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Acta Mechanica Sinica 2014年第1期30卷 59-66页

作者： ming-Song Zou You-Sheng Wu yan-min liu China Ship Scientific Research Center

The hydroelastic analysis and sonoelastic analysis methods are incorporated with the Green＇s function of the Pekeris ocean hydro-acoustic waveguide model to produce a three-dimensional sonoelastic analysis method for ships in the ocean hydro-acoustic environment. The seabed condition is represented by a penetrable boundary of prescribed density and sound speed. This method is employed in this paper to predict the vibration and acoustic radiation of a 1 500 t Small Water Area Twin Hull （SWATH） ship in shallow sea acoustic environment. The wet resonant frequencies and radiation sound source levels are predicted and compared with the measured results of the ship in trial.

关键词： Hydroelasticity Sonoelasticity Acousticwaves Shallow sea Free surface effect Seabed effect -SWATH ship

Vena cava thrombosis after vena cava filter placement： Incidence and risk factors

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Journal of Geriatric Cardiology 2011年第2期8卷 99-103页

作者： Ya-Juan Guo Jun Feng Tian-Rong Qu yan Qu Ya-min liu Yu-Shun Zhang Hong-yan Tian Ai-Qun Ma Department of Cardiology and Periphery Vascular Medicine the First Affiliated Hospital of Medical College of Xi＇an Jiaotong University Xi＇an 710061 Shaanxi Province China

Background The objective of this study was to assess the clinical safety and efficacy of vena cava filter （VCF） placement, with particular emphasis on the incidence and risk factors of inferior vena cava thrombosis （VCT） after VCF placement. Methods Clinical data of patients with venous thromboembolism （VTE）, with or without placement of VCF, were analyzed in a retrospective single-center audit of medical records from January 2005 to June 2009. The collected data included demographics, procedural details, filter type, indications, and complications. Results A total of 168 cases of VTE （82 with VCF; 86 without VCF） were examined. Over a median follow-up of 24.2 months, VCT occurred in 18 of 82 patients with VCFs （11 males, 7 females, mean age 55.4 years）. In 86 patients without VCFs, VCT occurred in only 6 individuals （4 males, 2 females） during the study period. VCT was observed more frequently in patients fitted with VCFs than in those without VCFs （22% vs. 7.0%）. Conclusions The incidence of VCT in patients with VTE after VCF implantation was 22% approximately. Anticoagulation therapy should be continued for all patients with VCF placement, unless there is a specific contraindication. Almost all instances of VCT in patients with VCF implants in our study occurred after stopping anticoagulation treatment. The use of VCFs is increasing, and more trials are needed to confirm their benefit and accurately assess their safety.

关键词： vena cava filters venous thromboembolism complication

Score model for predicting acute-on-chronic liver failure risk in chronic hepatitis B

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World Journal of Gastroenterology 2015年第27期21卷 8373-8381页

作者： Fang-Yuan Gao Yao liu Xiao-Shu Li Xie-Qiong Ye Le Sun ming-Fan Geng Rui Wang Hui-min liu Xiao-Bing Zhou Li-Li Gu yan-min liu Gang Wan Xian-Bo Wang Center of Integrative Medicine Beijing Ditan Hospital Capital Medical University Statistics Section Beijing Ditan Hospital Capital Medical University

AIM: To establish a clinical scoring model to predict risk of acute-on-chronic liver failure(ACLF) in chronic hepatitis B(CHB) ***: This was a retrospective study of 1457 patients hospitalized for CHB between October 2008 and October 2013 at the Beijing Ditan Hospital, Capital Medical University, China. The patients were divided into two groups: severe acute exacerbation(SAE) group(n = 382) and non-SAE group(n = 1075). The SAE group was classified as the high-risk group based on the higher incidence of ACLF in this group than in the non-SAE group(13.6% vs 0.4%). Two-thirds of SAE patients were randomly assigned to risk-model derivation and the other one-third to model validation. Univariate risk factors associated with the outcome were entered into a multivariate logistic regression model for screening independent risk factors. Each variable was assigned an integer value based on the regression coefficients, and the final score was the sum of these values in the derivation set. Model discrimination and calibration were assessed using area under the receiver operating characteristic curve and the Hosmer-Lemeshow test. RESULTS: The risk prediction scoring model includedthe following four factors: age ≥ 40 years, total bilirubin ≥ 171 μmol/L, prothrombin activity 40%-60%, and hepatitis B virus DNA > 107 copies/m L. The sum risk score ranged from 0 to 7; 0-3 identified patients with lower risk of ACLF, whereas 4-7 identified patients with higher risk. The Kaplan-Meier analysis showed the cumulative risk for ACLF and ACLF-related death in the two risk groups(0-3 and 4-7 scores) of the primary cohort over 56 d, and log-rank test revealed a significant difference(2.0% vs 33.8% and 0.8% vs 9.4%, respectively; both P mination(C index = 0.857, 95% confidence interval: 0.800-0.913 and C index = 0.889, 95% confidence interval: 0.820-0.957, respectively) and calibration demonstrated by t

