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CCS Chemistry 2024年第1期6卷 177-195页

作者： lang Zhao Shao-Hua Zhuo Tian-yang Wang Jun-Jun Wu Jing-Yun Su Wen-Hao Li Bo-Dou Zhang yan-mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084 Beijing Institute for Brain Disorders Beijing 100069 Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084

Cyclic dinucleotides(CDNs)are natural agonists of the stimulator of interferon genes(STING),which is an attractive immunotherapy ***,CDNs and their derivatives are being investigated ***,the poor bioavailability of exogenous CDNs has limited their application in *** nanocarriers are widely used for cytosolic delivery of CDNs,their loading capacity is insufficient,and their complicated composition and purification process raises bio-compatibility ***,we report a super-simplified CDN self-assembly strategy for carrier-free delivery of *** the presence of excess K^(+),CDNs form oligomers which further self-assemble with divalent metal ions(such as Mn^(2+))to form nanoparticles(NPs)in aqueous *** demonstrate that the self-assembled CDN NPs promote cellular uptake of CDNs and enhance tumor immunogenicity by remodeling the tumor microenvironment,inducing immunogenic tumor cell death and increasing tumorinfiltrating lymphocytes,which is conducive to the generation of tumor neoantigen-specific T-cell *** also demonstrate that the use of CDN NPs alone or in combination with immune checkpoint blockades inhibits tumor growth,highlighting the fact that CDN NPs are a potent platform for cancer immunotherapy.

关键词： cyclic dinucleotide STING carrierfree delivery tumor immunogenicity cancer immunotherapy

Synthesizing high-resolution satellite salinity data based on multi-fractal fusion

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Acta Oceanologica Sinica 2024年第7期43卷 112-124页

作者： Hengqian yan Jian Shi Ren Zhang Wangjiang Hu Yongchui Zhang mei Hong College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China

The spaceborne platform has unprecedently provided the global eddy-permitting(typically about 0.25°)products of sea surface salinity(SSS),however the existing SSS products can hardly resolve mesoscale motions due to the heavy noises therein and the over-smoothing in denoising *** means of the multi-fractal fusion(MFF),the high-resolution SSS product is synthesized with the template of sea surface temperature(SST).Two low-resolution SSS products and four SST products are considered as the source data and the templates respectively to determine the best *** fused products are validated by the in situ observations and intercompared via SSS maps,Singularity Exponent maps and wavenumber *** results demonstrate that the MFF can perform a good work in mitigating the noises and improving the *** combination of the climate change initiative SSS and the remote sensing system SST can produce the 0.1°denoised product whose global mean standard derivation of salinity against Argo is 0.21 and the feature resolution can reach 30−40 km.

关键词： sea surface salinity multi-fractal fusion high resolution

Enhancing Tea Leaf Disease Identification with Lightweight MobileNetV2

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Computers, Materials & Continua 2024年第7期80卷 679-694页

作者： Zhilin Li Yuxin Li Chunyu yan Peng yan Xiutong Li mei Yu Tingchi Wen Benliang Xie College of Big Data and Information Engineering Guizhou UniversityGuiyang550025China Power Semiconductor Device Reliability Engineering Center of the Ministry of Education Guiyang550025China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China The Mushroom Research Centre Guizhou UniversityGuiyang550025China The Engineering Research Center of Southwest Bio-Pharmaceutical Resources Ministry of EducationGuizhou UniversityGuiyang550025China

Diseases in tea trees can result in significant losses in both the quality and quantity of tea *** monitoring can help to prevent the occurrence of large-scale diseases in tea ***,existingmethods face challenges such as a high number of parameters and low recognition accuracy,which hinders their application in tea plantation monitoring *** paper presents a lightweight I-MobileNetV2 model for identifying diseases in tea leaves,to address these *** proposed method first embeds a Coordinate Attention(CA)module into the originalMobileNetV2 network,enabling the model to locate disease regions ***,a Multi-branch Parallel Convolution(MPC)module is employed to extract disease features across multiple scales,improving themodel’s adaptability to different disease ***,the AutoML for Model Compression(AMC)is used to compress themodel and reduce computational *** results indicate that our proposed algorithm attains an average accuracy of 96.12%on our self-built tea leaf disease dataset,surpassing the original MobileNetV2 by 1.91%.Furthermore,the number of model parameters have been reduced by 40%,making itmore suitable for practical application in tea plantation environments.

