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阿司匹林联合他汀类药物对脑血栓患者颈动脉斑块的改善作用

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中国生化药物杂志 2017年第6期37卷 283-285页

作者：谷海燕唐敏刘晓广宁波市康复医院神经康复科

目的探讨阿司匹林联合他汀类药物对脑血栓患者颈动脉斑块的改善作用.方法选取宁波市康复医院2014年5月-2016年5月收治的脑血栓患者80例,依据治疗方法将这些患者分为2组,即单纯阿司匹林治疗组（单独治疗组,40例）和阿司匹林联合他汀类... 详细信息

目的探讨阿司匹林联合他汀类药物对脑血栓患者颈动脉斑块的改善作用.方法选取宁波市康复医院2014年5月-2016年5月收治的脑血栓患者80例,依据治疗方法将这些患者分为2组,即单纯阿司匹林治疗组（单独治疗组,40例）和阿司匹林联合他汀类药物治疗组（联合治疗组,40例）,对2组患者的NIHSS评分、Barthel指数、临床疗效、IMT、斑块面积进行统计分析.结果联合治疗组患者的Barthel指数显著高于单独治疗组（P〈0.05）,NIHSS评分显著低于单独治疗组（P〈0.05）,治疗的总有效率95.0%（38/40）显著高于单独治疗组80.0%（32/40）（P〈0.05）,IMT显著短于单独治疗组（P〈0.05）,斑块面积显著小于单独治疗组（P〈0.05）.结论阿司匹林联合他汀类药物较单纯阿司匹林更能有效改善脑血栓患者的颈动脉斑块状况,值得在临床推广使用.

关键词：阿司匹林联合他汀类药物脑血栓颈动脉斑块改善作用

脂质转移蛋白SiLTP1基因参与谷子耐盐响应初探

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作物学报 2025年第1期51卷 58-67页

作者：孟凡花刘敏沈傲刘炜山东省农业科学院农作物种质资源研究所山东济南250100 上海应用技术大学生态技术与工程学院上海201418

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁... 详细信息

土壤盐渍化严重制约农业生产发展,通过提高植物耐盐性进行盐碱地综合利用,对于保障粮食安全,提升农业生产效率具有重要意义。脂质转移蛋白是一类在高等植物中广泛存在的小分子蛋白质,能够参与植株生长、信号转导以及多种生物和非生物胁迫过程。前期本课题组克隆到一个谷子中编码脂质转移蛋白的基因SiLTP1,本研究通过构建其原核表达载体和植物双元过表达载体,获得了该基因的原核表达蛋白及同源转化过表达阳性植株,经进一步筛选获得4个纯合株系。体外耐盐性试验显示, SiLTP1的原核表达蛋白具有一定耐盐性;转基因植株苗期耐盐生理指标测定显示,SiLTP1过表达植株在遭受盐胁迫时,植株体内MDA积累减少,抗氧化酶含量升高,可积累更少的过氧化氢,从而降低胁迫对植株的氧化损伤,显示基因过表达植株具有更好的耐盐性。本研究结果初步揭示, SiLTP1可正向调控谷子的耐盐性,其在谷子耐盐抗逆方面具有潜在功能,为耐盐谷子品种改良及新品种培育提供了理论基础和候选基因资源。

关键词：脂质转移蛋白 SiLTP1 盐胁迫谷子耐盐响应

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Reynolds number dependence of particle transport in a 90°bend with electrostatic effects

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Particuology 2023年第6期77卷 91-104页

作者： Yudong yan yanlin Zhao min liu Jun Yao International Joint Laboratory on Clean Energy Science and Technology Beijing Key Laboratory of Process Fluid Filtration and SeparationCollege of Mechanical and Transportation EngineeringChina University of Petroleum-BeijingBeijing102249China

In this work,particle transport in a fully developed turbulent 90°bend flow at the"electrostatic equi-librium"state is simulated using large eddy simulation coupled with Lagrangian particle tracking *** flow Reynolds numbers(based on bulk velocity)considered is from 34000 to *** particle size 5,10 and 50μm are considered and their corresponding St number are from 2.2 to *** results of the bend flow agree well with experimental *** electrostatic field formed in the bend is symmetric in the spanwise direction but asymmetric in the vertical direction and radial direction,which is independent of Reynolds *** minimum electrostatic field strength occurs at r/ra=0.25 near the inner wall of the *** transported in a bend gradually accumulate near the wall due to turbophoresis,such trend is improved by *** addition,under the effect of electrostatics,the plume pattern of particle distribution *** concentration at the inner wall of the bend is higher than that at the outer wall,which depends on the combined effect of elec-trostatics and Dean vortices in the bend.

