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Atomistic simulation of fcc-bcc phase transition in single crystal Al under uniform compression

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Chinese Physics B 2012年第2期21卷 425-430页

作者： li li Shao Jian-li li yan-fang Duan Su-Qing liang Jiu-Qing Institute of Theoretical Physics and Department of Physics Shanxi UniversityTaiyuan 030006China Institute of Applied Physics and Computational Mathematics Beijing 100088China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

By molecular dynamics simulations employing an embedded atom model potential, we investigate the fcc-to-bcc phase transition in single crystal Al, caused by uniform compression. Results show that the fcc structure is unstable when the pressure is over 250 GPa, in reasonable agreement with the calculated value through the density flmctional theory. The morphology evolution of the structural transition and the corresponding transition mechanism are analysed in detail. The bcc （011） planes are transited from the fcc （111） plane and the （111） plane. We suggest that the transition mechanism consists mainly of compression, shear, slid and rotation of the lattice. In addition, our radial distribution flmction analysis explicitly indicates the phase transition of Al from fee phase to bce structure.

关键词： molecular dynamics simulations phase transition microstructure

A rabbit model of pediatric nonalcoholic steatohepatitis: The role of adiponectin

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World Journal of Gastroenterology 2009年第8期15卷 912-918页

作者： Jun-Fen Fu yan-Lan fang li liang Chun-lin Wang fang Hong Guan-Ping Dong Department of Endocrinology The Children's Hospital of Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China

AIM： To create a rabbit model of pediatric nonalcoholic steatohepatitis （NASH） and to evaluate the role of adiponectin in the process. METHODS： Thirty-two specific pathogen-free male New Zealand rabbits were divided randomly into three groups：（1） the normal control group （n = 10） was fed with standard diet for 12 wk; （2） the model group A （n = 11）; and （3） model group B （n = 11） were fed with a highfat diet （standard diet ＋ 10% lard ＋ 2% cholesterol） for 8 and 12 wk, respectively. Hepatic histological changes were observed and biochemical parameters as well as serum levels of adiponectin, interleukin （IL）-6, IL-10 and tumor necrosis factor （TNF）-α were measured. RESULTS： Typical histological hepatic lesions of NASH were observed in both model groups described as liver steatosis, liver inflammatory infiltration, cytologic ballooning, perisinusoidal fibrosis and overall fibrosis. Compared with the normal control group, there were significant increases in model groups A and B in weight gain （1097.2 ± 72.3, 1360.5± 107.6 vs 928.0 ±58.1, P 〈 0.05, P 〈 0.01）, liver weight （93.81±6.64, 104.6±4.42 vs 54.4±1.71, P 〈 0.01）, Lg （ALT）（1.9±0.29, 1.84± 0.28 vs 1.60±0.17, P 〈 0.01）, and Lg （TG）（1.03 ±0.24, 1.16 ±0.33 vs 0.00 ±0.16, P 〈 0.01）. Weight gain was much more in model group B than in model group A （1360.5± 107.6 vs 1097.2 ±72.3, P 〈 0.05）. But, there was no significant difference between the two groups concerning the other indexes. Pro-inflammatory cytokines （IL-6 and TNF-α） increased in model group B compared with that of control and model group A （IL-6：1.86±0.21 vs 1.41 ±0.33, 1.38± 0.42, P 〈 0.01; TNF-α： 1.18±0.07 vs 0.66 ±0.08, 0.86 ±0.43, P 〈 0.01, P 〈 0.05）, whereas serum adiponectin and IL-10 decreased in model groups compared with that in the control （adiponectin： A： 21.87±4.84 and B： 21.48 ±4.60 vs 27.36 ±7.29, P 〈 0.05. IL-10： A： 1.72± 0.38 and B： 1.83 ±0.39 vs 2.26±0.24, P 〈 0.01）. Lg （TC） and the degree of liver fatty infiltration was an independent determi

关键词： Nonalcoholic steatohepatitis Pediatricanimal model Adiponectin Interleukin 6 Tumornecrosis factor

