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The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan liu Wei Wu Xuejuan li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing yao Chenlu li Zu-Cheng Ye Daijun Zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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Monitoring of urinary iodine concentration in naval pilots:should iodine be supplemented or limited at coastal stations?

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Military Medical Research 2025年第1期12卷 154-156页

作者： Jia Zeng Qi li Xiang Lu Dan-Dan liu Rong-Guan Jiao yan-Qing Jiang yan-Bing liu Wan-Qing Xu Jun Ma Guo-li Gu Department of Aeronautical Diseases Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China No.92853 Station Troops Hospital of Chinese PLA Huludao 125000LiaoningChina Department of Intensive Care Unit Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China Department III of Internal Medicine Naval Medical CenterNaval Medical University of Chinese PLAShanghai 200052China Department of General Surgery Air Force Medical CenterAir Force Medical University of Chinese PLABeijing 100142China

Dear Editor,In recent years,there has been a significant upward trend in the detection rate of thyroid diseases among military flight personnel[1].Thyroid diseases not only pose a serious threat to the health of flight personnel but also have negative impacts on the aviation safety and combat effectiveness of *** has been confirmed that the occurrence and progression of thyroid diseases are closely linked to dietary iodine *** have manifested that long-term excessive or insufficient iodine intake can lead to thyroid diseases[2,3].

关键词： Naval pilot Thyroid Urinary iodine

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Application of myxovirus resistance protein A in the etiological diagnosis of infections in adults

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World Journal of Emergency Medicine 2025年第1期16卷 35-42页

作者： Tianpeng Hu yan li Shengtao yan lichao Sun Rui lian Jieqiong Yu Jie Chen Xiaoyu liu Guoqiang Zhang Department of Emergency Medicine China-Japan Friendship HospitalBeijing 100029China Graduate School Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND: Inappropriate antibiotic treatment for patients with viral infections has led to a surge in antimicrobial resistance, increasing mortality and healthcare costs. Viral and bacterial infections are often difficult to distinguish. Myxovirus resistance protein A(MxA), an essential antiviral factor induced by interferon after viral infection, holds promise for distinguishing between viral and bacterial infections. This study aimed to determine the ability of Mx A to distinguish viral from bacterial ***: We quantified MxA in 121 infected patients via dry immunofluorescence chromatography. The Kruskal-Wallis test and receiver operating characteristic(ROC) curve analysis were used to determine the diagnostic value of Mx A, either alone or in combination with C-reactive protein(CRP) or procalcitonin(PCT), in patients with viral, bacterial, or ***: The value of MxA(ng/mL) was significantly higher in patients with viral infections than in those with bacterial and co-infections(82.3 [24.5–182.9] vs. 16.4 [10.8–26.5], Plity. MxA expression was low in cytomegalovirus(15.8 [9.6–47.6] ng/mL) and Epstein-Barr virus(12.9 [8.5–21.0] ng/mL) ***: Our study showed the diagnostic efficacy of Mx A in distinguishing between viral and bacterial infections, with further enhancement when it was combined with CRP or PCT. Moreover, EpsteinBarr virus and human cytomegalovirus infections did not elicit elevated Mx A expression.

关键词： Myxovirus resistance protein A Viral infections C-reactive protein Procalcitonin Biomarker

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Mediating role of health literacy in the relationship between social isolation and psychological distress among pre-frail older adults

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World Journal of Psychiatry 2025年第1期15卷 137-144页

