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Association between complementary factor H Y402H polymorphisms and age-related macular degeneration in Chinese: Systematic review and meta-analysis

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International Journal of Ophthalmology(English edition) 2012年第2期5卷 242-246页

作者： yan-long quan Ai-Yi Zhou and Zhao-Hui Feng Department of Ophthalmology the Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China

AIM: Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world and complement factor H (CFH) polymorphism has been found to associate with the AMD. To investigate whether the Y402H variant in CFH is associated with AMD in Chinese populations, a systematic review and meta-analysis were performed to estimate the magnitude of the gene effect and the possible mode of action. METHODS: A meta-analysis was performed using data available from ten case-control studies assessing association between the CFH Y402H polymorphism and AMD in Chinese populations involving 1538 AMD. Data extraction and study quality assessment were performed in duplicate. Summary odds ratios (ORs) and 95% confidence intervals (CIs) an allele contrast and genotype contrast were estimated usingfixed- effects models. The Q-statistic test was used to assess heterogeneity, and Funnel plot was used to evaluate publication bias. RESULTS: Seven of ten case-control studies were neovascular AMD, and few studies came from west and north of China. There was strong evidence for association between CFH and AMD in Chinese population, with those having risk allele C 2.35 times more likely to have AMD than subjects with T allele. Evidence of publication bias was not observed in our meta-analysis. CONCLUSION: This meta-analysis summarizes the strong evidence for an association between CFH and AMD in Chinese and indicates each C allele increasing the odds of AMD by 2.33-fold. But more evidences about the relation between CFH polymorphism and different type of Chinese AMD from various district were needed.

关键词： age-related macular degeneration complement factor H polymorphism meta-analysis Chinese population

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Panretinal photocoagulation versus panretinal photocoagulation plus intravitreal bevacizumab for high-risk proliferative diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2016年第12期9卷 1772-1778页

作者： Ai-Yi Zhou Chen-Jing Zhou Jing Yao yan-long quan Bai-Chao Ren Jian-Ming Wang Department of Ophthalmology the Second Affiliated Hospital of Medical College of Xi'an Jiaotong University

AIM： To evaluate the effects of panretinal photocoagulation （PRP） compared with PRP plus intravitreal bevacizumab （IVB） in patients with high-risk proliferative diabetic retinopathy （PDR） according to the Early Treatment Diabetic Retinopathy Study ***： The data were collected retrospectively from the eyes of high-risk PDR patients, which were divided into two groups. After treated with standard PRP, the eyes were randomly assigned to receive only PRP （PRP group） or PRP plus intravitreal injection of 1.25 mg of bevacizumab （PRP-Plus group）. Patients underwent complete ophthalmic evaluation, including best corrected visual acuity （BCVA）, intraocular pressure （IOP）, and new vessel size in fluorescein angiography （FA） and optical coherence tomography for the assessment of central subfield macular thickness （CSMT） at baseline and at weeks 12 （±2）, 16 （±2）, 24 （±2） and 48 （±2）. Main outcome measures also included vitreous clear-up time and neovascularization on the disc （NVD） regression time. Adverse events associated with intravitreal injection were ***： Thirty consecutive patients （n=36 eyes） completed the 48-week follow-up. There was no significant difference between the PRP and PRP-Plus groups with respect to age, gender, type or duration of diabetes, area of fluorescein leakage from active neovascularizations （NVs）, BCVA or CSMT at baseline. The mean vitreous clear-up time was 12.1±3.4wk after PRP and 8.4±3.5wk after PRP combined with IVB. The mean time interval from treatment to complete NVD regression on FA examination was 15.2±3.5wk in PRP group and 12.5±3.1wk in PRP-Plus group. No significant difference in CSMT was observed between the groups throughout the study period. However, the total area of actively leaking NVs was significantly reduced in the PRP-Plus group compared with the PRP group （P〈0.05）. Patients received an average of 1.3 injections （range： 1-2）. Ten eyes （27.8%） underwent 2 injections. Two eyes had ocular complicatio

关键词： panrctinal photocoagulation intravitreal bevacizumab high-risk proliferative diabetic retinopathy neovascularization on the disc

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脉络膜厚度与特发性黄斑前膜的关系研究

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国际眼科杂志 2018年第4期18卷 734-736页

作者：马君择权彦龙杨格强西安交通大学第二附属医院眼科中国陕西省西安市710004 中国陕西省西安市中心医院眼科 710004

目的:探讨脉络膜厚度和特发性黄斑前膜(idiopathic macular epiretinal membrane,IMEM)发生发展的关系。方法:回顾性分析2014-01/2016-12期间我院就诊的IMEM患者48例48眼,并选取同期体检健康者50例的右眼进行对照,比较IMEM组患眼、健眼... 详细信息

目的:探讨脉络膜厚度和特发性黄斑前膜(idiopathic macular epiretinal membrane,IMEM)发生发展的关系。方法:回顾性分析2014-01/2016-12期间我院就诊的IMEM患者48例48眼,并选取同期体检健康者50例的右眼进行对照,比较IMEM组患眼、健眼及对照组黄斑中心凹脉络膜厚度(subfoveal choroidal thickness,SFCT)水平,随访观察术后IMEM患者患眼及健眼SFCT水平变化,并分析术后脉络膜厚度和最佳矫正视力的相关性。结果:术前IMEM组患眼SFCT(362.22±40.75μm)明显较对侧健眼(410.56±38.45μm)及对照组右眼(420.73±39.63μm)低,且对侧健眼较对照组右眼低,差异均有统计学意义(均P0.05),而术后1mo患眼和健眼SFCT均显著升高,和术前相比差异有统计学意义(P0.05);术前不同SFCT值患者术后BCVA≥0.5患者构成比差异有统计学意义(P380μm组术后BCVA≥0.5患者构成比明显较<320μm组和320～380μm组高,经Fisher确切概率法分析,差异有统计学意义。经Pearson分析,IMEM患者术后脉络膜厚度和术后最佳矫正视力存在正相关性(r=0.629,P<0.05)。结论:脉络膜变薄可能是IMEM的重要诱因。

