检索结果-南通市图书馆

Assembling and releasing performance of supramolecular hydrogels formed from simple drug molecule as the hydrogelator

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2007年第8期18卷 1009-1012页

作者： Yu Jiang Wang liang yan li Ming Tang Jian Yu Laboratory of Advanced Materials Department of Chemical Engineering Tsinghua University Beijing 100084 China

A simple drug compound, 4-oxo-4-（2-pyridinylamino） butanoic acid （defined as AP）, was able to gel water at 4 wt% concentration under various conditions. In the superstructure, AP molecules assembled into fibrous aggregates driving by hydrogen bonds and π-π stacking interaction. The gels with different backbone structures released drug molecules in different speeds.

关键词： Supramolecular hydrogel Hydrogelator Releasing

Twist 1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 expression

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第48期20卷 18306-18315页

作者： Dong-Yuan Zhu Qi-Sen Guo yan-liang li Bin Cui Jun Guo Ji-Xiao liu Peng li Department of Medical Oncology Shandong Cancer Hospital and Institute Department of Medical Oncology Zhangqiu City People’s Hospital Department of Medical Oncology Gaomi City TCM Hospital Department of Medical Oncology Wenshang County People’s Hospital Department of Medical Oncology Yantai Yuhuangding Hospital affiliated to Qingdao University

AIM: To explore the correlation between Twist-related protein (Twist)1, fibroblast growth factor receptor (FGFR)2 and gastric adenocarcinoma differentiation and progression.

关键词： Twist-related protein 1 Fibroblast growth factor receptor 2 Gastric adenocarcinoma Cancer differentiation Cancer progression

As a Cultural and Spiritual Homeland:Pai Hsien-yung and His Kunqu Peony Pavilion:The Young Lovers’Version

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cultural and Religious Studies 2022年第7期10卷 345-351页

作者： liang yan-li Fudan University ShanghaiChina

As a Cultural and Spiritual Homeland,Pai Hsien-yung and His Kunqu Peony Pavilion:The Young Lovers’Version,the new version of The Jade Hairpin,how to be the most aesthetic version,cross-border version and young versio... 详细信息

关键词： Pai Hsien-yung Kunqu Peony Pavilion The Jade Hairpin The Young Lovers’Version

Preparation of poly（N-isopropylacrylamide） brush grafted silica particles via surface-initiated atom transfer radical polymerization used for aqueous chromatography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Materials Science 2012年第1期6卷 60-68页

作者： Zong-Jian liU yan-li liang Fang-Fang GENG Fang LV Rong-Ji DAI Yu-Kui ZHANG Yu-lin DENG School of life Science Beijing Institute of TechnologyBeijing 100081China Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023China

Thermoresponsive poly（N-isopropylacrylamide）（PNIPAAm） brushes were densely grafted onto silica surface via surface-initiated atom transfer radical polymeriza- tion （SI-ATRP）. The grafting reaction started from the surfaces of 2-bromoisobutyrate- functionalized silica particles in 2-propanol aqueous solution at ambient temperature using CuCIICuCI21N, N,N＇,N＇,N”.pentamethyldiethylenetriamine （PMDETA） as the catalytic system. Based on thermogravimetric analysis （TGA） results, the grafting amount and grafting density of PNIPAM chains on the surface of silica were calculated to be 1.29 mg/ m^2 and 0.0215 chains/nm^2, respectively. The gel permeation chromatography （GPC） result showed the relatively narrow molecular weight distribution （MwlMn= 1.21） of the grafted PNIPAAm. The modified silica particles were applied as high-performance liquid chromatography （HPLC） packing materials to successfully separate three aromatic compounds using water as mobile phase by changing column temperature. Temperature- dependent hydrophilic/hydrophobic property alteration of PNIPAAm brushes grafted on silica particles was determined with chromatographic interaction between stationary phase and analytes. Retention time was prolonged and resolution was improved with increasing temperature. Baseline separation with high resolution at relatively low temperatures was observed, demonstrating dense PNIPAAm brushes were grafted on silica surfaces.