关键词： Electrostatics Bend Turbulent flow Particle transport Largeeddy simulation

调整细胞培养条件提高间充质干细胞外泌体治疗骨关节炎的潜能

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中国组织工程研究 2025年第1期29卷 164-174页

作者：钱燕刘启颂深圳国家感染性疾病临床医学研究中心南方科技大学深圳市第三人民医院广东省深圳市518112

背景:间充质干细胞外泌体有望发展成为治疗骨关节炎的无细胞疗法,而通过调整细胞培养条件,可以进一步提高其治疗活性和临床转化潜能。目的:综述分析细胞培养条件对外泌体活性的影响,分析其临床转化潜力。方法:查阅国内外有关骨关节炎/... 详细信息

背景:间充质干细胞外泌体有望发展成为治疗骨关节炎的无细胞疗法,而通过调整细胞培养条件,可以进一步提高其治疗活性和临床转化潜能。目的:综述分析细胞培养条件对外泌体活性的影响,分析其临床转化潜力。方法:查阅国内外有关骨关节炎/软骨损伤修复与间充质干细胞来源外泌体的文献。检索词分别为“外泌体,间充质干细胞,骨关节炎,软骨修复”和“exosomes,extracellular vesicles,mesenchymal stem cells,osteoarthritis,cartilage repair”,检索数据库分别为PubMed和中国知网数据库,检索时限为2010-2023年,最后纳入100篇文献进行总结和分析。结果与结论:(1)在间充质干细胞的培养过程中,提供有利于软骨细胞生长的物理环境,或添加软骨保护小分子、成软骨诱导因子和炎症因子等刺激细胞,可以进一步提高间充质干细胞外泌体在维持软骨细胞表型、促进软骨再生和免疫抑制等方面的调控活性;因此,其他具有相似特征的物理或化学因素,也有可能提升间充质干细胞外泌体治疗骨关节炎的疗效。(2)低氧诱导、脉冲电磁场刺激、生物反应器及软骨保护分子(如人甲状旁腺素1-34)刺激等细胞培养方案具有安全、可规模化生产等优点,可用于制备临床用途的、疗效好的间充质干细胞外泌体。(3)间充质干细胞外泌体有望实现骨关节炎的修正治疗,通过调整细胞培养方案提升治疗活性,可进一步提高其临床转化的可行性。

关键词：间充质干细胞外泌体骨关节炎软骨修复细胞培养低氧诱导预处理三维培养软骨保护因子炎症因子

A Neural Network Recognition Method of Shape Pattern

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Journal of Iron and Steel Research International 2001年第1期8卷 16-20页

作者： PENG yan liu Hong-min yanshan University

A new pattern recognition method of shape was presented based on artificial neural network *** method avoids the defects of shape pattern recognition with polynomials and it has strong disturbance *** has been proved to be superior in recognizing different shape patterns by identifying many sorts of working sample books which the results are known.

关键词： shape pattern recognition artificial neural networ

四种辐射防护药对小鼠小肠隐窝再生的保护作用

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军事医学科学院院刊 1983年第1期 17-19页

作者：潘延延李元敏刘雪桐军事医学科学院放射医学研究所

本试验挑选了四种辐射防护药物,雌三醇,茜草双酯、茜草提取物及 WR-2721观察其对小白鼠的小肠隐窝再生的保护作用。材料与方法实验动物为10周龄、雄性 LACA 小鼠,体重25—35克,每组均为10只动物,第一批实验中以60Coγ线全身一次照射8、1... 详细信息

本试验挑选了四种辐射防护药物,雌三醇,茜草双酯、茜草提取物及 WR-2721观察其对小白鼠的小肠隐窝再生的保护作用。材料与方法实验动物为10周龄、雄性 LACA 小鼠,体重25—35克,每组均为10只动物,第一批实验中以60Coγ线全身一次照射8、10、12、14、16戈瑞,剂量率为82.9—82.0伦/

关键词：保护作用肠隐窝小肠戈瑞抗放药小鼠小家鼠茜草提取物

The dispersion of particles in turbulent semi-circular duct flows

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Petroleum Science 2021年第4期18卷 1240-1255页