关键词： Disease identification coordinate attention mechanism multi-scale feature extraction model pruning

Tuning the local coordination environment of silver(Ⅰ) coordination networks with counterions for enhanced electrocatalytic CO_(2) reduction

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Science China Chemistry 2024年第5期67卷 1524-1530页

作者： Xiaofeng Cui Xueting Wang Cong Fu Bing Liu mei-yan Gao Tingting Kong Yujie Xiong Anhui Engineering Research Center of Carbon Neutrality The Key Laboratory of Functional Molecular SolidsMinistry of EducationAnhui Laboratory of Molecular-Based MaterialsCollege of Chemistry and Materials ScienceAnhui Normal UniversityWuhu 241002China Department of Chemical Sciences Bernal InstituteUniversity of LimerickLimerick V94 T9PXRepublic of Ireland School of Chemistry and Materials Science University of Science and Technology of ChinaHefei 230026China School of Chemical and Material Engineering Jiangnan UniversityWuxi 214122China

Very recently, the local coordination environment of active sites has been found to strongly influence their performance in electrocatalytic CO_(2) reduction by tuning the intrinsic kinetics of CO_(2) activation and intermediate stabilization. It is imperative to elucidate the mechanism for such an influence towards the rational design of efficient catalysts;however, the complex interactions between the multiple factors involved in the system make it challenging to establish a clear structure–performance relationship. In this work, we chose ion-intercalated silver(I)-based coordination networks(AgCNs) with a well-defined structure as a model platform, which enables us to understand the regulation mechanism of counterions as the counterions are the only tuning factor involved in such a system. We prepared two isostructural Ag CNs with different intercalation ions or counterions of BF_(4)^(-) and ClO_(4)^(-)(named as AgCNs-BF_(4) and AgCNs-ClO_(4)) and found that the former has a more competitive CO_(2) electroreduction performance than the latter. AgCNs-BF_(4) achieves the highest Faradaic efficiency for CO_(2) to CO of 87.1% at-1.0 V(vs. RHE) with a higher partial current density, while AgCNs-ClO_(4) exhibits only 77.2% at the same applied *** characterizations and theoretical calculation reveal that the presence of BF_(4)^(-)is more favorable for stabilizing the COOH^(*) intermediate by weakening hydrogen bonds, which accounts for the superior activity of Ag CNs-BF_(4).

关键词： electrocatalytic CO_(2) reduction coordination networks local environment counterions intercalation ions

Magnetic, dielectric and luminescence synergetic switchable effects in molecular material [Et_(3)NCH_(2)Cl]_(2)[MnBr_(4)]

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Chinese Chemical Letters 2024年第4期35卷 502-505页

作者： yan Cheng Hua-Peng Ruan yan Peng Longhe Li Zhenqiang Xie lang Liu Shiyong Zhang Hengyun Ye Zhao-Bo Hu Chaotic Matter Science Research Center Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou 341000China College of Materials and Chemical Engineering Pingxiang UniversityPingxiang 337055China Jiangxi Provincial Key Laboratory of Functional Molecular Materials Chemistry Jiangxi University of Science and TechnologyGanzhou 341000China Key Laboratory of Jiangxi University for Functional Materials Chemistry School of Chemistry and Chemical EngineeringGannan Normal UniversityGanzhou 341000China

The application of multifunctional materials in various fields such as electronics and signal processors has attracted massive attention. Herein, a new organic-inorganic hybrid material [Et_(3)NCH_(2)Cl]_(2)[MnBr_(4)](1) is reported, which contains two organic amines cations and one [MnBr_(4)] tetrahedral ion. Compound 1 has a dielectric anomaly signal at 338 K, which proves its thermodynamic phase transition. The single crystal measurements at 200 K and 380 K show that the phase transition of compound 1 is caused by the thermal vibration of organic amine cations in the lattice. Moreover, compound 1 shows yellow-green luminescence under UV light irradiation. The magnetism measurements indicate that compound 1 shows switchable magnetic properties. This organic–inorganic material is a multifunctional material with dielectric, optical, and magnetic synergetic switchable effects, which expands a new direction for designing multifunctional materials.

