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Factors influencing quality of life in Chinese patients with dementia: a systematic review

Aging Communications 2023年第2期5卷 35-42页

作者： Jin-Long Ma Bao-Jian Wei yan-mei lang School of Nursing Yanbian UniversityYanji 133000China School of Nursing Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000China

Background:Dementia is a group of nervous system diseases characterized by progressive cognitive decline,leading to a loss of self-care ability and a decline in *** places a significant burden on the global healthcare system,with Chinese patients accounting for approximately one-quarter of the world’s dementia ***,it is crucial to identify factors that impact the quality of life(QOL)among elderly Chinese individuals with ***:To achieve this,we conducted a comprehensive search of several databases,including PubMed,Embase,Web of Science,the Cochrane Library,China National Knowledge Infrastructure,Wanfang Data,China VIP Database and China Biomedical Literature *** reviewed cross-sectional studies from the inception of these databases until March 27,*** outcomes were assessed using standardized scales in the studies included in this ***:The search yielded a total of 1,235 relevant articles,from which we finally included 21 cross-sectional studies and one longitudinal study after rigorous quality *** these,10 studies were classified as high quality,while 12 were classified as fair *** our analysis,we identified 28 patient-rated QOL factors and 14 caregiver-rated QOL *** factors were categorized into three groups:patient,disease-related and *** commonly found to influence patient-rated QOL included age,education,marital status,depression,self-care ability,dementia severity,cognitive function,behavioral and psychological symptoms of dementia and caregiver ***,factors commonly influencing caregiver-rated QOL included economic status,depression,self-care ability,dementia severity,cognitive function,behavioral and psychological symptoms of dementia and caregiving ***:This review clarifies the factors that influence the QOL of Chinese individuals with *** implementing interventions,it is crucial to consider the differences between pati

关键词： dementia Alzheimer’s disease quality of life social support protective factors

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Discovery of a new family member of arsenic–vanadium polyoxometalates with high catalytic performance for one-pot coupling of CO2, epoxides and amines

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Tungsten 2025年第1期7卷 80-87页

作者： Fang-Qian Wang Yin Zhang Wei-Wei Wang mei-Qian Fu Hong-Bing Mo Wei-Dong Yu Chao Liu Jun yan College of Chemistry and Chemical Engineering Central South University Junior Education Department Changsha Normal University School of Science Hunan University of Technology and Business

Arsenic-vanadium polyoxometalates（POMs） represent a family of tremendous potential catalysts owing to their peculiar physical and chemical *** in CO2conversion,using POMs to catalyze the conversion of CO2and epoxide into chemical intermediates is the research ***,A new family number of arsenic-vanadium POMs,[N（CH3）4]4[As8V12O38（H2O）]·2H2O({As8V12O38}),was reported and characterized by single-crystal X-ray diffraction,fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,*** from other allotropicity,{As8V12O38}shows a different structure pattern with an I-43d *** obtained {As8V12O38} was employed as a catalyst for the *** initial catalytic reaction confirmed that {As8V12O38} can catalyze the formation of epoxy carbonate by using 1.01 kPa CO2and epoxide at 70℃.Furtherly,when added amine in the catalytic system,oxazolidinone could be obtained by high yields,which provides an efficient way to convert CO2into profitable ***,a possible catalytic reaction mechanism was proposed by using different characterization analyses.{As8V12O38} first catalyzes the epoxide and CO2to form an epoxy carbonate and then catalyzes epoxy carbonate and benzylamine into oxazolidinone.

关键词： Arsenic CO2 conversion Oxazolidinone Polyoxometalates Vanadium

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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei mei yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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生成式人工智能对高校学术研究的影响与应对

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黑龙江高教研究 2025年第1期43卷 9-14页

作者：姜岩宋瑞梅曲阜师范大学山东曲阜273165 山东工商学院山东烟台264005 滨州医学院山东烟台264003

以ChatGPT为代表的生成式人工智能正催生出一种全新的知识生产模式,并颠覆了人类通过学术研究进行知识生产这唯一方式的系统性和平衡性。生成式人工智能凭借其强大的文本生成功能、知识发现功能和审查评议功能不断挤占人类学术研究的主... 详细信息

以ChatGPT为代表的生成式人工智能正催生出一种全新的知识生产模式,并颠覆了人类通过学术研究进行知识生产这唯一方式的系统性和平衡性。生成式人工智能凭借其强大的文本生成功能、知识发现功能和审查评议功能不断挤占人类学术研究的主体角色空间,并以特有的知识生成创新特征对原有学科体系下的知识形态、规训制度和组织建制等三个方面产生显著影响,传统学术研究的原有规范已不再完全适用当前的知识创造环境。基于机器对人类学术研究影响的多角度深入分析,提出通过完善学术研究规范体系、提升学术失范审查技术、构建人机共研学术生态、加快人工智能素养培育等四个步骤,顺应智能技术的快速发展趋势,合理且有效发挥生成式人工智能对人类学术研究正面赋能作用的建议。

