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Chinese Journal of Chemistry 2016年第10期34卷 1033-1038页

作者： Xu Shen Ningning Gu ping Liu Xiaowei ma Jianwei Xie yan Liu Bin Dai School of Chemistry and Chemical Engineering the Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan Shihezi University Shihezi Xinjiang 832003 China

Synthesis of triarylmethanes via metal-free reductive coupling of diaryl ketone, tosylhydrazide, and arylboronic acids has been developed. This methodology is realized via one-pot two-step reactions involving the preparation of N-tosylhydrazones by reacting tosylhydrazide with diaryl ketone derivatives, followed by the reductive coupling with arylboronic acid in the presence of potassium carbonate to afford various triarylmethanes analogues in moder- ate to good yields. Importantly, the system presented here enables the use of easily accessible starting materials and a series of substrates with diverse functional group could be tolerant in this reaction. This approach could also be particularly useful for the synthesis of triaryl-substituted carbazolyl compounds.

关键词： diaryl ketone arylboronic acid tosylhydrazide one-pot

Application of the WHO Growth Reference (2007) to Assess the Nutritional Status of Children in China

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Biomedical and Environmental Sciences 2009年第2期22卷 130-135页

作者： yan-ping LI XIAO-QI HU JING-ZHAO XIAO-GUANG yanG AND GUAN-SHENG ma National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention Beijing 100050 China

Objective To assess the nutrition status of children and adolescents in China using the WHO growth reference （2007） in comparison with that defined by the International Obesity Task Force （IOTF） and the Working Group on Obesity in China （WGOC）. Methods Overweight and obesity were defined by age-, sex-, specific BMI reference developed by WHO （2007）, IOTF （2000）, and WGOC （2004）, respectively. Stunting and thinness were defined as height and BMI less than two standard deviations （SD） of the WHO growth reference （2007）, respectively. Data of children and adolescents aged 5 to 19 years （n=54 857, 28 273 boys, 26 584 girls） from the 2002 China National Nutrition and Health Survey （CNNHS） were used in the study. Results The prevalence of overweight, obesity, stunting and thinness among Chinese children and adolescents aged 5-19 years was 5.0%, 1.2%, 13.8%, and 7.4%, respectively when the WHO growth reference （2007） was used, whereas the estimated absolute total number affected by these 4 conditions were 14.6, 3.7, 40.6, and 21.8 million, respectively. The prevalence of overweight and obesity was 18.1% in large cities, while the stunting prevalence was 25.1% in rural 4. Obesity prevalence assessed by the WHO growth reference was higher than that as assessed by the IOTF reference, and obesity prevalence assessed by the WGOC reference was lower than that as assessed by the IOTF reference. Conclusion The nutritional status of children and adolescents is not equal in different areas of China. Stunting is still the main health problem of the poor, while overweight and obesity are the main health problems in large cities.

关键词： WHO Obesity Stunting Children Adolescents China

A Rabbit Model of Hormone-induced Early Avascular Necrosis of the Femoral Head

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Biomedical and Environmental Sciences 2008年第5期21卷 398-403页

作者： QIAN WEN LI ma yan-ping CHEN LIN yanG WEI LUO AND XIAO-NING WANG Institute of Molecular Immunology Southern Medical University Guangzhou 510515 Guangdong China Imaging Diagnostic Center Nanfang Hospital Guangzhou 510515 Guangdong China School of Biosciences and Bioengineering South China University of Technology Guangzhou 510641 Guangdong China