关键词： Acute-on-chronic liver failure Chronichepatitis B Prediction model Risk score Severe acuteexacerbation

Comparison of three transgenic Bt rice lines for insecticidal protein expression and resistance against a target pest, Chilo suppressalis （Lepidoptera： Crambidae）

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Insect Science 2016年第1期23卷 78-87页

作者： Ya-Nan Wang Kai-Qie Ke Yun-He Li Lan-Zhi Han yan-min liu Hong-Xia Hua Yu-Fa Peng State Key Laboratory for Biology of Plant Disease and Insect Pests Institute of Plant Protection Chinese Academy of Agricultural ScienceBeUing 100193 College of Plant Science & Technology Huazhong Agricultural University Wuhan 430070 China

Two transgenic rice lines （T2A-1 and T1C-19b） expressing cry2A and crylC genes, respectively, were developed in China, targeting lepidopteran pests including Chilo suppressalis （Walker）（Lepidoptera： Crambidae）. The seasonal expression of Cry proteins in different tissues of the rice lines and their resistance to C. suppressalis were assessed in comparison to a Bt rice line expressing a crylAb/Ac fusion gene, Huahui 1, which has been granted a biosafety certificate. In general, levels of Cry proteins were T2A- 1 〉 Huahui I 〉 T1C-19b among rice lines, and leaf 〉 stern 〉 root among rice tissues. The expression patterns of Cry protein in the rice line plants were similar： higher level at early stages than at later stages with an exception that high Cry 1C level in T 1 C- 19b stems at the maturing stage. The bioassay results revealed that the three transgenic rice lines exhibited significantly high resistance against C. suppressalis larvae throughout the rice growing season. According to Cry protein levels in rice tissues, the raw and corrected mortalities of C. suppressalis caused by each Bt rice line were the highest in the seedling and declined through the j ointing stage with an exception for T1 C-19b providing an excellent performance at the maturing stage. By comparison, T1C-19b exhibited more stable and greater resistance to C. suppressalis larvae than T2A-1, being close to Huahui 1. The results suggest crylC is an ideal Bt gene for plant transformation for lepidopteran pest control, and T1C-19b is a promising Bt rice line for commercial use for tolerating lepidopteran rice pests.

关键词： Chilo suppressalis crylAb/Ac cryl C ery2A pest resistance transgenic rice

Ion mechanism of isoproterenol on delayed afterdepolarization and triggered activity in the infarcted ventricle

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Journal of Geriatric Cardiology 2010年第3期7卷 180-183页

作者： Jin-Liao Gao Hong-Juan Wang Yun-Feng Lan Zhou Fang yan liu min Lin Yi-Cheng Fu yang Li Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Objectives This study aimed at investigating the cellular mechanism of isoproterenol （ISO） on delayed afterdepolarizations （DADs） and triggered activity （TA） of the noninfarcted myocardium in the myocardial infarcted rabbit *** Rabbits with the left anterior descending coronary artery occlusion were prepared and recovered for 8 wk （healed myocardial infarction, HMI）. Myocytes were isolated from regions of the noninfarcted left ventricular free wall. ISO was added to cellular surface by perfusion way. Action potentials and ion currents were recorded with whole-cell patch clamp. Results The results showed that treatment with ISO induced more DADs and TA events in HMI myocytes. Iti and IC,_L of myocytes treated with ISO were increased significantly compared with HMI cells, which contributed to DADs-related triggered arrhythmia. Conclusions The results suggested that more arrhythmia events of DADs and TA developed in myocytes with ISO treatment. The underlying mechanism was associated with the augment of I6 and calcium influxing