Positive correlation between plasma PCSK9 and tissue factors levels in patients with angiographically diagnosed coronary artery disease and diabetes mellitus

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Journal of Geriatric Cardiology 2016年第4期13卷 312-315页

作者： M ei WANG yan-fang li yan-Ging GUO Meng-Meng CHEN Zhi-li JIANG Jun-Ying SONG Emergency & Critical Care Center Beo'ing Anzhen Hospital Capital Medical University No. 2 Anzhen Road Chaoyang District Beijing China Beijing Institute of Heart Lung and Blood Vessel Diseases Beijing China

Background Pro-protein convertase subtilisin/kexin type 9 （PCSK9） is a secreted protein that influences plasma levels of low-density lipoprotein cholesterol （LDL-C）. Both oxidized LDL and tissue factor （TF） contributed to the development of prothrombofic state. The pre- sent study aims to explore the relationship between plasma level of PCSK9 and that of TF in patient with coronary artery disease （CAD）. Methods From July 2013 to March 2014, we enrolled 197 consecutive patients who underwent coronary angiography because of suspected CAD at Beijing Anzhen Hospital in this study. All patients had no history of using lipid-lowering medication. Of these 197 patients （1B 1 male and 66 female, mean age 56.9 ± 11.8 years）, 81 had angiographically diagnosed CAD. Clinical data were collected. Plasma PCSK9 and TF were measured using enzyme-linked immunosorbent assay （EliSA）. Levels of plasma PCSK9 and TF were compared and their correlation analyzed among different patient groups. Results Both plasma levels of PCSK9 （279.8 ± 60.4μg/L vs. 216.5 ± 45.3μg/L, P 〈 0.01） and TF （156.4 ± 26.6 μg/mL vs. 112.1 ± 38.3 μg/L, P 〈 0.01） were significantly higher in patients with CAD, as compared with those with- out CAD. Correlation analysis showed plasma level of PCSK9 was significantly correlated with that of TF in both patients with and without CAD. However, multivariate regression analysis after adjustment for age, gender, smoking, alcohol, hypertension and hyperlipidemia showed that only in CAD patients with type 2 diabetes mellitus, there was significant positive correlation between plasma levels of PCSK9 and TF （β = 0.353, P 〈 0.01）. Coneluslons The plasma level of PCSK9 is independently and positively associated with that of TF in CAD patients with diabetes mellitus, but not in those without diabetes mellitus. Further study is needed to investigate the underlying mechanism.

关键词： Coronary artery disease PCSK9 Tissue factor Type 2 diabetes mellitus

Signature of symmetry of laterally coupled quantum dots in far-infrared spectrum

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Chinese Physics B 2012年第2期21卷 477-482页

作者： Gu li-Ying li yan-fang Chu Wei-Dong Wei Ying-Hui College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Institute of Applied Physics and Computational Mathematics Beijing 100088China

We study the effect of structure asymmetry on the energy spectrum and the far-infrared spectrum （FIR） of a lateral coupled quantum dot. The calculated spectrum shows that the parity break of coupled quantum dot results in more coherent superpositions in the low-lying states and exhibits unique anti-crossing in the two-electron FIR spectrum modulated by a magnetic field. We also find that the Coulomb correlation effect can make the FIR spectrum of coupled quantum dot without strict parity deviate greatly from Kohn theorem, which is just contrary to the symmetric case. Our results therefore suggest that FIR spectrum may be used to determine the symmetry of coupled quantum dot and to evaluate the degree of Coulomb interaction.

关键词： structure symmetry far-infrared spectrum coupled quantum dot Coulomb interaction

Synthesis and Biological Evaluation of Novel Tricyclic Oximino Derivatives as Antitumor Agents

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Chemical Research in Chinese Universities 2008年第1期24卷 47-53页

作者： GUO Shu-chun ZHAO yan-fang li Rong-dong XIE li-jun yanG You-bin GONG Ping School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of novel alkylthio/sulfinyl-8H-thieno[2,3-b]pyrrolizin-8-oximino derivatives Ⅴ1--Ⅷ15 were designed and synthesized as antitumor agents. Their structures were confirmed using IR, ^1H NMR, elemental analysis, and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402, HT-1080, SGC-7901, and A549 Cell lines. Among them, compound Ⅵ9 displayed a promising antitumor activity superior to that of Cisplatin.

