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Inetetamab combined with tegafur as second-line treatment for human epidermal growth factor receptor-2-positive gastric cancer: A case report

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World Journal of Clinical Cases 2024年第4期12卷 820-827页

作者： Jing-Hao Zhou Qi-Jun Yi ming-yan li yan Xu Qi Dong Cong-Ying Wang Hai-yan liu Department of Oncology The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina

BACKGROUND Human epidermal growth factor receptor-2(HER-2)plays a vital role in tumor cell proliferation and ***,the prognosis of HER2-positive gastric cancer is ***,a novel anti-HER2 targeting drug independently developed in China,exhibits more potent antibody-dependent cell-mediated cytotoxicity than trastuzumab,which is administered as the first-line treatment for HER2-positive gastric cancer in combination with *** this case,the efficacy and safety of inetetamab combined with tegafur was investigated as a second-line treatment for HER2-positive gastric *** SUMMARY A 52-year-old male patient with HER2-positive gastric cancer presented with abdominal distension,poor appetite,and fatigue two years after receiving six cycles of oxaliplatin combined with tegafur as first-line treatment after surgery,followed by tegafur monotherapy for six *** patient was diagnosed with postoperative recurrence of gastric *** received 17 cycles of a combination of inetetamab,an innovative domestically developed anti-HER2 monoclonal antibody,and tegafur chemotherapy as the second-line treatment(inetetamab 200 mg on day 1,every 3 wk combined with tegafur twice daily on days 1–14,every 3 wk).Evaluation of the efficacy of the second-line treatment revealed that the patient achieved a stable condition and progression-free survival of 17 *** tolerated the treatment well without exhibiting any grade 3-4 adverse *** Inetetamab combined with chemotherapy for the treatment of metastatic HER2-positive gastric cancer demonstrates significant survival benefits and acceptable safety.

关键词： Inetetamab Gastric cancer Human epidermal growth factor receptor-2 protein Tegafur Case report

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Inetetamab combined with S-1 and oxaliplatin as first-line treatment for human epidermal growth factor receptor 2-positive gastric cancer

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World Journal of Gastroenterology 2024年第40期30卷 4367-4375页

作者： Ying Kong Qi Dong Peng Jin ming-yan li li Ma Qi-Jun Yi Yu-E Miao Hai-yan liu Jian-Gang liu Department of Oncology The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina

BACKGROUND Patients with human epidermal growth factor receptor 2(HER2)-positive advanced gastric cancer have poor *** combined with chemotherapy is the first-line standard treatment for HER2-positive advanced gastric *** is a novel anti-HER2 drug,and its efficacy and safety in gastric cancer have not yet been *** To evaluate the efficacy and safety of the S-1 plus oxaliplatin(SOX)regimen combined with inetetamab as a first-line treatment for HER2-positive advanced gastric *** Thirty-eight patients with HER2-positive advanced gastric cancer or gastroeso-phageal junction adenocarcinoma were randomly divided into two groups:One group received inetetamab combined with the SOX regimen,and the other group received trastuzumab combined with the SOX *** 4-6 cycles,patients with stable disease received maintenance *** primary endpoints were progression-free survival(PFS)and overall survival(OS),and the secondary endpoints were the objective response rate,disease control rate,and adverse events(AEs).RESULTS Thirty-seven patients completed the trial,with 18 patients in the inetetamab group and 19 patients in the trastuzumab *** the inetetamab group,the median PFS was 8.5 months,whereas it was 7.3 months in the trastuzumab group(P=0.046);this difference was *** median OS in the inetetamab group vs the trastuzumab group was 15.4 months vs 14.3 months(P=0.33),and the objective response rate was 50%vs 42%(P=0.63),respectively;these differences were not *** AEs included leukopenia,thrombocytopenia,nausea,and *** incidence rates of grade≥3 AEs were 56%in the inetetamab group and 47%in the trastuzumab group(P=0.63),with no significant *** In the first-line treatment of HER2-positive advanced gastric cancer,inetetamab and trastuzumab showed comparable *** inetetamab group showed superior PFS,and both groups had good safety.

