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Comparative study of type 2 diabetes mellitus-associated gut microbiota between the Dai and Han populations

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World Journal of Diabetes 2023年第12期14卷 1766-1783页

作者： Ling-Tong Tang Lei Feng Hui-Ying Cao Rui Shi Bei-Bei Luo yan-Bi Zhang yan-mei liu Jian Zhang Shuang-Yue Li Department of Clinical Laboratory Yan’an Hospital Affiliated to Kunming Medical UniversityKunming 650051Yunnan ProvinceChina Department of Clinical Laboratory Sixth Affiliated Hospital of Kunming Medical UniversityKunming 650051Yunnan ProvinceChina

BACKGROUND The global prevalence of type 2 diabetes mellitus(T2DM)is increasing.T2DM is associated with alterations of the gut microbiota,which can be affected by age,illness,and genetics.Previous studies revealed that there are discriminating microbiota compositions between the Dai and the Han populations.However,the specific gut microbiota differences between the two populations have not been elucidated.AIM To compare the gut microbiota differences in subjects with and without T2DM in the Dai and Han populations.METHODS A total of 35 subjects of the Han population(including 15 healthy children,8 adult healthy controls,and 12 adult T2DM patients)and 32 subjects of the Dai population(including 10 healthy children,10 adult healthy controls,and 12 adult T2DM patients)were enrolled in this study.Fasting venous blood samples were collected from all the subjects for biochemical analysis.Fecal samples were collected from all the subjects for DNA extraction and 16S rRNA sequencing,which was followed by analyses of the gut microbiota composition.RESULTS No significant difference in alpha diversity was observed between healthy children and adults.The diversity of gut microbiota was decreased in T2DM patients compared to the healthy adults in both the Dai and Han populations. There was a significant difference in gut microbiota between healthy children and healthy adults in the Hanpopulation with an increased abundance of Bacteroidetes and decreased Firmicutes in children. However, thisdifference was less in the Dai population. Significant increases in Bacteroidetes in the Han population and Proteobacteriain the Dai population and decreases in Firmicutes in both the Han and Dai population were observed inT2DM patients compared to healthy adults. Linear discriminant analysis Effect Size analysis also showed that thegut microbiota was different between the Han and Dai populations in heathy children, adults, and T2DM patients.Four bacteria were consistently increased and two consistently decreased in the Han population compar

关键词： Gut microbiota Type 2 diabetes mellitus Dai population Han population Genetics Ethnic

Hydrothermal synthesis and photoluminescence behavior of CeO_2 nanowires with the aid of surfactant PVP

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International Journal of Minerals,Metallurgy and Materials 2010年第4期17卷 470-474页

作者： Ming-zai Wu yan-mei liu Peng Dai Zhao-qi Sun Xian-song liu Key Laboratory of Opto-electronic Information Acquisition and Manipulation Anhui University Hefei 230039 China Engineering Technology Research Center of Magnetic Materials Anhui University Hefei 230039 China

Well-crystalline CeO_2 nanowires were prepared via a surfactant-assisted hydrothermal process.Reaction temperature and reaction time were changed for the determination of optimal synthesis parameters.The as-obtained products were characterized by X-ray diffraction （XRD）,high-resolution transmission electron microscopy（HRTEM）,and field emission scanning electron microscopy（FESEM）.The results show that single crystal CeO_2 nanowires with high yield and good uniformity can be obtained hydrothermally at 180℃for 12 h with the aid of 2.0 g surfactant（polyvinyl pyrrolidone,PVP）.The role of PVP was then discussed and a possible growth mechanism was proposed. Moreover,room temperature photoluminescence（PL） spectra were obtained for these CeO2 nanowires,which are believed to be related to the abundant defects in these nanostructures.

关键词： cerium oxide polyvinyl pyrrolidone hydrothermal photoluminescence

Influence of Al Content on the Microstructure and Properties of the CrAlN Coatings Deposited by Arc Ion Plating

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Acta Metallurgica Sinica(English Letters) 2017年第12期30卷 1221-1230页

作者： Qi-Xiang Fan Jiao-Jiao Zhang Zheng-Huan Wu yan-mei liu Tao Zhang Bing yan Tie-Gang Wang Tianjin Key Laboratory of High Speed Cutting and Precision Machining Tianjin University of Technology and Education Tianjin 300222 China Division of State-Owned Assets Management Tianjin University of Technology and Education Tianjin 300222 China