关键词： Thieno[2,3-b] pyrrolizine Synthesis Antitumor activity

High-Temperature Oxidation Behavior of Vanadium,Titanium-Bearing Magnetite Pellet

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Journal of Iron and Steel Research International 2011年第8期18卷 14-19页

作者： HAN Gui-hong JIANG Tao ZHANG Yuan-bo HUANG yan-fang li Guang-hui School of Minerals Processing and Bioengineering Central South University Changsha 410083 Hunan China

By means of isothermal oxidation and chemical analysis, great importance was attached to the parameters that made effects on the oxidation degree of vanadium, titanium-bearing magnetite pellet in high-temperature processing （1 073- 1 323 K）. Based on the experimental data, oxidation kinetics of pellet was analyzed according to shrinking unreacted-core model subsequently. Experiment results display that the oxidation degree of pellet increases with increasing of oxidation time, oxidation temperature and oxygen content, as well as shrinking of pellet diameter. Under the condition of oxidation time 20 min, oxidation temperature 1223 K, oxygen content 15%, and pellet diameter 12 mm, oxidation degree of pellet reaches 92.92%. The analysis of oxidation kinetics indicates that oxidation process of pellet is controlled by chemical reaction with activation energy 68.64 kJ/mol at a relatively lower temperature （1073-1 173 K）. Oxidation process of pellet is mixed-controlled by chemistry reaction and diffusion with activation energy 39.66 kJ/mol in the temperature range of 1 173-1 273 K. When oxidation temperature is higher than 1 273 K, the limited link of oxidation reaction is the diffusion control with the activation energy 20.85 kJ/mol. These results can serve as a reference to the production of vanadium, titanium-hearing magnetite pellet.

关键词： vanadium titanium-bearing magnetite oxidation degree pellet shrinking unreaeted-core model oxidation kinetics

The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer

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Chinese Journal of Cancer 2016年第7期35卷 374-381页

作者： Xiao-Jing Wang Ying Xiong Ze-Biao Ma Jian-Chuan Xia yan-fang li Sun Yat-Sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer Medicine Guangzhou 510060Guangdong P.R.China Department of Gynecologic Oncology Sun Yat-Sen University Cancer CenterGuangzhou 510060GuangdongP.R. China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhou 510060GuangdongP.R. China

Background:Protein tyrosine kinase 6(PTK6) is overexpressed in many epithelial tumors and predicts poor ***,PTK6 expression status and its role in cervical squamous cell cancer are *** study aimed to investigate the expression level and clinical significance of PTK6 in early-stage cervical squamous cell ***:Quantitative reverse transcription-polymerase chain reaction(qRT-PCR) and western blotting analysis were performed to detect PTK6 mRNA and protein expression levels in 10 freshly frozen,early-stage cervical squamous cell cancer specimens and adjacent non-tumorous cervical *** expression of PTK6 was detected using immunohistochemical staining in 150 formalin-fixed,paraffin-embedded,early-stage cervical squamous cell cancer sections and 10 normal cervical tissue ***:The mRNA and protein levels of PTK6 in cancer tissues were higher than those in adjacent non-tumorous cervical *** analysis showed that PTK6 was not expressed in normal cervical tissues but was overexpressed in the cytoplasm of cervical squamous cell cancer *** level of PTK6 expression was significantly associated with tumor grade(P = 0.020).The 5-year overall survival rate of patients with high PTK6 expression was lower than that of patients with low PTK6 expression(81.3%vs.96.2%,P = 0.008).Multivariate Cox regression analysis showed that the expression level of PTK6 in cervical squamous cell cancer was an independent prognostic factor for patient survival(hazard ratio = 5.999,95%confidence interval 1.622-22.191,P< 0.05).Conclusions:PTK6 is overexpressed in cervical squamous ceil *** PTK6 expression is associated with reduced 5-year overall ***6 expression is an independent prognostic predictor for cervical cancer.