关键词： ChatCPT 学术研究知识生产学科模式

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A chitosan-mediated inhalable nanovaccine against SARS-CoV-2

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Nano Research 2022年第5期15卷 4191-4200页

作者： Shao-Hua Zhuo Jun-Jun Wu lang Zhao Wen-Hao Li Yu-Fen Zhao yan-mei Li Key Lab of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Institute for Brain Disorders Beijing 100069China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China Institute of Drug Discovery Technology Ningbo UniversityNingbo 315221China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),with several antigenic variants,has grown into a global challenge,and the rapid establishment of an immune barrier is crucial to achieving long-term control of the *** has led to a great demand for easy preparation and scalable vaccines,especially in low-income ***,we present an inhalable nanovaccine comprising chitosan and SARS-CoV-2 spike *** chitosan-mediated nanovaccine enabled a strong spike-specific antibody immune response and augmented local mucosal immunity in bronchoalveolar lavage and lungs,which might be capable of protecting the host from infection without systemic *** addition,the enhanced adaptive immunity stimulated by chitosan showed potential protection against ***,inhalation of the nanovaccine induced a comparable antibody response compared to intramuscular *** inhalable nanovaccine against SARS-CoV-2 offers a convenient and compliant strategy to reduce the use of needles and the need for medical staff.

关键词： severe acute respiratory syndrome coronavirus 2(SASR-CoV-2) inhalation nanovaccine chitosan

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DBST:a lightweight block cipher based on dynamic S-box

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Frontiers of Computer Science 2023年第3期17卷 177-185页

作者： Liuyan yan lang LI Ying GUO College of Computer Science and Technology Hengyang Normal UniversityHengyang 421002China Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang Normal UniversityHengyang 421002China

IoT devices have been widely used with the advent of *** devices contain a large amount of private data during *** is primely important for ensuring their ***,we proposed a lightweight block cipher based on dynamic S-box named *** is introduced for devices with limited hardware resources and high throughput *** is a 128-bit block cipher supporting 64-bit key,which is based on a new generalized Feistel variant *** retains the consistency and significantly boosts the diffusion of the traditional Feistel *** SubColumns of round function is implemented by combining bit-slice technology with *** S-box is dynamically associated with the *** has been demonstrated that DBST has a good avalanche effect,low hardware area,and high *** S-box has been proven to have fewer differential features than RECTANGLE *** security analysis of DBST reveals that it can against impossible differential attack,differential attack,linear attack,and other types of attacks.

关键词： internet of things 5G dynamic S-box bit-slice technology lightweight block cipher

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Stochastic resonance in coupled weakly-damped bistable oscillators subjected to additive and multiplicative noises

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Acta Mechanica Sinica 2012年第2期28卷 505-510页

作者： yan-mei Kang mei Wang Yong Xie Department of Applied Mathematics School of Mathematics and StatisticsXi'an Jiaotong University710049 Xi'anChina State Key Laboratory of Mechanical Structure Strength and Vibration School of AerospaceXi'an Jiaotong University710049 Xi'anChina

With coupled weakly-damped periodically driven bistable oscillators subjected to additive and multiplicative noises under concern, the objective of this paper is to check to what extent the resonant point predicted by the Gaussian distribution assumption can approximate the simulated one. The investigation based on the dynamical mean-field approx- imation and the direct simulation demonstrates that the pre- dicted resonant point and the simulated one are basically co- incident for the case of pure additive noise, but for the case including multiplicative noise the situation becomes some- what complex. Specifically speaking, when stochastic res- onance （SR） is observed by changing the additive noise in- tensity, the predicted resonant point is lower than the sim- ulated one; nevertheless, when SR is observed by chang- ing the multiplicative noise intensity, the predicted resonant point is higher than the simulated one. Our observations im- ply that the Gaussian distribution assumption can not exactly describe the actual situation, but it is useful to some extent in predicting the low-frequency stochastic resonance of the coupled weakly-damped bistable oscillator.