作者： Juan Fang li-Hui li Ming-Qian He Yue Ji Dong-yan Lu li-Bing Zhang Jin-Lan yao School of Medicine Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty has become a significant public health *** recent increase in the number of frail older adults has led to increased attention being paid to psycho-logical care services in *** social isolation of pre-frail older adults can impact their psychological *** To explore the mediating effect of health literacy between social isolation and psychological distress among communitydwelling older adults with *** This descriptive cross-sectional study was conducted with 254 pre-frail older individuals aged 60 years and *** isolation,health literacy,and psycholo-gical distress were comprehensively measured using the Lubben Social Network Scale-6,12-item Short-Form Health literacy Questionnaire,and the Kessler Psy-chological Distress *** were evaluated using the SPSS 27.0 package program and the PROCESS macro *** statistical analyses,correlation analyses,and bootstrap mediation tests were used to assess associations between the *** The results showed that social isolation had an effect on health literacy among pre-frail older adults(β=0.240,Pliteracy was identified effect on psychological distress among pre-frail older persons(β=-0.307,Pliteracy partially mediated the relationship between social isolation and psychological distress among community-dwelling older adults with pre-frailty,with a mediation effect of-0.074,accounting for 17.83%of the total effect.

关键词： Frail Ageing Psychological distress Health literacy Social isolation

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DNA walker induced “signal on” fluorescence aptasensor strategy for rapid and sensitive detection of extracellular vesicles in gastric cancer

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Chinese Chemical Letters 2025年第2期36卷 328-331页

作者： Gaojian yang Zhiyang li Rabia Usman Zhu Chen Yuan liu Song li Hui Chen yan Deng Yile Fang Nongyue He State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical Engineering Southeast University Department of Clinical Laboratory the Affiliated Drum Tower Hospital of Nanjing University Medical School Hunan Key Laboratory of Biomedical Nanomaterials and Devices Hunan University of Technology Institute of Cytology and Genetics School of Basic Medical Sciences Hengyang Medical School University of South China Institute for Future Sciences University of South China

The extracellular vesicles show great potential as a noninvasive biomarker for the early detection of cancer. Hence, there is an urgent requirement to create biosensors that are time-saving, simple, and easily scalable in order to accomplish rapid, sensitive, and quantitative detection of extracellular vesicles. In this study, we present a self-propelled DNA walker powered by endonuclease *** CI, which enables the development of a “signal on” sensing platform for the rapid and highly sensitive detection of extracellular vesicles. The DNA motor employed tracks made of streptavidin magnetic beads, which consisted of substrate strands labeled with fluorescein and motor strands locked by aptamers. The aptamer recognition of the target protein on extracellular vesicles unlocked the motor strand, initiating the DNA motor process. After replacing the optimal buffer solution containing the endonuclease *** I, the motor strands autonomously moved along the streptavidin magnetic beads track, continuously releasing fluorescent molecules and producing detectable fluorescence signals. Under optimal conditions, the detection range was from 2×10～4particles/mL to 2×10～9particles/mL, with a detection limit of 2.9×10～3particles/mL,demonstrating excellent selectivity. This method has demonstrated good selectivity in different tumorderived extracellular vesicles and performs well in complex biological samples. The ability to effectively analyze surface proteins of extracellular vesicles in a short period of time gives our DNA walker a tremendous potential for developing simple and cost-effective clinical diagnostic devices.

关键词： Aptamer Detection Extracellular vesicles Nt.BbvCI Streptavidin magnetic beads

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO_(2) in CO_(2)electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong liu Haorun li yan Wang Xiaojun Gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot 010021Inner MongoliaChina State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001ShanxiChina Institute of Catalysis Department of ChemistryZhejiang UniversityHangzhou 310058ZhejiangChina National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030Inner MongoliaChina

Conversion of CO_(2)back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO_(2)nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79%catalytic current density to hydrocarbons(excluding CO),with 49%faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO_(2)utilization.