关键词： isoproterenol healed myocardial infarction delayed afterdepolarization triggered activity ion channels

Study on the Interaction of Rare Earth with 3, 5, 3'-Triiodothyronine

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Chinese Chemical Letters 1997年第2期8卷 181-182页

作者： Feng GAO Shu Yun WANG Shu Lan MENG yan min liu Chun Ji NIU Jia Zuan NI(Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Appliet Chemistry, Chinese Academy of Sciences, Changchun 130022) Lab. of Rare Earth Chem. and Physics Changchun Inst. of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

The stability constants for rare earth complexes with 3, 5, 3'-triiodothyronine were determined at 37℃ and an ionic strength of 0.15 mole/L NaCl,The lanthanide induced shifts were measured for 1H nuclei of 3, 5, 3'-t... 详细信息

关键词： 110 Study on the Interaction of Rare Earth with 3

Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer:Integrating Bioinformatics Analysis with Experimental Confirmation

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Current Medical Science 2024年第3期44卷 529-544页

作者： yan-min liu Tie-cheng yanG Xiao-chang FANG Li-jie yanG Li-wen SHI Hua-qiao WANG Ting-ting DOU Lin SHU Tian-Liang CHEN Jun HU Xiao-ming YU Xuan-fei LI Department of Gastroenterology the Central Hospital of WuhanKey Laboratory for Molecular Diagnosis of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan430071China Hubei Provincial Clinical Research Center for Cancer Hubei Key Laboratory of Tumor Biological Behavi Wuhan430071China Department of General Surgery Taihe HospitalHubei University of MedicineShiyan442000China Department of Gastrointestinal Surgery Huangshi Central HospitalAffiliated Hospital of Hubei Polytechnic UniversityWuhan435001China

Objective To uncover the mechanisms underlying the development of colorectal cancer(CRC),we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and *** We performed Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis on differentially expressed genes(DEGs),constructed a protein-protein interaction(PPI)network to find the top 10 hub genes,and analyzed their expression in colon adenocarcinoma(COAD)and rectum adenocarcinoma(READ).We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western *** experiments were conducted in vitro to investigate the effects of SLC9A2 on tumor growth and *** We found 130 DEGs,with 45 up-regulated and 85 down-regulated in *** analysis indicated that these DEGs were primarily enriched in functions related to the regulation of cellular pH,zymogen granules,and transmembrane transporter *** pathway analysis revealed that the DEGs played pivotal roles in pancreatic secretion,rheumatoid arthritis,and the IL-17 signaling *** identified 10 hub genes:CXCL1,SLC26A3,CXCL2,MMP7,MMP1,SLC9A2,SLC4A4,CLCA1,CLCA4,and *** enrichment analysis showed that these hub genes were predominantly involved in the positive regulation of *** expression analysis revealed that CXCL1,CXCL2,MMP1,and MMP7 were highly expressed in CRC,whereas CLCA1,CLCA4,SLC4A4,SLC9A2,SLC26A3,and ZG16 were expressed at lower *** analysis revealed that 5 key genes were significantly associated with the prognosis of *** mRNA and protein expression levels of SLC9A2 were markedly reduced in CRC tissues and cell ***,SLC9A2 overexpression in SW480 cells led to a notable inhibition of cell proliferation,migration,and *** blotting analysis revealed tha

关键词： SLC9A2 colorectal cancer bioinformatic analysis biomarkers immune infiltrate

Inhibition on Telomerase Activity and Cytotoxic Effects by Cisplatin in Cultured Human Choroidal Melanoma Cells

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Eye Science 2003年第1期19卷 54-59页

作者： Hao Cheng, Zhongyao Wu, Jianliang Zheng, Guilan Lu, Jianhua yan min liu, Danping Huang, Jianxian LinZhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China.