关键词：蛋白酪氨酸激酶鳞状细胞癌子宫颈预后早期反转录聚合酶链反应免疫组化染色组织切片

Analysis of the influencing factors and clinical related characteristics of pulmonary tuberculosis in patients with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 196-208页

作者： Han Shi Yuan Yuan Xue li yan-fang li ling Fan Xue-Mei yang Department of Infectious Diseases The First Affiliated Hospital of Chengdu Medical CollegeChengdu 610500Sichuan ProvinceChina

BACKGROUND In China,the prevalence of type 2 diabetes mellitus(T2DM)among diabetic patients is estimated to be between 90%-95%.Additionally,China is among the 22 countries burdened by a high number of tuberculosis cases,with approximately 4.5 million individuals affected by active ***,T2DM poses a significant risk factor for the development of tuberculosis,as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis(T2DMPTB),which has risen from 19.3%to 24.1%.It is evident that these two diseases are intricately interconnected and mutually reinforcing in *** To elucidate the clinical features of individuals diagnosed with both T2DM and tuberculosis(T2DM-PTB),as well as to investigate the potential risk factors associated with active tuberculosis in patients with *** T2DM-PTB patients who visited our hospital between January 2020 and January 2023 were selected as the observation group,Simple DM patients presenting to our hospital in the same period were the control group,Controls and case groups were matched 1:2 according to the principle of the same sex,age difference(±3)years and disease duration difference(±5)years,patients were investigated for general demographic characteristics,diabetes-related characteristics,body immune status,lifestyle and behavioral habits,univariate and multivariate analysis of the data using conditional logistic regression,calculate the odds ratio(OR)values and 95%CI of OR *** A total of 315 study subjects were included in this study,including 105 subjects in the observation group and 210 subjects in the control *** of the results of both anthropometric and biochemical measures showed that the constitution index,systolic blood pressure,diastolic blood pressure and lymphocyte count were significantly lower in the case group,while fasting blood glucose and high-density lipoprotein cholesterol levels were significantly higher than those in the control ***

关键词： Type 2 diabetes Pulmonary tuberculosis Blood sugar Infection Risk factors

Efficiency Enhancement of MEH-PPV:PCBM Solar Cells by Addition of Ditertutyl Peroxide as an Additive

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Chinese Physics Letters 2013年第1期30卷 161-164页

作者： li yan-fang yanG li-Ying QIN Wen-Jing YIN Shou-Gen ZHANG Feng-ling Key Laboratory of Display Materials&Photoelectric Devices(Ministry of Education)and School of Materials Science&Engineering Tianjin University of TechnologyTianjin 300384 Tianjin Key Lab for Photoelectric Materials&Devices Tianjin 300384 Biomolecular and Organic Electronics Center of Organic ElectronicsDepartment of PhysicsChemistry and Biology(IFM)Linköping UniversitySE-58183 LinköpingSweden

Improved power conversion efficiency(PCE)and stability of organic bulk heterojunction(BHJ)solar cells based on poly(2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene)(MEH-PPV)and methanofullerene[6,6]-phenyl C_(61)-butyric acid methyl ester(PCBM)blends are obtained by using ditert butyl peroxide(DTBP)as an *** effect of the DTBP contents on the performance of photovoltaic cells is *** results reveal that efficiency enhancement of MEH-PPV:PCBM solar cells can be realized by carefully tuning the contents of *** to the control device,the optimized device with 0.5wt%DTBP additive exhibits enhanced performance with Jsc of(3.51±0.21)mA/cm^(2),FF of(44.45±0.71)%,and PCE of(1.31±0.08)%,increased by 9.3%,8.0%and 22.4%,*** stability of the device is found to be improved by adding 0.5wt%of DTBP.

关键词： PCBM additive Solar