关键词： poly(N-isopropylacrylamide) (PNIPAAm) atom transfer radical polymeriza-tion (ATRP) temperature-responsive chromatography separation

Immune Blot Analysis on Expression of the Mammalian Target of Rapamycin in Goat Fetal Fibroblasts with Recombinant Polyclonal Antibody

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2012年第6期11卷 1002-1008页

作者： liang yan li Shu-yu WANG Xiao-jing WU Man-lin yanG Jiao-fu li Jie HAO Xi-yan HAO Hui-fang BA Yin-ma CHEN Xian-wei WANG Zhi-gang College of life Science lnner Mongolia UniversityHohhot 010021P.R.China

To detect the mammalian target of rapamycin （mTOR） expressed in Cashmere goat fetal fibroblasts （GFb）, mTOR gene was cloned from Inner Mongolia Cashmere goat （Capra hircus） and expressed in Escherichia coli followed by immunizing mice with the purified recombinant protein as an irnmunogen to produce the anti-goat mTOR recombinant polyclonal antibody. Antiserum was collected from the immunized mice after the fifth immunization and its titer was determined with enzyme-linked immunosorbent assay （EliSA）. The results showed that the recombinant polyclonal antibody had a titer 1：200000 and could react with the roTOR expressed in GFb cells with a specific and sensitive affinity. Western blot showed that mTOR expression and phospho-mTOR （Ser 2448） activity were inhibited when GFb cells were treated with CCI-779, an mTOR specific inhibitor.

关键词： prokaryotic expression recombinant antibody goat mTOR CCI-779

The association analysis polymorphism of CDKAL1 and diabetic retinopathy in Chinese Han population

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2016年第5期9卷 707-712页

作者： Nai-Jia liu Qian Xiong Hui-Hui Wu yan-liang li Zhen yang Xiao-Ming Tao yan-Ping Du Bin Lu Ren-Ming Hu Xuan-Chun Wang Jie Wen Department of Endocrinology and Metabolism Huashan Hospital Affiliated to Fudan University Department of Endocrinology and Metabolism Jing'an District Center Hospital of Shanghai Department of Endocrinology and Metabolism Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Endocrinology and Metabolism Hua Dong Hospital Affiliated to Fudan University

AIM： To identify the contribution of CDKAL1 to the development of diabetic retinopathy（DR） in Chinese population.·METHODS： A case-control study was performed to investigate the genetic association between DR and polymorphic variants of CDKAL1 in Chinese Han population with type 2 diabetes mellitus（T2DM）. A welldefined population with T2 DM, consisting of 475 controls and 105 DR patients, was recruited. All subjects were genotyped for the genetic variant（rs10946398） of CDKAL1. Genotyping was performed by i PLEX technology. The association between rs10946398 and T2 DM was assessed by univariate and multivariate logistic regression（MLR） analysis.· RESULTS： There were significant differences in C allele frequencies of rs10946398（CDKAL1） between control and DR groups（45.06% versus 55.00%, P 〈0.05）.The rs10946398 of CDKAL1 was found to be associated with the increased risk of DR among patients with diabetes.·CONCLUSION： Our findings suggest that rs10946398 of CDKAL1 is independently associated with DR in a Chinese Han population.

关键词： CDKAL1 polymorphism association analysis diabetic retinopathy Chinese Han population

Functional Marker Development and Effect Analysis of Grain Size Gene GW2 in Extreme Grain Size Germplasm in Rice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice science 2015年第2期22卷 65-70页

作者： ZHANG Ya-dong ZHENG Jia liang yan-li ZHAO Chun-fang CHEN Tao ZHAO Qing-yong ZHU Zhen ZHOU li-hui YAO Shu ZHAO ling YU Xing WANG Cai-lin Institute of Food Crops Jiangsu Academy of Agricultural SciencesJiangsu High Quality Rice R & D CenterNanjing Branch of China National Center for Rice Improvement

GW2 is an important gene that regulates grain width and weight. We used cDNA clone to obtain the sequences of GW2 from large- and small-grained rice varieties, TD70 and Kasalath, respectively. Then, we developed a dCAPS （derived cleaved amplified polymorphic sequence） marker on the basis of the sequence difference between functional and nonfunctional GW2 genes to analyze the genotypes and phenotypes of recombinant inbred lines. Results showed that the sequence of GW2To7~ had a single nucleotide deletion at site 316 that generates a termination codon. This codon terminated the GW2 protein in advance. By contrast, the sequence of GW2Kasalath encoded an intact protein. A novel dCAPS marker was designed in accordance with a base A deletion at site 316 of the sequence. After the PCR product was digested by Apol, TD70 showed 21 and 30 bp fragments, and Kasalath showed a 51 bp fragment. Up to 82 lines contained GW2TDTO, and 158 lines contained GW2Kasalath. The lines that contained TD70 alleles displayed substantial increases in width and 1000-grain weight. This result suggested that GW2 played a critical role in rice breeding.