关键词：特发性黄斑前膜脉络膜厚度关系

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Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang quan Jin Haitao Zhang Zhao Liu Yuyang Wu longfei Zhang Renzhang yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

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急性视网膜坏死综合征误诊分析5例

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国际眼科杂志 2009年第4期9卷 802-804页

作者：冯朝晖周爱意权彦龙熊全臣西安交通大学医学院第二附属医院眼科中国陕西省西安市710004

目的:急性视网膜坏死综合征是一种以中到重度葡萄膜炎、血管炎以及血管闭塞性视网膜坏死为特征的严重眼病,其早期诊断比较困难,有的甚至在行玻璃体视网膜手术过程中才被确诊。分析临床上急性视网膜坏死综合征误诊的原因,总结早期诊断的... 详细信息

目的:急性视网膜坏死综合征是一种以中到重度葡萄膜炎、血管炎以及血管闭塞性视网膜坏死为特征的严重眼病,其早期诊断比较困难,有的甚至在行玻璃体视网膜手术过程中才被确诊。分析临床上急性视网膜坏死综合征误诊的原因,总结早期诊断的经验。方法:回顾我院5例未能及时诊断的急性视网膜坏死综合征病例的临床特点,诊治经过及最终预后,并分析误诊原因。结果:5例病例中,1例被误诊为虹膜睫状体炎,2例误诊为葡萄膜炎并视网膜脱离,1例误诊为视网膜中央动脉阻塞,1例被误诊为出血性视网膜血管炎。这些疾病在临床诊断过程中有必要考虑与急性视网膜坏死鉴别。结论:急性视网膜坏死综合征临床表现变异较大,有些表现不典型,临床工作中应充分认识此疾病。

关键词：急性视网膜坏死综合征视网膜血管炎视网膜脱离误诊视网膜中央动脉阻塞

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： Jiali Chen Yiyang Li Xingping quan Jinfen Chen yan Han Li yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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抗分解代谢阻遏纤维素酶变异株的选育

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无锡轻工大学学报（食品与生物技术） 2000年第3期19卷 244-247页

作者：管斌孙艳玲谢来苏隆言泉山东轻工业学院山东济南250100 天津轻工业学院天津300222

利用紫外线、亚硝基胍等对里氏木霉进行诱变处理 ,采用低剂量、多次复合诱变处理方法 ,以 2 脱氧葡萄糖作为降解产物阻遏物进行高效筛选 ,选育得到一株抗分解代谢阻遏的突变株 ,使纤维素酶活力提高了 3倍 .

关键词：纤维素酶抗分解代谢阻遏突变株筛选选育

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue Tang Mansheng Chu quan Shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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带蒂结膜瓣转移联合丝裂霉素C治疗复发性翼状胬肉的临床研究

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国际眼科杂志 2009年第2期9卷 391-392页

作者：佘华宁权彦龙王肖华任百超西安交通大学医学院第二附属医院眼科中国陕西省西安市710004

目的：探讨带蒂结膜瓣转移联合应用丝裂霉素C治疗复发性翼状胬肉的临床疗效。方法：对26例（26眼）复发性翼状胬肉患者，采用翼状胬肉切除、术中加用丝裂霉素C并行带蒂结膜瓣转移、术后低浓度丝裂霉素C点眼进行治疗并随访观察。结果：... 详细信息

目的：探讨带蒂结膜瓣转移联合应用丝裂霉素C治疗复发性翼状胬肉的临床疗效。方法：对26例（26眼）复发性翼状胬肉患者，采用翼状胬肉切除、术中加用丝裂霉素C并行带蒂结膜瓣转移、术后低浓度丝裂霉素C点眼进行治疗并随访观察。结果：所有患者均接受了6～12too随访，有1例患者复发，复发率为4％。没有并发症发生。结论：对复发性翼状胬肉，翼状胬肉切除术中加用带蒂结膜瓣转移联合应用丝裂霉素C，是一种有效的治疗方法。

关键词：翼状胬肉结膜瓣转移丝裂霉素C

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临床医学专业七年制眼科学试卷分析与评价

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国际眼科杂志 2011年第5期11卷 841-843页

作者：冯海晓赵琳权彦龙王建明王峰西安交通大学医学院第二附属医院眼科中国陕西省西安市710004

目的:通过分析西安交通大学临床医学系2006级七年制学生眼科学期末考试试卷,对试题质量和教学质量进行评估。方法:对参加考试的临床医学系2006级七年制学生的72份试卷进行统计分析。结果:考试成绩呈正态分布,平均成绩为82.93±9.26分,... 详细信息

目的:通过分析西安交通大学临床医学系2006级七年制学生眼科学期末考试试卷,对试题质量和教学质量进行评估。方法:对参加考试的临床医学系2006级七年制学生的72份试卷进行统计分析。结果:考试成绩呈正态分布,平均成绩为82.93±9.26分,难度为0.829,区分度为0.278,信度为0.636957。结论:本次考试试题能较全面地评价学生对课程的掌握程度,试题难度总体偏易中,区分度尚可,分析结果对今后眼科学教学改革和科学命题提供了一定的参考价值。

关键词：眼科学试卷分析教学质量

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