关键词： Stochastic resonance Dynamical mean-field approximation Direct simulation

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Zr-doped titanium lithium ion sieve and EP-granulated composite:Superb adsorption and recycling performance

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Particuology 2022年第10期20卷 100-110页

作者： Suyu Zhou Xiaojing Guo Xi yan yan Chen Wanzhong lang The Education Ministry Key Laboratory of Resource Chemistry Shanghai Key Laboratory of Rare Earth Functional MaterialsDepartment of Chemistry and Chemical EngineeringShanghai Normal UniversityShanghai 200234China

Lithium ion sieve(LIS)has attracted great attention due to its high adsorption selectivity towards Li+.Herein,a new type of Zr-doped Ti-LIS(HZrTO)was synthesized by a simple calcination *** adsorption capacity increased from 56.3 mgg-1(before doping)to 93.2 mgg-1 after doping in LiOH solution(lithium 1.8gL-1).The adsorption isotherm and adsorption kinetics of HZrTO accord with the langmuir isotherm and the pseudo-second-order kinetic equation,*** experiments showed that HZrTO has good stability and *** addition,HZrTO was granulated via epoxy resin(E-12),and the obtained granular adsorbent showed good adsorption capacity,excellent stability and high selectivity towards Li+.

关键词： Lithium ion sieve Lithium titanium oxide Zr-doped Granulation

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Effect of individualized nutrition interventions on clinical outcomes of pregnant women with gestational diabetes mellitus

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World Journal of Diabetes 2023年第10期14卷 1524-1531页

作者： Jian-Ying Luo lang-Gui Chen mei yan Yue-Jing mei Ya-Qian Cui Min Jiang Department of Clinical Nutrition Northern Jiangsu People's Hospital of Jiangsu ProvinceNorthern Jiangsu People's Hospital Affiliated to Yangzhou UniversityYangzhou 225001Jiangsu ProvinceChina Clinical Medical College Yangzhou UniversityYangzhou 225009Jiangsu ProvinceChina Clinical Medical College Dalian Medical UniversityDalian 116000Liaoning ProvinceChina Department of Gynaecology and Obstetrics Northern Jiangsu People's Hospital of Jiangsu ProvinceNorthern Jiangsu People's Hospital Affiliated to Yangzhou UniversityYangzhou 225001Jiangsu ProvinceChina

BACKGROUND Gestational diabetes mellitus(GDM)can lead to excessive pregnancy weight gain(PWG),abnormal glucolipid metabolism,and delayed ***,it is necessary to provide appropriate and effective interventions for pregnant women with *** To clarify the effects of individualized nutrition interventions on PWG,glucolipid metabolism,and lactation in pregnant women with *** The study population consisted of 410 pregnant women with GDM who received treatment at the Northern Jiangsu People's Hospital of Jiangsu Provinceand yangzhou Maternal and Child Health Hospital between December 2020 and December 2022,including 200 who received routine in-terventions[control(Con)group]and 210 who received individualized nutrition interventions[research(Res)group].Data on PWG,glucolipid metabolism[total cholesterol,(TC);triglycerides(TGs);fasting blood glucose(FPG);glycosylated hemoglobin(HbA1c)],lactation time,perinatal complications(cesarean section,premature rupture of membranes,postpartum hemorrhage,and pregnancy-induced hypertension),and neonatal adverse events(premature infants,fetal macrosomia,hypo-glycemia,and respiratory distress syndrome)were collected for comparative *** The data revealed markedly lower PWG in the Res group vs the Con group,as well as markedly reduced TG,TC,FPG and HbA1c levels after the intervention that were lower than those in the Con *** addition,obviously earlier lactation and statistically lower incidences of perinatal complications and neonatal adverse events were observed in the Res *** Individualized nutrition interventions can reduce PWG in pregnant women with GDM,improve their glucolipid metabolism,and promote early lactation,which deserves clinical promotion.

关键词： Individualized nutrition interventions Gestational diabetes mellitus Pregnancy weight gain Glycolipid metabolism Lactation time

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Weighted Least Squares Method for the Accelerated Failure Time Model with Auxiliary Covariates

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Acta Mathematica Sinica,English Series 2019年第7期35卷 1163-1178页

作者： Ling Hui JIN yan yan LIU lang WU School of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China City College Wuhan University of Science and Technology Wuhan 430083 P. R. China Department of Statistics University of British Columbia Vancouver Canada

This paper deals with the analysis of accelerated failure time model when the primary covariate is subject to missing. We assume that the true covariate is measured precisely on a randomly chosen validation set, whereas auxiliary information for primary covariate is available to all study subjects. The asymptotic properties for the proposed estimator are developed and the simulation studies show that the efficiency gain is remarkable compared to the method using only the validation sample. A real example is also provided as an illustration.

关键词： Survival analysis accelerated failure time model auxiliary covariates validation sample weighted least squares estimation

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