关键词： Synergetic switchable effects Molecular materials Magnetism Dielectric Luminescence

Banxia Xiexin Decoction Alleviated Cerebral Glucose Metabolism Disorder by Regulating Intestinal Microbiota in APP/PS1 Mice

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Chinese Journal of Integrative Medicine 2024年第8期30卷 701-712页

作者： GAO Chen-yan QIN Gao-feng ZHENG Ming-cui TIAN mei-jing HE yan-nan WANG Peng-wen Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing100700China Neurology Department Binzhou Medical University HospitalBinzhouShandong Province256603China

Objective To identify whether Banxia Xiexin Decoction(BXD)alleviates cerebral glucose metabolism disorder by intestinal microbiota regulation in APP/PS1 *** Forty-five 3-month-old male APP/PS1 mice were divided into 3 groups using a random number table(n=15 per group),including a model group(MG),a liraglutide group(LG)and a BXD group(BG).Fifteen 3-month-old male C57BL/6J wild-type mice were used as the control group(CG).Mice in the BG were administered BXD granules by gavage at a dose of 6 g/(kg·d)for 3 months,while mice in the LG were injected intraperitoneally once daily with Liraglutide Injection(25 nmol/kg)for 3 ***,liquid chromatography with tandem-mass spectrometry was used to analyze the active components of BXD granules and the medicated serum of ***,the cognitive deficits,Aβpathological change and synaptic plasticity markers,including synaptophysin(SYP)and postsynaptic density protein 95(PSD95),were measured in APP/PS1 *** glucose uptake was detected by micropositron emission *** microbial constituents were detected by 16S rRNA *** levels of intestinal glucagon-like peptide 1(GLP-1)and cerebral GLP-1 receptor(GLP-1R),as well as the phosphoinositide-3-kinase/protein kinase B/glycogen synthase kinase-3β(PI3K/Akt/GSK3β)insulin signaling pathway were determined by immunohistochemical(IHC)staining and Western blot analysis,*** BXD ameliorated cognitive deficits and Aβpathological features(P<0.01).The expressions of SYP and PSD95 in the BG were higher than those in the MG(P<0.01).Brain glucose uptake in the BG was higher than that in the MG(P<0.01).The intestinal microbial composition in the BG was partially *** levels of intestinal GLP-1 in the BG were higher than those in the MG(P<0.01).Compared with the MG,the expression levels of hippocampal GLP-1R,Akt,PI3K and p-PI3K in the BG were significantly increased(P<0.01),while the levels of GSK3βwere reduced(P<0.01).Conclusion BXD

关键词： Banxia Xiexin Decoction Alzheimer's disease intestinal microbiota glucagon-like peptide 1 cerebral insulin resistance phosphoinositide-3-kinase/proteinkinase B/glycogen synthase kinase-3β Chinese medicine

Migration mechanism of atrazine in the simulated lake icing process at different freezing temperatures based on density function theory

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Journal of Environmental Sciences 2024年第10期144卷 45-54页

作者： yan Zhang Hao Lin Aixin Yu Xiaozhuang Wang Yucan Liu Tongshuai Liu Chen Zhao Rui mei School of Civil Engineering Yantai UniversityYantai 264005China

Atrazine causes concern due to its resistant to biodegradation and could be accumulated in aquatic organisms,causing pollution in *** study measured the concentration of atrazine in ice and the water under ice through a simulated icing experiment and calculated the distribution coefficient K to characterize its migration ability in the freezing ***,density functional theory(DFT)calculations were employed to expatiate the migration law of atrazine during icing *** to the results,it could release more energy into the environment when atrazine staying in water phase(-15.077 kcal/mol)than staying in ice phase(-14.388 kcal/mol),therefore it was beneficial for the migration of atrazine from ice to *** explains that during the freezing process,the concentration of atrazine in the ice was lower than that in the *** calculations indicated thatwhen the temperature decreases from268 to 248 K,the internal energy contribution of the compound of atrazine and ice molecule(water cluster)decreases at the same vibrational frequency,resulting in an increase in the free energy difference of the compound from-167.946 to-165.390 kcal/*** demonstrated the diminished migratory capacity of *** study revealed the environmental behavior of atrazine during lake freezing,which was beneficial for the management of atrazine and other pollutants during freezing and environmental protection.