Objective To establish an experimental model of early stage avascular necrosis of the femoral head （ANFH） caused by corticosteroid in adult rabbits and to observe the pathological changes with various imaging techniques. Methods ANFH was induced by a combination of hypersensitivity vasculitis caused by injection of horse serum and subsequent administration of a high dose of corticosteroid. The pathological changes were detected with digital radiography （DR）, computed tomography （CT）, magnetic resonance imaging （MRI）, ink artery infusion angiography, hematoxylin-eosin staining, and immunohistochemistry. Results The imageological and pathological changes corresponded to the clinical characteristics of early stage ANFH. DR showed bilaterally increased bone density, an unclear epiphyseal line, and blurred texture of cancellous bone. CT showed spot-like low-density imaging of cancellous bone, thinner cortical bone, osteoporosis, and an unclear epiphyseal line. MR! showed bone marrow edema and spot-like high signals in T2-weighted imaging in cancellous bone. Ink artery infusion angiography showed fewer obstructed blood vessels in the femoral head. HE staining of pathological sections showed fewer trabeculae and thin bone, an increased proportion of empty osteocyte lacunae, decreased hematopoiesis, thrombosis, and fat cell hypertrophy. Immunohistochemistry showed attenuated expression of vascular endothelial growth factor in osteoblasts and chondrocytes, and on the inner membrane of blood vessels. Conclusion Experimental rabbit model of early stage ANFH caused by corticosteroid can be successfully established and provide the foundation for developing effective methods to treat early stage ANFH.

关键词： Avascular necrosis of the femoral head Corticosteroid Animal model

Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells

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Current Medical Science 2022年第5期42卷 958-965页

作者： yan-ni SUN yan-ni ma Xiao-qing JIA Qi YAO Jie-ping CHEN Hui LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing400038China

Objective Acute myeloid leukemia(AML)is a highly heterogeneous and recurrent hematological *** the emergence of novel chemotherapy drugs,AML patients’complete remission(CR)remains ***,it is imperative to discover new therapeutic targets or medications to treat *** epigenetic changes like DNA methylation and histone modification play vital roles in *** deminase(PAD)is a protein family of histone demethylases,among which the PAD2 and PAD4 expression have been demonstrated to be elevated in AML patients,thus suggesting a potential role of PADs in the development or maintenance of AML and the potential for the identification of novel therapeutic *** AML cells were treated in vitro with the pan-PAD inhibitor BB-Cl-Amidine(BB-Cl-A).The AML cell lines were effectively induced into apoptosis by ***,the PAD4-specific inhibitor GSK484 did *** PAD2 played a significant role in ***,we found that BB-Cl-A could activate the endoplasmic reticulum(ER)stress response,as evidenced by an increase in phosphorylated PERK(p-PERK)and eIF2α(p-eIF2α).As a result of the ER stress activation,the BB-Cl-A effectively induced apoptosis in the AML *** Our findings indicated that PAD2 plays a role in ER homeostasis maintenance and apoptosis ***,targeting PAD2 with BB-Cl-A could represent a novel therapeutic strategy for treating AML.

关键词： acute myeloid leukemia BB-Cl-Amidine peptidylarginine deminase endoplasmic reticulum stress apoptosis

Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells

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Chinese Chemical Letters 2017年第5期28卷 991-994页

作者： Ming-Ze Qin Lei Wang Shuang yan Jun-Jie ma Ye Tian yan-Fang Zhao ping Gong Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University) Ministry of Education School of Biomedical Sciences Huaqiao University

Based on our previous work,a series of hydrazone moiety-bearing aminopyrimidines were *** compounds were evaluated for inhibitory activities against EGFRT790M/L858 R and antiproliferative activities against H1975 and A549 NSCLC cell lines harboring different forms of *** 7f and7 k exhibited potent and selective activity in inhibition of gefitinib-resistant H1975 cancer cells（IC50;0.45,0.2μmol/L） while were much less active on A549 cancer cells（IC50;52.83,〉100μmol/L）.Both compounds could be served as promising lead compounds for further investigation.