Four CrAlN coatings with various Al content were prepared by arc ion plating technology under different target currents. The effect of the Al content on the microstructure, chemical compositions, element chemical bonding states and mechanical properties of the CrAlN coatings was analyzed. X-ray diffraction results show that the primary phase of the CrAlN coating is fcc-（Al, Cr）N when the Al content is about 44.02 at.%. However, when the Al content increases to about 53.34 at.%, hcp-AlN phase emerges in the coating. And the hcp-AlN phase becomes the main phase in the CrAlN coating with Al content of about 69.55 at.%. Cross-sectional images show that all the four coatings possess dense structures and the deposition rate of Al atom is higher than that of Cr atom. The hardness of the CrAlN coating with Al content about 44.02 at.% is the largest （3149.72 HV） due to the solid solution hardening effect of the Al element. When the hcp-AlN phase is generated in the CrAlN coating, the hardness declines. The tribological experiment shows that the wear resistance of the CrAlN coating decreases gradually with increasing Al content when sliding against 100Cr6 steel ball.

关键词： Arc ion plating Microstructure characterization Hardness Al content

Microstructure and Properties of the Cr–Si–N Coatings Deposited by Combining High-Power Impulse Magnetron Sputtering(HiPIMS) and Pulsed DC Magnetron Sputtering

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Acta Metallurgica Sinica(English Letters) 2017年第7期30卷 688-696页

作者： Tie-Gang Wang Yu Dong Belachew Abera Gebrekidan yan-mei liu Qi-Xiang Fan Kwang Ho Kim Tianjin Key Laboratory of High Speed Cutting and Precision Manufacturing Tianjin University of Technology and Education Global Frontier R&D Center for Hybrid Interface Materials Pusan National University

The Cr–Si–N coatings were prepared by combining system of high-power impulse magnetron sputtering and pulsed DC magnetron sputtering. The Si content in the coating was adjusted by changing the sputtering power of the Si target.By virtue of electron-probe microanalysis, X-ray diffraction analysis and scanning electron microscopy, the influence of the Si content on the coating composition, phase constituents, deposition rate, surface morphology and microstructure was investigated systematically. In addition, the change rules of micro-hardness, internal stress, adhesion, friction coefficient and wear rate with increasing Si content were also obtained. In this work, the precipitation of silicon in the coating was found.With increasing Si content, the coating microstructure gradually evolved from continuous columnar to discontinuous columnar and quasi-equiaxed crystals; accordingly, the coating inner stress first declined sharply and then kept almost constant. Both the coating hardness and the friction coefficient have the same change tendency with the increase of the Si content, namely increasing at first and then decreasing. The Cr–Si–N coating presented the highest hardness and average friction coefficient for an Si content of about 9.7 at.%, but the wear resistance decreased slightly due to the high brittleness.The above phenomenon was attributed to a microstructural evolution of the Cr–Si–N coatings induced by the silicon addition.

关键词： Cr–Si–N coating High-power impulse magnetron sputtering（HiPIMS） Pulsed DC magnetron sputtering Mechanical property Friction coefficient

Microstructure and Corrosion Resistance of the AlTiN Coating Deposited by Arc Ion Plating

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Acta Metallurgica Sinica(English Letters) 2016年第12期29卷 1119-1126页

作者： Qi-Xiang Fan Tie-Gang Wang yan-mei liu Zheng-Huan Wu Tao Zhang Tong Li Zu-Bing yang Tianjin Key Laboratory of High Speed Cutting and Precision Machining Tianjin University of Technology and EducationTianjin 300222 China Division of State-owned Assets Management Tianjin University of Technology and Education Tianjin 300222China College of Electronic Engineering Tianjin University of Technology and Education Tianjin 300222 China

A new type of AlTiN coating containing about 29.13 at.% Al,16.02 at.% Ti and 54.85 at.% N was prepared by arc ion plating technology. The coating is composed of singular fcc-（Al, Ti）N phase and has no hcp-AlN phase to be formed. Due to the high content of beneficial element Al, the hardness and effective elastic modulus of the coating are up to 33.9 and 486.1 GPa, respectively. The adhesion strength between the coating and substrate is about 39.7 N. Electro- chemical test shows that the corrosion current density of the AlTiN coating is nearly one-sixth of the substrate, and the charge transfer resistance Rct of the AlTiN coating is much larger than that of the substrate, which means that the coating could act as a protective barrier between the substrate and corrosive electrolyte, enhancing the corrosion resistance.