关键词： Density functional theory(DFT) Icing process Atrazine Migration behavior Free energy

Complement factor Ⅰ knockdown inhibits colon cancer development by affecting Wnt/β-catenin/c-Myc signaling pathway and glycolysis

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2646-2662页

作者： Yong-Jun Du Yue Jiang yan-mei Hou Yong-Bo Shi Department of Proctology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina School of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Proctology Zigong Hospital of Traditional Chinese MedicineZigong 643000Sichuan ProvinceChina

BACKGROUND Colon cancer(CC)occurrence and progression are considerably influenced by the tumor ***,the exact underlying regulatory mechanisms remain *** To investigate immune infiltration-related differentially expressed genes(DEGs)in CC and specifically explored the role and potential molecular mechanisms of complement factor I(CFI).METHODS Immune infiltration-associated DEGs were screened for CC using *** reverse transcription polymerase chain reaction was used to examine hub DEGs expression in the CC cell *** CFI-knockdown HT29 and HCT116 cell lines were constructed,and the diverse roles of CFI in vitro were assessed using CCK-8,5-ethynyl-2’-deoxyuridine,wound healing,and transwell *** and eosin staining and immunohistochemistry staining were employed to evaluate the influence of CFI on the tumorigenesis of CC xenograft models constructed using BALB/c male nude *** proteins associated with glycolysis and the Wnt pathway were measured using western *** Six key immune infiltration-related DEGs were screened,among which the expression of CFI,complement factor B,lymphoid enhancer binding factor 1,and SRY-related high-mobility-group box 4 was upregulated,whereas that of fatty acid-binding protein 1,and bone morphogenic protein-2 was ***,CFI could be used as a diagnostic biomarker for ***,CFI silencing inhibited CC cell proliferation,migration,invasion,and tumor ***,CFI knockdown downregulated the expression of key glycolysis-related proteins(glucose transporter type 1,hexokinase 2,lactate dehydrogenase A,and pyruvate kinase M2)and the Wnt pathway-related proteins(β-catenin and c-Myc).Further investigation indicated that CFI knockdown inhibited glycolysis in CC by blocking the Wnt/β-catenin/c-Myc *** The findings of the present study demonstrate that CFI plays a crucial role in CC development by influencing g

关键词： Colon cancer Immune infiltration Complement factor I Glycolysis Wnt/β-catenin/c-Myc pathway

Fully relativistic energies,transition properties,and lifetimes of lithium-like germanium

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Chinese Physics B 2024年第10期33卷 52-61页

作者： Shuang Li Jing Zhou Liu-Hong Zhu Xiu-Fei mei Jun yan School of Electrical and Optoelectronic Engineering West Anhui UniversityLu’an 237012China Institute of Applied Physics and Computational Mathematics Beijing 100088China Shanghai EBIT Laboratory Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghai 200433China

Employing two fully relativistic methods,the multi-reference configuration Dirac-Hartree-Fock(MCDHF)methodand the relativistic many-body perturbation theory(RMBPT)method,we report energies and lifetime values for the lowest35 energy levels of the(1s^(2))nl configurations(where the principal quantum number n=2-6 and the angular quantum numberl=0,...,n-1)of lithium-like germanium(Ge XXX),as well as complete data on the transition wavelengths,radiativerates,absorption oscillator strengths,and line strengths between the *** the allowed(E1)and forbidden(magneticdipole M1,magnetic quadrupole M2,and electric quadrupole E2)ones are *** results from the two methodsare consistent with each other and align well with previous accurate experimental and theoretical *** assess theoverall accuracies of present RMBPT results to be likely the most precise ones to *** present fully relativistic resultsshould be helpful for soft x-ray laser research,spectral line identification,plasma modeling and *** datasetspresented in this paper are openly available at https://***/10.57760/sciencedb.j00113.00135.

关键词： multi-reference Dirac-Hartree-Fock relativistic many-body perturbation radiative rate lifetime

Developing guanine base editors for G-to-T editing in rice

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Journal of Integrative Plant Biology 2024年第8期66卷 1557-1560页

作者： lang Liu Zhongming Zhang Chenyang Wang Fang yan Wenxian Sun Xueping Zhou Weiguo Miao Huanbin Zhou State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Department of Plant Pathology China Agricultural UniversityBeijing 100193China Scientiﬁc Observing and Experimental Station of Crop Pests in Guilin Ministry of Agriculture and Rural AffairsGuilin 541399China School of Plant Protection Hainan UniversityHaikou 570228China State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058China Key Laboratory of Gene Editing Technologies Ministry of Agricultural and Rural AffairsSanya 572024China

Single nucleotide polymorphisms (SNPs) are widely present and related to desirable agronomic traits in *** regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated nuclease 9 (Cas9)-mediated base editors have been frequently used to correct defective alleles and create novel alleles by artificial evolution for rapid crop genetic improvement (Ma et al.,2021).

关键词： alleles agronomic base