关键词： Aminopyrimidines EGFR T790M/L858R Selectivity Anti-resistance Antiproliferative activity

Comparative analysis of cytochrome P450-like genes from Locusta migratoria manilensis： expression profiling and response to insecticide exposure

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Insect Science 2012年第1期19卷 75-85页

作者： yan-Qiong Guo Jian-Zhen Zhang Mei-Ling yang Liang-Zhen yan Kun yan Zhu Ya-ping Guo En-Bo ma Institute of Appfied Biology Shanxi UniversityTaiyuan College of Agriculture Shanxi Agricultural UniversityTaiguShanxi ProvinceChina Department of Entomology Kansas State UniversityManhattanKansasUSA

The cytochrome P450 monooxygenase （cytochrome P450） gene superfamily comprises many genes that may be involved in the biotransformations of pesticides and other xenobiotics. To date, very little is known about cytochrome P450 genes in the oriental migratory locust, Locusta migratoria manilensis. In this study, we carried out a genomewide analysis ofcytochrome P450 genes of the locust to identify putative cytochrome P450 genes and characterize their expression responses to insecticide exposures. We identified 15 cytochrome P450-1ike genes from a locust expressed sequence tag database （LocustDB）. Reverse transcription polymerase chain reaction （RT-PCR） analysis showed that most cytochrome P450-1ike genes displayed different tissue and developmental stage expression patterns. However, most of them were predominantly expressed in the midgnt, gastric caeca, fatbodies, and/or hindgut. Biochemical analysis showed that cytochrome P450 was differentially affected by three different insecticides. Deltamethrin caused significant inductions in 12 h at LD30 （dose to kill 30% of the tested individuals） in the nymphs, whereas malathion and carbaryl did not have significant effect on cytochrome P450 enzyme activity. Further RT-PCR analysis Showed significant increases of transcriptions of several cytochrome P450 genes in deltamethrin-treated locusts. Thus, the increased cytochrome P450 enzyme activity is likely due to increased transcriptions of multiple cytochrome P450 genes in response to deltamethrin exposure. These results are expected to help us better understand the interactions between insecticides and major detoxification enzymes, and possible changes of the susceptibility to other insecticides in deltamethrin-treated insects at various molecular levels.

关键词： cytochrome P450 monooxygenase deltamethrin gene expression profiling insecticide Locusta migratoria manilensis

Operating efficiency in Chinese universities:An extended two-stage network DEA approach

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Journal of management Science and Engineering 2021年第4期6卷 482-498页

作者： Ya Chen Xuanxuan ma ping yan Mengyuan Wang School of Economics Hefei University of TechnologyHefei230009China Huaibei Rural Commercial Bank Xiangshan DistrictHuaibei235000China Criminal Justice School Zhongnan University of Economics and LawWuhan430073China

Operating efficiency of universities is widely concerned by the education *** a non-parametric method for efficiently handling multiple inputs and outputs,data envelopment analysis(DEA)is often used for measuring the operating ***,shared input resources are often ignored in the existing DEA *** order to remedy the shortcoming with a focus on teaching and research processes of universities,this paper adopts an extended two-stage network DEA approach to measure the operating efficiency of 52 universities in China using a data set in *** main findings show that:(1)Among the operating efficiency of 52 universities,about one third and two thirds of universities are efficient and inefficient,*** may reflect some problems such as inefficient use of resources or unsatisfactory outcomes for these inefficient *** giving first priority to universities’teaching or research process,we provide alternative ways for teaching-oriented or research-oriented universities to benchmark and improve their performance.(2)For the heterogeneity efficiency analysis of different universities,the operating efficiency of“non-985”universities are significantly higher than that of“985”universities,while there is only a small difference on the operating efficiency between comprehensive universities and science&engineering *** the efficiency of the central and western universities is slightly better than that of the eastern universities in terms of the average efficiency,there is no significant efficiency difference among the eastern,central,and western regions ***,to improve the operating efficiency of Chinese universities,the Chinese government should improve the financial allocation mechanism and introduce successful budget performance *** the Chinese universities,they should formulate teaching and scientific research plans according to their own research needs and development goals.