关键词： rice grain size GW2 gene derived cleaved amplified polymorphic sequence phenotype

Effect of puerarin on myocardial perfusion and ventricular wall motion in patients with acute coronary syndrome

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2008年第3期5卷 155-158页

作者： ling Niu Dongye li Yong Xia Defeng Pan Xiaoping Wang yan yan li liang Tongda Xu Cardiovascular Institute of Xuzhou Medical College, Department of Cardiology, Affiliated Hospital, Xuzhou Medical College, Xuzhou, Jiangsu 221002, China Cardiovascular Institute of Xuzhou Medical College Department of Cardiology Affiliated Hospital Xuzhou Medical College

Objective To investigate the effects of puerarin (Pur) on myocardial perfusion and ventricular wall motion in patients with acute coronary syndrome (ACS).Methods Thirty-seven patients with ACS were randomly divided into two groups:conventional treatment group (n= 17,11 males,range of age:32-80 years,average age:60.9±4.9 years) and Pur treatment group (n=20,12 males,range of age:40-76 years,average age:62.7±3.5 years).Patients in the conventional treatment group received standard treatment according to the current guidelines,while patients in the Pur treatment group received intravenous administration of Pur (500 mg/day) for 10 days plus conventional ***-time myocardial contrast echocardiography (RT-MCE) was performed to evaluate the change in myocardial perfusion index (MPI) and ventricular wall motion index (VWMI) at admission and 10 days after *** At 10 days after treatment,MPI was significantly higher (P<0.01) and VWMI significantly lower (P<0.01) in the Pur group comparing with those in the conventional *** Puerarin might improve myocardial microcirculation perfusion and ventricular wall motion in patients with ACS.

关键词： acute coronary syndrome myocardial perfusion index ventricular wall motion index puerarin

在线全文

学校读者我要写书评

暂无评论

台湾地区百年话剧中的民族寓言

厦门大学学报（哲学社会科学版） 2023年第6期73卷 81-93页

作者：梁燕丽复旦大学中文系上海200433

民族寓言是民族叙事的一种独特形式,台湾地区百年话剧的民族寓言包括原型叙事、历史叙事和乌托邦叙事等。原型叙事作为文化记忆与集体潜意识的民族寓言,体现在《琴韵千秋》《楚汉风云》《和氏璧》等剧目中,知音、君子、英雄等“原型”... 详细信息

民族寓言是民族叙事的一种独特形式,台湾地区百年话剧的民族寓言包括原型叙事、历史叙事和乌托邦叙事等。原型叙事作为文化记忆与集体潜意识的民族寓言,体现在《琴韵千秋》《楚汉风云》《和氏璧》等剧目中,知音、君子、英雄等“原型”意象隐藏着文化特质和人格,以新型话剧形式,延续中华民族的文化根脉和文化精魂。历史叙事作为历史记忆与现代转型的民族寓言,体现在《国姓爷》《阉鸡》《胜利进行曲》《光复进行曲》《牛犁分家》等剧目中,以个人和家庭的故事展现台湾地区人民在荷占和日据时期集体的反抗斗争和后殖民论述,也展现台湾地区人民和祖国血脉相连的认同感和归属感。乌托邦叙事作为社会理想与现实指涉的民族寓言,体现在《猪八戒做和尚》《武陵人》《暗恋桃花源》等剧目中,“桃花源”作为中国人理想世界的象征,在台湾地区剧场重生,创造乌托邦叙事的民族寓言。民族寓言使台湾地区话剧激活深厚的民族文化底蕴,蕴含集体无意识能量,焕发出更加璀璨的理想色彩和艺术光芒。

关键词：台湾地区话剧民族寓言原型叙事历史叙事乌托邦叙事