作者： min liu Jun Yao yan-Lin Zhao International Joint Laboratory on Clean Energy Science and Technology College of Mechanical and Transportation EngineeringChina University of Petroleum-BeijingBeijing102249People's Republic of China Beijing Key Laboratory of Process Fluid Filtration and Separation College of Mechanical and Transportation EngineeringChina University of Petroleum-BeijingBeijing102249People's Republic of China

The flow field in a semi-circular duct is simulated by Large Eddy Simulation(LES)and its particle field is simulated by Lagrange particle tracking *** number Reb(based on bulk velocity and hydraulic diameter)is 80,000 and Ret(based on friction velocity and hydraulic diameter)is *** diameter dpis chosen as 10,50,100,500 mm corresponding to St as 0.10,2.43,9.72,*** results show that the intensity of the secondary flow near the ceiling is less than that near the floor because the ceiling is curved and able to inhibit the secondary *** is found that the difference between the semicircular duct and the square duct is that the secondary flow in a corner of the semi-circular duct is not symmetrical along the diagonal although they have the same generation *** the particles,small particles(dp≤10 mm)are found to uniformly distribute in the duct,while large particles(dp≥50 mm)preferentially distribute in the corner and floor *** maximum particles(dp=500mm)fall on the floor quickly and their dispersion mainly depends on the secondary flow near the *** deposition in the corner depends on particle size due to the effect of secondary flow and *** effect of lift force on particles becomes more significant for 50 and 100 mm particles in comparison with other smaller *** the end,the effect of secondary flow is found to be more significant to dominate particle behavior than that of flow fluctuation.

关键词： Semi-circular duct Secondary flow Particle dispersion Turbulence Large eddy simulation

A novel molecular mechanism for nitrated α-synuclein-induced cell death

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Journal of Molecular Cell Biology 2011年第4期3卷 239-249页

作者： yanying liu min Qiang yan Wei Rongqiao He State Key Laboratory of Brain and Cognitive Sciences Institute of BiophysicsChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China Key Laboratory of Mental Health Institute of PsychologyChinese Academy of Sciences15 Datun RoadChaoyang DistrictBeijing 100101China

Although previous studies have demonstrated the involvement of nitrated a-synuclein in neurodegenerative disorders(synucleinopathies),the effects of nitrated α-synuclein and the molecular mechanisms underlying its toxicity are still *** the present study,nitrated α-synuclein with four 3-nitrotyrosines(Tyr^(39),Tyr^(125),Tyr^(133),and Tyr^(136))was obtained non-enzymatically by incubation with *** nitrated protein existed as a mixture of monomers,dimers,and polymers in *** nitrated a-synuclein could induce cell death in a time-and concentration-dependent manner when SH-SY5Y cells(a human neuroblastoma cell line)were incubated with the dimers and *** with anti-integrin α5β1 antibody partially rescued the SH-SY5Y cells from the cell *** blotting and immunoprecipitation revealed that the nitrated protein bound to integrin on the cell *** of nitric oxide(NO)and calcium-independent inducible NO synthase(iNOS)activity increased during the initial stages of the *** expression of phosphorylated focal adhesion kinase(FAK)decreased in the ***,an increase in caspase 3 activity was observed in SH-SY5Y *** results demonstrate that activation of iNOS and inhibition of FAK may both be responsible for the cell death induced by nitrated α-*** data suggest that the cytotoxicity of nitrated a-synuclein is mediated via an integrin-iNOS/-FAK signaling pathway,and that the nitration of α-synuclein plays a role in neuronal degeneration.

关键词： nitric oxide nitration neuronal death toxicity focal adhesion kinase calcium-independent inducible nitric oxide synthase

Differentiation therapy:a promisingstrategy for cancer treatment

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Chinese Journal of Cancer 2016年第1期35卷 1-3页

作者： min yan Quentin liu State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center510060 GuangzhouGuangdongP.R.China Institute of Cancer Stem Cell Cancer CenterDalian Medical University116044 DalianLiaoningP.R.China

Poor differentiation is an important hallnnark of cancer cells,and differentiation therapy holds great promise for cancer *** restoration of IkB kinase a(IKKa)leads to the differentiation of nasopharyngeal carcinoma cells with reduced *** findings by yan et *** the polycomb protein enhancer of zeste homologue2(EZH2)as a target for intervention.

关键词： Differentiation therapy, Cancer treatment, IkB kinase α