关键词： Data envelopment analysis(DEA) Data enabled analytics Two-stage network DEA Higher education institutions(HEIs) Chinese universities Operating efficiency

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： Xiaodong yang Haochen Shen Xiaoming Xiao Zhichao Li Qi Zhou Wei yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 ma cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 ma cm-2and exhibited high structural robustness,maintaining stability at 1000 ma cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

Integrative SMRT sequencing and ginsenoside profiling analysis provide insights into the biosynthesis of ginsenoside in Panax quinquefolium

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Chinese Journal of Natural Medicines 2022年第8期20卷 614-626页

作者： DI Peng yan yan WANG ping yan Min WANG Ying-ping HUANG Lu-Qi State Key Laboratory Breeding Base of Dao-Di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Center for Post-doctoral Research China Academy of Chinese Medical SciencesBeijing 100700China State Local Joint Engineering Research Center of Ginseng Breeding and Application Jilin Agricultural UniversityChangchun 130118China

Panax quinquefolium is one of the most common medicinal plants *** are the major pharmaceutical components in *** biosynthesis of ginsenosides in different tissues of *** remained largely *** the current study,an integrative method of transcriptome and metabolome analysis was used to elucidate the ginsenosides biosynthesis pathways in different tissues of ***,22 ginsenosides in roots,leaves,and flower buds showed uneven distribution patterns.A comprehensive *** transcriptome was generated through single molecular real-time(SMRT)and second-generation sequencing(NGS)technologies,which revealed the ginsenoside pathway genes and UDP-glycosyltransferases(UGT)family genes explicitly expressed in roots,leaves,and flower *** weighted gene co-expression network analysis(WGCNA)of ginsenoside biosynthesis genes,UGT genes and ginsenoside contents indicated that three UGT genes were positively correlated to pseudoginsenoside F11,notoginsenoside R1,notoginsenoside R2 and pseudoginsenoside *** results provide insights into ginsenoside biosynthesis in different tissues ***.

关键词： Panax quinquefolium SMRT sequencing Ginsenoside biosynthesis UDP-glycosyltransferases

二氢杨梅素分子结构与性质的密度泛函理论研究

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原子与分子物理学报 2025年第1期42卷 29-34页

作者：辛国鹏毛敏刘信平马文涛马杰张煜湖北民族大学化学与环境工程学院恩施445000

本文基于密度泛函理论(DFT),采用B3LYP泛函结合6-31G基组上对二氢杨梅素的分子几何结构进行了优化,在此基础上以水为溶剂计算二氢杨梅素分子的活性位点以及红外光谱进行分析.静电势结果表明二氢杨梅素的亲核活性位点位于酚羟基氢原子(H... 详细信息

本文基于密度泛函理论(DFT),采用B3LYP泛函结合6-31G基组上对二氢杨梅素的分子几何结构进行了优化,在此基础上以水为溶剂计算二氢杨梅素分子的活性位点以及红外光谱进行分析.静电势结果表明二氢杨梅素的亲核活性位点位于酚羟基氢原子(H23)附近;而亲电活性位点位于氧原子(O32)及其附近.前线分子轨道研究结果表明二氢杨梅素分子的最高占据轨道(HOMO)都位于酮基氧(O32)和羟基氧(O20)附近,说明这些位点易与亲电试剂反应.而最低空轨道(LUMO)位于碳原子(C12、C13、C14)区域,表明这些区域可与亲核试剂反应.简缩福井函数(f)结果证实了位于C-O-C键中的氧原子的f-值的亲电活性较其他位点氧原子大;而位于C8碳原子的f^(+)值较大,因此该位点亲核活性较强.通过理论计算所得到的二氢杨梅素的红外光谱数据与实验所得到的红外光谱数据相差不大,这就说明理论计算结果是较为可靠的.从而为实验和理论研究二氢杨梅素结构与性质的关系提供了一定的理论参考.

关键词：二氢杨梅素密度泛函理论反应活性位点量子化学计算

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