关键词： Human epidermal growth factor receptor 2-positive Advanced gastric cancer Inetetamab Trastuzumab Efficacy Safety

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初中历史跨学科作业设计的偏差及其矫正

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教学与管理 2024年第19期 45-48页

作者：严立明福建省长汀县馆前中学福建龙岩366306

积极探索初中历史跨学科作业设计既是全面贯彻落实“双减”政策的有效施为,也是践行新课标中开展跨学科主题学习要求的关键举措。然而,在当下的教学实践中,受限于种种因素,教师在设计初中历史跨学科作业时出现了作业主题离散化、作业目... 详细信息

积极探索初中历史跨学科作业设计既是全面贯彻落实“双减”政策的有效施为,也是践行新课标中开展跨学科主题学习要求的关键举措。然而,在当下的教学实践中,受限于种种因素,教师在设计初中历史跨学科作业时出现了作业主题离散化、作业目标模糊化、作业内容浅表化、作业评价简单化等偏差。想要矫正这些偏差,可以通过以下策略来实现:一是聚焦作业主题,锚定历史跨学科作业的价值引领;二是明确作业目标,靶向历史跨学科作业的素养定位;三是优化作业内容,深化历史跨学科作业的问题设计;四是改进作业评价,完善历史跨学科作业的评价量规。

关键词：跨学科作业设计初中历史跨学科主题学习

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初中历史结构化教学的基本理念与实现路径

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教学与管理 2024年第1期 55-58页

作者：严立明杨佳攀福建省长汀县馆前中学福建龙岩366306 福建省龙岩市教育科学研究院福建龙岩361000

“碎片化知识”既不利于学生自主建构认知体系,又影响学生学科核心素养的培育。结构化教学是化解“碎片化教学”的有效措施。在结构化教学基本理念的指导下,历史结构化教学可从以下几个方面开展:一是融通素养内涵,确定整体化目标;二是... 详细信息

“碎片化知识”既不利于学生自主建构认知体系,又影响学生学科核心素养的培育。结构化教学是化解“碎片化教学”的有效措施。在结构化教学基本理念的指导下,历史结构化教学可从以下几个方面开展:一是融通素养内涵,确定整体化目标;二是整合教学内容,建构系列化知识;三是聚焦学习主题,设计逻辑化问题;四是触发学习动力,实施体系化评价。

关键词：初中历史结构化教学知识结构化

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Chemiluminescence determination of 20 amino acids and the mechanism study

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Chinese Chemical Letters 2010年第7期21卷 856-859页

作者： yan ming liu Zhuan li liu College of Chemistry and Chemical Engineering Xinyang Normal UniversityXinyang 464000China

It was found that 20 amino acids could inhibit the intensity of the luminol-H_2O_2-CuSO_4 chemiluminescence *** this character,a rapid and sensitive method for the determination of 20 amino acids was developed with flow injection coupled with chemiluminescence *** the optimal conditions,the detection limits of 20 amino acids were in the range of 4.5×10^（-7）- 4.3×10^（-10） mol/L,and the relative standard deviations were less than 3.2%.The proposed method was successfully applied to drug *** possible mechanism was also discussed.

关键词： Chemiluminescence Flow injection Amino acid Mechanism study

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Intrinsic feature extraction using discriminant diffusion mapping analysis for automated tool wear evaluation

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Frontiers of Information Technology & Electronic Engineering 2018年第11期19卷 1352-1361页

作者： Yi-xiang HUANG Xiao liU Cheng-liang liU yan-ming li State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Aerospace Equipment Manufacturer Shanghai 200245China

We present a method of discriminant diffusion maps analysis(DDMA) for evaluating tool wear during milling processes. As a dimensionality reduction technique, the DDMA method is used to fuse and reduce the original features extracted from both the time and frequency domains, by preserving the diffusion distances within the intrinsic feature space and coupling the features to a discriminant kernel to refine the information from the high-dimensional feature space. The proposed DDMA method consists of three main steps:(1) signal processing and feature extraction;(2) intrinsic dimensionality estimation;(3) feature fusion implementation through feature space mapping with diffusion distance preservation. DDMA has been applied to current signals measured from the spindle in a machine center during a milling experiment to evaluate the tool wear status. Compared with the popular principle component analysis method, DDMA can better preserve the useful intrinsic information related to tool wear status. Thus, two important aspects are highlighted in this study: the benefits of the significantly lower dimension of the intrinsic features that are sensitive to tool wear, and the convenient availability of current signals in most industrial machine centers.

