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Transcatheter mitral valve implantation using a novel system:preclinical results

Journal of Geriatric Cardiology 2020年第9期17卷 566-573页

作者： Jia-You TANG Lin-he LU yang LIU lan-lan LI yan-yan MA Shi-Qiang YU Jin-Cheng LIU Jian yanG Department of Cardiovascular Surgery the First Affiliated Hospital of Air Force Military Medical UniversityXi’anChina

Background This preclinical study in sheep sought to demonstrate the initial safety and feasibility of a novel transcatheter mitral valve system(Mi-thos valve)composed of a self-expanding frame and a bovine pericardial tissue *** The valve was implanted in 26 sheep using a transapical approach for short-and long-term *** technical feasibility,safety,durability,and valve function were evaluated during and 6 months after the procedure using intracardiac and transthoracic echocardiography,multisliced computed tomography,histological analysis,and electron *** The success rate of valve implantation was 100%,and the immediate survival rate after surgery was 84%.Five animals died within 90 min after the development of the prosthetic valve due to an acute left ventricular outflow tract obstruction(n=2)and sudden intraoperative ventricular fibrillation(n=3).Twelve animals died within 1 month due to acute left heart ***(n=5)and moderate(n=2)paravalvular leakage occurred in seven animals,and two moderate PVL animals died of chronic heart failure within three *** imaging studies of the remaining seven animals showed excellent function and alignment of the valves,with no coronary artery obstruction,no left ventricular outflow tract obstruction,no severe transvalvular gradients and no paravalvular *** evaluation demonstrated stable,secure positioning of the valve,with full endothelialization of the valve leaflets without injury to the ventricular or atrial *** and electron microscopic examinations at six months showed no obvious macro-or microcalcification in the *** Preclinical studies indicate that transcatheter implantation of the Mi-thos valve is technically safe and *** durability,functionality,and lack of leaflet calcification were all verified in animal *** information from these preclinical studies will be applied to patient select

关键词： Mitral regurgitation Mitral valve implantation Preclinical study Transapical Transcatheter

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Topic Modeling Analysis of Chinese Medicine Literature on Potential Treatment

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Chinese Journal of Integrative Medicine 2024年第12期30卷 1128-1136页

作者： QIAN Jia-nan KANG yan-lan he You-cheng HU Hong-yi Department of Gastroenterology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Institute of Digestive Diseases Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Institute of Al and Robotics Academy for Engineering&TechnologyFudan UniversityShanghai 200433China Clinical Research Center Longhua HospitalShanghai 200032China

Objective:To analyze Chinese medicine(CM)prescriptions for gastroesophageal reflux disease(GERD),we model topics on GERD-related classical CM literature,providing insights into the potential ***:Clinical guidelines were used to identify symptom terms for GERD,and CM literature from the database"Imedbooks"was retrieved for related prescriptions and their corresponding sources,indications,and other *** was applied to identify the main topics and visualize the ***:A total of 36,207entries are queried and 1,938 valid entries were acquired after manually *** topics were identified by BERTopic,including digestion function abate,stomach flu,respiratory-related symptoms,gastric dysfunction,regurgitation and gastrointestinal dysfunction in pediatric patients,vomiting,stroke and alcohol accumulation are associated with the risk of GERD,vomiting and its causes,regurgitation,epigastric pain,and symptoms of ***:Topic modeling provides an unbiased analysis of classical CM literature on GERD in a time-efficient and scale-efficient *** on this analysis,we present a range of treatment options for relieving symptoms,including herbal remedies and non-pharmacological interventions such as acupuncture and dietary therapy.

关键词： gastroesophageal reflux disease BERTopic prescription topic modeling Chinese medicine

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系统性红斑狼疮成年女性患者月经及相关情况变化

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中国妇幼健康研究 2016年第10期27卷 1201-1203页

作者：李欣王香丽张乐石燕杰何岚王明旭西安交通大学第一附属医院风湿免疫科陕西西安710061 西安交通大学第一附属医院产科陕西西安710061 西安交通大学医学部公共卫生学院陕西西安710061

目的探讨系统性红斑狼疮（SLE）成年女性患者月经及相关情况的变化。方法选取2015年11月至2016年4月西安交通大学第一附属医院风湿免疫科收住入院的72例SLE成年女性患者,选取同期来自本院体检中心60例健康成年女性作为对照,比较SLE患者... 详细信息

