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Incidence and warning signs for complications of human brucellosis: a multi-center observational study from China

Infectious Diseases of Poverty 2024年第1期13卷 53-62页

作者： Qing-Nan Shi Hui-Jie Qin Qiao-Shan Lu hu Li Zhong-Fa Tao Meng-Guang Fan Mu-Heta Aishan Zeng-Qiang Kou Qiu-Lan Chen Wen-Wu Yin yan-ping zhang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases Chinese Center for Disease Control and PreventionChangbai RoadChangping DistrictBejing 102206China School of Public Health Guangxi Medical UniversityNanningChina Nanning Center for Disease Control and Prevention NanningChina Guizhou Center for Disease Control and Prevention GuiyangChina Inner Mongolia Center for Disease Control and Prevention HohhotChina Xinjiang Uighur Autonomous Region Center for Disease Control and Prevention UrumqiChina Shandong Center for Disease Control and Prevention JinanChina

Background Brucellosis is a severe zoonotic disease that is often overlooked, particularly in impoverished countries. Timely identification of focal complications in brucellosis is crucial for improving treatment outcomes. However, there is currently a lack of established indicators or biomarkers for diagnosing these complications. Therefore, this study aimed to investigate potential warning signs of focal complications in human brucellosis, with the goal of providing practical parameters for clinicians to aid in the diagnosis and management of *** A multi-center cross-sectional study was conducted in China from December 2019 to August 2021. The study aimed to investigate the clinical characteristics and complications of patients with brucellosis using a questionnaire survey and medical record system. The presence of warning signs for complications was assessed using univariate and multivariate logistic regression models. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used for variable screening and model *** A total of 880 participants diagnosed with human brucellosis were enrolled. The median age of the patients was 50 years [interquartile range (IQR): 41.5-58.0], and 54.8% had complications. The most common organ system affected by complications was the osteoarticular system (43.1%), with peripheral arthritis (30.0%), spondylitis (16.6%), paravertebral abscess (5.0%), and sacroiliitis (2.7%) being the most prevalent. Complications in other organ systems included the genitourinary system (4.7%), respiratory system (4.7%), and hematologic system (4.6%). Several factors were found to be associated with focal brucellosis. These factors included a long delay in diagnosis [odds ratio (OR) = 3.963, 95% confidence interval(CI): 1.906-8.238 for > 90 days], the presence of underlying disease (OR = 1.675, 95%CI: 1.176-2.384), arthralgia (OR = 3.197, 95%CI: 1.986-5.148), eye bulging pain (OR = 3.482, 95%CI:

关键词： Brucellosis Complications Clinical spectrum Warning signs

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MODEL ANALYSIS AND PARAMETER EXTRACTION FOR MOS CAPACITOR INCLUDING QUANTUM MECHANICAL EFFECTS

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Journal of Computational Mathematics 2006年第3期24卷 401-411页

作者： Hai-yan Jiang ping-wen zhang LMAM CCSE and School of Mathematical Sciences.Peking University Beijing 100871 China

The high frequency CV curves of MOS capacitor have been studied. It is shown that semiclassical model is a good approximation to quantum model and approaches to classical model when the oxide layer is thick. This conclusion provides us an efficient （semiclassical） model including quantum mechanical effects to do parameter extraction for ultrathin oxide device. Here the effective extracting strategy is designed and numerical experiments demonstrate the validity of the strategy.

关键词： Poisson Equation SchrSdinger Equation MOS Capacitor Quantum Effect,Sensitivity Parameter Extraction.