关键词： Arc ion plating AITiN coating Corrosion behavior Microstructure Hardness

Long-term Efficacy of Subthalamic Nucleus Deep Brain Stimulation in Parkinson＇s Disease： A 5-year Follow-up Study in China

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Chinese Medical Journal 2015年第18期128卷 2433-2438页

作者： Lu-Lu Jiang Jin-Long liu Xiao-Li Fu Wen-Biao Xian Jing Gu yan-mei liu Jing Ye Jie Chen Hao Qian Shao-Hua Xu Zhong Pei Ling Chen Department of Neurology First Affiliated Hospital Sun Yat-sen University Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department National Key Discipline Guangzhou Guangdong 510080 China Department of Neurosurgery First Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Neurology Dongguan People's Hospital Dongguan Guangdong 523059 China Department of Medical Statistics and Epidemiology School of Public Health Sun Yat-sen University Guangzhou Guangdong 510080 China Department of General Internal Medicine Guangzhou Nansha Central Hospital Guangzhou Guangdong 511457 China Department of Neurology Second Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou Guangdong 510300 China

Background： Subthalarnic nucleus deep brain stimulation （STN DBS） is effective against advanced Parkinson＇s disease （PD）, allowing dramatic improvement of Parkinsonism, in addition to a significant reduction in medication. Here we aimed to investigate the long-term effect of STN DBS in Chinese PD patients, which has not been thoroughly studied in China. meihods： Ten PD patients were assessed before DBS and followed up 1, 3, and 5 years later using Unified Parkinson＇s Disease Rating Scale Part Ⅲ （UPDRS Ill）, Parkinson＇s Disease Questionnatire-39, Parkinson＇s Disease Sleep Scale-Chinese Version, Mini-mental State Examination, Montreal Cognitive Assessment, Hamilton Anxiety Scale and Hamilton Depression Scale. Stimulation parameters and drug dosages were recorded at each follow-up. Data were analyzed using the ANOVA for repeated measures. Resulis： In the ＂oft＂ state （off medication）, DBS improved UPDRS Ill scores by 35.87% in 5 years, compared with preoperative baseline （P 〈 0.001 ）. In the ＂on＂ state （on medication）, motor scores at 5 years were similar to the results of preoperative levodopa challenge test. The quality of life is improved by 58.18% （P 〈 0.001 ） from baseline to 3 years and gradually declined afterward. Sleep, cognition, and emotion were mostly unchanged. Levodopa equivalent daily dose was reduced from 660.4 ± 210.1 mg at baseline to 310.6 ± 158.4 mg at 5 years （by 52.96%, P 〈 0.001 ）. The average pulse width, frequency and amplitude at 5 years were 75.0 ± 18.21 Its, 138.5 ± 19.34 Hz, and 2.68 ± 0.43 V, respectively. Conclusions： STN DBS is an effective intervention for PD, although with other studies, patients in our study required lower voltage and associated with a slightly diminished efficacy after 5 years. Compared medication for satisfactory symptom control.

关键词： Deep Brain Stimulation Follow-Up Studies Parkinson Disease Subthalamic Nucleus Treatment Outcome

Status quo and influencing factors of comfort with touch among nursing staff in rehabilitation department:A cross-sectional study

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Journal of Integrative Nursing 2021年第3期3卷 122-127页

作者： Yun Jie TONG Dan-Dan LU mei-Fen LYU yan-mei liu Shi-Yun TAN School of Nursing Shaanxi University of Chinese MedicineXianyangShaanxiChina Department of Rehabilitation Qujing First People’s HospitalQujingYunnanChina Department of Acupuncture Shaanxi Hospital of Traditional Chinese MedicineXi’anShaanxiChina

Objective:The objective of this study is to investigate the current status of comfort with touch among nursing staff in the rehabilitation department and analyze its influencing factors.Materials and Methods:The convenience sampling method was used to select 131 nursing staff in the rehabilitation department of 3A-level hospitals in Yunnan Province,China,from March to June 2020 to conduct a questionnaire survey.Results:The nurses’comfort with touch score of 131 clinical nurses in the rehabilitation department was 58.82±4.85.Multivariate regression analysis showed that compassion fatigue(t=‒2.968,P<0.01)and occupational social support(t=2.767,P<0.01)were the influencing factors of the physical comfort of nursing staff;average monthly income(t=‒2.160,P<0.05),occupational cognitive evaluation(t=4.924,P<0.01),and secondary traumatic stress(t=2.833,P<0.01)were the influencing factors of task-oriented contact among nursing staff;marital status(t=2.656,P<0.01)and occupational social support(t=2.078,P<0.05)were the influencing factors for private nursing comfort of nurses.Conclusion:The comfort with touch among nurses in the rehabilitation department is at a medium level.Nursing managers should pay attention to their comfort with touch.In order to promote the development of medical service,hospitals should constantly improve the security and social support of nursing practitioners from the aspects of system,management,and salary performance.

