望,以期为豆浆及其制品的品质提升和市场推广提供理论依据,为推动我国大豆制品市场的发展做出贡献。

关键词：豆浆风味物质-蛋白质互作生物方法风味改良

布比卡因用于蛛网膜下腔阻滞在高海拔与低海拔的比较

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中国新药与临床杂志 2017年第10期36卷 614-617页

作者：祁延杰杨晓黎龙勤蒋燕沈茜雷晓峰昌都市人民医院麻醉科西藏昌都854000 重庆市肿瘤研究所麻醉科重庆400030

目的评价布比卡因用于蛛网膜下腔阻滞在高海拔与低海拔的麻醉效果。方法择期行下肢手术男性患者156例,ASAⅠ~Ⅱ级,均采用椎管内联合阻滞麻醉。高海拔组78例来自昌都市(海拔3 200 m),低海拔组78例来自重庆市(海拔250 m)。两组患者蛛网膜... 详细信息

目的评价布比卡因用于蛛网膜下腔阻滞在高海拔与低海拔的麻醉效果。方法择期行下肢手术男性患者156例,ASAⅠ~Ⅱ级,均采用椎管内联合阻滞麻醉。高海拔组78例来自昌都市(海拔3 200 m),低海拔组78例来自重庆市(海拔250 m)。两组患者蛛网膜下腔均给予0.5%布比卡因注射液2 mL(10 mg)。记录两组的麻醉阻滞起效时间、麻醉阻滞最高平面、感觉阻滞持续时间及运动阻滞持续时间,观察围术期患者心率和血压变化。结果高海拔组麻醉阻滞起效时间(16±3)min,长于低海拔组[(10±2)min,P<0.05],且高海拔组麻醉阻滞最高平面高于低海拔组(P<0.05)。高海拔组的感觉阻滞持续时间和运动阻滞持续时间均短于低海拔组[(172±37)和(260±47)min vs.(223±39)和(336±50)min,P<0.05]。围术期高海拔组患者心率均低于低海拔组,平均动脉压均高于低海拔组(P<0.05)。结论 0.5%布比卡因10 mg蛛网膜下腔阻滞用于高海拔的患者有效,所需局麻药剂量高于低海拔地区。

关键词：布比卡因麻醉,脊椎高海拔

内脂素对2型糖尿病kkay小鼠骨骼肌组织PI3K和GLUT-4的影响

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中国现代医学杂志 2017年第7期27卷 1-4页

作者：王倩阳琰陈其荣张晗高琳廖鑫王茜遵义医学院附属医院内分泌科贵州遵义563003

目的观察内脂素(visfatin)对kkay糖尿病小鼠骨骼肌组织磷脂酰肌醇-3-激酶(PI3K)和葡萄糖转运蛋白4(GLUT-4)的影响。方法 C57BL/6J小鼠随机分为普通饲料喂养组(CON)、高脂饲料喂养组(HFD),kkay小鼠随机分为糖尿病模型组(DM)和visfatin治... 详细信息

目的观察内脂素(visfatin)对kkay糖尿病小鼠骨骼肌组织磷脂酰肌醇-3-激酶(PI3K)和葡萄糖转运蛋白4(GLUT-4)的影响。方法 C57BL/6J小鼠随机分为普通饲料喂养组(CON)、高脂饲料喂养组(HFD),kkay小鼠随机分为糖尿病模型组(DM)和visfatin治疗组(V)。采用实时荧光定量PCR和Western blot方法测定各组小鼠骨骼肌中PI3K和GLUT-4的mRNA和蛋白表达。结果 V组腹腔注射visfatin后的血糖较注射前下降(P=0.013),差异有统计学意义。DM组PI3K、GLUT-4的mRNA及蛋白表达量较CON组、HFD组降低(P<0.05),差异有统计学意义;V组PI3K、GLUT-4的mRNA及蛋白表达量较DM组增加(P<0.05),差异有统计学意义。结论内脂素可上调骨骼肌组织PI3K和GLUT-4的表达。

关键词：内脂素 kkay小鼠骨骼肌 P13K GLUT-4