关键词： Cu/CeO_(2)-x Oxygen vacancy Hydrocarbon production Reaction mechanism

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Synergistic promotion strategy of “dual-site” and “dual-path” to enhance the C–C coupling between CO_(2) and HCHO driven by photoelectrocatalysis

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Journal of Energy Chemistry 2025年第1期100卷 39-49页

作者： Hongqiang yang Jianfeng Zheng Guoyu Wang Yifei Gao Yatao yang Jia li Xiaojin Han yan Cui Zhanggen Huang National Key Laboratory of High Efficiency and Low Carbon Utilization of Coal Institute of Coal ChemistryChinese Academy of ScienceTaiyuan 030001ShanxiChina University of Chinese Academy of Science Beijing 100049China Shenyang University of Chemical Technology Shenyang 110142LiaoningChina

Photoelectrocatalytic coupling CO_(2)and volatile organic compounds (VOCs) is a promising green strategy for the synergistic conversion of the two carbon-containing resources to *** catalytic efficiency is always at the mercy of chemical inertness of CO_(2)and the competitive hydrogen evolution of ***,a modified g-C_(3)N_(4)/ZnAl-LDH Z-scheme heterojunction catalyst with dual reaction site was rationally designed and precisely *** Faraday efficiency of ethanol reached 68.67%with a corresponding formation rate of 227.3μmol g^(-1)h^(-1).As revealed by in-situ characterizations and density functional theory calculations,CO_(2)and HCHO were absorbed at Zn site and N site,***,*CO generated from CO_(2)and HCHO was converted to*CH_(3)O and*CHO on the dual-active-site *** detailed reaction mechanism experiments indicated that C–C coupling only occurred between*CO and*CH_(3)O in electrocatalysis *** from the“*CO+*CH_(3)O”path,another“*CO+*CHO”coupling path was also detected in photoelectrocatalytic *** selectivity of ethanol was significantly enhanced due to the synthesis of dual-site catalyst and the dual-path coupling path between CO_(2)and HCHO simultaneously driven by light and electricity.

关键词： g-C_(3)N_(4)/ZnAl-LDH heterojunction Z-scheme C-C coupling Ethanol

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Gradient nanostructure enabled exceptional fretting fatigue properties of Inconel 718 superalloy through submerged abrasive waterjet peening

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Chinese Journal of Aeronautics 2025年第1期38卷 586-606页

作者： Shulei yao Yuxin CHI Xianhao ZHU Kaiming ZHANG Tiwen LU Kaishang li Ning WANG Chengcheng ZHANG Shuang liU Xiancheng ZHANG Shantung TU Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China AECC Commercial Aircraft Engine Co.LTD Shanghai Engineering Research Center for Commercial Aircraft EngineShanghai 201108China

Submerged Abrasive Waterjet Peening(SAWJP)shows great application potential in augmenting the fatigue properties of metallic ***,the present work aims to investigate the influence of SAWJP on the Surface Integrity(SI)and Fretting Fatigue(FF)properties of Inconel 718(IN718)superalloy and illustrate the microstructural evolution,FF life improvement,and fretting wear ***,the SI of the IN718 specimen was examined following treatment via *** showed that the specimen subjected to SAWJP formed a total plastic deformation layer of 56μ*** maximum microhardness and Compressive Residual Stress(CRS)measured across the depth of the SAWJP-treated specimens exhibited an increase in values ranging between 522 HV and 541 HV and 1171–1380 MPa,*** FF test results of the specimen before and after SAWJP treatment at ambient temperatures indicated that the FF life of the SAWJP-treated specimen surpassed that of the as-received specimen by a factor of *** examination of the FF fracture,contact surface,and crack propagation behavior revealed the crucial factors contributing to the enhanced FF resistance of the IN718 specimen,including the gradient nanostructure characterized by ultra-refined grains,substantial CRS,and elevated microhardness,which were all induced by the SAWJP treatment.