关键词： Tool condition monitoring Manifold learning Dimensionality reduction Diffusion mapping analysis Intrinsic feature extraction

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Assembling and releasing performance of supramolecular hydrogels formed from simple drug molecule as the hydrogelator

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Chinese Chemical Letters 2007年第8期18卷 1009-1012页

作者： Yu Jiang Wang liang yan li ming Tang Jian Yu Laboratory of Advanced Materials Department of Chemical Engineering Tsinghua University Beijing 100084 China

A simple drug compound, 4-oxo-4-（2-pyridinylamino） butanoic acid （defined as AP）, was able to gel water at 4 wt% concentration under various conditions. In the superstructure, AP molecules assembled into fibrous aggregates driving by hydrogen bonds and π-π stacking interaction. The gels with different backbone structures released drug molecules in different speeds.

关键词： Supramolecular hydrogel Hydrogelator Releasing

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Genome-wide identification and expression analysis of anthocyanin biosynthetic genes in Brassica juncea

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Journal of Integrative Agriculture 2020年第5期19卷 1250-1260页

作者： ZHANG Da-wei liU li-li ZHOU Ding-gang liU Xian-jun liU Zhong-song yan ming-li School of life Science Hunan University of Science and TechnologyXiangtan 411201P.R.China Hunan Key Laboratory of Economic Crops Genetic Improvement and Integrated Utilization Xiangtan 411201P.R.China College of life Sciences Resources and Environment SciencesYichun UniversityYichun 333600P.R.China Oilseed Research Institute Hunan Agricultural UniversityChangsha 410128P.R.China

Anthocyanins confer the wide range of colors for plants and also play beneficial health roles as potentially protective factors against heart disease and cancer. Brassica juncea is cultivated as an edible oil resource and vegetable crop worldwide, thus elucidating the anthocyanin biosynthetic pathway would be helpful to improve the nutritional quality of Brassica juncea through the breeding and cultivating of high anthocyanin content varieties. Herein, 129 genes in B. juncea were identified as orthologs of 41 anthocyanin biosynthetic genes(ABGs) in Arabidopsis thaliana by comparative genomic analyses. The B. juncea ABGs have expanded by whole genome triplication and subsequent allopolyploidizatoin, but lost mainly during the whole genome triplication between B. rapa/B. nigra and A. thaliana, rather than the allopolyploidization process between B. juncea and B. rapa/B. nigra, leading to different copy numbers retention of A. thaliana homologous genes. Although the overall expansion levels ABGs were similar to the whole genome, more negative regulatory genes were retained in the anthocyanin biosynthesis regulatory system. Transcriptional analysis of B. juncea with different anthocyanin accumulation showed that BjDFR, BjTT19, BjTT8 are significantly up-regulated in plants with purple leaves as compared with green leaves. The overexpression of BjTT8 and these target genes which were involved in late anthocyanin biosynthesis and transport might account for increasing levels of anthocyanin accumulation in purple leaves. Our results could promote the understanding of the genetic mechanism of anthocyanin biosynthesis in B. juncea.

关键词： anthocyanin biosynthetic genes B.juncea comparative genomic analysis transcriptome leaf color

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黑芥和埃塞俄比亚芥PAP2基因克隆及B基因组PAP2功能验证

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中国油料作物学报 2024年第2期46卷 274-283页

作者：谢娜娜黄伟高国应张大为周定港吴金锋向建华刘丽莉严明理湖南科技大学生命科学与健康学院湖南湘潭411201 经济作物遗传改良与综合利用湖南省重点实验室湖南湘潭411201 湖南省作物研究所湖南长沙410125

PAP2(Production of anthocyanin pigment 2)编码MYB转录因子,与bHLH、WD40形成MYB-bHLH-WD40复合体来调控花青素合成。本研究从埃塞俄比亚芥和黑芥中分别克隆出2个和1个PAP2基因拷贝,分别命名为***2、***2、***2,这三个基因均由3个外... 详细信息