Purpose: To study the changes of telomerase activity and cytotoxic effects by Cisplatin;cis-dichlorodiamine platinum (CDDP) in cultured human choroidal *** and Methods: The primary cultured human choroidal melanoma cells werecultured in the presence and absence of CDDP with different concentration and timerespectively. The toxic effects were evaluated by MTT and the level of telormarse wasdetected by PCR-ELISA assay. And the relationship between telomerase activity andcytotoxic effects were analyzed by a correlation ***: Following the increase of the concentration and the time of CDDP, graduallyrepressed telomerase activity was detected in cultured cells. Meanwhile, the restrain rateof the cells increased. The telomerase activity at 24h and 1μg/ml was repressedsignificantly compared with the control cells. However, the appearance of cell deathlagged behind the decreasing of ***: CDDP is an effective telomerase inhibitor in cultured choroidal melanomacells of human eyes, which presents concentration and time dependency and can causethe death of cultured cells.

关键词：端粒酶细胞毒素脉络膜黑色素瘤细胞顺铂细胞培养 PCR-ELISA

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采用人体树图与混合粒子群聚类的行人检测

光学精密工程 2018年第7期26卷 1802-1812页

作者：孟晓燕段建民刘丹北京工业大学信息学部北京100124

为提升辅助驾驶系统的可靠性及安全系数,实现更高精度的行人检测,基于人体树图模型提出了一种改进的离线训练、在线检测的行人检测方法。首先,定义人体部件间的共生关系,得到对应父子部件对,结合K-means算法对其位置关系进行聚类获得部... 详细信息

为提升辅助驾驶系统的可靠性及安全系数,实现更高精度的行人检测,基于人体树图模型提出了一种改进的离线训练、在线检测的行人检测方法。首先,定义人体部件间的共生关系,得到对应父子部件对,结合K-means算法对其位置关系进行聚类获得部件类型。为兼顾类内紧密性与类间分离性,采用MSE和DBI构建具有两阶段适应度函数的混合粒子群聚类算法,在有效估计各部件最优聚类中心数量的同时,消除随机初始化对聚类准确率造成的影响。其次,将优化聚类得到的部件类型作为隐藏变量,通过求解隐结构SVM获取改进后的人体检测模型。最后,通过动态规划算法求解状态转移方程,在多个尺度上有效估计人体部件位置及检测包围盒,并结合非极大值抑制思想得到最终的行人检测结果。实验结果表明,所提方法在检测性能上明显优于5种行人检测方法,并且相比于原始Pose-original方法,在INRIA和ETH数据集上的丢失率分别下降了8.14%和5.05%。实验证明该方法检测性能良好且具有较高的准确性和鲁棒性。

关键词：行人检测人体树图模型 K-means聚类粒子群算法

Pan-Specific Antibodies as Novel Tools to Detect Valyllysine

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Reproductive and Developmental Medicine 2020年第2期4卷 78-83页

作者： Ya-Ling Wang min-yan liu Yu-Hua Li Yi-Tingyang Wei-Wei Wang He-GuoYu Zhi-Yu Shao Hua Diao Department of Reproductive Biology NHC Key Laboratory of Reproduction Regulation(Shanghai Institute of Planned Parenthood Research)School of Basic Medical SciencesFudan UniversityShanghai 200032China College of Chemistry Chemical Engineering and BiotechnologyDonghua UniversityShanghai 201620China

Objective:Amino acyl modification of lysine residues is an essential mechanism of nutrient sensing that regulates various biological functions including *** present,the lack of pan-specific antibodies for a recently identified lysine valylation hinders the characterization and detection of this *** objective of this study is to raise pan-specific antibodies that may facilitate the identification of novel expression patterns of lysine ***:Chicken ovalbumin was valylated as an immunogen to raise polyclonal antibodies(PcAbs)in *** population of the pan-specific antibodies recognizing valylated lysine was purified using the chemically synthesized valylated peptides consisting of random amino *** specificity of the antibodies was evaluated using ELISA,dot blots,Western blots,and immunohistochemistry(IHC)staining in human epididymis as ***:A preliminary and simple strategy to make an anti-valylated lysine PcAb was *** recognition of the antibodies to valyllysine was evaluated as pan *** was useful for the detection of the newly identified valyl modification using ELISA,dot blots,and Western *** antibodies were also successfully utilized in IHC assays,which revealed novel valyllysine modification patterns in epididymis tissues of ***:A new antibody tool was provided for the study of lysine *** novel expression patterns of valyllysine in the epididymis suggest that this modification may be involved in sperm maturation.

关键词： Anti-Valyllysine Antibody Epididymis Posttranslational Modifications Valyllysine