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Second Virtual Pitch Shift in Cochlea Observed In Situ via Laser Interferometry

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Chinese Physics Letters 2021年第2期38卷 36-40页

作者： zhang-Cai Long yan-ping zhang Lin Luo School of Physics Huazhong University of Science and TechnologyWuhan 430074China Affiliated Hospital Huazhong University of Science and TechnologyWuhan 430074China Department of Chinese Language and Literature Huazhong University of Science and TechnologyWuhan 430074China

Pitch is the most important auditory perception characteristic of sound with respect to speech intelligibility and music appreciation,and corresponds to a frequency of sound ***,in some cases,we can perceive virtual pitch,where the corresponding frequency component does not exist in the stimulating *** virtual pitch contains a deviation from the de Boer pitch shift formula,which is known as second pitch *** has been theoretically suggested that nonlinear dynamics in the cochlea or in the neural network produce a nonlinear resonance with a frequency corresponding to the virtual pitch;however,there is no direct experimental observation to support this *** second virtual pitch shift,expressed via basilar membrane nonlinear vibration temporal patterns,and consistent with psychoacoustic experiments,is observed in situ in the cochlea via laser interferometry.

关键词： auditory stimulating pitch

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Effects of electroacupuncture on pain sensation in a rat model of hyperalgesia with nicotine dependence

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Neural Regeneration Research 2022年第4期17卷 905-910页

作者： Shu-Ju Wang yan-ping zhang Keith A.Candiotti College of Acupuncture and Orthopedics Hubei University of Chinese Medicine/Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and MoxibustionWuhanHubei ProvinceChina Department of Anesthesiology Perioperative Medicine and Pain ManagementUniversity of Miami Miller School of MedicineMiamiFLUSA

Tobacco smoking is considered to be one of the main risk factors in the development of chronic ***-term chronic exposure to nicotine and other forms of tobacco have been shown to be associated with an increased incidence of *** have shown that acupuncture can help smokers to reduce their desire to smoke,reduce their withdrawal symptoms,and avoid a relapse after ***,little has been reported about the effects of acupuncture on pain sensitivity caused by long-term *** of hyperalgesia were established in rats exposed to nicotine for 6 *** 6 weeks of continuous nicotine exposure,electroacupuncture at bilateral acupoints Zusanli(ST36)and Taichong(LR3)was performed 20 minutes per day for 6 days at a continuous wave with a frequency of 2 Hz and a stimulus intensity of 1 m *** results revealed that electroacupuncture treatment increased the mechanical response threshold of hind paw of nicotine-dependent rats with hyperalgesia and up-regulated the protein expression of pain-related factorsμ-opioid receptor,β-endorphin and glutamic acid decarboxylase 65 in the spinal cord and midbrain periaqueductal gray and the protein expression of glutamic acid decarboxylase 67 in the spinal *** findings suggest that electroacupuncture treatment has positive analgesic effects on pain sensitivity caused by long-term chronic nicotine *** possible mechanism for the improved analgesia is that electroacupuncture increases the expression of painrelated factors in the spinal cord and midbrain periaqueductal *** study was approved by Institutional Animal Care and Use Committee(IACUC)of the University of Miami(#18-167)on December 12,2018.

关键词： chronic pain electroacupuncture glutamic acid decarboxylase 65 glutamic acid decarboxylase 67 hyperalgesia nicotine dependence pain sensation smoking β-endorphin μ-opioid receptor

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MiCPhot:A prime-focus multicolor CCD photometer on the 85-cm Telescope

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Chinese Journal of Astronomy and Astrophysics 2009年第3期9卷 349-366页

作者： Ai-Ying Zhou Xiao-Jun Jiang yan-ping zhang Jian-yan Wei National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Department of Astronomy Beijing Normal University Beijing 100875 China

We describe a new BVRI multicolor CCD photometric system situated at the prime focus of the 85-cm telescope at the Xinglong Station of NAOC. Atmospheric extinction effects, photometric accuracy and color calibration dependence of the system are investigated. Additional attention was paid to giving observers guidance in estimating throughput, detection limit, signal-to-noise ratio and exposure time.