目的探讨系统性红斑狼疮（SLE）成年女性患者月经及相关情况的变化。方法选取2015年11月至2016年4月西安交通大学第一附属医院风湿免疫科收住入院的72例SLE成年女性患者,选取同期来自本院体检中心60例健康成年女性作为对照,比较SLE患者与健康对照者月经、绝经、生育史等情况,评估SLE疾病活动指数及糖皮质激素治疗剂量对女性月经情况的影响。结果在入选的72例SLE成年女性患者中,75.00%（54/72）出现月经异常,SLE患者中绝经年龄较健康对照者提前（t=3.477,P〈0.05）。已婚的SLE患者中流产或异常产比例高于健康对照者（χ^2=6.610,P〈0.05）。与无月经异常表现的SLE患者相比,有月经异常表现的SLE患者的疾病活动性指数（SLEDAI）评分相对较高（t=2.451,P〈0.05）、糖皮质激素服用剂量（mg/d）相对较大（t=2.086,P〈0.05）,在SLE发病年龄、病程、初潮年龄、体重指数方面无差异（t值分别为0.418、1.692、1.622、0.289,均P〉0.05）。结论 SLE患者中月经异常、流产或异常产比例较高,绝经年龄提前,有月经异常的SLE患者病情活动度相对高,服用糖皮质激素的平均剂量较大,医护人员需关注SLE患者的月经及相关情况的变化,对SLE患者提供更适宜的治疗方案和护理措施,提高SLE成年女性患者的生活质量。

关键词：系统性红斑狼疮月经绝经流产或异常产史疾病活动性指数

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Fabrication of Ni–Mo–Nb metallic glass/micro-nano lattice composite for nonenzymatic glucose sensing

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Progress in Natural Science:Materials International 2023年第5期33卷 601-606页

作者： Sihan Zhang Wentao Zhang Yu Lou Zixin Rui Zhongzheng Yao Ao yan lan Tan Sinan Liu Jiacheng Ge he Zhu Si lan herbert Gleiter Institute of Nanoscience School of Materials Science and Engineering Nanjing University of Science and Technology School of Materials Science and Engineering Henan University of Technology Center for Neutron Scattering City University of Hong Kong Shenzhen Research Institute

The rising global diabetic population has ignited significant interest in enzyme-free electrochemical glucose ***,their widespread usage has been severely impeded by the lack of sensing probes with both high sensitivity and *** this work,we present a novel approach for conformally depositing a Ni-Mo-Nb metallic-glass film onto a three-dimensional printed polymer skeleton for glucose *** printing template is designed based on a six-membered tricapped trigonal prism(6M-TTP) structure,which is derived from a medium-range order structure motif observed in amorphous *** fabricated composite combines the high electrochemical activity of Ni-Mo-Nb amorphous alloy with the stability afforded by the micro-nano lattice structure,resulting in a high sensitivity(482 μA mM-1cm-2),a wide linear range(0-1 mM and 1-5 mM),a low detection limit(2.94 μM),and good long-term stability and selectivity in alkaline *** work has proposed a new avenue to fabricate complex micro-nano electrodes,potentially offering significant versatility and great promise for widespread applications in the field of electrochemistry.

关键词： Glucose

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Existence of Pseudo-Almost Automorphic Solutions for Nonlinear Differential Equations

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Acta Mathematicae Applicatae Sinica 2014年第4期30卷 977-988页

作者： lan LI yan WANG College of Mathematics and Computational Science Shenzhen University School of Mathematical Sciences Dalian University of Technology

In this paper, we discuss the existence of pseudo-almost automorphic solutions to linear differential equation which has an exponential trichotomy~ and the results also hold for some nonlinear equations with the form x＇（t） = f（t,x（t））＋ λg（t,x（t））, where f,g are pseudo-almost automorphic functions. We prove our main result by the application of Leray-Schauder fixed point theorem.

关键词： Pseudo-almost automorphic exponential trichotomy Leray-Schauder fixed point theorem

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Wind-Induced Vibration Control for Substation Frame on Viscous Damper

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Computers, Materials & Continua 2020年第3期62卷 1303-1315页

作者： Bingji lan Kanghao yan North China University of Water Resources and Electric Power Zhengzhou450045China

In order to study the wind-induced vibration control effect of the viscous damper on the large-scale substation frame,this paper takes the large-scale 1000 kV substation frame of western Inner Mongolia as an *** time-history sample of pulsating wind load is simulated by harmonic superposition method based on Matlab software.6 kinds of viscous damper arrangement schemes have been designed,and SAP2000 finite element software is used for fine modeling and input wind speed time history load for nonlinear time history *** displacement and acceleration of a typical node are the indicators of wind vibration *** wind-induced vibration control effects of different schemes under different damping parameters have compared,and the damping parameters are analyzed for the optimal layout *** results show that a viscous damper has installed in the lower layers of the substation;a viscous damper is placed between the ground column and the lattice *** is an integrated optimal *** wind-induced vibration control effect of the optimal scheme is sensitive to the viscous damper parameters,and the control effect does not increase linearly with the increase of the damping index and the damping *** to different damping indexes,the damping coefficient has a better range of values.

关键词： Viscous damper wind-induced vibration control arrangement plan damping coefficient damping index

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Orthonormal Bases Associated with Multi-knot Piecewise Linear Function Sequences on[0,1)~n

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Acta Mathematica Sinica,English Series 2009年第11期25卷 1835-1848页

作者： Yu lan LI Dun yan yan Shanghai High School No. 989 Shanghai 200231 P. R. China School of Information Science and Engineering Graduate University of Chinese Academy of Sciences Beijing 100190 P. R. China

We investigate two classes of orthonormal bases for L^2（[0, 1）^n）. The exponential parts of those bases are multi-knot piecewise linear functions which are called spectral sequences. We characterize the multi-knot piecewise linear spectral sequences and give an application of the first class of piecewise linear spectral sequences.