关键词： Comfort with touch compassion fatigue nursing staff occupational identity rehabilitation

入侵植物紫茎泽兰根围土壤化学及微生物属性海拔变化格局

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Journal of Plant Ecology 2022年第3期15卷 561-570页

作者： Wei-Tao Li Yu-Long Zheng Rui-Fang Wang Zheng-Ying Wang yan-mei liu Xiong Shi Zhi-Yong Liao yang-Ping Li Yu-Long Feng CAS Key Laboratory of Tropical Forest Ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMengla 666303China Center of Conservation Biology Core Botanical GardensChinese Academy of SciencesMengla 666303China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China College of Agriculture and Forestry Puer UniversityPuer 665000China College of Bioscience and Biotechnology Liaoning Key Laboratory for Biological Invasions and Global ChangesShenyang Agricultural UniversityShenyang 110866China

热带地区山地生态系统是外来植物入侵的重要区域,是研究外来植物扩散机制的“天然实验室”。本研究试图探明入侵植物紫茎泽兰(Ageratina adenophora)根围土壤化学(pH及土壤养分)和微生物(酶活性和细菌群落)特性沿海拔梯度的变化规律。... 详细信息

热带地区山地生态系统是外来植物入侵的重要区域,是研究外来植物扩散机制的“天然实验室”。本研究试图探明入侵植物紫茎泽兰(Ageratina adenophora)根围土壤化学(pH及土壤养分)和微生物(酶活性和细菌群落)特性沿海拔梯度的变化规律。本研究以哀牢山(1400–2400 m)不同海拔梯度分布的紫茎泽兰为研究对象,采集根围土,测定土壤有机碳及养分含量,以及植物根系碳和氮含量。分析与土壤有机碳、氮及磷循环的酶活性,通过计算土壤酶化学计量参数,探究微生物生长代谢利用碳、氮及磷的规律。借助高通量测序技术对16S rDNA的V4区测序,分析细菌群落结构。研究结果显示,海拔显著影响紫茎泽兰根系氮及及其根围土壤有机碳含量,且这些测量指标在海拔2000 m出现拐点。处在低海拔,入侵植物快速生长耗竭土壤中相对缺乏的磷,磷素是限制微生物生长的重要养分元素;而在高海拔,微生物需要投入更多的能量降解有机质获取碳,导致微生物生长的碳限制。细菌群落β多样性及pH是决定不同海拔酶化学计量参数差异的重要因子;变形菌门和酸杆菌门是决定微生物养分利用状况的主要细菌门类。这些结果阐明了不同海拔梯度上紫茎泽兰根围土壤微生物的养分利用规律,有助于认识入侵植物沿海拔扩散机制。

关键词：紫茎泽兰(Ageratina adenophora) 养分生态酶化学计量数微生物代谢限制细菌群落

Voltage adjustment improves rigidity and tremor in Parkinson's disease patients receiving deep brain stimulation

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Neural Regeneration Research 2018年第2期13卷 347-352页

作者： Shao-hua Xu Chao yang Wen-biao Xian Jing Gu Jin-long liu Lu-lu Jiang Jing Ye yan-mei liu Qi-yu Guo Yi-fan Zheng Lei Wu Wan-ru Chen Zhong pei Ling Chen Department of Neurology National Key Clinical Department and Key Discipline of NeuroloryThe First Affiliated HospitalSun Yat-senUniversityGuangzhouGuangdong ProvinceChina Department of Neurosurgery First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Tangshan Worker's HospitalTangshanHebei ProvinceChina

Deep brain stimulation of the subthalamic nucleus is recognized as the most effective treatment for moderate and advanced Parkinson＇s disease. Programming of the stimulation parameters is important for maintaining the efficacy of deep brain stimulation. Voltage is consid- ered to be the most effective programming parameter. The present study is a retrospective analysis of six patients with Parkinson＇s disease （four men and two women, aged 37-65 years）, who underwent bilateral deep brain stimulation of the subthalamic nucleus at the First Affiliated Hospital of Sun Yat-sen University, China, and who subsequently adjusted only the stimulation voltage. We evaluated motor symptom severity using the Unified Parkinson＇s Disease Rating Scale Part III, symptom progression using the Hoehn and Yahr scale, and the levodopa equivalent daily dose, before surgery and 1 and 2 years after surgery. The 2-year follow-up results show that rigidity and tremor improved, and clinical symptoms were reduced, while pulse width was maintained at 60 ps and frequency at 130 Hz. Voltage adjust- ment alone is particularly suitable for patients who cannot tolerate multiparameter program adjustment. Levodopa equivalent daily dose was markedly reduced 1 and 2 years after surgery compared with baseline. Our results confirm that rigidity, tremor and bradykinesia can be best alleviated by voltage adjustment. The trial was registered at ClinicalTrials.gov （identifier： NCT01934881）.

关键词： nerve regeneration deep brain stimulation Parkinson＇s disease subthalamic nucleus voltage pulse width frequency tremor rigidity bradykinesia axial symptoms neural regeneration