关键词： instrumentation photometers CCD photometer- techniques photometric

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Potential Anti-cancer Activity of Furanodiene

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Chinese Journal of Cancer Research 2009年第2期21卷 154-158页

作者： Zhen-zhen Ba yan-ping Zheng Hui zhang Xiu-yan Sun Dong-hai Lin School of Pharmaceutical Science Yantai University Yantai 264005 China

Objective： To study the isolated from the essential oil VIVO anti-tumor activities of furanodiene of the rhizome of Curcuma wenyujin （C15H200）, a primary sesquiterpene compound YH Chen et C. Ling（Wen Ezhu）, in vitro and in Methods： In vitro MTT assay was used to further study the effects of time and dosage on anti-proliferation of furanodiene against the sensitive Hela, Hep-2, HL-60, U251 cells, based on the cytotoxic effects of furanodiene on 12 human malignant tumor cell lines with the essential oil of Wen Ezhn as control., and the half-inhibitory concentration （IC50） was observed. In vivo uterine cervix （U14） tumor cell was selected and the conventional assay method of anti-tumor activity was employed. Furanodiene liposome was administered intraperitoneally, and tumor-inhibitory rate, thymus and spleen indexes were observed. Results： The inhibitive effects on cell proliferation were shown in all of the twelve cell lines and the cytotoxic effects of furanodiene against Hela, Hep-2, HL-60, U251 cells were observed after 12 h of administration, the effect could last for at least 48 h in a dose dependent manner, and the IC50 values were 0.6, 1.7, 1.8, 7.0μg/ml, respectively. Furanodiene was also found to show inhibitive effects on the proliferation of uterine cervix （U14） tumor induced in mice. The tumor inhibition rates were 36.09% （40 mg/kg）, 41.55% （60 mg/kg）, 58.29% （80 mg/kg）, respectively. Conclusion： Furanodiene is one of primary anti-cancer active components in the essential oil of Wen Ezhu, and also a very effective agent against uterine cervix cancer, and has protection effect on the immune function.

关键词： Essential oil of Wen Ezhu Furanodiene Anti-cancer Uterine cervix cancer

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β-Cyclodextrin inclusion complex： preparation, characterization, and its aspirin release in vitro

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Frontiers of Materials Science 2012年第3期6卷 259-267页

作者： Hui-Yun ZHOU Ling-Juan JIANG yan-ping zhang Jun-Bo LI The Chemical Engineering&Pharmaceutics College Henan University of Science and TechnologyLuoyang 471003China

In this work, the optimal clathration condition was investigated for the preparation of aspirin-β-cyclodextrin （Asp-β-CD） inclusion complex using design of experiment （DOE） methodology. A 3-level, 3-factor Box-Behnken design with a total of 17 experimental runs was used. The Asp-β-CD inclusion complex was prepared by saturated solution method. The influence on the embedding rate was investigated, including molar ratio of β-CD to Asp, clathration temperature and clathration time, and the optimum values of such three test variables were found to be 0.82, 49C and 2.0 h, respectively. The embedding rate could be up to 61.19%. The formation of the bonding between -COOH group of Asp and O-H group of β-CD might play an important role in the process of clathration according to FT-IR spectra. Release kinetics of Asp from inclusion complex was studied for the evaluation of drug release mechanism and diffusion coefficients. The results showed that the drug release from matrix occurred through Fickian diffusion mechanism. The cumulative release of Asp reached only 40% over 24 h, so the inclusion complex could potentially be applied as a long-acting delivery system.

关键词： β-cyclodextrin (β-CD) aspirin (Asp) saturated solution method Box-Behnken design release kinetics

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Sevelamer as an efficient and reusable heterogeneous catalyst for the Knoevenagel reaction in water

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Chinese Chemical Letters 2014年第8期25卷 1141-1144页

作者： Xian-Liang Zhao Ke-Fang yang yan-ping zhang Ju Zhu Li-Wen Xu School of Biological and Chemical Engineering Zhejiang University of Science and Technology Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal University

A catalyst system of Sevelamer, a phosphate-binding drug, has been prepared and used in the Knoevenagel reaction of aromatic aldehydes in water to produce substituted electrophilic alkenes. The products were obtained in excellent yields. Several novel, related catalytic systems showed promising catalytic properties for aromatic and heterocyclic aldehydes. The Sevelamer catalyst can be recovered using simple filtration and reused numerous times（up to 15 times） in the aqueous Knoevenagel reaction without any significant lowering of activity.