关键词： spectral sequences orthonormal basis Fourier basis

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Radiomics-based predictive risk score: A scoring system for preoperatively predicting risk of lymph node metastasis in patients with resectable non-small cell lung cancer

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Chinese Journal of Cancer Research 2019年第4期31卷 641-652页

作者： lan he yanqi Huang Lixu yan Junhui Zheng Changhong Liang Zaiyi Liu Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Pathology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Objective: To develop and validate a radiomics-based predictive risk score(RPRS) for preoperative prediction of lymph node(LN) metastasis in patients with resectable non-small cell lung cancer(NSCLC).Methods: We retrospectively analyzed 717 who underwent surgical resection for primary NSCLC with systematic mediastinal lymphadenectomy from October 2007 to July 2016. By using the method of radiomics analysis, 591 computed tomography(CT)-based radiomics features were extracted, and the radiomics-based classifier was constructed. Then, using multivariable logistic regression analysis, a weighted score RPRS was derived to identify LN metastasis. Apparent prediction performance of RPRS was assessed with its calibration,discrimination, and clinical ***: The radiomics-based classifier was constructed, which consisted of 13 selected radiomics *** models demonstrated that radiomics-based classifier, age group, tumor diameter, tumor location, and CT-based LN status were independent predictors. When we assigned the corresponding score to each variable,patients with RPRSs of 0-3, 4-5, 6, 7-8, and 9 had distinctly very low(0%-20%), low(21%-40%), intermediate(41%-60%), high(61%-80%), and very high(81%-100%) risks of LN involvement, respectively. The developed RPRS showed good discrimination and satisfactory calibration (C-index: 0.785, 95% confidence interval(95% CI):0.780-0.790)Additionally, RPRS outperformed the clinicopathologic-based characteristics model with net reclassification index(NRI) of 0.711(95% CI: 0.555-0.867).Conclusions: The novel clinical scoring system developed as RPRS can serve as an easy-to-use tool to facilitate the preoperatively individualized prediction of LN metastasis in patients with resectable NSCLC. This stratification of patients according to their LN status may provide a basis for individualized treatment.

关键词： Lymph node radiomics risk score CT non-small cell lung cancer

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Molecular Cloning and Characterization of a New Cold-active Extradiol Dioxygenase from a Metagenomic Library Derived from Polychlorinated Biphenyl-contaminated Soil

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Chemical Research in Chinese Universities 2012年第4期28卷 666-671页

作者： REN he-jun LU yang ZHOU Rui DAI Chun-yan WANG Yah ZHANG lan-ying Key Laboratory of Groudwater Resources and Environment Ministry of EducationCollege of Environment and ResourcesJilin UniversityChangehun 130021P.R.China Jilin Academy of Agricultural Sciences Changehun 130033P.R.China Institute of Virology and AIDS Research the First Hospital of Jilin UniversityChangchun 130061P.R.China

To find new extradiol dioxygenases（EDOs,EC 1.***.11.2）,a metagenomics library was constructed from polychlorinated biphenyl-contaminated soil and was screened for some dioxygenase with aromatic ring cleavage activity.A novel EDO,designated as BphC_A,was identified and heterologously expressed in Escherichia *** deduced amino acid sequence of BphC_A exhibited a homology of less than 60% with other known *** analysis of BphC_A suggests that the protein is a novel member of the EDO *** enzyme exhibits higher substrate affinity and catalytic efficiency toward 3-methylcatechol than toward 2,3-dihydroxybiphenyl or catechol,the preferred substrate of other known *** optimum activity of purified BphC_A occurred at pH=8.5 and 35 °C,and BphC_A showed more than 40% of its initial activity at 5 °*** activity of purified BphC_A was significantly induced by Mn^2＋ and slightly reduced by Al^3＋,Cu^2＋ and Zn^2＋.

关键词： Extradiol dioxygenase Metagenome Cold-active enzyme Gene cloning Functional characterization

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Enantioselective Addition of Diethylzinc to Benzaldehyde by Catalysts of Chiral heterocyclic Ligands

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Chinese Chemical Letters 1999年第9期10卷 717-718页

作者： yan he Yue lan LI Ye Di GUAN(Department of Chemistry, Peking University, Beijing 100871) Peking Univ Dept Chem Beijing 100871 Peoples R China

Several kinds of chiral heterocyclic ligands without hydroxyl group have been synthesized and used as catalysts for the asymmetric addition of diethylzinc to benzaldehyde. These ligands promoted the formation of (S)-1... 详细信息

关键词： chiral heterocyclic ligands hydroxyl group asymmetric catalysis enantioselectivity

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