关键词： Submerged abrasive waterjet peening Inconel 718 superalloy Microstructural evolution Surface integrity Fretting fatigue

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Pretreatment with nano-silver extends the post-harvest longevity of gladiolus cut flowers by reducing free water mobility

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Horticultural Plant Journal 2025年第1期11卷 377-388页

作者： Xiumei li Qinjian liu Hongbo li Yuanyuan Chen Zhongjian Chen Shenggen He Jun liu Shijuan yan Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhouGuangdong 510640China College of Agriculture and Biology Zhongkai University of Agriculture and EngineeringGuangzhouGuangdong 510225China

The water content of cut flowers is a significant factor in their post-harvest *** this study,we examine the efficacy of silver nanoparticles(NS)on the longevity of cut gladiolus,with a focus on water state and *** used Low-field nuclear magnetic resonance(LF-NMR)technology to identify three water fractions with different transverse relaxation times(T2)values:bound water T21(lized water T22(10-100 ms),and the slowest component free water T23(>10 ms).During the opening process,T23increased at stages 2 and 3 and then decreased,T22 decreased slowly,and T21 remained *** water values were consistently higher than bound water and immobilized water and reached their maximum from stage 2 until stage 4,when the petals were extended and began to *** vascular bundles responsible for transporting water had higher water content,as detected by proton density-weighted magnetic resonance imaging(MRI).Bound water and free water with NS pretreatments in bracts were initially lower but then two days later the signal amplitude of each water state exceeded those of the control,indicating that the treatment enhanced the water-holding capacity over ***,NS pretreatments reduced the free water mobility of the cut flowers and inhibited stem ***,we found that NS can enter the stem and are primarily transported upward along the xylem with water using scanning electron microscopy(SEM)and energy-dispersive X-ray spectroscopy(EDS)***,our findings indicate that NS pretreatment reduces free water in gladiolus cut flowers,enhancing their water retention and prolonging their vase life.

关键词： Water state Nanoparticles Vase life Nuclear magnetic resonance Cut flowers

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Evaluating the effectiveness of ultrasound-assisted wound debridement in managing diabetic foot ulcers:A systematic review and meta-analysis

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World Journal of Diabetes 2025年第2期16卷 246-256页

作者： Rui yang Geng Chen Qing-Yun Pan yao yao yan-Fen li Hai-Ting Chen Chang-Jiang Lei Xia liang Department of Thoracic and Cardiovascular Surgery The Second Affiliated Hospital of Jianghan University(The Fifth Hospital of Wuhan)Wuhan 430050Hubei ProvinceChina Jianghan University Wuhan 430050Hubei ProvinceChina Department of Endocrinology The Fifth Hospital of WuhanWuhan 430050Hubei ProvinceChina Department of Anorectal Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina Department of Emergency Medical Center Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina Department of Oncology The Second Affiliated Hospital of Jianghan University(The Fifth Hospital of Wuhan)Wuhan 430050Hubei ProvinceChina Department of Nursing Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524001Guangdong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)present a significant clinical challenge due to their high prevalence and profound impact on ***-assisted wound debridement(UAWD)has emerged as a potential therapeutic modality to improve healing outcomes in DFU *** To evaluate the efficacy of UAWD in treating DFUs on wound closure rates,treatment duration,and quality of life *** This systematic review and meta-analysis followed PRISMA guidelines,systematically searching PubMed,Embase,Web of Science,and the Cochrane library with no date *** controlled trials(RCTs)that evaluated the efficacy of UAWD in DFU treatment were *** were independently extracted by two reviewers,with discrepancies resolved through consensus or third-party *** risk of bias was assessed using the Cochrane tool.χ2 and I2 statistics assessed heterogeneity,informing the use of fixed or random-effects models for meta-analysis,supplemented by sensitivity analysis and publication bias assessment through funnel plots and Egger's *** From 1255 articles,seven RCTs met the inclusion *** studies demonstrated that UAWD significantly reduced DFU healing time(standardized mean difference=-0.78,95%CI:-0.97 to-0.60,Pling rates(odds ratio=9.96,95%CI:5.99 to 16.56,Plity of these results,and no significant publication bias was *** UAWD is a promising adjunctive treatment for DFUs,significantly reducing healing times and increasing healing *** findings advocate for the integration of UAWD into standard DFU care protocols.

关键词： Diabetic foot ulcers Ultrasound-assisted wound debridement Healing time Healing rates Meta-analysis

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