关键词： Knoevenagel reaction Sevelamer Recycle Heterogeneous

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Effects of the crude extract of Polygala tenuifolia Willd on human sperm in vitro

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第6期12卷 448-454页

作者： Yi QIU Lei-guang WANG Yi-fang JIA Dan-tong yanG Mei-hua zhang yan-ping zhang Li-hong zhang Ling GAI Key Laboratory for Improving Birth Outcome Technique Shandong Provincial Institute of Science and Technology for Family Planning Jinan 250002 China

The aim of the present study is to analyze sperm membrane changes and the spermicidal effect in treatment with the crude extract from Polygala tenuifo/ia Willd （PTW） in vitro. The root of PTW was extracted in distilled water. Normal human spermatozoa were used to assess the spermicidal activity （Sander-Cramer assay） of the extract from the PTW root. The hypo-osmotic swelling （HOS） test and the eosin Y （EY） staining were used to detect the integrity of sperm membrane and vitality. The sperm chromatin dispersion （SCD） test was performed to determine sperm DNA integrity. N-9 was used as a reference standard and semen added to physiological saline was used as the control. Semen samples were donated by 42 healthy fertile men. The crude extract from the root of PTW could immobilize and kill 100% spermatozoa within 20 s in vitro at the concentrations of 20.0 and 10.0 mg/ml; at the concentration of 5.0 mg/ml, spermatozoa were immobilized in （39.5±3.2） s. In the groups of the crude extract from the root of PTW and N-9 solution the rate of the normal HOS （tails swollen） and the white head （unstained） was 0%, and the rate of the abnormal HOS （tails unswollen） and red head （stained） was 100%. Sperm DNA fragmentation showed no change in exposure to the crude extract from the root of PTW and N-9 solution. The sperm revival test did not show any spermatozoa that recovered their motilities. The rapid spermicidal activity of the crude extract from the root of PTW in vitro may occur by the disruption of the sperm membrane integrity.

关键词： Polygala tenuifofia Willd Crude extract Spermicidal effect in vitro Sperm membrane DNA integrity

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A deoxidation thermodynamic model for 304 stainless steel considering multiple-components coupled reactions

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Journal of Iron and Steel Research International 2024年第1期31卷 74-91页

作者： yan yan Guang-hao Shang Li-ping zhang Shao-ying Li Han-jie Guo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Henan Jinhui Stainless Steel Industry Group Co. Ltd.Xuchang461500HenanChina Changge Jinhui Recycling Metal R&D Co. Ltd.Xuchang461500HenanChina

A thermodynamic model for predicting the equilibrium oxygens of 304 stainless steel was developed based on the theory of slag-steel equilibrium,the law of mass conservation,and the ion and molecule coexistence *** the developed model,the Fe-Cr-Mn-Si-Al-S-O-melts reaction system and CaO-MgO-CaF_(2)-FeO-MnO-Al_(2)O_(3)-SiO_(2)-Cr2O_(3)slags were *** oxygen contents calculated by the model are in good agreement with experimental results and reference *** equilibrium oxygen contents in 304 stainless steel mainly decrease with increasing binary basicity(w(CaO)/w(SiO_(2)),where w(i)is the mass percentage of component i)and decreasing *** binary basicity at 2.0 while maintaining temperatures lower than 1823 K will keep the oxygen contents in the 304 stainless steel lower than 15×10^(-6).The equilibrium oxygen contents may also be decreased with increasing content of MgO in slags,which is more significant at lower binary ***,a small amount of FeO,MnO,and Al_(2)O_(3)(about 0-2.5 wt.%)in slags has little effect on equilibrium oxygen ***,it is found that the[C]-[O]reaction may occur during refining process but will not significantly affect the equilibrium oxygen contents.

关键词： Complex deoxidation Thermodynamic model Ion and molecule coexistence theory 304 stainless steel Slag-steel reaction

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