PAP2(Production of anthocyanin pigment 2)编码MYB转录因子,与bHLH、WD40形成MYB-bHLH-WD40复合体来调控花青素合成。本研究从埃塞俄比亚芥和黑芥中分别克隆出2个和1个PAP2基因拷贝,分别命名为***2、***2、***2,这三个基因均由3个外显子和2个内含子组成,均编码247个氨基酸。基于本研究克隆的PAP2基因序列和已报道的其他芸薹属PAP2基因序列,设计了3对能分别检测A、B、C基因组PAP2基因的引物,通过等位特异PCR可以区分芸薹属禹氏三角中的6个物种PAP2的基因组来源。选取芥菜型油菜B基因组的***2基因构建过表达载体,转化拟南芥,其叶片变紫,表明PAP2基因正调控花青素合成。遮光处理10天后紫叶埃塞俄比亚芥的叶片紫色变淡,花青素含量下降了41.22%。荧光定量PCR和转录组研究表明,遮光处理植株叶片中***2和***2表达量均下降,花青素合成的结构基因查尔酮合成酶基因(CHS)、查尔酮异构酶基因(CHI)、黄烷酮3-羟化酶基因(F3H)、二氢黄酮醇还原酶基因(DFR)、花青素合成酶基因(ANS)、类黄酮3-葡糖基转移酶基因(UFGT)等基因的表达量也下降。本研究完成了对芸薹属植物中埃塞俄比亚芥和黑芥PAP2基因的克隆,并对其进行进化分析。根据本实验中克隆及其他已报道的PAP2基因序列设计等位基因特异性PCR引物,为芸薹属种间杂交后代PAP2基因的基因组传递鉴定提供了分子标记。通过***2基因转拟南芥植株结果表明PAP2基因参与花青素的积累。紫叶埃塞俄比亚芥经遮光处理后,发现BcaPAP2基因及花青素合成结构基因的表达受光照的诱导。本研究在芸薹属中克隆PAP2基因,并初步验证PAP2的功能,为进一步解析芸薹属植物花青素合成的调控机制提供参考。

关键词： PAP2基因花青素芸薹属克隆功能验证

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Sleep-disordered breathing is associated with depletion of circulating endothelial progenitor cells and elevation in pulmonary arterial pressure in patients with decompensated systolic heart failure

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Journal of Geriatric Cardiology 2015年第4期12卷 424-430页

作者： Han ZHANG liu FENG Qi-lin WAN yan HONG yan-ming li Guan-Chang CHENG Xin-Qiang HAN Department of Cardiology Huaihe Hospital of Henan University No.8 Baogonghu Road Kaifeng Henan China Department of Intensive Care Unit Huaihe Hospital of Henan University No.8 Baogonghu Road Kaifeng Henan China Reid Hospital and Health Care Services Indiana University School of Medicine Richmond USA

Background Sleep-disordered breathing （SDB） is known to occur frequently in and may predict worsening progression of patients with congestive heart failure （CHF）. SDB is also known to play an important role in the development of idiopathic pulmonary arterial hyper- tension （PAH） via inducing endothelial dysfunction and vascular remodeling, a pathological process that can be significantly influenced by factors such as osteoprotegerin （OPG） and endothelial progenitor cells （EPCs）. The objective of this study is to determine if CHF with SDB is associated with changes in OPG, EPCs, and PAIl. Methods EPCs were isolated, cultured, and quantified from CHF patients with SDB （n = 52）, or without SDB （n - 68）. OPG and N-terminal pro-brain natriuretic peptide （NT-proBNP） from each group was analyzed and cor- related with EPCs and the mean pulmonary artery pressure （mPAP） measured by right heart catheterization. Results A significant decrease in circulating EPCs （29.30 ± 9.01 vs. 45.17 ± 10.51 EPCs/x 200 field; P 〈 0.05） was found in CHF patients with SDB compared to those without SDB. Both OPG （789.83 ±89.38 vs. 551.29 ± 42.12 pg/mL; P 〈 0.05） and NT-proBNP （5946.50 ± 1434.50 vs. 3028.60 ± 811.90 ng/mL; P 〈 0.05） were also significantly elevated in SDB CHF patients who also had significantly elevated mPAP （50.2 ± 9.5 vs. 36.4 ± 4.1 mm Hg; P 〈 0.05）. EPC numbers correlated inversely with the episodes of apnea and hypopnea per hour （RDI, r = -0.45, P = 0.037） and blood level of OPG （r =-0.53, P = 0.011）. Although NT-proBNP was also increased significantly in patients with SDB, it had no correlation with either EPCs or RD1. Conclusions SDBdue to hypoxemia from decompensated CHF is associated with （1） OPG elevation, （2） EPC depletion, and （3） mPAP elevation. The inverse relationship of circulating OPG with EPCs suggests a likely mechanism for hypoxemia and OPG in the development of pulmonary vascular dysfunction via depleting EPCs, thus worsening prognosis of CHF.

关键词： Congestive heart failure Endothelial progenitor cells Osteoprotegerin Sleep-disordered breathing

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